ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1361–1380 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The HPA axis in the pathogenesis of chronic fatigue syndrome].

Ursini, F, Succurro, E, Grembiale, A et al.·La Clinica terapeutica·2010

This review examines whether problems with the HPA axis—a system in your brain and body that manages stress and energy—might explain ME/CFS symptoms. The HPA axis controls cortisol and other hormones that help your body respond to stress and maintain energy levels. This article summarizes what scientists have found so far about whether HPA axis dysfunction could be a key cause of ME/CFS.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The chronic asthenia syndrome: a clinical approach].

Young, Pablo, Finn, Bárbara C, Bruetman, Julio et al.·Medicina·2010

Fatigue is one of the most common reasons people visit doctors, affecting about 30% of patients. This article explains how doctors should think about different types of fatigue—including chronic fatigue syndrome (ME/CFS), which affects 0.2–0.7% of people. The authors emphasize that finding and treating the underlying cause is the best approach, though about 20% of patients never get a clear diagnosis.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.

Rusmevichientong, Alice, Chow, Samson A·Immunologic research·2010

Scientists discovered a new virus called XMRV and found it in some people with prostate cancer and chronic fatigue syndrome (CFS). This review article summarizes what was known about this virus at the time, how it might work in the body, and what still needs to be studied to understand whether XMRV actually causes disease in humans.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Endogenous retroviruses as potential hazards for vaccines.

Miyazawa, Takayuki·Biologicals : journal of the International Association of Biological Standardization·2010

This article reviews the concern that certain viruses called endogenous retroviruses (ERVs) may be present in animal cell lines used to make some vaccines. Scientists discovered a virus called XMRV in some patients with ME/CFS and prostate cancer. Because some vaccines are made using animal cells that naturally contain ERVs, there is a theoretical risk that these viruses could contaminate vaccines, though this has not been well studied.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuroendocrine and immune contributors to fatigue.

Silverman, Marni N, Heim, Christine M, Nater, Urs M et al.·PM & R : the journal of injury, function, and rehabilitation·2010

This review explores how three body systems—the stress response system, the nervous system, and the immune system—may work together to cause the overwhelming tiredness experienced in ME/CFS. The researchers found that people with chronic fatigue often have an underactive stress-response system, an overactive fight-or-flight response, and immune system imbalances. Understanding how these systems interact may help explain why rest alone doesn't always resolve the fatigue.

Autonomic Nervous SystemImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

Groom, Harriet C T, Yap, Melvyn W, Galão, Rui Pedro et al.·Proceedings of the National Academy of Sciences of the United States of America·2010

Scientists studied a virus called XMRV that had been linked to ME/CFS to understand how it survives in human cells. They discovered that the body's natural antiviral defense proteins can block this virus, but XMRV does not appear to have developed ways to escape these defenses like some other viruses do. This finding helps researchers understand which cells XMRV can infect and how to design better laboratory studies of this virus.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The cerebralization of fatigue: an analysis of the cerebral hypothesis in the case of chronic fatigue syndrome].

Ortega, Francisco, Zorzanelli, Rafaela·Historia, ciencias, saude--Manguinhos·2010

This article examines how ME/CFS came to be understood as a brain-based illness rather than purely a physical one. The authors explore the history of how brain imaging and neuroscience research influenced medical thinking about ME/CFS, and how this shift reflected broader changes in how society views illness in general—increasingly looking to the brain as the primary source of disease.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Frequency and content analysis of chronic fatigue syndrome in medical text books.

Jason, Leonard A, Paavola, Erin, Porter, Nicole et al.·Australian journal of primary health·2010

This study looked at how much information about ME/CFS appears in medical textbooks that doctors and medical students use for training. Researchers found that while about 4 out of 10 textbooks mentioned ME/CFS at all, the information took up less than 0.1% of the total pages. Compared to other diseases like multiple sclerosis that are actually rarer, ME/CFS received much less coverage in these important educational materials.

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic fatigue syndrome/myalgic encephalomyelitis: an update.

Capelli, E, Zola, R, Lorusso, L et al.·International journal of immunopathology and pharmacology·2010

ME/CFS is a serious illness of unknown cause that affects about 1 in every 100 people worldwide, with women affected six times more often than men. Most people develop it between ages 20-40, and symptoms typically last several years. While doctors don't yet have a cure, treatment focuses on managing individual symptoms to help patients improve their quality of life.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.

Mikovits, Judy A, Lombardi, Vincent C, Pfost, Max A et al.·Virulence·2010

This 2010 study reported finding a virus called XMRV in blood samples from over 75% of people with ME/CFS using multiple detection methods. The researchers emphasized that different laboratory techniques found the virus at different rates, with some methods being much more sensitive than others. The findings were controversial because other research groups had difficulty reproducing these results.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome and an approach to its treatment].

Akarachkova, E S·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2010

This is a review article discussing chronic fatigue syndrome (ME/CFS) and treatment approaches. The authors examine what is known about the condition and offer clinical guidance on how to manage it. While not a new research study, it provides a medical perspective on understanding and treating this complex illness.

Interventions

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Hebrew version of the FibroFatigue scale: validation of a questionnaire for assessment of fibromyalgia and chronic fatigue syndrome.

Ablin, Jacob N, Odes, Lisa, Neumann, Lily et al.·Rheumatology international·2010

This study tested whether a Hebrew-language questionnaire called the FibroFatigue Scale (FFS) accurately measures symptoms in fibromyalgia patients. Researchers gave 100 patients with fibromyalgia this questionnaire along with other standard symptom-measuring tools, and found that the FFS reliably detected and measured how severe their symptoms were.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Disease-associated XMRV sequences are consistent with laboratory contamination.

Hué, Stéphane, Gray, Eleanor R, Gall, Astrid et al.·Retrovirology·2010

This study investigated whether XMRV, a virus that some researchers claimed to find in ME/CFS patients, was actually a real discovery or a result of laboratory contamination. The researchers found strong evidence that the XMRV sequences reported in patient samples likely came from contamination with mouse DNA and a cancer cell line used in laboratories, rather than from actual infection in patients.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Beliefs about Emotions Scale: validity, reliability and sensitivity to change.

Rimes, Katharine A, Chalder, Trudie·Journal of psychosomatic research·2010

Researchers created a new questionnaire called the Beliefs about Emotions Scale to measure how much people with ME/CFS tend to think negative emotions are unacceptable or shouldn't be expressed. They found that people with ME/CFS had much higher scores on this scale than healthy people, and that the scores improved after cognitive behavioral therapy (CBT), suggesting the scale can detect real changes in these unhelpful beliefs.

E3 PreliminaryMechanismPEM not requiredMechanistic

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.

Stieler, Kristin, Schulz, Claudia, Lavanya, Madakasira et al.·Virology·2010

This study examined how XMRV, a virus found in some ME/CFS patients' blood cells, infects different types of human cells. Researchers tested which cells the virus could enter and grow in, finding that it could infect various cell types including immune cells and prostate cells. The virus appeared to replicate most efficiently in prostate tissue, suggesting the virus may have preferred targets in the body.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Efficiency evaluation of autonomic heart control by using the principal component analysis of ECG P-wave.

Krisciukaitis, A, Simoliuniene, R, Tamosiunas, M et al.·Methods of information in medicine·2010

This study developed a new computer method to measure how well the heart's nerves (autonomic nervous system) work by analyzing changes in the electrical activity of the heart during a simple tilt test, where a person moves from lying down to standing up. The researchers tested this method in healthy people and those with heart rhythm problems, and found it could detect differences in how the heart responds to position changes. This type of measurement might eventually help doctors diagnose problems with heart control earlier.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine.

De Luca, C, Scordo, G, Cesareo, E et al.·Indian journal of experimental biology·2010

Some people with ME/CFS and related conditions may have difficulty processing chemicals, metals, and other substances they encounter in the environment because of inherited or acquired differences in how their bodies handle these toxins. This review suggests that genetic variations affecting enzymes responsible for detoxifying chemicals, combined with problems in the body's antioxidant systems, might explain why some people react strongly to very small amounts of environmental exposures. Understanding these biological mechanisms could help develop personalized treatments.

Pain and Sensitization

E3 PreliminaryCommentaryPEM unclearEditorial

Perspectives on fatigue from the study of chronic fatigue syndrome and related conditions.

Clauw, Daniel J·PM & R : the journal of injury, function, and rehabilitation·2010

This article explains that ME/CFS is a complex illness with roots in both the body and brain, involving several connected problems at the same time. Researchers have found that ME/CFS shares similar patterns with other conditions like fibromyalgia and irritable bowel syndrome, and involves issues with sleep, pain, cognitive problems, and extreme tiredness after activity. The article describes how inflammation, infection, problems with stress hormones, and nerve signal problems may all contribute to ME/CFS, though we don't yet know which problems matter most.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of corticosteroids and stress in chronic pain conditions.

McEwen, Bruce S, Kalia, Madhu·Metabolism: clinical and experimental·2010

This review explores how stress hormones (corticosteroids) and the body's stress response system affect chronic pain conditions, including ME/CFS. The authors explain that these hormones can have surprising and contradictory effects—sometimes reducing pain, sometimes increasing it—depending on the dose and where they act in the body. They examine how chronic stress and nervous system changes in conditions like ME/CFS, fibromyalgia, and IBS may be linked to pain through brain changes and immune system activity.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy.

Smith, Howard S, Barkin, Robert L·American journal of therapeutics·2010

Fibromyalgia is a condition that causes widespread pain throughout the body, along with fatigue, sleep problems, brain fog, and mood changes. This article explains that fibromyalgia may share common features with ME/CFS and other conditions involving heightened pain sensitivity. While there is no cure, doctors can help manage symptoms through exercise, therapy, patient education, and specific medications.

Pain and SensitizationSleepCognitive Impairment

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[The HPA axis in the pathogenesis of chronic fatigue syndrome].

[The chronic asthenia syndrome: a clinical approach].

Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.

Endogenous retroviruses as potential hazards for vaccines.

Neuroendocrine and immune contributors to fatigue.

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

[The cerebralization of fatigue: an analysis of the cerebral hypothesis in the case of chronic fatigue syndrome].

Frequency and content analysis of chronic fatigue syndrome in medical text books.

Chronic fatigue syndrome/myalgic encephalomyelitis: an update.

Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.

[Chronic fatigue syndrome and an approach to its treatment].

The Hebrew version of the FibroFatigue scale: validation of a questionnaire for assessment of fibromyalgia and chronic fatigue syndrome.

Disease-associated XMRV sequences are consistent with laboratory contamination.

The Beliefs about Emotions Scale: validity, reliability and sensitivity to change.

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.

Efficiency evaluation of autonomic heart control by using the principal component analysis of ECG P-wave.

Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine.

Perspectives on fatigue from the study of chronic fatigue syndrome and related conditions.

The role of corticosteroids and stress in chronic pain conditions.

Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy.

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