ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1381–1400 of 2,420 studies

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Decker, Michael J, Eyal, Shulamit, Shinar, Zvika et al.·Sleep & breathing = Schlaf & Atmung·2010

Researchers tested a new computer method that analyzes heart rate patterns to measure sleep quality and breathing problems during sleep, comparing it to the traditional gold-standard method of manually reviewing sleep recordings. The new method worked very well for measuring overall sleep time, wake time, and most sleep stages, though it was less accurate at distinguishing between deep and light sleep. This could eventually allow easier and cheaper sleep testing for patients with ME/CFS who often have sleep problems.

Sleep

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Lacerda, Eliana M, Nacul, Luis, Pheby, Derek et al.·Journal of clinical pathology·2010

This study explored whether it would be possible and acceptable to create a tissue bank in the UK specifically for ME/CFS—a place where donated tissues from people with ME/CFS could be studied after death to better understand the disease. Researchers interviewed patients, held discussion groups, and consulted experts to find out what people thought about this idea. The findings show that both patients and experts believe such a tissue bank would be valuable and could work in practice, as long as certain concerns were properly addressed.

E3 PreliminaryReviewPEM unclearReview-Narrative

Gut inflammation in chronic fatigue syndrome.

Lakhan, Shaheen E, Kirchgessner, Annette·Nutrition & metabolism·2010

Many ME/CFS patients experience gut problems similar to irritable bowel syndrome. This review discusses how three interconnected gut issues—changes in the bacteria that live in your intestines, a weakened intestinal lining, and an altered immune response in the gut—may contribute to ME/CFS. The authors suggest that treatments like probiotics (beneficial bacteria) might help by restoring healthy gut bacteria and reducing inflammation.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Baraniuk, James N·Current allergy and asthma reports·2010

This study examined whether a virus called XMRV might be connected to ME/CFS. Researchers found this virus in about half to two-thirds of ME/CFS patients tested, compared to only about 4% of healthy people. The virus was able to spread from patient blood to laboratory cells, raising questions about whether it could be transmitted between people.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Frequency and content analysis of chronic fatigue syndrome in medical text books.

Jason, Leonard A, Paavola, Erin, Porter, Nicole et al.·Australian journal of primary health·2010

This study looked at how much information about ME/CFS appears in medical textbooks that doctors and medical students use for training. Researchers found that while about 4 out of 10 textbooks mentioned ME/CFS at all, the information took up less than 0.1% of the total pages. Compared to other diseases like multiple sclerosis that are actually rarer, ME/CFS received much less coverage in these important educational materials.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome and fibromyalgia: a status report in 2010.

Natelson, Benjamin H·MD advisor : a journal for New Jersey medical community·2010

This 2010 report by Dr. Benjamin Natelson reviews the current understanding of ME/CFS and fibromyalgia, two conditions that cause persistent fatigue and pain. The report summarizes what doctors and researchers knew at that time about how these conditions develop, how they affect the body, and how they are treated. It provides an overview of the scientific evidence available in 2010 to help explain why people with these conditions experience their symptoms.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

What is fatigue? Pathological and nonpathological fatigue.

Jason, Leonard A, Evans, Meredyth, Brown, Molly et al.·PM & R : the journal of injury, function, and rehabilitation·2010

This article explores what fatigue really is and how doctors can tell the difference between normal tiredness and the severe, disabling fatigue that comes with illnesses like ME/CFS. Fatigue is common in many diseases and conditions, but researchers have had difficulty measuring it consistently and understanding why it happens. The authors review the scientific literature to help clarify these important questions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The HPA axis in the pathogenesis of chronic fatigue syndrome].

Ursini, F, Succurro, E, Grembiale, A et al.·La Clinica terapeutica·2010

This review examines whether problems with the HPA axis—a system in your brain and body that manages stress and energy—might explain ME/CFS symptoms. The HPA axis controls cortisol and other hormones that help your body respond to stress and maintain energy levels. This article summarizes what scientists have found so far about whether HPA axis dysfunction could be a key cause of ME/CFS.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.

Rusmevichientong, Alice, Chow, Samson A·Immunologic research·2010

Scientists discovered a new virus called XMRV and found it in some people with prostate cancer and chronic fatigue syndrome (CFS). This review article summarizes what was known about this virus at the time, how it might work in the body, and what still needs to be studied to understand whether XMRV actually causes disease in humans.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Changes on definition and diagnostic criteria of the chronic fatigue syndrome].

Qin, You, Pang, Feng-Shun, Cai, Bei-Yuan·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2009

This article reviews how the definition and diagnostic criteria for ME/CFS have changed over time. The authors examine the evolution of how doctors identify and classify this condition using different diagnostic frameworks. Understanding these changes helps patients and doctors communicate more clearly about the disease.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome and complement activation.

Geller, Robert Dennis, Giclas, Patricia C·BMJ case reports·2009

This report follows one patient who developed ME/CFS after a severe Epstein-Barr virus infection. Standard medical tests came back normal, but when doctors tested for complement activation (part of the immune system's inflammatory response), they found it was abnormally active. The patient remained unwell for about 2 years while showing these signs of complement activation, then recovered.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome.

Turan, Tayfun, Izgi, Hasan Basri, Ozsoy, Saliha et al.·Psychiatry investigation·2009

This study tested whether a medication called galantamine, which increases a brain chemical called acetylcholine, could help ME/CFS patients by improving hormone imbalances. Researchers measured two stress hormones (cortisol and DHEAS) in 29 ME/CFS patients before and after 4 weeks of treatment, comparing them to healthy controls. They found that in patients who improved with the medication, the abnormal hormone levels shifted back toward normal, suggesting the cholinergic system may play a role in ME/CFS.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.

Vij, Garima, Gupta, Amit, Chopra, Kanwaljit·Fundamental & clinical pharmacology·2009

Researchers tested whether naringin, a natural compound found in citrus fruits, could help reduce fatigue-like symptoms in mice exposed to immune challenges and stress. Mice treated with naringin showed improvements in their activity levels, pain sensitivity, and markers of cellular damage compared to untreated mice, suggesting that reducing oxidative stress might help manage fatigue symptoms.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Q Fever in Tunisia].

Kaabia, N, Letaief, A·Pathologie-biologie·2009

Q fever is an infection caused by bacteria from animals that spreads to humans, usually through breathing contaminated air. While most people infected have no symptoms or mild flu-like illness, some can develop a chronic form that includes long-term fatigue. This review examines how common Q fever is in Tunisia and why doctors there often miss or misdiagnose it.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: a psychoneuroimmunological perspective].

van Houdenhove, B, Heijnen, C J·Tijdschrift voor psychiatrie·2009

This review explores how stress, the immune system, and the brain interact in ME/CFS. The authors suggest that both physical and emotional stress may contribute to developing and maintaining the illness. While some research shows that people with ME/CFS have unusual stress responses and immune activity, the results haven't been fully consistent, indicating we still need more research to understand exactly what's happening.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Functional somatic syndrome in dental practice].

Inamitsu, Tetsuaki·Nihon rinsho. Japanese journal of clinical medicine·2009

Many people experience pain and discomfort in their face, jaw, and mouth that doctors and dentists cannot easily explain with standard tests. This review discusses how conditions like temporomandibular disorder (jaw pain), burning mouth syndrome, and facial pain are related to each other and to broader conditions like fibromyalgia and chronic fatigue syndrome. These conditions often occur alongside anxiety, depression, and other mental health challenges, and treating them effectively requires a team approach including medication, physical therapy, and counseling.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

A gene signature for post-infectious chronic fatigue syndrome.

Gow, John W, Hagan, Suzanne, Herzyk, Pawel et al.·BMC medical genomics·2009

This study looked at whether certain genes are turned on or off differently in people with ME/CFS compared to healthy people. Researchers examined blood cells from 8 men with post-infectious ME/CFS and 7 healthy men, testing the activity of nearly 39,000 genes. They found that 366 genes were expressed differently between the two groups, particularly in areas related to immune function, oxidative stress, and cell death.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Kindling and Oxidative Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Jason, L A, Porter, N, Herrington, J et al.·Journal of behavioral and neuroscience research·2009

ME/CFS is a complex illness that often starts suddenly, sometimes after a viral infection, and affects multiple body systems including the immune system, nervous system, and heart. This study proposes that two processes—'kindling' (where repeated small stresses build up over time) and oxidative stress (cellular damage from harmful molecules)—may help explain why different ME/CFS patients have such different symptoms and test results.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Functional somatic syndromes from the view of cultural anthropology].

Nakagami, Ayako, Tsujiuchi, Takuya·Nihon rinsho. Japanese journal of clinical medicine·2009

This study explains how culture and society shape the way people experience and describe illnesses like ME/CFS. The authors point out that doctors and patients often understand illness differently—doctors focus on what they can measure (disease), while patients focus on how the illness affects their daily life (illness). Understanding these different viewpoints can help doctors and patients communicate better and work together.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.

Maes, Michael, Twisk, Frank Nm·Neuro endocrinology letters·2009

This review examines why people with ME/CFS may develop heart problems earlier than others. The researchers found that ME/CFS involves abnormal inflammation and oxidative stress (damage from harmful molecules in the body), along with low levels of protective antioxidants. These biological changes can damage the heart and blood vessels, potentially explaining why some ME/CFS patients experience heart failure at much younger ages than the general population.

Immune System

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Evidence browser

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Gut inflammation in chronic fatigue syndrome.

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Frequency and content analysis of chronic fatigue syndrome in medical text books.

Chronic fatigue syndrome and fibromyalgia: a status report in 2010.

What is fatigue? Pathological and nonpathological fatigue.

[The HPA axis in the pathogenesis of chronic fatigue syndrome].

Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.

[Changes on definition and diagnostic criteria of the chronic fatigue syndrome].

Chronic fatigue syndrome and complement activation.

The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome.

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.

[Q Fever in Tunisia].

[Chronic fatigue syndrome: a psychoneuroimmunological perspective].

[Functional somatic syndrome in dental practice].

A gene signature for post-infectious chronic fatigue syndrome.

Kindling and Oxidative Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

[Functional somatic syndromes from the view of cultural anthropology].

Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.

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