ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1421–1440 of 2,420 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Web usage data as a means of evaluating public health messaging and outreach.

Tian, Hao, Brimmer, Dana J, Lin, Jin-Mann S et al.·Journal of medical Internet research·2009

This study looked at how many people visited the CDC's ME/CFS website over 18 months and what information they searched for. The website received millions of visits from around the world, showing that many people are looking for reliable information about ME/CFS. The researchers found that a public awareness campaign successfully brought more visitors to the site, and that people were more interested in professional medical information after the campaign ended.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

An integrated approach to infer causal associations among gene expression, genotype variation, and disease.

Lee, Eunjee, Cho, Seoae, Kim, Kyunga et al.·Genomics·2009

Researchers developed a new method to find which genes might cause ME/CFS by combining three types of medical data: genetic variations people are born with, how active those genes are in the body, and whether someone has the disease. When they tested this method on ME/CFS patients, they found that certain genes—especially one called NR3C1—appear to influence disease risk, and that patients with ME/CFS plus depression may have different genetic causes than those with ME/CFS alone.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: a psychoneuroimmunological perspective].

van Houdenhove, B, Heijnen, C J·Tijdschrift voor psychiatrie·2009

This review explores how stress, the immune system, and the brain interact in ME/CFS. The authors suggest that both physical and emotional stress may contribute to developing and maintaining the illness. While some research shows that people with ME/CFS have unusual stress responses and immune activity, the results haven't been fully consistent, indicating we still need more research to understand exactly what's happening.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.

Kumar, Anil, Garg, Ruchika·Fundamental & clinical pharmacology·2009

Researchers tested whether three common antidepressant medications could help reduce fatigue-like symptoms and improve mood and activity levels in mice subjected to repeated stress. All three medications tested—imipramine, desipramine, and citalopram—reduced immobility (fatigue-like behavior), improved movement and activity, decreased anxiety, and reduced markers of cellular damage caused by oxidative stress in the stressed mice.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Changes on definition and diagnostic criteria of the chronic fatigue syndrome].

Qin, You, Pang, Feng-Shun, Cai, Bei-Yuan·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2009

This article reviews how the definition and diagnostic criteria for ME/CFS have changed over time. The authors examine the evolution of how doctors identify and classify this condition using different diagnostic frameworks. Understanding these changes helps patients and doctors communicate more clearly about the disease.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Functional somatic syndrome in dental practice].

Inamitsu, Tetsuaki·Nihon rinsho. Japanese journal of clinical medicine·2009

Many people experience pain and discomfort in their face, jaw, and mouth that doctors and dentists cannot easily explain with standard tests. This review discusses how conditions like temporomandibular disorder (jaw pain), burning mouth syndrome, and facial pain are related to each other and to broader conditions like fibromyalgia and chronic fatigue syndrome. These conditions often occur alongside anxiety, depression, and other mental health challenges, and treating them effectively requires a team approach including medication, physical therapy, and counseling.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Kindling and Oxidative Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Jason, L A, Porter, N, Herrington, J et al.·Journal of behavioral and neuroscience research·2009

ME/CFS is a complex illness that often starts suddenly, sometimes after a viral infection, and affects multiple body systems including the immune system, nervous system, and heart. This study proposes that two processes—'kindling' (where repeated small stresses build up over time) and oxidative stress (cellular damage from harmful molecules)—may help explain why different ME/CFS patients have such different symptoms and test results.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM unclearObservational

The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome.

Turan, Tayfun, Izgi, Hasan Basri, Ozsoy, Saliha et al.·Psychiatry investigation·2009

This study tested whether a medication called galantamine, which increases a brain chemical called acetylcholine, could help ME/CFS patients by improving hormone imbalances. Researchers measured two stress hormones (cortisol and DHEAS) in 29 ME/CFS patients before and after 4 weeks of treatment, comparing them to healthy controls. They found that in patients who improved with the medication, the abnormal hormone levels shifted back toward normal, suggesting the cholinergic system may play a role in ME/CFS.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

[Q Fever in Tunisia].

Kaabia, N, Letaief, A·Pathologie-biologie·2009

Q fever is an infection caused by bacteria from animals that spreads to humans, usually through breathing contaminated air. While most people infected have no symptoms or mild flu-like illness, some can develop a chronic form that includes long-term fatigue. This review examines how common Q fever is in Tunisia and why doctors there often miss or misdiagnose it.

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome and complement activation.

Geller, Robert Dennis, Giclas, Patricia C·BMJ case reports·2009

This report follows one patient who developed ME/CFS after a severe Epstein-Barr virus infection. Standard medical tests came back normal, but when doctors tested for complement activation (part of the immune system's inflammatory response), they found it was abnormally active. The patient remained unwell for about 2 years while showing these signs of complement activation, then recovered.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Functional somatic syndromes from the view of cultural anthropology].

Nakagami, Ayako, Tsujiuchi, Takuya·Nihon rinsho. Japanese journal of clinical medicine·2009

This study explains how culture and society shape the way people experience and describe illnesses like ME/CFS. The authors point out that doctors and patients often understand illness differently—doctors focus on what they can measure (disease), while patients focus on how the illness affects their daily life (illness). Understanding these different viewpoints can help doctors and patients communicate better and work together.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.

Vij, Garima, Gupta, Amit, Chopra, Kanwaljit·Fundamental & clinical pharmacology·2009

Researchers tested whether naringin, a natural compound found in citrus fruits, could help reduce fatigue-like symptoms in mice exposed to immune challenges and stress. Mice treated with naringin showed improvements in their activity levels, pain sensitivity, and markers of cellular damage compared to untreated mice, suggesting that reducing oxidative stress might help manage fatigue symptoms.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

Veldman, Joan, Van Houdenhove, Boudewijn, Verguts, Jasper·Archives of gynecology and obstetrics·2009

This case describes a woman with chronic fatigue syndrome who developed a rare condition called membranous dysmenorrhea (where the uterine lining sheds in one piece) after starting a hormonal birth control pill. Interestingly, when she stopped the medication and the tissue was expelled, her fatigue symptoms completely disappeared and she was able to return to work. While this is just one patient's experience, it raises the possibility that hormone imbalances might contribute to chronic fatigue in some cases.

E3 PreliminaryCohortPEM not requiredCase-Control

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Fluge, Øystein, Mella, Olav·BMC neurology·2009

This study examined whether a drug called rituximab, which reduces B cells (a type of immune cell), could help ME/CFS patients. Three ME/CFS patients received rituximab infusions and all experienced significant symptom improvement lasting several months. When symptoms returned, patients were retreated and improved again, suggesting that B cells may play a role in ME/CFS for at least some patients.

Immune System

E3 PreliminaryBehavioralPEM unclear

Acupuncture treatment of chronic fatigue syndrome.

Hui, Jin-Sheng·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2009

This study looked at whether acupuncture, a traditional Chinese medicine treatment involving thin needles placed on the skin, might help people with ME/CFS. The researchers compared a group of patients who received acupuncture treatment with a control group to see if there were differences in their symptoms and fatigue levels.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--more than just chronic fatigue].

Forstenius, Lisa, Helmfrid, Sten·Lakartidningen·2009

This article explains that ME/CFS is much more than simply feeling tired all the time. The authors describe how the condition affects multiple body systems and causes real, measurable problems with energy, cognition, and physical function. The paper emphasizes that ME/CFS is a serious medical condition deserving proper recognition and treatment.

E3 PreliminaryReviewPEM unclearReview-Narrative

Immunological aspects of chronic fatigue syndrome.

Lorusso, Lorenzo, Mikhaylova, Svetlana V, Capelli, Enrica et al.·Autoimmunity reviews·2009

This review examines how the immune system may be involved in ME/CFS. Researchers have found that people with ME/CFS often have unusual patterns in immune cells and signaling molecules called cytokines, particularly higher levels of inflammatory markers. These immune system changes might explain some of the main symptoms, like fatigue and flu-like feelings, though the exact role these changes play in causing the disease remains unclear.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome.

Lin, Eugene, Hsu, Sen-Yen·Pharmacogenomics·2009

Researchers used advanced statistical methods to look for interactions between genes and between genes and environmental factors (like age, sex, and weight) in ME/CFS patients. They found that a gene called NR3C1 appeared to be involved in patterns that might be related to ME/CFS, and that gender seemed to influence how this gene affected the condition. This suggests that ME/CFS likely develops from a combination of genetic and personal factors rather than from a single cause.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

A gene signature for post-infectious chronic fatigue syndrome.

Gow, John W, Hagan, Suzanne, Herzyk, Pawel et al.·BMC medical genomics·2009

This study looked at whether certain genes are turned on or off differently in people with ME/CFS compared to healthy people. Researchers examined blood cells from 8 men with post-infectious ME/CFS and 7 healthy men, testing the activity of nearly 39,000 genes. They found that 366 genes were expressed differently between the two groups, particularly in areas related to immune function, oxidative stress, and cell death.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns.

Podolecki, Tomasz, Podolecki, Andrzej, Hrycek, Antoni·Polskie Archiwum Medycyny Wewnetrznej·2009

Fibromyalgia is a condition causing widespread muscle and joint pain that affects many people worldwide. This review examines what we know about fibromyalgia's causes, how doctors diagnose it, and how it can be treated. The authors note that fibromyalgia likely results from multiple factors involving the nervous system, brain chemistry, and immune function, and that treatment typically involves antidepressants, therapy, and other approaches.

Pain and SensitizationDiagnostics

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Evidence browser

Web usage data as a means of evaluating public health messaging and outreach.

An integrated approach to infer causal associations among gene expression, genotype variation, and disease.

[Chronic fatigue syndrome: a psychoneuroimmunological perspective].

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.

[Changes on definition and diagnostic criteria of the chronic fatigue syndrome].

[Functional somatic syndrome in dental practice].

Kindling and Oxidative Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome.

[Q Fever in Tunisia].

Chronic fatigue syndrome and complement activation.

[Functional somatic syndromes from the view of cultural anthropology].

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.

Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Acupuncture treatment of chronic fatigue syndrome.

[Chronic fatigue syndrome--more than just chronic fatigue].

Immunological aspects of chronic fatigue syndrome.

A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome.

A gene signature for post-infectious chronic fatigue syndrome.

Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns.

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