ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1441–1460 of 2,423 studies

E3 PreliminaryMechanismPEM not requiredObservational

Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome.

Armitage, Roseanne, Landis, Carol, Hoffmann, Robert et al.·Journal of psychosomatic research·2009

Researchers compared brain wave patterns during sleep between identical twins where one had ME/CFS and one did not. They found no significant differences in the electrical activity of the brain during sleep between the sick and healthy twins, even though those with ME/CFS reported more sleep problems. This suggests that genetic factors may influence sleep patterns more strongly than the illness itself.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Can sustained arousal explain the Chronic Fatigue Syndrome?

Wyller, Vegard B, Eriksen, Hege R, Malterud, Kirsti·Behavioral and brain functions : BBF·2009

This study proposes that ME/CFS may be caused by the body getting stuck in a constant state of high alert, similar to being continuously stressed. This sustained arousal could develop after infections or emotional stress, especially in people with certain genetic traits or personality types. The researchers suggest this constant activation creates harmful cycles affecting the immune system, hormones, muscles, and thinking—ultimately leading to the overwhelming fatigue that defines ME/CFS.

Autonomic Nervous SystemImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Immunological aspects of chronic fatigue syndrome.

Lorusso, Lorenzo, Mikhaylova, Svetlana V, Capelli, Enrica et al.·Autoimmunity reviews·2009

This review examines how the immune system may be involved in ME/CFS. Researchers have found that people with ME/CFS often have unusual patterns in immune cells and signaling molecules called cytokines, particularly higher levels of inflammatory markers. These immune system changes might explain some of the main symptoms, like fatigue and flu-like feelings, though the exact role these changes play in causing the disease remains unclear.

Immune System

E3 PreliminaryBehavioralPEM unclear

Acupuncture treatment of chronic fatigue syndrome.

Hui, Jin-Sheng·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2009

This study looked at whether acupuncture, a traditional Chinese medicine treatment involving thin needles placed on the skin, might help people with ME/CFS. The researchers compared a group of patients who received acupuncture treatment with a control group to see if there were differences in their symptoms and fatigue levels.

E3 PreliminaryMechanismPEM not requiredMechanistic

[Cellular and molecular mechanisms of interaction between the neuroendocrine and immune systems under chronic fatigue syndrome in experiment].

Rybakina, E G, Shanin, S N, Fomicheva, E E et al.·Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2009

This study used laboratory rats to understand how ME/CFS might develop by triggering an immune response with a synthetic molecule. Researchers found that during this fatigue-like state, immune cells became less active, brain cell communication pathways were dampened, and the body's stress-response system (which normally helps us cope) became less effective. These findings suggest ME/CFS involves problems in how the immune system and brain communicate with each other.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue?

Meeus, Mira, Mistiaen, Wilhelm, Lambrecht, Luc et al.·Anticancer research·2009

This research review compares immune system abnormalities found in both cancer and ME/CFS, focusing on whether similar immune problems might explain why both conditions cause severe fatigue. The authors identified several immune dysfunctions that appear in both diseases—including problems with natural killer cells, abnormal inflammatory signaling, and increased cellular stress—and suggest these shared immune problems may contribute to the fatigue experienced by patients with either condition.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.

Vij, Garima, Gupta, Amit, Chopra, Kanwaljit·Fundamental & clinical pharmacology·2009

Researchers tested whether naringin, a natural compound found in citrus fruits, could help reduce fatigue-like symptoms in mice exposed to immune challenges and stress. Mice treated with naringin showed improvements in their activity levels, pain sensitivity, and markers of cellular damage compared to untreated mice, suggesting that reducing oxidative stress might help manage fatigue symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?

Van Houdenhove, Boudewijn, Van Den Eede, Filip, Luyten, Patrick·Medical hypotheses·2009

This study explores why many ME/CFS patients have problems with their stress hormone system, particularly a gland in the brain called the hypothalamus. The researchers suggest that ME/CFS might involve a breakdown in how the body normally responds to stress, leading to an imbalance that triggers excessive inflammation and sickness symptoms like exhaustion and pain sensitivity.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

Chronic fatigue syndrome with autoantibodies--the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant.

Nancy, Agmon-Levin, Shoenfeld, Yehuda·Autoimmunity reviews·2008

This report describes one woman who developed ME/CFS symptoms after receiving hepatitis-B vaccine doses, with her condition worsening after the third dose. Around the time of her vaccinations, she also discovered a silicone leak from breast implants she had received years earlier. The authors suggest that the combination of the vaccine's immune-stimulating ingredient (adjuvant) and leaking silicone may have together triggered her illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME).

Dietert, Rodney R, Dietert, Janice M·Toxicology·2008

This review suggests that ME/CFS may originate from immune system problems that begin early in life, possibly from exposure to harmful substances, infections, or stress during pregnancy or infancy. Just as we now understand that autism and asthma can be triggered by early-life events, the authors propose that ME/CFS might also have roots in these early developmental periods, when the immune system is particularly vulnerable.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years.

Allen, Peggy Rosati·Journal of midwifery & women's health·2008

This review examines what happens to women with ME/CFS when they become pregnant, give birth, and recover after having a baby. The authors looked at existing research and expert knowledge to understand how ME/CFS affects pregnancy and provide guidance for doctors and midwives caring for these women. The study highlights that very little research has been done on this important topic, even though millions of women with ME/CFS may experience pregnancy.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Kerr, Jonathan R, Petty, Robert, Burke, Beverley et al.·The Journal of infectious diseases·2008

Researchers analyzed blood samples from 25 ME/CFS patients and 50 healthy people to look for differences in which genes were active. They found that 88 genes behaved differently in ME/CFS patients compared to healthy controls—most were working overtime, while a few were underactive. When they studied a larger group, they discovered that ME/CFS patients could be divided into 7 distinct subtypes based on their gene activity patterns, and these subtypes differed in symptom severity and how the illness affected their daily lives.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes.

Kerr, J R, Burke, B, Petty, R et al.·Journal of clinical pathology·2008

This study found that ME/CFS is not a single disease but actually seven different types, each with its own genetic fingerprint and specific symptoms. Researchers looked at blood samples and identified which genes were turned on or off differently in patients compared to healthy people, and then grouped patients based on these genetic patterns. Each genetic subtype had different combinations of symptoms—some people struggled mainly with brain fog, others with pain and muscle problems, and some with multiple severe issues affecting sleep, mood, and digestion.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis.

Hollingsworth, Kieren G, Newton, Julia L, Taylor, Roy et al.·Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2008

This study examined how muscles produce and use energy in patients with primary biliary cirrhosis (PBC), a liver disease where the immune system attacks mitochondria—the energy factories inside cells. Using a special MRI technique, researchers measured how quickly muscles recovered after exercise and found that PBC patients had problems with this energy recovery process. The study also included people with ME/CFS and found that how quickly muscles can clear acid buildup after exercise may determine whether patients feel severely fatigued.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Sub-health state and chronic fatigue syndrome].

Wang, Tian-Fang, Xue, Xiao-Lin·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2008

This study clarifies that 'sub-health'—a state of feeling unwell that falls short of diagnosed disease—is different from ME/CFS. The authors explain what fatigue, chronic fatigue, and ME/CFS actually are, and discuss how doctors can tell them apart using established diagnostic criteria. Understanding these differences helps ensure people with ME/CFS receive appropriate diagnosis and care.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome.

Presson, Angela P, Sobel, Eric M, Papp, Jeanette C et al.·BMC systems biology·2008

Researchers used a computer-based approach to analyze genes from ME/CFS patients to understand which genes are involved in the illness and how severely they affect people. They identified a group of 299 genes that work together and are linked to how severe someone's ME/CFS symptoms are. By using genetic information alongside gene activity data, they were able to figure out which genes might actually be causing the problem versus just responding to it.

E3 PreliminaryBehavioralPEM not requiredObservational

Clinical observation on the effects of Bo's abdominal acupuncture in 40 cases of chronic fatigue syndrome.

Huang, Yong, Liao, Xiao-ming, Li, Xiao-xi et al.·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2008

This study looked at whether a traditional Chinese acupuncture technique called Bo's abdominal acupuncture could help 40 people with chronic fatigue syndrome. Patients received acupuncture treatments once daily for 2 weeks, and researchers measured their symptoms and fatigue levels before and after treatment. The results showed that patients reported improvements in fatigue, loss of appetite, sleep problems, memory issues, diarrhea, and general pain.

Interventions

E3 PreliminaryPEM not required

Obstructions for quality care experienced by patients with chronic fatigue syndrome (CFS)--a case study.

Gilje, Ann Marit, Söderlund, Atle, Malterud, Kirsti·Patient education and counseling·2008

This study asked 12 ME/CFS patients about their experiences with doctors and healthcare. Patients reported that doctors often didn't believe them, didn't listen carefully, or treated them dismissively. Many felt that doctors blamed their symptoms on psychological causes or didn't take them seriously, which was sometimes as painful as the illness itself.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

An extended concept of altered self: chronic fatigue and post-infection syndromes.

Jones, James F·Psychoneuroendocrinology·2008

This paper proposes that ME/CFS and post-infection fatigue may develop when the brain's ability to sense and respond to the body becomes stuck in a protective 'sickness mode' even after the infection has cleared. Rather than being a true ongoing disease, the authors suggest it may be an altered state where the brain continues to trigger immune and stress responses as if the body is still fighting an infection, causing ongoing fatigue and other symptoms.

E3 PreliminaryCohortPEM not requiredObservational

Anaesthesia for patients with idiopathic environmental intolerance and chronic fatigue syndrome.

Fisher, M McD, Rose, M·British journal of anaesthesia·2008

This study looked at how anesthesia should be safely given to ME/CFS patients undergoing surgery. Researchers found that while some patients experienced side effects after anesthesia, these were not severe allergic reactions and were usually temporary. The study suggests that doctors can use standard anesthesia techniques for ME/CFS patients, simply avoiding any drugs the patient has previously reacted badly to.

Pain and Sensitization

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Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome.

Can sustained arousal explain the Chronic Fatigue Syndrome?

Immunological aspects of chronic fatigue syndrome.

Acupuncture treatment of chronic fatigue syndrome.

[Cellular and molecular mechanisms of interaction between the neuroendocrine and immune systems under chronic fatigue syndrome in experiment].

Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue?

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.

Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?

Chronic fatigue syndrome with autoantibodies--the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant.

Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME).

Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years.

Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes.

Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis.

[Sub-health state and chronic fatigue syndrome].

Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome.

Clinical observation on the effects of Bo's abdominal acupuncture in 40 cases of chronic fatigue syndrome.

Obstructions for quality care experienced by patients with chronic fatigue syndrome (CFS)--a case study.

An extended concept of altered self: chronic fatigue and post-infection syndromes.

Anaesthesia for patients with idiopathic environmental intolerance and chronic fatigue syndrome.

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