Smith, Howard S, Barkin, Robert L · American journal of therapeutics · 2010 · DOI
Fibromyalgia is a condition that causes widespread pain throughout the body, along with fatigue, sleep problems, brain fog, and mood changes. This article explains that fibromyalgia may share common features with ME/CFS and other conditions involving heightened pain sensitivity. While there is no cure, doctors can help manage symptoms through exercise, therapy, patient education, and specific medications.
This review is relevant to ME/CFS patients and researchers because it identifies fibromyalgia as a condition that commonly overlaps with ME/CFS and shares similar central sensitization mechanisms. Understanding fibromyalgia's diagnostic approach and treatment strategies may inform better recognition and management of similar symptoms in the ME/CFS population.
This editorial does not provide original research data or clinical trial results, so it does not prove efficacy of any specific treatment in a controlled setting. The review acknowledges that the pathophysiology remains uncertain, so it does not establish definitive biological mechanisms. It also does not directly address ME/CFS-specific outcomes or whether fibromyalgia treatments would be equally effective in ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Smith, Howard S & Barkin, Robert L (2010). Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy.. American journal of therapeutics. https://doi.org/10.1097/MJT.0b013e3181df8e1b
BibTeX
@article{mecfsatlas-smith-2010-fibromyalgia-syndrome,
author = {Smith, Howard S and Barkin, Robert L},
title = {Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy.},
journal = {American journal of therapeutics},
year = {2010},
doi = {10.1097/MJT.0b013e3181df8e1b},
note = {PubMed: 20562596},
url = {https://www.mecfsatlas.com/evidence/smith-2010-fibromyalgia-syndrome},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/smith-2010-fibromyalgia-syndrome
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