Vij, Garima, Gupta, Amit, Chopra, Kanwaljit · Fundamental & clinical pharmacology · 2009 · DOI
Researchers tested whether naringin, a natural compound found in citrus fruits, could help reduce fatigue-like symptoms in mice exposed to immune challenges and stress. Mice treated with naringin showed improvements in their activity levels, pain sensitivity, and markers of cellular damage compared to untreated mice, suggesting that reducing oxidative stress might help manage fatigue symptoms.
This study provides experimental evidence supporting the hypothesis that oxidative stress and immune activation contribute to chronic fatigue, and identifies a potential nutritional intervention that warrants further investigation. If findings translate to humans, naringin or similar antioxidants could represent an accessible, low-risk therapeutic approach for ME/CFS patients.
This animal model study does not prove that naringin would be effective in human ME/CFS patients, nor does it establish that oxidative stress and TNF-α elevation are primary causes (rather than secondary consequences) of ME/CFS. The water-immersion stress model may not fully recapitulate the complex pathophysiology of human ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Vij, Garima, Gupta, Amit, & Chopra, Kanwaljit (2009). Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.. Fundamental & clinical pharmacology. https://doi.org/10.1111/j.1472-8206.2009.00675.x
BibTeX
@article{mecfsatlas-vij-2009-modulation-antigen,
author = {Vij, Garima and Gupta, Amit and Chopra, Kanwaljit},
title = {Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.},
journal = {Fundamental & clinical pharmacology},
year = {2009},
doi = {10.1111/j.1472-8206.2009.00675.x},
note = {PubMed: 19469804},
url = {https://www.mecfsatlas.com/evidence/vij-2009-modulation-antigen},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/vij-2009-modulation-antigen
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