ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1661–1680 of 2,420 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Exercise prescription for individuals with chronic fatigue syndrome.

Wallman, Karen E, Morton, Alan R, Goodman, Carmel et al.·The Medical journal of Australia·2005

This review article examines how exercise should be prescribed for people with ME/CFS, looking at what is known from medical literature. The authors discuss different approaches to exercise and what safety considerations are important for this patient group. The review helps clarify when and how exercise might be appropriate for ME/CFS patients.

E3 PreliminaryCommentaryPEM unclearEditorial

Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.

Durlach, J, Pagès, N, Bac, P et al.·Magnesium research·2005

This paper proposes that low magnesium levels combined with disrupted biological clocks (your body's natural 24-hour rhythm) may contribute to asthma that gets worse at night. The authors suggest that magnesium depletion is different from simple magnesium deficiency—it involves a deeper dysregulation that cannot be fixed by supplements alone. They propose two subtypes based on whether the biological clock is overactive (linked to nighttime asthma) or underactive (linked to daytime symptoms).

Sleep

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls.

Tomoda, Akemi, Joudoi, Takako, Rabab, El-Mezayen et al.·Psychiatry research·2005

This study examined immune system chemicals called cytokines in people with ME/CFS compared to healthy volunteers. Researchers took blood cells from both groups and stimulated them in the laboratory to see how they would respond. They found that ME/CFS patients produced lower levels of certain immune chemicals, particularly one called TGF-beta1, which might play a role in the inflammation seen in ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Practitioner review: chronic fatigue syndrome in childhood.

Elena Garralda, M, Chalder, Trudie·Journal of child psychology and psychiatry, and allied disciplines·2005

This review examines how ME/CFS appears in children and teenagers and discusses the best ways to help them recover. The authors found that ME/CFS in young people is often triggered by infections and can be diagnosed using the same criteria as in adults. They recommend a family-based approach using cognitive behavior therapy and gradually increasing activity, which has shown promise in helping children regain function.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Neuro endocrinology letters·2005

This study found that people with ME/CFS have lower levels of omega-3 fatty acids (healthy fats found in fish) and higher levels of other types of fats compared to healthy people. These imbalances were linked to lower zinc levels and problems with immune cells called T cells, which help fight infection. The researchers suggest that omega-3 supplements might help ME/CFS patients.

Immune System

E3 PreliminaryBehavioralPEM unclear

Ayurvedic treatment of chronic fatigue syndrome--a case report.

Vinjamury, Sivarama Prasad, Singh, Betsy B·Alternative therapies in health and medicine·2005

This case report describes one patient with chronic fatigue syndrome (ME/CFS) who received treatment using Ayurveda, a traditional medicine system from India. The authors documented whether Ayurvedic treatments helped reduce the patient's fatigue and other symptoms. While the patient showed some improvement, this is just one person's experience and cannot tell us whether this approach works for most people with ME/CFS.

Interventions

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Contesting stigma and contested emotions: personal experience and public perception of specific phobias.

Davidson, Joyce·Social science & medicine (1982)·2005

This study interviewed people with specific phobias (intense, irrational fears of particular objects or situations) in the UK to understand how stigma and disbelief affect their daily lives. Like ME/CFS patients, people with phobias face judgment and skepticism from doctors and the public, even though their symptoms are real and distressing. The research shows that people with phobias develop ways to cope with and manage others' dismissive attitudes toward their condition.

E3 PreliminaryPEM not required

Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder?

Doljansky, J T, Kannety, H, Dagan, Y·Chronobiology international·2005

A 47-year-old man with chronic fatigue syndrome developed a severely disrupted sleep-wake cycle after 20 years of working under very bright lights (used for diamond grading) often late into the night. When he switched to treatment combining melatonin at bedtime, bright light therapy in the morning, and avoiding bright light at night, his sleep pattern stabilized and his daytime tiredness improved significantly within one week.

Sleep

E3 PreliminaryCohortPEM not requiredCross-Sectional

Can the social model explain all of disability experience? Perspectives of persons with chronic fatigue syndrome.

Taylor, Renee R·The American journal of occupational therapy : official publication of the American Occupational Therapy Association·2005

This study asked 47 people with ME/CFS about their disability experiences and found that the most common way doctors and society think about disability doesn't fully explain what ME/CFS patients go through. Many participants felt their condition wasn't believed or understood, experienced real physical and cognitive problems from the illness itself, and didn't feel connected to the broader disability community. The researchers concluded that ME/CFS—as an invisible disability with variable, complex impairments—requires a more nuanced approach than typical disability frameworks offer.

E3 PreliminaryMechanismPEM not requiredMechanistic

2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.

Frémont, Marc, El Bakkouri, Karim, Vaeyens, Freya et al.·Experimental and molecular pathology·2005

In ME/CFS, immune cells produce abnormal levels of proteins involved in fighting viral infections. This study found that a protective molecule called 2-5A can shield a key antiviral protein (RNase L) from being broken down by inflammatory enzymes. However, in ME/CFS patients, cells tend to produce smaller versions of 2-5A, which cannot provide this protection, leading to the accumulation of damaged RNase L protein.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Diagnosing asthenia and chronic fatigue syndrome].

Aslangul, Elisabeth, Le Jeunne, Claire·La Revue du praticien·2005

This article discusses how doctors can distinguish between general tiredness (asthenia) and ME/CFS, which is a serious long-term illness characterized by severe fatigue that doesn't improve with rest. The authors review the clinical features and diagnostic approaches that help healthcare providers identify ME/CFS in their patients. Understanding these differences is important so patients receive appropriate diagnosis and care.

Diagnostics

E3 PreliminaryBehavioralPEM unclearCase-Control

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Driver, Christine·The Journal of analytical psychology·2005

This study examines how the mind and body become deeply connected in people with ME/CFS, making it hard to regulate both emotions and physical symptoms. Through detailed analysis of one patient's therapy, the researcher explores how early experiences with parents may affect how the body and mind communicate and function together in ME/CFS.

E3 PreliminaryMechanismPEM not requiredMechanistic

Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.

Kerr, J R·Journal of veterinary medicine. B, Infectious diseases and veterinary public health·2005

This study examined how parvovirus B19 might trigger chronic fatigue syndrome (CFS) in some people. Researchers found that patients with prolonged symptoms after B19 infection had high levels of inflammatory chemicals in their blood, and identified certain genetic variations that may make some people more susceptible to developing CFS after B19 infection. They also discovered that the virus may persist in the body by hiding in human genes, and found that people carrying B19 virus DNA had altered expression of several genes involved in cell structure and immune function.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization.

Casado, Begoña, Zanone, Chiara, Annovazzi, Laura et al.·Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2005

Researchers collected urine samples from people with ME/CFS, people with ME/CFS plus fibromyalgia, and healthy controls to look for chemical differences. Using a specialized lab technique called electrophoresis, they found that the urine samples from people with these conditions showed distinct patterns of chemicals compared to healthy people. These patterns might potentially be used as biological markers to help identify and understand these illnesses.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

The role of enterovirus in chronic fatigue syndrome.

Chia, J K S·Journal of clinical pathology·2005

This review examines whether enteroviruses—common viruses that cause respiratory and stomach infections—might play a role in ME/CFS. Researchers found that these viruses can sometimes persist in the body long-term and produce symptoms similar to ME/CFS. Laboratory and animal studies showed that viral RNA (genetic material) can remain in muscles and cause ongoing inflammation, which matches what has been seen in tissue samples from ME/CFS patients.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

Glozier, N·Occupational medicine (Oxford, England)·2005

This is a detailed review article about ME/CFS written for occupational health professionals. The article examines what is known about ME/CFS, including how it affects people's ability to work, and highlights the significant gaps in our understanding of the condition. The main message is that ME/CFS remains poorly understood, which makes it difficult for doctors, employers, and patients to manage effectively.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

An experimental study of determinants of the extent of disagreement within clinical guideline development groups.

Hutchings, A, Raine, R, Sanderson, C et al.·Quality & safety in health care·2005

This study looked at how doctors and mental health professionals reach agreement on which treatments are appropriate for different conditions, including chronic fatigue syndrome (ME/CFS). Researchers tested whether different ways of running these decision-making meetings affected how much the professionals disagreed with each other. They found that the way meetings were structured didn't really change how much disagreement there was—doctors were more likely to agree on some treatments (like cognitive behavioral therapy) than others.

E3 PreliminaryReviewPEM unclearReview-Narrative

Symptom overlap and comorbidity of irritable bowel syndrome with other conditions.

Frissora, Christine L, Koch, Kenneth L·Current gastroenterology reports·2005

This review examined how irritable bowel syndrome (IBS) frequently occurs alongside other conditions, both in the digestive system and elsewhere in the body, including chronic fatigue syndrome and fibromyalgia. The authors explored why these conditions often happen together and what they might have in common. Understanding these connections could help doctors better recognize and treat patients who experience multiple overlapping symptoms.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Persistent nonallergic rhinosinusitis.

Staevska, Maria, Baraniuk, James N·Current allergy and asthma reports·2005

This review describes different types of nasal and sinus inflammation that are not caused by allergies. The authors propose a new way to organize these conditions based on whether they involve certain immune cells (eosinophils or neutrophils) or other mechanisms like hormonal changes. Interestingly, they mention that nonallergic rhinitis can occur in chronic fatigue syndrome (ME/CFS) and may involve nerve-related sensitivity.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Search for disease-specific cardiovascular reactivity patterns: developing the methodology.

Naschitz, Jochanan E, Rozenbaum, Michael, Fields, Madeline et al.·Clinical science (London, England : 1979)·2005

Researchers developed new methods to detect specific patterns in how the body's heart rate and blood pressure respond to physical stress (tilting upright) in people with familial Mediterranean fever (FMF). They found that people with FMF show distinctive cardiovascular responses that can be measured and used to help identify the condition. The study shows this approach might also work for other diseases, including ME/CFS.

Autonomic Nervous System

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Evidence browser

Exercise prescription for individuals with chronic fatigue syndrome.

Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.

Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls.

Practitioner review: chronic fatigue syndrome in childhood.

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

Ayurvedic treatment of chronic fatigue syndrome--a case report.

Contesting stigma and contested emotions: personal experience and public perception of specific phobias.

Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder?

Can the social model explain all of disability experience? Perspectives of persons with chronic fatigue syndrome.

2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.

[Diagnosing asthenia and chronic fatigue syndrome].

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.

Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization.

The role of enterovirus in chronic fatigue syndrome.

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

An experimental study of determinants of the extent of disagreement within clinical guideline development groups.

Symptom overlap and comorbidity of irritable bowel syndrome with other conditions.

Persistent nonallergic rhinosinusitis.

Search for disease-specific cardiovascular reactivity patterns: developing the methodology.

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