ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1421–1440 of 2,423 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome.

Lin, Eugene, Hsu, Sen-Yen·Pharmacogenomics·2009

Researchers used advanced statistical methods to look for interactions between genes and between genes and environmental factors (like age, sex, and weight) in ME/CFS patients. They found that a gene called NR3C1 appeared to be involved in patterns that might be related to ME/CFS, and that gender seemed to influence how this gene affected the condition. This suggests that ME/CFS likely develops from a combination of genetic and personal factors rather than from a single cause.

E3 PreliminaryCohortPEM unclearCase-Control

On the question of infectious aetiologies for multiple sclerosis, schizophrenia and the chronic fatigue syndrome and their treatment with antibiotics.

Frykholm, B O·Medical hypotheses·2009

This small pilot study tested whether antibiotics could help patients with severe psychiatric symptoms and ME/CFS, based on the idea that certain bacteria might be involved in these conditions. Two ME/CFS patients received 60 days of antibiotics combined with vitamin B injections; one reported complete recovery and one reported significant improvement at the one-year follow-up.

E3 PreliminaryBehavioralPEM not requiredObservational

Can pacing self-management alter physical behavior and symptom severity in chronic fatigue syndrome? A case series.

Nijs, Jo, van Eupen, Inge, Vandecauter, Jo et al.·Journal of rehabilitation research and development·2009

This small study looked at whether a strategy called "pacing" — learning to balance activity and rest — could help people with ME/CFS feel better and do more. Seven patients received three sessions teaching pacing techniques, and researchers measured their activity levels and symptoms before and after. Patients reported improvements in their ability to do daily tasks and some symptoms like muscle weakness and concentration problems got better, though the changes were modest.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?

Boone, Kyle Brauer·The Clinical neuropsychologist·2009

Some people with ME/CFS report serious cognitive problems in their daily life, but when given standard memory and thinking tests, their scores are completely normal. This study presents one case and suggests that some patients may worry excessively about cognitive problems that aren't actually measurable on formal tests—a condition the author calls 'neurocognitive hypochondriasis.' The study notes this pattern may occur in ME/CFS and several other conditions.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.

Gupta, Amit, Vij, Garima, Sharma, Sameer et al.·Immunobiology·2009

This study tested whether curcumin, a natural compound found in turmeric, could help reduce fatigue in mice infected with bacteria-like substances. Mice treated with curcumin showed less fatigue behavior and had lower levels of inflammation markers compared to untreated mice. The results suggest curcumin might be worth exploring as a potential treatment for ME/CFS.

Immune System

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies.

Kuwabara, Natsuko, Itoh, Yasuhiko, Igarshi, Tohru et al.·Autoimmunity·2009

This study found that a specific antibody called anti-Sa, detected in people with chronic fatigue and positive autoimmune markers, is actually targeting a protein called LEDGF/p75. Researchers developed a simple blood test (ELISA) to detect this antibody more accurately than previous methods. This new test could help doctors identify which patients with chronic fatigue may have an autoimmune component to their illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

Staines, Donald R, Brenu, Ekua W, Marshall-Gradisnik, Sonya·Neuropsychiatric disease and treatment·2009

This paper proposes that ME/CFS, along with MS, Parkinson's disease, and ALS, may involve immune system problems affecting the protective barriers around the brain and spinal cord. Specifically, the authors suggest that certain signaling molecules called PACAP and VIP, which normally help maintain these barriers, may become targets of autoimmune attack. They propose that a class of drugs called phosphodiesterase inhibitors might help restore normal function by boosting protective immune responses.

NeuroinflammationImmune System

E3 PreliminaryCohortPEM not requiredCase-Control

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Fluge, Øystein, Mella, Olav·BMC neurology·2009

This study examined whether a drug called rituximab, which reduces B cells (a type of immune cell), could help ME/CFS patients. Three ME/CFS patients received rituximab infusions and all experienced significant symptom improvement lasting several months. When symptoms returned, patients were retreated and improved again, suggesting that B cells may play a role in ME/CFS for at least some patients.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Immunological aspects of chronic fatigue syndrome.

Lorusso, Lorenzo, Mikhaylova, Svetlana V, Capelli, Enrica et al.·Autoimmunity reviews·2009

This review examines how the immune system may be involved in ME/CFS. Researchers have found that people with ME/CFS often have unusual patterns in immune cells and signaling molecules called cytokines, particularly higher levels of inflammatory markers. These immune system changes might explain some of the main symptoms, like fatigue and flu-like feelings, though the exact role these changes play in causing the disease remains unclear.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Practice Nurses' views of their role in the management of Chronic Fatigue Syndrome/Myalagic Encephalitis: a qualitative study.

Chew-Graham, Carolyn, Dixon, Rebecca, Shaw, Jonathan W et al.·BMC nursing·2009

This study asked 29 practice nurses (nurses who work in doctor's offices) about their understanding and views of ME/CFS. The researchers found that most nurses knew very little about ME/CFS, had not received formal training, and some held negative attitudes toward the condition. While nurses thought they could help manage ME/CFS patients, they often didn't understand the best evidence-based treatments available.

E3 PreliminaryMechanismPEM not requiredMechanistic

[Cellular and molecular mechanisms of interaction between the neuroendocrine and immune systems under chronic fatigue syndrome in experiment].

Rybakina, E G, Shanin, S N, Fomicheva, E E et al.·Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2009

This study used laboratory rats to understand how ME/CFS might develop by triggering an immune response with a synthetic molecule. Researchers found that during this fatigue-like state, immune cells became less active, brain cell communication pathways were dampened, and the body's stress-response system (which normally helps us cope) became less effective. These findings suggest ME/CFS involves problems in how the immune system and brain communicate with each other.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Memory and attention problems in children with chronic fatigue syndrome or myalgic encephalopathy.

Haig-Ferguson, A, Tucker, P, Eaton, N et al.·Archives of disease in childhood·2009

This study looked at 20 children with ME/CFS who had memory and attention problems. Researchers asked the children, their parents, and teachers about these difficulties, and then gave the children a series of tests to measure how well they could focus, remember things, and process information. The children's test scores showed they had real difficulties with attention and memory compared to healthy children their age.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pathogenic mechanisms of idiopathic nonallergic rhinitis.

Baraniuk, James N·The World Allergy Organization journal·2009

This study examines why some people develop chronic nasal symptoms like congestion and runny nose that don't have an obvious allergic cause. Researchers found that this condition may actually involve several different problems: structural issues in the nose, nerve sensitivity problems, and autonomic nervous system dysfunction—the same type of nervous system problem found in ME/CFS.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredObservational

When a parent is chronically ill: chronic fatigue syndrome.

Donalek, Julie G·Nursing research·2009

This study interviewed 8 parents with ME/CFS and their family members to understand how the illness affects everyone at home. Families described struggling to get a diagnosis, dealing with changed roles and responsibilities, losing income, feeling isolated, and trying to maintain normal family life despite ongoing uncertainty about the illness.

E3 PreliminaryMechanismPEM requiredMechanistic

Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome.

Sorensen, Bristol, Jones, James F, Vernon, Suzanne D et al.·Molecular medicine (Cambridge, Mass.)·2009

After exercise, people with ME/CFS show higher levels of certain immune molecules (particularly C4a) that may contribute to their post-exercise symptoms. This study looked at which genes were turned on or off in immune cells after exercise and found that people with ME/CFS activated different immune pathways than healthy people—specifically, a pathway called the lectin pathway responded differently. This suggests their immune system may be producing excess inflammatory signals after physical activity.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome.

Armitage, Roseanne, Landis, Carol, Hoffmann, Robert et al.·Journal of psychosomatic research·2009

Researchers compared brain wave patterns during sleep between identical twins where one had ME/CFS and one did not. They found no significant differences in the electrical activity of the brain during sleep between the sick and healthy twins, even though those with ME/CFS reported more sleep problems. This suggests that genetic factors may influence sleep patterns more strongly than the illness itself.

Sleep

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome: aetiology, diagnosis and treatment.

Avellaneda Fernández, Alfredo, Pérez Martín, Alvaro, Izquierdo Martínez, Maravillas et al.·BMC psychiatry·2009

ME/CFS is a serious condition marked by extreme exhaustion that lasts at least six months and doesn't improve with rest. The fatigue is so severe that it can force people to reduce their daily activities by half or more. Doctors don't yet have a single test to diagnose it, so they diagnose it by ruling out other illnesses. There is currently no cure, but treatment works best when doctors, mental health professionals, and social support services work together to help patients.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

[Activity of hypotnalamic-pituitary-adrenal axis by induction of experimental chronic fatigue syndrom].

Fomicheva, E E, Filatenkova, T A, Rybakina, E G·Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2009

Researchers used an animal model to study how ME/CFS might affect the stress hormone system in the body. They gave rats a substance that mimics a viral infection, then tested whether the animals' adrenal glands (which produce cortisol, the main stress hormone) still responded normally. They found that the stress hormone system became less responsive, suggesting that an infection-like trigger could disrupt how the body regulates stress hormones.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.

Kumar, Anil, Garg, Ruchika·Fundamental & clinical pharmacology·2009

Researchers tested whether three common antidepressant medications could help reduce fatigue-like symptoms and improve mood and activity levels in mice subjected to repeated stress. All three medications tested—imipramine, desipramine, and citalopram—reduced immobility (fatigue-like behavior), improved movement and activity, decreased anxiety, and reduced markers of cellular damage caused by oxidative stress in the stressed mice.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Continuing medical education challenges in chronic fatigue syndrome.

Brimmer, Dana J, McCleary, K Kimberly, Lupton, Teresa A et al.·BMC medical education·2009

Most doctors don't know much about ME/CFS, which means many patients don't get diagnosed or treated. Researchers created an educational program to teach healthcare providers about ME/CFS between 2000 and 2006. They found that online courses were much more popular than printed materials, and that targeting specific audiences at smaller conferences was most effective at spreading information.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome.

On the question of infectious aetiologies for multiple sclerosis, schizophrenia and the chronic fatigue syndrome and their treatment with antibiotics.

Can pacing self-management alter physical behavior and symptom severity in chronic fatigue syndrome? A case series.

Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.

Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies.

Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Immunological aspects of chronic fatigue syndrome.

Practice Nurses' views of their role in the management of Chronic Fatigue Syndrome/Myalagic Encephalitis: a qualitative study.

[Cellular and molecular mechanisms of interaction between the neuroendocrine and immune systems under chronic fatigue syndrome in experiment].

Memory and attention problems in children with chronic fatigue syndrome or myalgic encephalopathy.

Pathogenic mechanisms of idiopathic nonallergic rhinitis.

When a parent is chronically ill: chronic fatigue syndrome.

Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome.

Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome.

Chronic fatigue syndrome: aetiology, diagnosis and treatment.

[Activity of hypotnalamic-pituitary-adrenal axis by induction of experimental chronic fatigue syndrom].

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.

Continuing medical education challenges in chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research