ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1641–1660 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredCross-Sectional

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Neuro endocrinology letters·2005

This study found that people with ME/CFS have lower levels of omega-3 fatty acids (healthy fats found in fish) and higher levels of other types of fats compared to healthy people. These imbalances were linked to lower zinc levels and problems with immune cells called T cells, which help fight infection. The researchers suggest that omega-3 supplements might help ME/CFS patients.

Immune System

E3 PreliminaryBehavioralPEM unclearCase-Control

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Driver, Christine·The Journal of analytical psychology·2005

This study examines how the mind and body become deeply connected in people with ME/CFS, making it hard to regulate both emotions and physical symptoms. Through detailed analysis of one patient's therapy, the researcher explores how early experiences with parents may affect how the body and mind communicate and function together in ME/CFS.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome.

Wagner, Dieter, Nisenbaum, Rosane, Heim, Christine et al.·Population health metrics·2005

Researchers created and tested a new questionnaire called the CDC CFS Symptom Inventory to help measure the many different symptoms that people with ME/CFS experience—not just fatigue, but also other important symptoms like problems with memory, sleep, and pain. They gave this questionnaire to 164 people (some with ME/CFS, some with other illnesses, and some without fatigue) and found that the questionnaire reliably distinguished people with ME/CFS from others and worked well when compared to existing fatigue measurement tools.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Aetiology and pathogenesis of chronic fatigue syndrome: a review.

Mihrshahi, Robin, Beirman, Robyn·The New Zealand medical journal·2005

This review article examines what scientists currently understand about what causes ME/CFS and how the illness develops. The authors looked at research across four main areas: infections, immune system problems, hormonal and nervous system imbalances, and mental health factors. They suggest that ME/CFS likely results from a combination of these factors rather than a single cause.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Drug targets in stress-related disorders.

Covelli, Vito, Passeri, Maria Elena, Leogrande, Domenica et al.·Current medicinal chemistry·2005

This review examines how stress affects both the nervous and immune systems, and explores potential drug treatments for stress-related disorders. The authors discuss how the body's stress response systems can trigger or worsen conditions like chronic fatigue syndrome (CFS), and suggest that medicines targeting immune cell activity and inflammatory chemicals may help. They found that CFS patients have different immune patterns compared to depressed patients, which could guide future treatment approaches.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Lange, G, Steffener, J, Cook, D B et al.·NeuroImage·2005

This study used brain imaging to see what happens when people with ME/CFS listen to complex spoken information. Researchers found that people with ME/CFS could understand the information just as well as healthy people, but their brains had to work much harder to do it—using more brain regions and requiring greater effort. This provides scientific proof that the thinking and concentration difficulties ME/CFS patients report are real and visible on brain scans.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

Nijs, Jo, Vaes, Peter, De Meirleir, Kenny·Occupational therapy international·2005

Researchers created a simple questionnaire called the CFS-APQ to measure how much ME/CFS affects a patient's ability to do daily activities. They tested this questionnaire on hundreds of patients and found it works reliably—meaning patients give consistent answers when asked the same questions again—and it accurately reflects how sick someone is.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

An experimental study of determinants of the extent of disagreement within clinical guideline development groups.

Hutchings, A, Raine, R, Sanderson, C et al.·Quality & safety in health care·2005

This study looked at how doctors and mental health professionals reach agreement on which treatments are appropriate for different conditions, including chronic fatigue syndrome (ME/CFS). Researchers tested whether different ways of running these decision-making meetings affected how much the professionals disagreed with each other. They found that the way meetings were structured didn't really change how much disagreement there was—doctors were more likely to agree on some treatments (like cognitive behavioral therapy) than others.

E3 PreliminaryCommentaryPEM unclearEditorial

Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.

Durlach, J, Pagès, N, Bac, P et al.·Magnesium research·2005

This paper proposes that low magnesium levels combined with disrupted biological clocks (your body's natural 24-hour rhythm) may contribute to asthma that gets worse at night. The authors suggest that magnesium depletion is different from simple magnesium deficiency—it involves a deeper dysregulation that cannot be fixed by supplements alone. They propose two subtypes based on whether the biological clock is overactive (linked to nighttime asthma) or underactive (linked to daytime symptoms).

Sleep

E3 PreliminaryCohortPEM unclearCase-Control

A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid.

Baraniuk, James N, Casado, Begona, Maibach, Hilda et al.·BMC neurology·2005

Researchers examined fluid from around the spine (cerebrospinal fluid) in people with ME/CFS and found specific proteins that were present in patients but absent in healthy people. Using advanced laboratory techniques, they identified a set of 5 key proteins that could correctly identify ME/CFS in 80% of cases. These findings suggest ME/CFS may involve immune system and brain inflammation, offering hope for an objective test in the future.

NeuroinflammationBiomarkers

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neuropathology in rhinosinusitis.

Baraniuk, James N, Petrie, Kristina Naranch, Le, Uyenphuong et al.·American journal of respiratory and critical care medicine·2005

Researchers tested how the nasal passages of people with ME/CFS, sinusitis, allergies, and healthy controls responded to salt water spray. They found that people with ME/CFS experienced unusual nerve sensitivity (feeling more pain) but their mucus-producing glands didn't respond normally to the stimulus. This suggests that ME/CFS involves a different pattern of how nerves and mucus glands work in the nose compared to other nasal conditions.

Neuroinflammation

E3 PreliminaryCohortPEM not requiredCase-Control

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Masuda, Akinori, Kihara, Takashi, Fukudome, Tsuyoshi et al.·Journal of psychosomatic research·2005

This study followed two ME/CFS patients who tried a type of heat therapy called far-infrared sauna (heated to 60°C) combined with warming afterward. After about 15-25 sessions, both patients reported major improvements in fatigue, pain, sleep problems, and fever. They continued the therapy once or twice a week for a year and did not get worse, even after stopping their previous medication.

Pain and SensitizationSleep

E3 PreliminaryCohortPEM not requiredCross-Sectional

Can the social model explain all of disability experience? Perspectives of persons with chronic fatigue syndrome.

Taylor, Renee R·The American journal of occupational therapy : official publication of the American Occupational Therapy Association·2005

This study asked 47 people with ME/CFS about their disability experiences and found that the most common way doctors and society think about disability doesn't fully explain what ME/CFS patients go through. Many participants felt their condition wasn't believed or understood, experienced real physical and cognitive problems from the illness itself, and didn't feel connected to the broader disability community. The researchers concluded that ME/CFS—as an invisible disability with variable, complex impairments—requires a more nuanced approach than typical disability frameworks offer.

E3 PreliminaryBehavioralPEM unclear

Ayurvedic treatment of chronic fatigue syndrome--a case report.

Vinjamury, Sivarama Prasad, Singh, Betsy B·Alternative therapies in health and medicine·2005

This case report describes one patient with chronic fatigue syndrome (ME/CFS) who received treatment using Ayurveda, a traditional medicine system from India. The authors documented whether Ayurvedic treatments helped reduce the patient's fatigue and other symptoms. While the patient showed some improvement, this is just one person's experience and cannot tell us whether this approach works for most people with ME/CFS.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Staines, Donald R·Medical hypotheses·2005

This paper proposes that ME/CFS and similar fatigue disorders may be caused by the immune system attacking special messenger molecules in the body called vasoactive neuropeptides. These molecules normally help control energy metabolism, nerve function, and immune responses. The authors suggest that when antibodies damage these molecules, it could explain the severe fatigue and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Are vasoactive neuropeptide autoimmune fatigue-related disorders mediated via G protein-coupled receptors?

Staines, Donald·Medical hypotheses·2005

This paper proposes that ME/CFS might involve problems with special proteins on cell surfaces called G protein-coupled receptors (GPCRs), which normally help cells respond to stress and manage energy. The author suggests that certain immune molecules and genetic variations could damage these receptors, disrupting the cell's ability to produce energy and causing fatigue. This is a theoretical explanation rather than a proof based on patient data.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Fernández-Solà, Joaquim, Lluís Padierna, Meritxell, Nogué Xarau, Santiago et al.·Medicina clinica·2005

This study followed 26 people who developed ME/CFS after being exposed to insecticide sprays at their workplace. Most patients were women who first experienced airway inflammation and digestive problems, followed by brain fog, muscle pain, and fatigue. About one-third also developed chemical sensitivity. The researchers emphasize that proper ventilation and safety precautions during and after insecticide use are crucial to prevent these illnesses.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Coxiella burnetii infection.

Kazar, Jan·Annals of the New York Academy of Sciences·2005

Coxiella burnetii is a bacterium that causes Q fever, a disease spread mainly through contact with infected animals like cattle, sheep, and goats. Most people infected have no symptoms or mild flu-like illness, but some develop chronic complications including chronic fatigue syndrome. This review examines how the bacterium survives in the body and causes different forms of disease depending on a person's immune system and overall health.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Shin, Yong-Il, Lee, Myeong Soo·The American journal of Chinese medicine·2005

This study looked at whether Qi therapy (a hands-on energy-based technique from traditional Chinese medicine) might help people with ME/CFS feel better. Two patients who received Qi therapy reported feeling more mentally relaxed and found it easier to cope with their pain and tiredness. While these are only two cases and more research is needed, the results suggest Qi therapy might be worth studying further as a complementary approach.

Pain and Sensitization

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Moss, Jill·Journal of child health care : for professionals working with children in the hospital and community·2005

Children and young people with ME/CFS often have difficulty explaining what activities they can or cannot do on any given day, making it hard for parents and doctors to understand their abilities. Researchers worked with 251 young people from a ME support organization to create a simple 0-100% scale that young people themselves helped design and test. The result was a practical tool that 99% of young people felt accurately measured their functional abilities.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome.

Aetiology and pathogenesis of chronic fatigue syndrome: a review.

Drug targets in stress-related disorders.

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

An experimental study of determinants of the extent of disagreement within clinical guideline development groups.

Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.

A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid.

Neuropathology in rhinosinusitis.

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Can the social model explain all of disability experience? Perspectives of persons with chronic fatigue syndrome.

Ayurvedic treatment of chronic fatigue syndrome--a case report.

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Are vasoactive neuropeptide autoimmune fatigue-related disorders mediated via G protein-coupled receptors?

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Coxiella burnetii infection.

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research