ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1441–1460 of 2,420 studies

Acupuncture treatment of chronic fatigue syndrome.

Hui, Jin-Sheng·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2009

This study looked at whether acupuncture, a traditional Chinese medicine treatment involving thin needles placed on the skin, might help people with ME/CFS. The researchers compared a group of patients who received acupuncture treatment with a control group to see if there were differences in their symptoms and fatigue levels.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--more than just chronic fatigue].

Forstenius, Lisa, Helmfrid, Sten·Lakartidningen·2009

This article explains that ME/CFS is much more than simply feeling tired all the time. The authors describe how the condition affects multiple body systems and causes real, measurable problems with energy, cognition, and physical function. The paper emphasizes that ME/CFS is a serious medical condition deserving proper recognition and treatment.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Continuing medical education challenges in chronic fatigue syndrome.

Brimmer, Dana J, McCleary, K Kimberly, Lupton, Teresa A et al.·BMC medical education·2009

Most doctors don't know much about ME/CFS, which means many patients don't get diagnosed or treated. Researchers created an educational program to teach healthcare providers about ME/CFS between 2000 and 2006. They found that online courses were much more popular than printed materials, and that targeting specific audiences at smaller conferences was most effective at spreading information.

E3 PreliminaryReviewPEM unclearReview-Narrative

Immunological aspects of chronic fatigue syndrome.

Lorusso, Lorenzo, Mikhaylova, Svetlana V, Capelli, Enrica et al.·Autoimmunity reviews·2009

This review examines how the immune system may be involved in ME/CFS. Researchers have found that people with ME/CFS often have unusual patterns in immune cells and signaling molecules called cytokines, particularly higher levels of inflammatory markers. These immune system changes might explain some of the main symptoms, like fatigue and flu-like feelings, though the exact role these changes play in causing the disease remains unclear.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?

Van Houdenhove, Boudewijn, Van Den Eede, Filip, Luyten, Patrick·Medical hypotheses·2009

This study explores why many ME/CFS patients have problems with their stress hormone system, particularly a gland in the brain called the hypothalamus. The researchers suggest that ME/CFS might involve a breakdown in how the body normally responds to stress, leading to an imbalance that triggers excessive inflammation and sickness symptoms like exhaustion and pain sensitivity.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Hypothesis: the chaos and complexity theory may help our understanding of fibromyalgia and similar maladies.

Martinez-Lavin, Manuel, Infante, Oscar, Lerma, Claudia·Seminars in arthritis and rheumatism·2008

This article proposes a new way to understand fibromyalgia, ME/CFS, and similar conditions by applying complexity theory—the study of how complex systems work. Instead of looking for a single cause or structural damage, the authors suggest these illnesses result from the body's systems losing their ability to adapt flexibly to stress. This perspective could help explain why these conditions involve so many different symptoms affecting different body systems.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Contentious diseases--a medico-social phenomenon from an insurance medicine perspective].

Regenauer, A·Versicherungsmedizin·2008

This article examines a group of conditions—including ME/CFS, fibromyalgia, and others—that are difficult to diagnose with standard medical tests and have become controversial in healthcare and insurance systems. The author explores why these illnesses are questioned by insurers, what they have in common, and why cases are increasing in Western societies. The paper aims to help insurance companies better understand these conditions rather than dismiss them as imaginary.

Diagnostics

E3 PreliminaryPEM not required

Obstructions for quality care experienced by patients with chronic fatigue syndrome (CFS)--a case study.

Gilje, Ann Marit, Söderlund, Atle, Malterud, Kirsti·Patient education and counseling·2008

This study asked 12 ME/CFS patients about their experiences with doctors and healthcare. Patients reported that doctors often didn't believe them, didn't listen carefully, or treated them dismissively. Many felt that doctors blamed their symptoms on psychological causes or didn't take them seriously, which was sometimes as painful as the illness itself.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

An extended concept of altered self: chronic fatigue and post-infection syndromes.

Jones, James F·Psychoneuroendocrinology·2008

This paper proposes that ME/CFS and post-infection fatigue may develop when the brain's ability to sense and respond to the body becomes stuck in a protective 'sickness mode' even after the infection has cleared. Rather than being a true ongoing disease, the authors suggest it may be an altered state where the brain continues to trigger immune and stress responses as if the body is still fighting an infection, causing ongoing fatigue and other symptoms.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis.

Hollingsworth, Kieren G, Newton, Julia L, Taylor, Roy et al.·Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2008

This study examined how muscles produce and use energy in patients with primary biliary cirrhosis (PBC), a liver disease where the immune system attacks mitochondria—the energy factories inside cells. Using a special MRI technique, researchers measured how quickly muscles recovered after exercise and found that PBC patients had problems with this energy recovery process. The study also included people with ME/CFS and found that how quickly muscles can clear acid buildup after exercise may determine whether patients feel severely fatigued.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years.

Allen, Peggy Rosati·Journal of midwifery & women's health·2008

This review examines what happens to women with ME/CFS when they become pregnant, give birth, and recover after having a baby. The authors looked at existing research and expert knowledge to understand how ME/CFS affects pregnancy and provide guidance for doctors and midwives caring for these women. The study highlights that very little research has been done on this important topic, even though millions of women with ME/CFS may experience pregnancy.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

'That was my old life; it's almost like a past-life now': identity crisis, loss and adjustment amongst people living with Chronic Fatigue Syndrome.

Dickson, Adele, Knussen, Christina, Flowers, Paul·Psychology & health·2008

This study asked 14 people with ME/CFS about their personal experiences living with the condition. Participants described feeling a loss of identity and control over their lives, struggling with not being able to plan for the future, and feeling worthless. They also mentioned how disbelief from others made these feelings worse. The study found that learning to accept the illness and adapt to their new life helped people cope better.

E3 PreliminaryCohortPEM unclearCase-Control

Chronic fatigue syndrome with autoantibodies--the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant.

Nancy, Agmon-Levin, Shoenfeld, Yehuda·Autoimmunity reviews·2008

This report describes one woman who developed ME/CFS symptoms after receiving hepatitis-B vaccine doses, with her condition worsening after the third dose. Around the time of her vaccinations, she also discovered a silicone leak from breast implants she had received years earlier. The authors suggest that the combination of the vaccine's immune-stimulating ingredient (adjuvant) and leaking silicone may have together triggered her illness.

Immune System

E3 PreliminaryBehavioralPEM not requiredObservational

Clinical observation on the effects of Bo's abdominal acupuncture in 40 cases of chronic fatigue syndrome.

Huang, Yong, Liao, Xiao-ming, Li, Xiao-xi et al.·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2008

This study looked at whether a traditional Chinese acupuncture technique called Bo's abdominal acupuncture could help 40 people with chronic fatigue syndrome. Patients received acupuncture treatments once daily for 2 weeks, and researchers measured their symptoms and fatigue levels before and after treatment. The results showed that patients reported improvements in fatigue, loss of appetite, sleep problems, memory issues, diarrhea, and general pain.

Interventions

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A train-the-trainer education and promotion program: chronic fatigue syndrome--a diagnostic and management challenge.

Brimmer, Dana J, McCleary, K Kimberly, Lupton, Teresa A et al.·BMC medical education·2008

This study tested whether training primary care doctors about ME/CFS could help more patients get diagnosed and treated. Researchers trained 79 doctors and nurse practitioners to recognize and manage ME/CFS, and these trained providers then taught over 2,000 other healthcare workers. The training improved doctors' knowledge and confidence in diagnosing ME/CFS, showing that education programs can help address the problem of missed diagnoses.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Possible links between behavioral and physiological indices of tiredness, fatigue, and exhaustion in advanced cancer.

Olson, Karin, Turner, A Robert, Courneya, Kerry S et al.·Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2008

This paper proposes a new framework for understanding tiredness and fatigue in advanced cancer patients. The researchers suggest that cancer and its treatments stress the body, which then affects four key systems: thinking ability, sleep quality, nutrition, and muscle strength. They propose that problems in all four of these areas together—not just one alone—are what cause severe fatigue, and that studying how these systems interact could lead to better treatments.

SleepCognitive Impairment

E3 PreliminaryMechanismPEM unclearMechanistic

Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls.

Thambirajah, Anita A, Sleigh, Kenna, Stiver, H Grant et al.·Clinical and investigative medicine. Medecine clinique et experimentale·2008

This study looked at special protective proteins called heat shock proteins (HSPs) in the blood cells of ME/CFS patients and healthy people before and after exercise. The researchers found that ME/CFS patients had higher levels of these proteins at rest, but their levels dropped after exercise and stayed low for a week. In contrast, healthy people's HSP levels stayed stable or increased after exercise. This difference suggests ME/CFS patients may have trouble recovering from physical stress.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome.

Presson, Angela P, Sobel, Eric M, Papp, Jeanette C et al.·BMC systems biology·2008

Researchers used a computer-based approach to analyze genes from ME/CFS patients to understand which genes are involved in the illness and how severely they affect people. They identified a group of 299 genes that work together and are linked to how severe someone's ME/CFS symptoms are. By using genetic information alongside gene activity data, they were able to figure out which genes might actually be causing the problem versus just responding to it.

E3 PreliminaryReviewPEM unclearReview-Narrative

The potential toxicity of artificial sweeteners.

Whitehouse, Christina R, Boullata, Joseph, McCauley, Linda A·AAOHN journal : official journal of the American Association of Occupational Health Nurses·2008

This article reviews what we know about artificial sweeteners—sugar substitutes used in diet drinks and other products. Scientists have debated whether these sweeteners are safe, and some have suggested links to various diseases including chronic fatigue syndrome, though the evidence is mixed. The authors provide an overview of different types of sweeteners, how they work in the body, and what research shows so far.

E3 PreliminaryCohortPEM not requiredObservational

Anaesthesia for patients with idiopathic environmental intolerance and chronic fatigue syndrome.

Fisher, M McD, Rose, M·British journal of anaesthesia·2008

This study looked at how anesthesia should be safely given to ME/CFS patients undergoing surgery. Researchers found that while some patients experienced side effects after anesthesia, these were not severe allergic reactions and were usually temporary. The study suggests that doctors can use standard anesthesia techniques for ME/CFS patients, simply avoiding any drugs the patient has previously reacted badly to.

Pain and Sensitization

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Evidence browser

Acupuncture treatment of chronic fatigue syndrome.

[Chronic fatigue syndrome--more than just chronic fatigue].

Continuing medical education challenges in chronic fatigue syndrome.

Immunological aspects of chronic fatigue syndrome.

Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?

Hypothesis: the chaos and complexity theory may help our understanding of fibromyalgia and similar maladies.

[Contentious diseases--a medico-social phenomenon from an insurance medicine perspective].

Obstructions for quality care experienced by patients with chronic fatigue syndrome (CFS)--a case study.

An extended concept of altered self: chronic fatigue and post-infection syndromes.

Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis.

Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years.

'That was my old life; it's almost like a past-life now': identity crisis, loss and adjustment amongst people living with Chronic Fatigue Syndrome.

Chronic fatigue syndrome with autoantibodies--the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant.

Clinical observation on the effects of Bo's abdominal acupuncture in 40 cases of chronic fatigue syndrome.

A train-the-trainer education and promotion program: chronic fatigue syndrome--a diagnostic and management challenge.

Possible links between behavioral and physiological indices of tiredness, fatigue, and exhaustion in advanced cancer.

Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls.

Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome.

The potential toxicity of artificial sweeteners.

Anaesthesia for patients with idiopathic environmental intolerance and chronic fatigue syndrome.

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