ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1641–1660 of 2,420 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Improving the diagnostic criteria and procedures for chronic fatigue syndrome.

King, Caroline, Jason, Leonard A·Biological psychology·2005

Doctors have used different definitions to diagnose ME/CFS since 1988, but these definitions were never tested scientifically to see if they actually work well. This study compared 15 people with ME/CFS, 15 with depression, and 15 healthy people to find better ways to diagnose ME/CFS. The researchers found that adding new symptoms, measuring how severe symptoms are, and using specific tests could help doctors diagnose ME/CFS more accurately.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

Nijs, Jo, De Meirleir, Kenny·In vivo (Athens, Greece)·2005

This study looks at a specific immune system pathway called the 2-5A synthetase/RNase L pathway that may be broken in ME/CFS patients. Researchers found that in ME/CFS, this pathway is overactive but also working improperly—it's being broken down into unusual pieces instead of functioning normally. This abnormal pathway appears connected to reduced natural killer cell function and problems with how cells die when they should.

Immune System

E3 PreliminaryBehavioralPEM unclearCase-Control

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Driver, Christine·The Journal of analytical psychology·2005

This study examines how the mind and body become deeply connected in people with ME/CFS, making it hard to regulate both emotions and physical symptoms. Through detailed analysis of one patient's therapy, the researcher explores how early experiences with parents may affect how the body and mind communicate and function together in ME/CFS.

E3 PreliminaryCohortPEM not required

The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Kodama, Mitsuo, Kodama, Toshiko·International journal of molecular medicine·2005

This study describes a treatment approach combining high-dose vitamin C infusions with hormonal supplements (DHEA and cortisol) in patients with interstitial pneumonia, which the authors propose may be related to ME/CFS. Over 9 years, the researchers tracked whether this treatment reduced flare-ups and prevented complications like cancer and depression. The treatment appeared to help reduce active pneumonia symptoms, though it did not prevent long-term scarring of the lungs.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Characterization of virus isolates by particle-associated nucleic acid PCR.

Stang, Alexander, Korn, Klaus, Wildner, Oliver et al.·Journal of clinical microbiology·2005

Researchers developed a new laboratory method called PAN-PCR that can identify viruses in patient samples even when standard tests fail to detect them. This technique works by finding viral genetic material protected inside virus particles and then copying and analyzing it. As a test case, they used this method on a mouth sample from a ME/CFS patient and successfully identified herpes simplex virus type 1, which had been missed by conventional testing.

E3 PreliminaryReviewPEM unclearReview-Narrative

A new view on hypocortisolism.

Fries, Eva, Hesse, Judith, Hellhammer, Juliane et al.·Psychoneuroendocrinology·2005

Some people with ME/CFS, fibromyalgia, and PTSD have abnormally low levels of cortisol, a stress hormone their body normally produces. This review suggests that this low cortisol may develop after the body's stress system works overtime for a long time. Interestingly, while low cortisol contributes to symptoms like fatigue, pain, and stress sensitivity, it may also provide some protective benefits to the body.

Endocrine Disruption

E3 PreliminaryCommentaryPEM not requiredEditorial

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

Nijs, Jo, Van de Velde, Bart, De Meirleir, Kenny·Medical hypotheses·2005

This study proposes a theory about why ME/CFS patients experience widespread pain. The researchers suggest that a molecule called nitric oxide may cause the central nervous system (the brain and spinal cord) to become overly sensitive, amplifying pain signals throughout the body. They propose that viral infections or other pathogens associated with ME/CFS may trigger this chain reaction, and that behaviors like catastrophizing or avoiding activity may either contribute to or result from this heightened sensitivity.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Gutenbrunner, C, Linden, M, Gerdes, N et al.·Die Rehabilitation·2005

This paper discusses how chronic fatigue and exhaustion affect people undergoing rehabilitation for various medical conditions. The authors reviewed how fatigue is defined, how often it occurs in different patient groups (from 50-90% depending on the condition), and whether rehabilitation can help improve it. They suggest that fatigue symptoms do improve somewhat with rehabilitation, though some symptoms can remain.

E3 PreliminaryCohortPEM not requiredCase-Control

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Mears, Tim·Acupuncture in medicine : journal of the British Medical Acupuncture Society·2005

This case report describes one patient with ME/CFS (chronic fatigue syndrome) who received electroacupuncture treatment. While the acupuncture did not cure the condition, the patient reported significant symptom improvement and was eventually able to return to work. This is one of the first published studies looking at how acupuncture might help ME/CFS patients.

Interventions

E3 PreliminaryCommentaryPEM unclearEditorial

Supporting people with severe myalgic encephalomyelitis.

Crowhurst, Greg·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2005

This article helps nurses better understand ME/CFS, a serious condition that is often misunderstood by healthcare providers. The author describes the main symptoms people experience and discusses how healthcare services can support patients. The article emphasizes that ME/CFS is a real physical illness that needs more research to help doctors and nurses care for people with it properly.

Interventions

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Moss, Jill·Journal of child health care : for professionals working with children in the hospital and community·2005

Children and young people with ME/CFS often have difficulty explaining what activities they can or cannot do on any given day, making it hard for parents and doctors to understand their abilities. Researchers worked with 251 young people from a ME support organization to create a simple 0-100% scale that young people themselves helped design and test. The result was a practical tool that 99% of young people felt accurately measured their functional abilities.

E3 PreliminaryCohortPEM unclearCross-Sectional

Why did I get chronic fatigue syndrome? A qualitative interview study of causal attributions in women patients.

Soderlund, Atle, Malterud, Kirsti·Scandinavian journal of primary health care·2005

This study asked eight women with ME/CFS about what they thought caused their illness. The women felt that stress, overwork without rest, emotional problems, and pressure to meet others' expectations may have made them more vulnerable to ME/CFS. Most believed a virus infection triggered their condition, and some thought women might catch viruses more easily or have weaker immune systems than men.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

Nijs, Jo, Vaes, Peter, De Meirleir, Kenny·Occupational therapy international·2005

Researchers created a simple questionnaire called the CFS-APQ to measure how much ME/CFS affects a patient's ability to do daily activities. They tested this questionnaire on hundreds of patients and found it works reliably—meaning patients give consistent answers when asked the same questions again—and it accurately reflects how sick someone is.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Lange, G, Steffener, J, Cook, D B et al.·NeuroImage·2005

This study used brain imaging to see what happens when people with ME/CFS listen to complex spoken information. Researchers found that people with ME/CFS could understand the information just as well as healthy people, but their brains had to work much harder to do it—using more brain regions and requiring greater effort. This provides scientific proof that the thinking and concentration difficulties ME/CFS patients report are real and visible on brain scans.

Cognitive Impairment

E3 PreliminaryBehavioralPEM not requiredCase-Control

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Shin, Yong-Il, Lee, Myeong Soo·The American journal of Chinese medicine·2005

This study looked at whether Qi therapy (a hands-on energy-based technique from traditional Chinese medicine) might help people with ME/CFS feel better. Two patients who received Qi therapy reported feeling more mentally relaxed and found it easier to cope with their pain and tiredness. While these are only two cases and more research is needed, the results suggest Qi therapy might be worth studying further as a complementary approach.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredCase-Control

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Masuda, Akinori, Kihara, Takashi, Fukudome, Tsuyoshi et al.·Journal of psychosomatic research·2005

This study followed two ME/CFS patients who tried a type of heat therapy called far-infrared sauna (heated to 60°C) combined with warming afterward. After about 15-25 sessions, both patients reported major improvements in fatigue, pain, sleep problems, and fever. They continued the therapy once or twice a week for a year and did not get worse, even after stopping their previous medication.

Pain and SensitizationSleep

E3 PreliminaryCohortPEM not requiredObservational

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Fernández-Solà, Joaquim, Lluís Padierna, Meritxell, Nogué Xarau, Santiago et al.·Medicina clinica·2005

This study followed 26 people who developed ME/CFS after being exposed to insecticide sprays at their workplace. Most patients were women who first experienced airway inflammation and digestive problems, followed by brain fog, muscle pain, and fatigue. About one-third also developed chemical sensitivity. The researchers emphasize that proper ventilation and safety precautions during and after insecticide use are crucial to prevent these illnesses.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Chronic fatigue syndrome is associated with diminished intracellular perforin.

Maher, K J, Klimas, N G, Fletcher, M A·Clinical and experimental immunology·2005

This study found that people with ME/CFS have lower levels of a protein called perforin in their immune cells, particularly in natural killer cells. Perforin is a weapon that immune cells use to fight off infections and abnormal cells. The researchers suggest this deficiency might help explain why people with ME/CFS often have weakened immune function.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neuropathology in rhinosinusitis.

Baraniuk, James N, Petrie, Kristina Naranch, Le, Uyenphuong et al.·American journal of respiratory and critical care medicine·2005

Researchers tested how the nasal passages of people with ME/CFS, sinusitis, allergies, and healthy controls responded to salt water spray. They found that people with ME/CFS experienced unusual nerve sensitivity (feeling more pain) but their mucus-producing glands didn't respond normally to the stimulus. This suggests that ME/CFS involves a different pattern of how nerves and mucus glands work in the nose compared to other nasal conditions.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Staines, Donald R·Medical hypotheses·2005

This paper proposes that ME/CFS and similar fatigue disorders may be caused by the immune system attacking special messenger molecules in the body called vasoactive neuropeptides. These molecules normally help control energy metabolism, nerve function, and immune responses. The authors suggest that when antibodies damage these molecules, it could explain the severe fatigue and other symptoms seen in ME/CFS.

Immune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Improving the diagnostic criteria and procedures for chronic fatigue syndrome.

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Characterization of virus isolates by particle-associated nucleic acid PCR.

A new view on hypocortisolism.

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Supporting people with severe myalgic encephalomyelitis.

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Why did I get chronic fatigue syndrome? A qualitative interview study of causal attributions in women patients.

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Chronic fatigue syndrome is associated with diminished intracellular perforin.

Neuropathology in rhinosinusitis.

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research