ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

801–820 of 2,784 studies

E2 ModerateCohortPEM unclearCross-Sectional

Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Almenar-Pérez, Eloy, Sarría, Leonor, Nathanson, Lubov et al.·Scientific reports·2020

This study looked for biological markers (tiny genetic molecules called microRNAs) in blood samples from severely ill ME/CFS patients that could help doctors diagnose the disease. Researchers found that certain microRNAs and physical characteristics of particles in the blood appeared different in ME/CFS patients compared to healthy controls. If validated in larger studies, these findings could eventually lead to a simple blood test for diagnosis.

BiomarkersImmune System

E2 ModerateCohortPEM unclearCross-Sectional

Paradigm shift to disequilibrium in the genesis of orthostatic intolerance in patients with myalgic encephalomyelitis and chronic fatigue syndrome.

Miwa, Kunihisa, Inoue, Yukichi·International Journal of Cardiology. Hypertension·2020

This study looked at why people with ME/CFS struggle to stand up without feeling dizzy or unsteady. Researchers tested 72 patients and found that balance problems while standing (disequilibrium) were much more common in those who couldn't complete a 10-minute standing test than previously thought. The study suggests that poor balance, rather than just heart rate problems, may be a main reason why standing is so difficult for many ME/CFS patients.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Maximal handgrip strength can predict maximal physical performance in patients with chronic fatigue.

Jammes, Yves, Stavris, Chloé, Charpin, Caroline et al.·Clinical biomechanics (Bristol, Avon)·2020

Researchers tested whether hand grip strength could predict how well patients with ME/CFS could exercise on a stationary bike. They found that patients with stronger hand grip were able to exercise harder and use more oxygen. This suggests that a simple hand grip test might help doctors understand a patient's exercise capacity without needing expensive equipment.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredObservational

Feedback on underperformance in patients with Chronic Fatigue Syndrome: The impact on subsequent neuropsychological test performance.

Roor, Jeroen J, Knoop, Hans, Dandachi-FitzGerald, Brechje et al.·Applied neuropsychology. Adult·2020

This study looked at whether telling ME/CFS patients about their poor performance on memory tests could help them do better on brain function tests afterward. Researchers gave one group of patients feedback about underperformance while another group got no feedback. The group that received feedback showed meaningful improvement in processing speed (how quickly the brain handles information), suggesting that simple feedback might help doctors get a more accurate picture of a patient's actual cognitive abilities.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Assessing functioning in adolescents with chronic fatigue syndrome: psychometric properties and factor structure of the School and Social Adjustment Scale and the Physical Functioning Subscale of the SF36.

Loades, M E, Vitoratou, S, Rimes, K A et al.·Behavioural and cognitive psychotherapy·2020

This study tested two short questionnaires to measure how much ME/CFS affects young people's daily activities—both at school and socially, and their physical abilities. The researchers found that both questionnaires work well, are reliable, and accurately capture the impact of the illness. These tools could help doctors and researchers better track how adolescents with ME/CFS are functioning over time.

E2 ModerateCohortPEM unclearObservational

Paediatric patients with myalgic encephalomyelitis/chronic fatigue syndrome value understanding and help to move on with their lives.

Rowe, Katherine·Acta paediatrica (Oslo, Norway : 1992)·2020

This study followed 784 young people (ages 6-18) with ME/CFS over 14 years at a specialized clinic in Melbourne. The patients received help with symptom management and personalized lifestyle plans adjusted to their severity of illness and individual circumstances. Most patients who responded said the management approach helped them regain control of their lives and stay socially connected and engaged in school.

E2 ModerateCohortPEM not requiredCross-Sectional

The presence of overlapping quality of life symptoms in primary antibody deficiency (PAD) and chronic fatigue syndrome (CFS).

Bansal, Rhea A, Tadros, Susan, Bansal, Amolak S·Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2020

This study looked at whether people with primary antibody deficiency (PAD)—a condition where the immune system doesn't make enough protective proteins—also experience ME/CFS-like symptoms. Researchers sent questionnaires to over 680 PAD patients and found that about 16% of those who responded had symptoms matching ME/CFS criteria, which is much higher than the general population. The study also found that sleep problems, fatigue, anxiety, and low mood were very common in PAD patients.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Clinically accessible tools for documenting the impact of orthostatic intolerance on symptoms and function in ME/CFS.

Lee, Jihyun, Wall, Pelle, Kimler, Chris et al.·Work (Reading, Mass.)·2020

This study looked at how much time ME/CFS patients can spend upright (standing or walking around) each day and how this relates to dizziness and other symptoms caused by orthostatic intolerance—a condition where symptoms get worse when standing or being active. Researchers compared 25 women with ME/CFS to 25 healthy women and found that ME/CFS patients spend far fewer hours upright and experience much worse symptoms that interfere with daily life. The study suggests that measuring upright hours and asking patients about orthostatic symptoms could be helpful tools for doctors diagnosing and managing ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Confirmatory factor analysis of a myalgic encephalomyelitis and chronic fatigue syndrome stigma scale.

Terman, Julia M, Awsumb, Jessica M, Cotler, Joseph et al.·Journal of health psychology·2020

This study measured how much stigma (negative judgments and social shame) people with ME/CFS experience. Over 550 people with ME/CFS from around the world filled out a survey designed to assess stigma, feelings of isolation, and concerns about disclosing their illness. The researchers found that people with ME/CFS reported high levels of stigma and struggled with whether to tell others about their condition.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Associations of occupational stress, workplace violence, and organizational support on chronic fatigue syndrome among nurses.

Li, Mengyao, Shu, Qianyi, Huang, Hao et al.·Journal of advanced nursing·2020

This study examined whether workplace stress, violence, and lack of organizational support increase the risk of ME/CFS in nurses. Researchers surveyed 1,080 Chinese nurses and found that those experiencing high levels of overcommitment, workplace violence, and little support from their employers were significantly more likely to have ME/CFS. The findings suggest that improving workplace safety, support, and reducing internal stress could help prevent ME/CFS in this high-risk group.

SleepCognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy.

Mueller, Christina, Lin, Joanne C, Sheriff, Sulaiman et al.·Brain imaging and behavior·2020

Researchers used advanced brain imaging to measure chemical substances in the brains of ME/CFS patients and compared them to healthy people. They found several differences in brain chemistry and temperature in ME/CFS patients, particularly in areas involved in processing pain and regulating energy. These changes suggest that inflammation in the brain may contribute to ME/CFS symptoms.

Neuroinflammation

E2 ModerateCohortPEM not requiredObservational

Evaluation of Fatigue in Cancer Patients in An Area Affected by The Great East Japan Earthquake.

Sato, Daisuke·Asia-Pacific journal of oncology nursing·2020

This study looked at fatigue in cancer patients receiving chemotherapy who lived in an area affected by a major earthquake in Japan. Researchers measured both what patients reported about their tiredness and objective measurements of nervous system function and activity levels. The main finding was that patients showed changes in how their nervous system was functioning, with their stress-response system becoming more dominant over time.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Physical activity measures in patients with myalgic encephalomyelitis/chronic fatigue syndrome: correlations between peak oxygen consumption, the physical functioning scale of the SF-36 questionnaire, and the number of steps from an activity meter.

van Campen, C M C, Rowe, Peter C, Verheugt, Freek W A et al.·Journal of translational medicine·2020

This study compared three different ways to measure physical activity in ME/CFS patients: a questionnaire about daily functioning, a step counter worn during normal activities, and a fitness test measuring oxygen use during exercise. All three methods showed similar patterns—patients with lower scores on one test also tended to have lower scores on the others—but individual patients showed wide variations between the different measurements.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Patterns of daytime physical activity in patients with chronic fatigue syndrome.

King, E, Beynon, M, Chalder, T et al.·Journal of psychosomatic research·2020

Researchers studied how 579 ME/CFS patients moved and exercised during their daily lives using activity monitors. They found that patients fell into four different activity patterns: some stayed quite inactive, some stayed fairly active, some had a 'boom and bust' pattern (very active then very inactive), and some had mixed patterns. Each group showed different health characteristics—inactive patients had more physical disability, active patients had more anxiety, and boom-and-bust patients had more sleep problems.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Patients with ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) and chronic pain report similar level of sickness behavior as individuals injected with bacterial endotoxin at peak inflammation.

Jonsjö, Martin A, Åström, Jenny, Jones, Michael P et al.·Brain, behavior, & immunity - health·2020

This study compared how 'sick' people with ME/CFS and chronic pain feel compared to other groups. Researchers found that ME/CFS and chronic pain patients reported feeling as sick as healthy people who were given a bacterial toxin to trigger temporary inflammation. These high levels of sickness feelings were similar across both conditions and higher than what primary care patients reported, suggesting that the persistent sickness sensation in ME/CFS and chronic pain may involve similar biological mechanisms related to inflammation and how the brain processes illness signals.

Immune System

E2 ModerateCohortPEM requiredCross-Sectional

A hierarchical logistic regression predicting rapid respiratory rates from post-exertional malaise.

Cotler, Joseph, Katz, Ben Z, Reurts-Post, Corine et al.·Fatigue : biomedicine, health & behavior·2020

This study looked at whether faster breathing rates could be a sign of post-exertional malaise (PEM)—the worsening of symptoms that many ME/CFS patients experience after activity. Researchers measured breathing rates in 216 ME/CFS patients over two days and compared them to information about PEM and other symptoms. They found that patients with more severe PEM tended to have faster resting breathing rates, while depression, anxiety, and activity level did not explain the faster breathing.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

The Prevalence of Pediatric Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a Community‑Based Sample.

Jason, Leonard A, Katz, Ben Z, Sunnquist, Madison et al.·Child & youth care forum·2020

Researchers studied over 10,000 children and teenagers in the Chicago area to find out how many have ME/CFS. They found that about 0.75% (roughly 1 in 133) young people have the condition, with higher rates among African American and Latino youth. Importantly, less than 5% of these children had been diagnosed before the study, meaning many young people with ME/CFS are going unrecognized by doctors.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Multi-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome.

Raijmakers, Ruud P H, Roerink, Megan E, Jansen, Anne F M et al.·Journal of translational medicine·2020

This study compared people with Q fever fatigue syndrome (a prolonged tiredness that develops after a Q fever infection) to people with ME/CFS and healthy controls. Researchers examined three types of biological markers: gut bacteria, blood chemicals, and inflammatory proteins. They found that people with Q fever fatigue syndrome have very similar patterns to ME/CFS patients, suggesting these two conditions may share similar underlying biological mechanisms.

Energy MetabolismImmune System

E2 ModerateCohortPEM unclearCross-Sectional

Predicting GP visits: A multinomial logistic regression investigating GP visits amongst a cohort of UK patients living with Myalgic encephalomyelitis.

Walsh, R Stephen, Denovan, Andrew, Drinkwater, Kenneth et al.·BMC family practice·2020

This study looked at how often people with ME visit their GP and what factors affect these visits. Researchers surveyed 476 ME patients across the UK and found that several things—including how long someone has had ME, where they live, whether they trust their GP, how quickly they got diagnosed, and their gender—all predict how many GP visits they make each year. The study highlights that the relationship between ME patients and their doctors is really important for getting good care.

E2 ModerateCohortPEM not requiredCase-Control

Cortisol levels in chronic fatigue syndrome and atypical depression measured using hair and saliva specimens.

Herane-Vives, Andres, Papadopoulos, Andrew, de Angel, Valeria et al.·Journal of affective disorders·2020

This study compared stress hormone (cortisol) levels in people with ME/CFS and people with a specific type of depression called atypical depression, both with and without fatigue. Researchers measured cortisol in two ways: through hair samples (showing levels over 3 months) and saliva samples (showing daily patterns). Both ME/CFS and atypical depression groups had lower daily cortisol output than healthy people, but normal cortisol levels when measured over longer periods, suggesting the low levels might be temporary or related to how the body's rhythm changes.

Endocrine Disruption

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Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Paradigm shift to disequilibrium in the genesis of orthostatic intolerance in patients with myalgic encephalomyelitis and chronic fatigue syndrome.

Maximal handgrip strength can predict maximal physical performance in patients with chronic fatigue.

Feedback on underperformance in patients with Chronic Fatigue Syndrome: The impact on subsequent neuropsychological test performance.

Assessing functioning in adolescents with chronic fatigue syndrome: psychometric properties and factor structure of the School and Social Adjustment Scale and the Physical Functioning Subscale of the SF36.

Paediatric patients with myalgic encephalomyelitis/chronic fatigue syndrome value understanding and help to move on with their lives.

The presence of overlapping quality of life symptoms in primary antibody deficiency (PAD) and chronic fatigue syndrome (CFS).

Clinically accessible tools for documenting the impact of orthostatic intolerance on symptoms and function in ME/CFS.

Confirmatory factor analysis of a myalgic encephalomyelitis and chronic fatigue syndrome stigma scale.

Associations of occupational stress, workplace violence, and organizational support on chronic fatigue syndrome among nurses.

Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy.

Evaluation of Fatigue in Cancer Patients in An Area Affected by The Great East Japan Earthquake.

Physical activity measures in patients with myalgic encephalomyelitis/chronic fatigue syndrome: correlations between peak oxygen consumption, the physical functioning scale of the SF-36 questionnaire, and the number of steps from an activity meter.

Patterns of daytime physical activity in patients with chronic fatigue syndrome.

Patients with ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) and chronic pain report similar level of sickness behavior as individuals injected with bacterial endotoxin at peak inflammation.

A hierarchical logistic regression predicting rapid respiratory rates from post-exertional malaise.

The Prevalence of Pediatric Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a Community‑Based Sample.

Multi-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome.

Predicting GP visits: A multinomial logistic regression investigating GP visits amongst a cohort of UK patients living with Myalgic encephalomyelitis.

Cortisol levels in chronic fatigue syndrome and atypical depression measured using hair and saliva specimens.

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