ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1581–1600 of 2,422 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women?

Ouyang, Ann, Wrzos, Helena F·The American journal of gastroenterology·2006

This review article examines why irritable bowel syndrome (IBS)—a condition causing digestive discomfort—affects more women than men. The authors discuss how biological sex differences, hormones, and gender roles may influence who develops IBS and how severe their symptoms are. They suggest that while men and women are treated similarly for IBS, paying attention to stress and gender-specific factors might improve care.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Nursing times·2006

This article provides an overview of chronic fatigue syndrome (ME/CFS) for nursing professionals. It covers the basic understanding of the condition, its impact on patients, and how healthcare providers can better support people living with ME/CFS.

E3 PreliminaryBehavioralPEM not requiredObservational

Chronic Fatigue Syndrome: An Evaluation of a Community Based Management Programme for Adolescents and their Families.

Ashby, Bernadette, Wright, Barry, Jordan, Jo·Child and adolescent mental health·2006

This study looked at how a community-based treatment program helped young people with ME/CFS and their families. Researchers interviewed teenagers and parents about their experience with an approach that combined physical rehabilitation with attention to both body and mind. The families reported improvements across the key areas addressed, and most valued this collaborative treatment method.

E3 PreliminaryReviewPEM unclearReview-Narrative

Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome.

van Staden, Werdie C W·Current opinion in psychiatry·2006

This paper examines why it can be difficult to distinguish between two conditions that both cause severe tiredness: undifferentiated somatoform disorder (a condition where physical symptoms occur without clear medical causes) and ME/CFS. The author argues that a key difference may be how patients experience their fatigue—some describe it as purely physical rather than mental—and that this distinction has not been properly studied or recognized in ME/CFS research.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Brain cytokines and the 5-HT system during poly I:C-induced fatigue.

Katafuchi, Toshihiko, Kondo, Tetsuya, Take, Sachiko et al.·Annals of the New York Academy of Sciences·2006

This study investigated how the brain's immune system might cause fatigue by looking at what happens when rats are exposed to a viral-like trigger. Researchers found that certain immune molecules in the brain (interferons) increased while a key fatigue-related brain chemical (serotonin) decreased. When they gave the rats a medication that boosted serotonin activity, the fatigue improved, suggesting that low serotonin in a specific brain region may play a role in fatigue.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Staines, Donald R·Clinical & developmental immunology·2006

This paper proposes that ME/CFS and similar conditions may develop when the immune system mistakenly attacks certain chemical messengers in the body called vasoactive neuropeptides (VNs). These VNs normally help control heart rate, breathing, temperature, memory, and mood. The authors suggest that after infections or other triggers, people's bodies may lose the ability to recognize these messengers as 'self,' leading to immune attacks that could cause the widespread symptoms seen in ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Komaroff, Anthony L·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study reviews evidence about whether a virus called human herpesvirus-6 (HHV-6) might cause ME/CFS. Researchers found that active HHV-6 infection appears more frequently in ME/CFS patients than in healthy people, and the virus may be connected to some of the nervous system and immune system problems seen in ME/CFS. However, not all ME/CFS patients test positive for active HHV-6, suggesting it may only trigger the illness in some people.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Translation and validation of the Dutch language version of the CDC Symptom Inventory for assessment of Chronic Fatigue Syndrome (CFS).

Vermeulen, Ruud C W·Population health metrics·2006

This study tested whether a Dutch translation of a symptom checklist used to diagnose ME/CFS works as well as the original English version. Researchers asked 139 ME/CFS patients and 43 healthy people to complete the questionnaire and compared the results. The Dutch version performed well and gave similar results to the English version, confirming it's a useful tool for doctors and researchers in Dutch-speaking countries.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue after spinal cord injury.

Barat, M, Dehail, P, de Seze, M·Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique·2006

This review looked at fatigue that develops after spinal cord injury and found two main types: one caused by muscle weakness and paralysis from nerve damage, and another that develops over time and resembles conditions like chronic fatigue syndrome. The authors suggest that exercise programs and electrical stimulation of muscles might help reduce this fatigue and improve quality of life for people with spinal cord injuries.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Vernon, Suzanne D, Reeves, William C·Pharmacogenomics·2006

Researchers invited people with ME/CFS, people with other unexplained fatigue illnesses, and healthy controls to stay in a hospital for 2 days. During the visit, they measured brain chemicals, nervous system function, immune markers, and gene activity. A team of 20 scientists from different fields worked together to find new ways to understand all this information and look for biological markers that might explain ME/CFS.

Sleep

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Interpreter of maladies: redescription mining applied to biomedical data analysis.

Waltman, Peter, Pearlman, Alex, Mishra, Bud·Pharmacogenomics·2006

This paper describes a new computational method for analyzing complex medical data to better understand disease causes. The authors explain how combining genetic, protein, and clinical information from patients and healthy people can reveal hidden patterns that explain why diseases like ME/CFS occur and progress. They demonstrate this approach using a large CDC dataset from patients with ME/CFS.

Biomarkers

E3 PreliminaryCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Neuro endocrinology letters·2006

This study found that people with ME/CFS have higher levels of immune antibodies (IgM) attacking damaged fats and proteins in their bodies. These antibodies target substances created when cells are damaged by oxidative stress—a harmful process where the body's natural defenses become imbalanced. The more severe someone's ME/CFS symptoms were, the higher their antibody levels tended to be.

BiomarkersImmune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Challenges for molecular profiling of chronic fatigue syndrome.

Vernon, Suzanne D, Whistler, Toni, Aslakson, Eric et al.·Pharmacogenomics·2006

This paper discusses why it's been difficult for scientists to find reliable blood tests (biomarkers) to diagnose ME/CFS and develop treatments. The authors explain that ME/CFS is complex because it affects many body systems at once, and each researcher may focus on different areas based on their expertise. They suggest that blood tests show promise for understanding ME/CFS and that combining genetic information, protein data, and information about patients' environments and behaviors could help researchers better understand why different patients experience the illness differently.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Gene expression correlates of unexplained fatigue.

Whistler, Toni, Taylor, Renee, Craddock, R Cameron et al.·Pharmacogenomics·2006

Researchers examined blood samples from hundreds of people to find which genes are connected to fatigue in ME/CFS. They looked at over 20,000 genes and found that 839 of them showed a relationship with fatigue levels. Many of these genes are involved in energy production and metabolism in the body, though about half of the genes they found don't yet have clear functions identified.

Energy Metabolism

E3 PreliminaryCohortPEM unclearCase-Control

Efficacy of neurotropin in chronic fatigue syndrome: a case report.

Toda, Katsuhiro, Kimura, Hiroaki·Hiroshima journal of medical sciences·2006

This case report describes one 28-year-old man with ME/CFS who was treated with a medication called Neurotropin (four tablets daily). His fatigue and widespread pain began improving within a week, and his sleep, focus, and memory improved within two weeks. He stopped taking the medication after 11 weeks and remained symptom-free for at least 5 months afterward.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryCohortPEM not requiredObservational

Causes of death among patients with chronic fatigue syndrome.

Jason, Leonard A, Corradi, Karina, Gress, Sara et al.·Health care for women international·2006

This study looked at 166 people with ME/CFS who had passed away to understand what caused their deaths. The researchers found that heart failure, suicide, and cancer were the three leading causes, together accounting for nearly 60% of deaths. Notably, people with ME/CFS who died from cancer or suicide were much younger—in their late 30s to mid-40s—compared to people in the general population who died from these same causes.

E3 PreliminaryMechanismPEM not requiredMechanistic

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Takahashi, Takashi, Yu, Fei, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2006

Researchers gave mice a brewer's yeast extract to see if it could help restore activity levels in a mouse model of ME/CFS. Mice treated with the yeast extract showed significantly better activity levels compared to untreated mice, and the treated mice also had better survival rates. The study suggests that brewer's yeast extract may help by adjusting immune system responses that become imbalanced in ME/CFS.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Craddock, R Cameron, Taylor, Renee, Broderick, Gordon et al.·Pharmacogenomics·2006

Researchers tested a new statistical method called the entropy correlation coefficient to identify which ME/CFS symptoms and test results are related to each other. They studied 130 women and found that fatigue-related measures were strongly connected to each other, as were general quality-of-life measures and depression scores. Importantly, they discovered some relationships between cognitive test results and ME/CFS that hadn't been found with traditional statistical methods.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Maoz, Daniel, Shoenfeld, Yehuda·Harefuah·2006

ME/CFS is a serious illness that causes extreme tiredness and other symptoms that interfere with daily life. Doctors often fail to diagnose it correctly, and we still don't fully understand what causes it. This review suggests that ME/CFS likely results from multiple different factors working together, and that two treatments—cognitive behavioral therapy and graded exercise therapy—might help some patients.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

Lundell, Kathleen, Qazi, Sanjive, Eddy, Linda et al.·Arzneimittel-Forschung·2006

This study looked at 58 ME/CFS patients and found that most had weakened immune systems with low levels of a type of immune cell called B-lymphocytes, and most also had reactivated Epstein-Barr virus (EBV) infection. When researchers gave patients folinic acid (a form of vitamin B), about 81% reported feeling better. The findings suggest that folinic acid might help some ME/CFS patients and that immune problems may play a role in the illness.

Immune System

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Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women?

Chronic fatigue syndrome.

Chronic Fatigue Syndrome: An Evaluation of a Community Based Management Programme for Adolescents and their Families.

Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome.

Brain cytokines and the 5-HT system during poly I:C-induced fatigue.

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Translation and validation of the Dutch language version of the CDC Symptom Inventory for assessment of Chronic Fatigue Syndrome (CFS).

Fatigue after spinal cord injury.

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Interpreter of maladies: redescription mining applied to biomedical data analysis.

Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins.

Challenges for molecular profiling of chronic fatigue syndrome.

Gene expression correlates of unexplained fatigue.

Efficacy of neurotropin in chronic fatigue syndrome: a case report.

Causes of death among patients with chronic fatigue syndrome.

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

[Chronic fatigue syndrome].

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

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