ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1381–1400 of 2,423 studies

E3 PreliminaryCohortPEM unclearCross-Sectional

A Comparison of Immune Functionality in Viral versus Non-Viral CFS Subtypes.

Porter, Nicole, Lerch, Athena, Jason, Leonard A et al.·Journal of behavioral and neuroscience research·2010

This study compared immune system function between ME/CFS patients whose illness started after a viral infection versus those without a clear viral trigger. Researchers tested blood samples to measure different types of immune cells. They found that the two groups had different patterns of immune cell activity, suggesting that how the immune system becomes unbalanced may differ depending on what caused the illness to start.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.

Gupta, Amit, Vij, Garima, Chopra, Kanwaljit·Journal of neuroimmunology·2010

Researchers used mice to study whether oxidative stress (chemical damage in cells) and immune activation play a role in ME/CFS-like symptoms. They found that mice treated with immune-triggering substances showed increased fatigue and pain sensitivity, along with signs of cellular damage. When given olive extract, these mice showed improvement in fatigue, pain, and markers of cellular damage.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effects of exercise on behavior and peripheral blood lymphocyte apoptosis in a rat model of chronic fatigue syndrome.

Zou, Jun, Yuan, Jianqi, Lv, Shuang et al.·Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban·2010

Researchers created a rat model of ME/CFS using stress and shock, then tested whether exercise could help. Rats with the CFS-like condition showed decreased activity, memory problems, and abnormal immune cell death. When stressed rats were given access to a running wheel, their activity improved and their immune cell death decreased, suggesting exercise may help counteract some effects of the condition.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Immune and hemorheological changes in chronic fatigue syndrome.

Brenu, Ekua W, Staines, Donald R, Baskurt, Oguz K et al.·Journal of translational medicine·2010

This study looked at immune system cells and blood cell properties in people with ME/CFS compared to healthy people. Researchers found that ME/CFS patients had weaker immune responses in certain white blood cells (neutrophils and NK cells) but normal blood cell flexibility and clumping. These immune differences might help explain why people with ME/CFS feel so tired and unwell.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR kit is amplified using standard primers for XMRV.

Sato, Eiji, Furuta, Rika A, Miyazawa, Takayuki·Retrovirology·2010

Researchers testing for a virus called XMRV in ME/CFS patients discovered that one commercial laboratory test kit was contaminated with mouse virus DNA. This contamination meant that positive results from this kit could not be trusted, since the positive signal came from the kit itself rather than from patient samples. The researchers are warning other scientists to carefully check their test kits for this contamination before using them in studies.

E3 PreliminaryMechanismPEM unclearMechanistic

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity.

Vermeulen, Ruud C W, Kurk, Ruud M, Visser, Frans C et al.·Journal of translational medicine·2010

This study compared how well people with ME/CFS and healthy controls performed during two exercise tests done 24 hours apart. Patients became exhausted at much lower exercise levels than controls, and performed even worse on the second test. Surprisingly, when researchers tested the energy-producing structures (mitochondria) in patients' blood cells, they appeared to work normally, suggesting the problem may lie elsewhere in the energy production process.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearEditorial

Of Mice and Men: On the Origin of XMRV.

van der Kuyl, Antoinette Cornelia, Cornelissen, Marion, Berkhout, Ben·Frontiers in microbiology·2010

This study examines XMRV, a virus that was found in some ME/CFS patients but whose existence remains hotly debated in the scientific community. The authors suggest that XMRV may have entered humans through contamination in medical products like vaccines that were made using mouse cells. They explore how this virus, which is very similar to viruses naturally found in mice, could have crossed into humans.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study.

Meeus, Mira, Roussel, Nathalie A, Truijen, Steven et al.·Journal of rehabilitation medicine·2010

This study compared how people with ME/CFS, chronic back pain, and healthy people respond to exercise. Researchers found that people with ME/CFS have more sensitive pain responses than others, and importantly, their pain sensitivity got worse after light exercise—opposite to what happened in the other groups. This suggests ME/CFS involves different pain processing in the nervous system.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

Mikovits, Judy A, Huang, Ying, Pfost, Max A et al.·AIDS reviews·2010

Researchers tested blood samples from ME/CFS patients for a virus called XMRV using different detection methods. They found that simple DNA tests alone missed infections that were caught by more sensitive techniques. This study explains why different research teams got different results—the testing method matters a lot.

E3 PreliminaryCommentaryPEM not requiredEditorial

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Baraniuk, James N·Current allergy and asthma reports·2010

This study examined whether a virus called XMRV might be connected to ME/CFS. Researchers found this virus in about half to two-thirds of ME/CFS patients tested, compared to only about 4% of healthy people. The virus was able to spread from patient blood to laboratory cells, raising questions about whether it could be transmitted between people.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.

Chia, J, Chia, A, Voeller, M et al.·Journal of clinical pathology·2010

This study tracked patients who had acute enterovirus infections (common viral illnesses) and then developed ME/CFS symptoms. Researchers found that in three patients, the virus persisted in their stomach tissue years after the initial infection. This suggests that some ME/CFS cases may be triggered by enterovirus infections that don't fully clear from the body.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies.

Qiu, Xiaoxing, Swanson, Priscilla, Luk, Ka-Cheung et al.·Retrovirology·2010

Researchers studied how the body's immune system responds to XMRV infection by infecting three monkeys and tracking antibodies (immune markers) over time. They found that infected animals developed detectable antibodies within two weeks and created three new blood tests to reliably detect XMRV infection, which could help researchers study whether XMRV is connected to ME/CFS.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?

Boone, Kyle Brauer·The Clinical neuropsychologist·2009

Some people with ME/CFS report serious cognitive problems in their daily life, but when given standard memory and thinking tests, their scores are completely normal. This study presents one case and suggests that some patients may worry excessively about cognitive problems that aren't actually measurable on formal tests—a condition the author calls 'neurocognitive hypochondriasis.' The study notes this pattern may occur in ME/CFS and several other conditions.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome.

Lin, Eugene, Hsu, Sen-Yen·Pharmacogenomics·2009

Researchers used advanced statistical methods to look for interactions between genes and between genes and environmental factors (like age, sex, and weight) in ME/CFS patients. They found that a gene called NR3C1 appeared to be involved in patterns that might be related to ME/CFS, and that gender seemed to influence how this gene affected the condition. This suggests that ME/CFS likely develops from a combination of genetic and personal factors rather than from a single cause.

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

Veldman, Joan, Van Houdenhove, Boudewijn, Verguts, Jasper·Archives of gynecology and obstetrics·2009

This case describes a woman with chronic fatigue syndrome who developed a rare condition called membranous dysmenorrhea (where the uterine lining sheds in one piece) after starting a hormonal birth control pill. Interestingly, when she stopped the medication and the tissue was expelled, her fatigue symptoms completely disappeared and she was able to return to work. While this is just one patient's experience, it raises the possibility that hormone imbalances might contribute to chronic fatigue in some cases.

E3 PreliminaryCohortPEM not requiredCase-Control

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Fluge, Øystein, Mella, Olav·BMC neurology·2009

This study examined whether a drug called rituximab, which reduces B cells (a type of immune cell), could help ME/CFS patients. Three ME/CFS patients received rituximab infusions and all experienced significant symptom improvement lasting several months. When symptoms returned, patients were retreated and improved again, suggesting that B cells may play a role in ME/CFS for at least some patients.

Immune System

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies.

Kuwabara, Natsuko, Itoh, Yasuhiko, Igarshi, Tohru et al.·Autoimmunity·2009

This study found that a specific antibody called anti-Sa, detected in people with chronic fatigue and positive autoimmune markers, is actually targeting a protein called LEDGF/p75. Researchers developed a simple blood test (ELISA) to detect this antibody more accurately than previous methods. This new test could help doctors identify which patients with chronic fatigue may have an autoimmune component to their illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns.

Podolecki, Tomasz, Podolecki, Andrzej, Hrycek, Antoni·Polskie Archiwum Medycyny Wewnetrznej·2009

Fibromyalgia is a condition causing widespread muscle and joint pain that affects many people worldwide. This review examines what we know about fibromyalgia's causes, how doctors diagnose it, and how it can be treated. The authors note that fibromyalgia likely results from multiple factors involving the nervous system, brain chemistry, and immune function, and that treatment typically involves antidepressants, therapy, and other approaches.

Pain and SensitizationDiagnostics

E3 PreliminaryBehavioralPEM unclear

Acupuncture treatment of chronic fatigue syndrome.

Hui, Jin-Sheng·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2009

This study looked at whether acupuncture, a traditional Chinese medicine treatment involving thin needles placed on the skin, might help people with ME/CFS. The researchers compared a group of patients who received acupuncture treatment with a control group to see if there were differences in their symptoms and fatigue levels.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--more than just chronic fatigue].

Forstenius, Lisa, Helmfrid, Sten·Lakartidningen·2009

This article explains that ME/CFS is much more than simply feeling tired all the time. The authors describe how the condition affects multiple body systems and causes real, measurable problems with energy, cognition, and physical function. The paper emphasizes that ME/CFS is a serious medical condition deserving proper recognition and treatment.

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A Comparison of Immune Functionality in Viral versus Non-Viral CFS Subtypes.

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.

Effects of exercise on behavior and peripheral blood lymphocyte apoptosis in a rat model of chronic fatigue syndrome.

Immune and hemorheological changes in chronic fatigue syndrome.

An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR kit is amplified using standard primers for XMRV.

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity.

Of Mice and Men: On the Origin of XMRV.

Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study.

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.

Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies.

Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?

A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome.

Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies.

Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns.

Acupuncture treatment of chronic fatigue syndrome.

[Chronic fatigue syndrome--more than just chronic fatigue].

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