ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1661–1680 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Are attention deficit hyperactivity disorder and chronic fatigue syndrome allergy related? what is fibromyalgia?

Bellanti, Joseph A, Sabra, Aderbal, Castro, Henry J et al.·Allergy and asthma proceedings·2005

This review article explores whether allergies and immune system problems might play a role in three conditions: ADHD, chronic fatigue syndrome (CFS), and fibromyalgia. The authors suggest that while the exact causes of these disorders remain unknown, allergic reactions—including reactions to foods—may trigger or worsen symptoms in all three conditions. They propose that problems in the body's neuroendocrine-immune system (the network connecting the brain, hormones, and immune function) are central to understanding these illnesses.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Lange, G, Steffener, J, Cook, D B et al.·NeuroImage·2005

This study used brain imaging to see what happens when people with ME/CFS listen to complex spoken information. Researchers found that people with ME/CFS could understand the information just as well as healthy people, but their brains had to work much harder to do it—using more brain regions and requiring greater effort. This provides scientific proof that the thinking and concentration difficulties ME/CFS patients report are real and visible on brain scans.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Aetiology and pathogenesis of chronic fatigue syndrome: a review.

Mihrshahi, Robin, Beirman, Robyn·The New Zealand medical journal·2005

This review article examines what scientists currently understand about what causes ME/CFS and how the illness develops. The authors looked at research across four main areas: infections, immune system problems, hormonal and nervous system imbalances, and mental health factors. They suggest that ME/CFS likely results from a combination of these factors rather than a single cause.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Are vasoactive neuropeptide autoimmune fatigue-related disorders mediated via G protein-coupled receptors?

Staines, Donald·Medical hypotheses·2005

This paper proposes that ME/CFS might involve problems with special proteins on cell surfaces called G protein-coupled receptors (GPCRs), which normally help cells respond to stress and manage energy. The author suggests that certain immune molecules and genetic variations could damage these receptors, disrupting the cell's ability to produce energy and causing fatigue. This is a theoretical explanation rather than a proof based on patient data.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Masuda, Akinori, Kihara, Takashi, Fukudome, Tsuyoshi et al.·Journal of psychosomatic research·2005

This study followed two ME/CFS patients who tried a type of heat therapy called far-infrared sauna (heated to 60°C) combined with warming afterward. After about 15-25 sessions, both patients reported major improvements in fatigue, pain, sleep problems, and fever. They continued the therapy once or twice a week for a year and did not get worse, even after stopping their previous medication.

Pain and SensitizationSleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Staines, Donald R·Medical hypotheses·2005

This paper proposes that ME/CFS and similar fatigue disorders may be caused by the immune system attacking special messenger molecules in the body called vasoactive neuropeptides. These molecules normally help control energy metabolism, nerve function, and immune responses. The authors suggest that when antibodies damage these molecules, it could explain the severe fatigue and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Drug targets in stress-related disorders.

Covelli, Vito, Passeri, Maria Elena, Leogrande, Domenica et al.·Current medicinal chemistry·2005

This review examines how stress affects both the nervous and immune systems, and explores potential drug treatments for stress-related disorders. The authors discuss how the body's stress response systems can trigger or worsen conditions like chronic fatigue syndrome (CFS), and suggest that medicines targeting immune cell activity and inflammatory chemicals may help. They found that CFS patients have different immune patterns compared to depressed patients, which could guide future treatment approaches.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

Nijs, Jo, Van de Velde, Bart, De Meirleir, Kenny·Medical hypotheses·2005

This study proposes a theory about why ME/CFS patients experience widespread pain. The researchers suggest that a molecule called nitric oxide may cause the central nervous system (the brain and spinal cord) to become overly sensitive, amplifying pain signals throughout the body. They propose that viral infections or other pathogens associated with ME/CFS may trigger this chain reaction, and that behaviors like catastrophizing or avoiding activity may either contribute to or result from this heightened sensitivity.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Gutenbrunner, C, Linden, M, Gerdes, N et al.·Die Rehabilitation·2005

This paper discusses how chronic fatigue and exhaustion affect people undergoing rehabilitation for various medical conditions. The authors reviewed how fatigue is defined, how often it occurs in different patient groups (from 50-90% depending on the condition), and whether rehabilitation can help improve it. They suggest that fatigue symptoms do improve somewhat with rehabilitation, though some symptoms can remain.

E3 PreliminaryCohortPEM not requiredCase-Control

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Mears, Tim·Acupuncture in medicine : journal of the British Medical Acupuncture Society·2005

This case report describes one patient with ME/CFS (chronic fatigue syndrome) who received electroacupuncture treatment. While the acupuncture did not cure the condition, the patient reported significant symptom improvement and was eventually able to return to work. This is one of the first published studies looking at how acupuncture might help ME/CFS patients.

Interventions

E3 PreliminaryCohortPEM not requiredObservational

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Fernández-Solà, Joaquim, Lluís Padierna, Meritxell, Nogué Xarau, Santiago et al.·Medicina clinica·2005

This study followed 26 people who developed ME/CFS after being exposed to insecticide sprays at their workplace. Most patients were women who first experienced airway inflammation and digestive problems, followed by brain fog, muscle pain, and fatigue. About one-third also developed chemical sensitivity. The researchers emphasize that proper ventilation and safety precautions during and after insecticide use are crucial to prevent these illnesses.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neuropathology in rhinosinusitis.

Baraniuk, James N, Petrie, Kristina Naranch, Le, Uyenphuong et al.·American journal of respiratory and critical care medicine·2005

Researchers tested how the nasal passages of people with ME/CFS, sinusitis, allergies, and healthy controls responded to salt water spray. They found that people with ME/CFS experienced unusual nerve sensitivity (feeling more pain) but their mucus-producing glands didn't respond normally to the stimulus. This suggests that ME/CFS involves a different pattern of how nerves and mucus glands work in the nose compared to other nasal conditions.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

A new view on hypocortisolism.

Fries, Eva, Hesse, Judith, Hellhammer, Juliane et al.·Psychoneuroendocrinology·2005

Some people with ME/CFS, fibromyalgia, and PTSD have abnormally low levels of cortisol, a stress hormone their body normally produces. This review suggests that this low cortisol may develop after the body's stress system works overtime for a long time. Interestingly, while low cortisol contributes to symptoms like fatigue, pain, and stress sensitivity, it may also provide some protective benefits to the body.

Endocrine Disruption

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

Nijs, Jo, Vaes, Peter, De Meirleir, Kenny·Occupational therapy international·2005

Researchers created a simple questionnaire called the CFS-APQ to measure how much ME/CFS affects a patient's ability to do daily activities. They tested this questionnaire on hundreds of patients and found it works reliably—meaning patients give consistent answers when asked the same questions again—and it accurately reflects how sick someone is.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Shin, Yong-Il, Lee, Myeong Soo·The American journal of Chinese medicine·2005

This study looked at whether Qi therapy (a hands-on energy-based technique from traditional Chinese medicine) might help people with ME/CFS feel better. Two patients who received Qi therapy reported feeling more mentally relaxed and found it easier to cope with their pain and tiredness. While these are only two cases and more research is needed, the results suggest Qi therapy might be worth studying further as a complementary approach.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Coxiella burnetii infection.

Kazar, Jan·Annals of the New York Academy of Sciences·2005

Coxiella burnetii is a bacterium that causes Q fever, a disease spread mainly through contact with infected animals like cattle, sheep, and goats. Most people infected have no symptoms or mild flu-like illness, but some develop chronic complications including chronic fatigue syndrome. This review examines how the bacterium survives in the body and causes different forms of disease depending on a person's immune system and overall health.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Moss, Jill·Journal of child health care : for professionals working with children in the hospital and community·2005

Children and young people with ME/CFS often have difficulty explaining what activities they can or cannot do on any given day, making it hard for parents and doctors to understand their abilities. Researchers worked with 251 young people from a ME support organization to create a simple 0-100% scale that young people themselves helped design and test. The result was a practical tool that 99% of young people felt accurately measured their functional abilities.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Chronic fatigue syndrome is associated with diminished intracellular perforin.

Maher, K J, Klimas, N G, Fletcher, M A·Clinical and experimental immunology·2005

This study found that people with ME/CFS have lower levels of a protein called perforin in their immune cells, particularly in natural killer cells. Perforin is a weapon that immune cells use to fight off infections and abnormal cells. The researchers suggest this deficiency might help explain why people with ME/CFS often have weakened immune function.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome: a syndrome in search of definition].

Sánchez Rodríguez, A, González Maroño, C, Sánchez Ledesma, M·Revista clinica espanola·2005

This review examines how ME/CFS is defined and understood in clinical practice. The authors discuss the challenges doctors face in recognizing and diagnosing this condition, since it affects different people in different ways. The study highlights why having clear, consistent definitions is essential for helping patients get proper care and advancing research.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Characterization of virus isolates by particle-associated nucleic acid PCR.

Stang, Alexander, Korn, Klaus, Wildner, Oliver et al.·Journal of clinical microbiology·2005

Researchers developed a new laboratory method called PAN-PCR that can identify viruses in patient samples even when standard tests fail to detect them. This technique works by finding viral genetic material protected inside virus particles and then copying and analyzing it. As a test case, they used this method on a mouth sample from a ME/CFS patient and successfully identified herpes simplex virus type 1, which had been missed by conventional testing.

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Evidence browser

Are attention deficit hyperactivity disorder and chronic fatigue syndrome allergy related? what is fibromyalgia?

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Aetiology and pathogenesis of chronic fatigue syndrome: a review.

Are vasoactive neuropeptide autoimmune fatigue-related disorders mediated via G protein-coupled receptors?

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Drug targets in stress-related disorders.

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Neuropathology in rhinosinusitis.

A new view on hypocortisolism.

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Coxiella burnetii infection.

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Chronic fatigue syndrome is associated with diminished intracellular perforin.

[Chronic fatigue syndrome: a syndrome in search of definition].

Characterization of virus isolates by particle-associated nucleic acid PCR.

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