ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1141–1160 of 2,422 studies

E3 PreliminaryBehavioralPEM not requiredCase-Control

A case of chronic fatigue syndrome improved by traditional Korean medicine.

Son, Chang-Gue·Integrative medicine research·2013

This report describes one woman with ME/CFS who experienced significant improvement in her fatigue after receiving traditional Korean medicine treatments, including herbal medicine, acupuncture, and moxibustion over three months. Her fatigue severity scores were cut roughly in half during treatment. While this single case suggests these treatments may help some people, it does not prove they work for everyone with ME/CFS.

E3 PreliminaryMechanismPEM unclearMechanistic

Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins.

De Meirleir, Kenny L, Khaiboullina, Svetlana F, Frémont, Marc et al.·In vivo (Athens, Greece)·2013

Researchers found that a specific type of immune cell in the gut (called plasmacytoid dendritic cells) reacts to remnants of ancient viral DNA in 8 out of 12 ME/CFS patients, but not in healthy controls. These cells appear to be displaying signs of viral proteins on their surface, which suggests the gut may be involved in triggering immune problems seen in ME/CFS.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome.

Ocon, Anthony J·Frontiers in physiology·2013

ME/CFS causes cognitive difficulties that patients often describe as "brain fog"—a feeling of foggy thinking, slow mental processing, and trouble concentrating. This review suggests brain fog may result from reduced blood flow to the brain combined with the physical stress of standing (which worsens symptoms in many patients), plus the extra mental effort required to complete tasks. Understanding these overlapping factors could help explain why cognitive symptoms feel so exhausting.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryCohortPEM unclearObservational

Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit.

Myhill, Sarah, Booth, Norman E, McLaren-Howard, John·International journal of clinical and experimental medicine·2013

This study looked at 138 ME/CFS patients and found that all of them had problems with their mitochondria—the parts of cells that produce energy. Patients received personalized treatment based on diet, sleep, supplements, and rest-activity balance, adjusted according to their specific mitochondrial problems. Those who followed the full treatment plan improved their mitochondrial function by about four times on average.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurocardiogenic syncope and associated conditions: insight into autonomic nervous system dysfunction.

Kossaify, Antoine, Kallab, Kamal·Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir·2013

This study examines why people faint or feel faint due to problems with their autonomic nervous system—the part of your nervous system that controls heart rate, blood pressure, and breathing automatically. The authors review how fainting episodes are connected to several conditions that ME/CFS patients often experience, including migraines, dizziness upon standing, rapid heartbeat with position changes, and chronic fatigue syndrome. They discuss how autonomic dysfunction may explain these related conditions.

Autonomic Nervous System

E3 PreliminaryReviewPEM requiredReview-Narrative

A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome.

Morris, Gerwyn, Maes, Michael·Metabolic brain disease·2013

This study proposes a theory about how ME/CFS develops and persists. The researchers suggest that an initial infection triggers the immune system, which then gets stuck in an overactive state even after the infection is cleared. This causes ongoing inflammation, energy problems in cells, and damage to the nervous system, leading to the characteristic symptoms including post-exertional malaise (feeling worse after activity).

NeuroinflammationAutonomic Nervous SystemImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fatigue syndromes--an overview of terminology, definitions and classificatory concepts].

Dörr, Johanna, Nater, Urs·Psychotherapie, Psychosomatik, medizinische Psychologie·2013

This article reviews how doctors classify and differentiate between different fatigue conditions, including ME/CFS, burnout, and an older condition called neurasthenia. The authors found that while these conditions share some symptoms, they have important differences—but there currently isn't enough research to clearly separate them. Depression often occurs alongside ME/CFS and burnout, making diagnosis more complicated.

Diagnostics

E3 PreliminaryPEM not required

[Neurasthenia in Norway 1880-1920].

Lillestøl, Kristine, Bondevik, Hilde·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2013

This study looked at historical medical records from Norway between 1880 and 1920 to understand how doctors understood and treated a condition called neurasthenia, which many believe was similar to today's ME/CFS. Doctors at that time described it as a weakness of the nervous system with exhaustion as the main symptom, though they couldn't find any physical cause. Treatment focused on rest and electrical therapy to strengthen the nerves.

E3 PreliminaryBehavioralPEM unclear

[Moxibustion at Yongquan (KI 1) for sleep disorders of chronic fatigue syndrome].

Chen, Xiao-Qin, Gang, Zhi-Xiu, Xu, Zhi-Peng·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2013

This study explored whether moxibustion—a traditional Chinese medicine technique involving burning herbs near the skin—might help improve sleep problems in people with ME/CFS. The treatment focused on a specific acupuncture point on the sole of the foot called Yongquan (KI 1). While the study suggests this approach may have helped some patients sleep better, the research quality is limited and more rigorous testing is needed.

Sleep

E3 PreliminaryPEM not requiredRegistry-Resource

A pilot registry of unexplained fatiguing illnesses and chronic fatigue syndrome.

Brimmer, Dana J, Maloney, Elizabeth, Devlin, Rebecca et al.·BMC research notes·2013

This study tested whether doctors and patient groups could help identify people with ME/CFS for a patient registry (a database of medical information). Researchers in Georgia contacted healthcare providers and a local ME/CFS support group to refer patients for evaluation. Of 104 people who completed clinic visits, 36% had ME/CFS, 17% had fatigue that didn't quite meet ME/CFS criteria, and 47% had other medical or psychiatric conditions instead. This shows that many people with fatigue symptoms may have treatable conditions other than ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Energy Conservation/Envelope Theory Interventions to Help Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Jason, Leonard A, Brown, Molly, Brown, Abigail et al.·Fatigue : biomedicine, health & behavior·2013

This study reviewed research on the Energy Envelope approach, a self-management strategy that helps ME/CFS patients track and limit their daily activities to stay within their available energy level. Rather than pushing through exhaustion, patients learn to pace themselves carefully to avoid crashes. Research shows this approach can reduce symptom flare-ups and improve quality of life for people with ME/CFS.

Post-Exertional Malaise

E3 PreliminaryBehavioralPEM not requiredMechanistic

Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation.

Shreevathsa, M, Ravishankar, B, Dwivedi, Rambabu·Ayu·2013

Researchers tested an Ayurvedic herbal mixture called Mamsyadi Kwatha to see if it could help with depression and fatigue-like symptoms in mice. The mixture contains three plant ingredients and showed some ability to reduce signs of depression and fatigue in animal tests, suggesting it might have antidepressant properties.

E3 PreliminaryMechanismPEM not requiredMechanistic

Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine.

Tokizane, Kyohei, Konishi, Hiroyuki, Yasui, Masaya et al.·Molecular and cellular endocrinology·2013

When the body experiences prolonged stress, it can affect how the pituitary gland (a small gland in the brain that controls many hormones) works. In this rat study, researchers found that stress caused increased production of a protein called VGF in certain pituitary cells. Interestingly, this increase happened because stress reduced levels of dopamine, a chemical messenger that normally keeps VGF levels low.

Endocrine Disruption

E3 PreliminaryReviewPEM requiredReview-Narrative

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics.

Morris, Gerwyn, Maes, Michael·BMC medicine·2013

This review compares ME/CFS with multiple sclerosis (MS), another recognized neurological disease, and found striking similarities between them. Both conditions cause severe fatigue that worsens with exercise, autonomic problems (like dizziness and heart rate issues), and involve similar patterns of immune system activation and mitochondrial dysfunction (problems with how cells produce energy). The study suggests ME/CFS should be recognized as a genuine neuroimmune illness, similar to MS.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

α-1 antitrypsin and chronic fatigue syndrome: a case study from pathophysiology to clinical practice.

Alegre, José, Camprubí, Sandra, García-Quintana, Ana·Pain management·2013

Researchers tested whether a protein called alpha-1 antitrypsin (AAT), which naturally reduces inflammation in the body, could help a woman with ME/CFS. She received weekly intravenous infusions for 8 weeks. After treatment, she showed improvements in how much physical work she could do, her memory, and thinking skills, and her inflammatory markers normalized. She was eventually able to return to part-time work.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Molecular mechanisms underpinning laser printer and photocopier induced symptoms, including chronic fatigue syndrome and respiratory tract hyperresponsiveness: pharmacological treatment with cinnamon and hydrogen.

Lucas, Kurt, Maes, Michael·Neuro endocrinology letters·2013

This review examines how emissions from laser printers and photocopiers might trigger symptoms in sensitive people, including fatigue, breathing problems, and chronic fatigue syndrome (CFS). The study suggests that particles and chemicals released during printing can trigger inflammation and oxidative stress in the body. The authors propose that two substances—cinnamon and hydrogen—might help reduce these symptoms by reducing inflammation.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurocognitive impairment in childhood chronic fatigue syndrome.

Mizuno, Kei, Watanabe, Yasuyoshi·Frontiers in physiology·2013

This study examined how ME/CFS affects thinking and attention skills in children and teenagers. Researchers found that young people with ME/CFS have difficulty with tasks that require switching between activities or paying attention to multiple things at once. The brain regions responsible for these skills are still developing during childhood, and severe fatigue may slow down or disrupt this normal development.

Cognitive Impairment

E3 PreliminaryCommentaryPEM unclearEditorial

New developments in the diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome.

Pontari, Michel, Giusto, Laura·Current opinion in urology·2013

This article discusses how chronic prostatitis and chronic pelvic pain syndrome in men can present differently—some men have pain localized to the pelvic area, while others experience widespread body symptoms similar to other chronic conditions. The authors review new treatment options including physical therapy, acupuncture, psychological support, and medications, and note that these conditions often occur alongside other chronic pain disorders like fibromyalgia and chronic fatigue syndrome.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome in the UK armed forces.

Le Blackadder-Coward, J C Q, Perry, S·Journal of the Royal Naval Medical Service·2013

This study examined how ME/CFS (also called CFS) affects people serving in the UK military, and how the condition should be recognized and managed in this specific setting. ME/CFS can significantly impact a service member's career and ability to work in challenging military environments. The article discusses how doctors can better identify and treat this condition in military personnel.

Diagnostics

E3 PreliminaryCohortPEM not requiredCross-Sectional

Role of reactive oxygen species and antioxidants in atopic dermatitis.

Sivaranjani, N, Rao, S Venkata, Rajeev, G·Journal of clinical and diagnostic research : JCDR·2013

This study looked at whether skin damage from harmful molecules called reactive oxygen species plays a role in atopic dermatitis (eczema). Researchers compared 25 people with atopic dermatitis to 25 healthy people and measured levels of damaging molecules and protective antioxidants in their bodies. They found that people with eczema had more damage and lower levels of natural protective substances, suggesting that antioxidants might help treat the condition.

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A case of chronic fatigue syndrome improved by traditional Korean medicine.

Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins.

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome.

Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit.

Neurocardiogenic syncope and associated conditions: insight into autonomic nervous system dysfunction.

A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome.

[Fatigue syndromes--an overview of terminology, definitions and classificatory concepts].

[Neurasthenia in Norway 1880-1920].

[Moxibustion at Yongquan (KI 1) for sleep disorders of chronic fatigue syndrome].

A pilot registry of unexplained fatiguing illnesses and chronic fatigue syndrome.

Energy Conservation/Envelope Theory Interventions to Help Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation.

Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine.

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics.

α-1 antitrypsin and chronic fatigue syndrome: a case study from pathophysiology to clinical practice.

Molecular mechanisms underpinning laser printer and photocopier induced symptoms, including chronic fatigue syndrome and respiratory tract hyperresponsiveness: pharmacological treatment with cinnamon and hydrogen.

Neurocognitive impairment in childhood chronic fatigue syndrome.

New developments in the diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome.

Chronic fatigue syndrome in the UK armed forces.

Role of reactive oxygen species and antioxidants in atopic dermatitis.

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