ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1581–1600 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Iasiukiavichene, L, Vasiliauskas, D·Kardiologiia·2006

This review examines why people with heart disease often experience severe fatigue and how the body's stress response system may be involved. The authors explain that chronic fatigue is a condition affecting the immune system, hormones, and nervous system, and can be triggered by stress, surgery, infections, or other illnesses. They suggest that measuring a stress hormone called cortisol could help doctors identify and treat fatigue in heart patients.

Endocrine Disruption

E3 PreliminaryCohortPEM unclearObservational

Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis.

Whitehead, Lisa Claire·Social science & medicine (1982)·2006

This study looked at how 17 people with ME/CFS describe their illness and make sense of it. Researchers found that people often go through different ways of telling their story: first trying to get back to normal (restitution), then feeling overwhelmed by chaos, and eventually finding new meaning in their lives (quest narrative). Understanding these patterns helps explain how people cope with a long-term illness that's hard to diagnose and often misunderstood.

E3 PreliminaryReviewPEM unclearReview-Narrative

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Staines, Donald R·Clinical & developmental immunology·2006

This paper proposes that ME/CFS and similar conditions may develop when the immune system mistakenly attacks certain chemical messengers in the body called vasoactive neuropeptides (VNs). These VNs normally help control heart rate, breathing, temperature, memory, and mood. The authors suggest that after infections or other triggers, people's bodies may lose the ability to recognize these messengers as 'self,' leading to immune attacks that could cause the widespread symptoms seen in ME/CFS.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Craddock, R Cameron, Taylor, Renee, Broderick, Gordon et al.·Pharmacogenomics·2006

Researchers tested a new statistical method called the entropy correlation coefficient to identify which ME/CFS symptoms and test results are related to each other. They studied 130 women and found that fatigue-related measures were strongly connected to each other, as were general quality-of-life measures and depression scores. Importantly, they discovered some relationships between cognitive test results and ME/CFS that hadn't been found with traditional statistical methods.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Takahashi, Takashi, Yu, Fei, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2006

Researchers gave mice a brewer's yeast extract to see if it could help restore activity levels in a mouse model of ME/CFS. Mice treated with the yeast extract showed significantly better activity levels compared to untreated mice, and the treated mice also had better survival rates. The study suggests that brewer's yeast extract may help by adjusting immune system responses that become imbalanced in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Identifying illness parameters in fatiguing syndromes using classical projection methods.

Broderick, Gordon, Craddock, R Cameron, Whistler, Toni et al.·Pharmacogenomics·2006

Researchers studied 111 women to find common patterns that distinguish ME/CFS patients from healthy controls by looking at both their symptoms and gene activity in blood cells. They used a statistical method to combine multiple pieces of information—like fatigue scores, quality of life measures, and which genes were active—rather than looking at single factors alone. The analysis identified key differences related to stress in cells, immune problems, and imbalanced minerals, particularly reflected in abnormal heart rate patterns during sleep.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Psychomotor speed: possibly a new marker for overtraining syndrome.

Nederhof, Esther, Lemmink, Koen A P M, Visscher, Chris et al.·Sports medicine (Auckland, N.Z.)·2006

This study proposes that measuring how quickly someone can respond to mental tasks (psychomotor speed) might help identify athletes who are overtraining before serious problems develop. The researchers noticed that overtraining syndrome shares some features with chronic fatigue syndrome and depression, both of which involve slowed mental processing, and suggest this slowness could be an early warning sign.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredObservational

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome.

Saggini, R, Vecchiet, J, Iezzi, S et al.·Europa medicophysica·2006

This small study tested whether a special exercise machine that combines gentle exercise with vibrations could help ME/CFS patients feel better. Ten patients did submaximal aerobic exercise using a Galileo 2000 device over six months. After the treatment, patients reported improvements in pain sensitivity, fatigue, and muscle strength compared to before they started.

E3 PreliminaryDiagnosticPEM unclearCross-Sectional

The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue.

Aslakson, Eric, Vollmer-Conna, Uté, White, Peter D·Pharmacogenomics·2006

Researchers used statistical methods to identify distinct groups among people with chronic unexplained fatigue, including those with ME/CFS. They tested whether these groups were real and consistent by running their analysis multiple ways. They found that the groups they identified were valid and matched well with established ME/CFS diagnostic criteria, suggesting that ME/CFS is not one single condition but rather several related conditions with potentially different underlying causes.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Highlights from 5th International Conference on HHV-6 and -7.

Komaroff, Anthony L, Jacobson, Steven, Ablashi, Dharam V et al.·Herpes : the journal of the IHMF·2006

Scientists at an international conference discussed new tests to detect two common viruses (HHV-6 and HHV-7) in the body and whether they might trigger nervous system diseases. These viruses can infect brain cells, and researchers think they may play a role in conditions like chronic fatigue syndrome, along with multiple sclerosis and other neurological problems. Better tests are being developed to tell if someone has an active infection or just carries the virus dormant.

E3 PreliminaryCommentaryPEM not requiredEditorial

Challenges for molecular profiling of chronic fatigue syndrome.

Vernon, Suzanne D, Whistler, Toni, Aslakson, Eric et al.·Pharmacogenomics·2006

This paper discusses why it's been difficult for scientists to find reliable blood tests (biomarkers) to diagnose ME/CFS and develop treatments. The authors explain that ME/CFS is complex because it affects many body systems at once, and each researcher may focus on different areas based on their expertise. They suggest that blood tests show promise for understanding ME/CFS and that combining genetic information, protein data, and information about patients' environments and behaviors could help researchers better understand why different patients experience the illness differently.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

[Multiple chemical sensitivity in sick-building syndrome].

Arnold Llamosas, Pablo A, Arrizabalaga Clemente, Pilar, Bonet Agusti, Montserrat et al.·Medicina clinica·2006

This study describes a dialysis worker who developed severe chronic fatigue and chemical sensitivities after prolonged exposure to poor indoor air quality in a poorly ventilated building. The person experienced eye irritation, breathing problems, and other symptoms that improved when the environmental conditions were examined and their connection to the illness was confirmed. The case highlights that healthcare facilities can expose workers to unhealthy air and chemical environments that may trigger ME/CFS-like illnesses.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredCase-Control

Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome.

Goertzel, Benjamin N, Pennachin, Cassio, de Souza Coelho, Lucio et al.·Pharmacogenomics·2006

Researchers looked at genetic variations (called SNPs) in genes related to stress hormones and brain chemistry to see if they could predict who has ME/CFS. Using patterns from 28 specific genetic variants, they correctly identified ME/CFS in about 76% of patients tested. This suggests that genetics play a role in ME/CFS, though genes are not the whole story.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Immunological dysfunction, vaccination and Gulf War illness.

Peakman, Mark, Skowera, Ania, Hotopf, Matthew·Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2006

This study investigated whether vaccines given to soldiers during the Gulf War might have caused Gulf War illness, a condition similar to ME/CFS. Researchers looked at both epidemiological data (patterns of illness across groups) and immune system studies from veterans. They found a weak link between multiple vaccines and illness, but could not find evidence that vaccines changed the immune system in a way that would explain the illness.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Gene expression profile exploration of a large dataset on chronic fatigue syndrome.

Fang, Hong, Xie, Qian, Boneva, Roumiana et al.·Pharmacogenomics·2006

Researchers studied the genes that are turned on or off differently in people with ME/CFS compared to healthy controls. They looked at blood samples from 167 people and used computer analysis to identify 24 key genes and 11 biological pathways that appear to be involved in ME/CFS. These genes are involved in immune function, cell communication, and nerve activity—areas that scientists already suspect play a role in the illness.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Four problems with the clinical control of interstitial pneumonia, or chronic fatigue syndrome, using the megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Kodama, Mitsuo, Kodama, Toshiko·In vivo (Athens, Greece)·2006

This study describes a clinic's experience treating patients with interstitial pneumonia (a lung condition) using high-dose vitamin C infusions combined with hormones and antibiotics since 1996. The authors discuss four main challenges they encountered: deciding whether to continue treatment when patients seemed stable, dealing with bacteria becoming resistant to antibiotics, observing bone marrow damage in one patient, and noting one patient developed breast cancer during treatment.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.

Smith, Alicia K, White, Peter D, Aslakson, Eric et al.·Pharmacogenomics·2006

This study looked at whether different genetic variations in the stress-response system (HPA axis) and mood-related brain chemistry might explain why ME/CFS affects people differently. Researchers identified five distinct subgroups of people with chronic fatigue and found that three of these groups had different versions of specific genes compared to healthy people, suggesting that ME/CFS may not be one disease but rather several different conditions with different underlying genetic causes.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

Engel, Charles C·CNS spectrums·2006

This paper discusses two different ways to approach studying and treating illnesses like ME/CFS that don't have a clear, well-understood cause. One approach focuses on finding the root cause in controlled settings; the other focuses on whether treatments actually work in real-world patient care. The authors argue that for conditions like ME/CFS, the practical approach—focusing on what helps patients in everyday life—may be more useful than searching for a single underlying cause.

Diagnostics

E3 PreliminaryBehavioralPEM unclearLongitudinal

Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study.

Whitehead, Lisa·International journal of nursing studies·2006

This study followed 17 people with ME/CFS over time to understand how the illness changed how they saw themselves. The researchers found that people's sense of identity shifted depending on how sick they were and how others treated them. Over the long term, most people developed ways to cope that helped them build a more stable sense of who they were, even while managing their illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Neuropsychiatric symptoms related to interferon alpha].

Małyszczak, Krzysztof, Inglot, Małgorzata, Pawłowski, Tomasz et al.·Psychiatria polska·2006

Interferon alpha, a medication used to treat hepatitis C and B, cancer, and other serious illnesses, commonly causes psychiatric and neurological side effects including depression, fatigue, anxiety, and cognitive problems in up to half of patients. These symptoms occur because interferon directly affects the brain and triggers a cascade of chemical changes, including alterations to serotonin and other neurotransmitters. The good news is that these symptoms can often be managed with antidepressants, therapy, and behavioral support.

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[Chronic fatigue syndrome in cardiology neurohumoral changes].

Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis.

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Identifying illness parameters in fatiguing syndromes using classical projection methods.

Psychomotor speed: possibly a new marker for overtraining syndrome.

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome.

The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue.

Highlights from 5th International Conference on HHV-6 and -7.

Challenges for molecular profiling of chronic fatigue syndrome.

[Multiple chemical sensitivity in sick-building syndrome].

Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome.

Immunological dysfunction, vaccination and Gulf War illness.

Gene expression profile exploration of a large dataset on chronic fatigue syndrome.

Four problems with the clinical control of interstitial pneumonia, or chronic fatigue syndrome, using the megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study.

[Neuropsychiatric symptoms related to interferon alpha].

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