ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1581–1600 of 2,420 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.

Glass, Jennifer M·Current rheumatology reports·2006

Many people with fibromyalgia and chronic fatigue syndrome report problems with memory and thinking clearly. When researchers tested these patients' cognitive abilities, they found real difficulties with memory and how quickly patients process information. Brain imaging studies showed that patients' brains work differently during thinking tasks, requiring more activation than expected.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredObservational

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome.

Saggini, R, Vecchiet, J, Iezzi, S et al.·Europa medicophysica·2006

This small study tested whether a special exercise machine that combines gentle exercise with vibrations could help ME/CFS patients feel better. Ten patients did submaximal aerobic exercise using a Galileo 2000 device over six months. After the treatment, patients reported improvements in pain sensitivity, fatigue, and muscle strength compared to before they started.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.

Smith, Alicia K, White, Peter D, Aslakson, Eric et al.·Pharmacogenomics·2006

This study looked at whether different genetic variations in the stress-response system (HPA axis) and mood-related brain chemistry might explain why ME/CFS affects people differently. Researchers identified five distinct subgroups of people with chronic fatigue and found that three of these groups had different versions of specific genes compared to healthy people, suggesting that ME/CFS may not be one disease but rather several different conditions with different underlying genetic causes.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

The debate: myalgic encephalomyelitis and chronic fatigue syndrome.

Shepherd, Charles·British journal of nursing (Mark Allen Publishing)·2006

This article discusses the ongoing disagreement among doctors and researchers about ME/CFS, including what causes it and how to treat it. The author explains that while we still don't fully understand what causes the illness, we are learning more about the factors that may trigger or worsen it. Good news: doctors now have treatments available that can help reduce symptoms and improve quality of life for patients, rather than simply accepting the illness as untreatable.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Q fever.

Parker, Neil R, Barralet, Jennifer H, Bell, Alan Morton·Lancet (London, England)·2006

Q fever is an infection spread from animals to humans that usually causes flu-like symptoms, pneumonia, and liver inflammation. While most people recover on their own, some develop serious heart infections or long-term complications including chronic fatigue syndrome. This review describes Q fever's various presentations and available vaccines, with notes that awareness and symptoms vary by region.

E3 PreliminaryCommentaryPEM not requiredEditorial

Psychomotor speed: possibly a new marker for overtraining syndrome.

Nederhof, Esther, Lemmink, Koen A P M, Visscher, Chris et al.·Sports medicine (Auckland, N.Z.)·2006

This study proposes that measuring how quickly someone can respond to mental tasks (psychomotor speed) might help identify athletes who are overtraining before serious problems develop. The researchers noticed that overtraining syndrome shares some features with chronic fatigue syndrome and depression, both of which involve slowed mental processing, and suggest this slowness could be an early warning sign.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Iasiukiavichene, L, Vasiliauskas, D·Kardiologiia·2006

This review examines why people with heart disease often experience severe fatigue and how the body's stress response system may be involved. The authors explain that chronic fatigue is a condition affecting the immune system, hormones, and nervous system, and can be triggered by stress, surgery, infections, or other illnesses. They suggest that measuring a stress hormone called cortisol could help doctors identify and treat fatigue in heart patients.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Identifying illness parameters in fatiguing syndromes using classical projection methods.

Broderick, Gordon, Craddock, R Cameron, Whistler, Toni et al.·Pharmacogenomics·2006

Researchers studied 111 women to find common patterns that distinguish ME/CFS patients from healthy controls by looking at both their symptoms and gene activity in blood cells. They used a statistical method to combine multiple pieces of information—like fatigue scores, quality of life measures, and which genes were active—rather than looking at single factors alone. The analysis identified key differences related to stress in cells, immune problems, and imbalanced minerals, particularly reflected in abnormal heart rate patterns during sleep.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[On the important role of Siguan points in treatment of chronic fatigue syndrome].

Wang, Jing-jing, Meng, Hong, Cui, Cheng-bin et al.·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2006

This study examined whether a traditional Chinese medicine acupuncture technique called Siguan points might help treat chronic fatigue syndrome (ME/CFS). The researchers reviewed existing literature on this acupuncture method and concluded that using Siguan points as the main treatment approach showed promise for improving ME/CFS symptoms.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

Engel, Charles C·CNS spectrums·2006

This paper discusses two different ways to approach studying and treating illnesses like ME/CFS that don't have a clear, well-understood cause. One approach focuses on finding the root cause in controlled settings; the other focuses on whether treatments actually work in real-world patient care. The authors argue that for conditions like ME/CFS, the practical approach—focusing on what helps patients in everyday life—may be more useful than searching for a single underlying cause.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Immunological dysfunction, vaccination and Gulf War illness.

Peakman, Mark, Skowera, Ania, Hotopf, Matthew·Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2006

This study investigated whether vaccines given to soldiers during the Gulf War might have caused Gulf War illness, a condition similar to ME/CFS. Researchers looked at both epidemiological data (patterns of illness across groups) and immune system studies from veterans. They found a weak link between multiple vaccines and illness, but could not find evidence that vaccines changed the immune system in a way that would explain the illness.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Cardiovascular systemic regulation by plantar surface stimulation.

Madhavan, Guruprasad, Stewart, Julian M, McLeod, Kenneth J·Biomedical instrumentation & technology·2006

This study tested whether gentle vibrations applied to the bottom of the foot could help stabilize blood pressure and heart rate when people sit down. Researchers found that vibrations at a specific frequency (around 44 Hz) significantly reduced the normal drop in blood pressure that occurs with sitting, and were especially helpful for people whose blood pressure drops excessively.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The problem of fatigue in neurological disorders].

Kumor, Klaudiusz, Pierzchała, Krystyna·Wiadomosci lekarskie (Warsaw, Poland : 1960)·2006

Fatigue is an extremely common and often severely disabling symptom in many neurological disorders, affecting 40–90% of patients with conditions like multiple sclerosis, Parkinson's disease, and stroke. This review explains that fatigue is a real medical symptom that should be carefully distinguished from depression, weakness, and sleepiness, though these conditions often occur together. Currently, doctors assess fatigue mainly through patient questionnaires, and there is no clear biological test or proven cure—treatments focus on addressing the underlying disease and using behavioral and psychological approaches.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

Ablin, Jacob N, Shoenfeld, Yehuda, Buskila, Dan·Journal of autoimmunity·2006

This review examines whether infections and vaccinations might trigger fibromyalgia and related conditions like chronic fatigue syndrome. Researchers found that certain infections (like Lyme disease and hepatitis C) have been linked to fibromyalgia, and some people report symptoms starting after vaccinations, but antibiotics and antivirals don't appear to help treat fibromyalgia effectively. The authors suggest that vaccinations might act as one trigger among several factors that together cause these conditions.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Komaroff, Anthony L·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study reviews evidence about whether a virus called human herpesvirus-6 (HHV-6) might cause ME/CFS. Researchers found that active HHV-6 infection appears more frequently in ME/CFS patients than in healthy people, and the virus may be connected to some of the nervous system and immune system problems seen in ME/CFS. However, not all ME/CFS patients test positive for active HHV-6, suggesting it may only trigger the illness in some people.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Translation and validation of the Dutch language version of the CDC Symptom Inventory for assessment of Chronic Fatigue Syndrome (CFS).

Vermeulen, Ruud C W·Population health metrics·2006

This study tested whether a Dutch translation of a symptom checklist used to diagnose ME/CFS works as well as the original English version. Researchers asked 139 ME/CFS patients and 43 healthy people to complete the questionnaire and compared the results. The Dutch version performed well and gave similar results to the English version, confirming it's a useful tool for doctors and researchers in Dutch-speaking countries.

E3 PreliminaryCohortPEM not requiredObservational

Causes of death among patients with chronic fatigue syndrome.

Jason, Leonard A, Corradi, Karina, Gress, Sara et al.·Health care for women international·2006

This study looked at 166 people with ME/CFS who had passed away to understand what caused their deaths. The researchers found that heart failure, suicide, and cancer were the three leading causes, together accounting for nearly 60% of deaths. Notably, people with ME/CFS who died from cancer or suicide were much younger—in their late 30s to mid-40s—compared to people in the general population who died from these same causes.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women?

Ouyang, Ann, Wrzos, Helena F·The American journal of gastroenterology·2006

This review article examines why irritable bowel syndrome (IBS)—a condition causing digestive discomfort—affects more women than men. The authors discuss how biological sex differences, hormones, and gender roles may influence who develops IBS and how severe their symptoms are. They suggest that while men and women are treated similarly for IBS, paying attention to stress and gender-specific factors might improve care.

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Richards, Jo, Chaplin, Robert, Starkey, Caroline et al.·Child and adolescent mental health·2006

This study asked 21 young people with ME/CFS and their parents about what they thought caused the illness and how they managed it. Most people believed the illness started from an infection, while fewer thought it was psychological. Many found that resting and reducing activity helped manage symptoms. The study highlights that doctors should listen carefully to what patients and families believe about ME/CFS before deciding on treatment.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue after spinal cord injury.

Barat, M, Dehail, P, de Seze, M·Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique·2006

This review looked at fatigue that develops after spinal cord injury and found two main types: one caused by muscle weakness and paralysis from nerve damage, and another that develops over time and resembles conditions like chronic fatigue syndrome. The authors suggest that exercise programs and electrical stimulation of muscles might help reduce this fatigue and improve quality of life for people with spinal cord injuries.

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Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome.

Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.

The debate: myalgic encephalomyelitis and chronic fatigue syndrome.

Q fever.

Psychomotor speed: possibly a new marker for overtraining syndrome.

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Identifying illness parameters in fatiguing syndromes using classical projection methods.

[On the important role of Siguan points in treatment of chronic fatigue syndrome].

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

Immunological dysfunction, vaccination and Gulf War illness.

Cardiovascular systemic regulation by plantar surface stimulation.

[The problem of fatigue in neurological disorders].

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Translation and validation of the Dutch language version of the CDC Symptom Inventory for assessment of Chronic Fatigue Syndrome (CFS).

Causes of death among patients with chronic fatigue syndrome.

Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women?

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Fatigue after spinal cord injury.

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