ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1661–1680 of 2,423 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Characterization of virus isolates by particle-associated nucleic acid PCR.

Stang, Alexander, Korn, Klaus, Wildner, Oliver et al.·Journal of clinical microbiology·2005

Researchers developed a new laboratory method called PAN-PCR that can identify viruses in patient samples even when standard tests fail to detect them. This technique works by finding viral genetic material protected inside virus particles and then copying and analyzing it. As a test case, they used this method on a mouth sample from a ME/CFS patient and successfully identified herpes simplex virus type 1, which had been missed by conventional testing.

E3 PreliminaryReviewPEM unclearReview-Narrative

A new view on hypocortisolism.

Fries, Eva, Hesse, Judith, Hellhammer, Juliane et al.·Psychoneuroendocrinology·2005

Some people with ME/CFS, fibromyalgia, and PTSD have abnormally low levels of cortisol, a stress hormone their body normally produces. This review suggests that this low cortisol may develop after the body's stress system works overtime for a long time. Interestingly, while low cortisol contributes to symptoms like fatigue, pain, and stress sensitivity, it may also provide some protective benefits to the body.

Endocrine Disruption

E3 PreliminaryCommentaryPEM not requiredEditorial

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

Nijs, Jo, Van de Velde, Bart, De Meirleir, Kenny·Medical hypotheses·2005

This study proposes a theory about why ME/CFS patients experience widespread pain. The researchers suggest that a molecule called nitric oxide may cause the central nervous system (the brain and spinal cord) to become overly sensitive, amplifying pain signals throughout the body. They propose that viral infections or other pathogens associated with ME/CFS may trigger this chain reaction, and that behaviors like catastrophizing or avoiding activity may either contribute to or result from this heightened sensitivity.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Gutenbrunner, C, Linden, M, Gerdes, N et al.·Die Rehabilitation·2005

This paper discusses how chronic fatigue and exhaustion affect people undergoing rehabilitation for various medical conditions. The authors reviewed how fatigue is defined, how often it occurs in different patient groups (from 50-90% depending on the condition), and whether rehabilitation can help improve it. They suggest that fatigue symptoms do improve somewhat with rehabilitation, though some symptoms can remain.

E3 PreliminaryCohortPEM not requiredCase-Control

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Mears, Tim·Acupuncture in medicine : journal of the British Medical Acupuncture Society·2005

This case report describes one patient with ME/CFS (chronic fatigue syndrome) who received electroacupuncture treatment. While the acupuncture did not cure the condition, the patient reported significant symptom improvement and was eventually able to return to work. This is one of the first published studies looking at how acupuncture might help ME/CFS patients.

Interventions

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Moss, Jill·Journal of child health care : for professionals working with children in the hospital and community·2005

Children and young people with ME/CFS often have difficulty explaining what activities they can or cannot do on any given day, making it hard for parents and doctors to understand their abilities. Researchers worked with 251 young people from a ME support organization to create a simple 0-100% scale that young people themselves helped design and test. The result was a practical tool that 99% of young people felt accurately measured their functional abilities.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

Nijs, Jo, Vaes, Peter, De Meirleir, Kenny·Occupational therapy international·2005

Researchers created a simple questionnaire called the CFS-APQ to measure how much ME/CFS affects a patient's ability to do daily activities. They tested this questionnaire on hundreds of patients and found it works reliably—meaning patients give consistent answers when asked the same questions again—and it accurately reflects how sick someone is.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Lange, G, Steffener, J, Cook, D B et al.·NeuroImage·2005

This study used brain imaging to see what happens when people with ME/CFS listen to complex spoken information. Researchers found that people with ME/CFS could understand the information just as well as healthy people, but their brains had to work much harder to do it—using more brain regions and requiring greater effort. This provides scientific proof that the thinking and concentration difficulties ME/CFS patients report are real and visible on brain scans.

Cognitive Impairment

E3 PreliminaryBehavioralPEM not requiredCase-Control

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Shin, Yong-Il, Lee, Myeong Soo·The American journal of Chinese medicine·2005

This study looked at whether Qi therapy (a hands-on energy-based technique from traditional Chinese medicine) might help people with ME/CFS feel better. Two patients who received Qi therapy reported feeling more mentally relaxed and found it easier to cope with their pain and tiredness. While these are only two cases and more research is needed, the results suggest Qi therapy might be worth studying further as a complementary approach.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredCase-Control

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Masuda, Akinori, Kihara, Takashi, Fukudome, Tsuyoshi et al.·Journal of psychosomatic research·2005

This study followed two ME/CFS patients who tried a type of heat therapy called far-infrared sauna (heated to 60°C) combined with warming afterward. After about 15-25 sessions, both patients reported major improvements in fatigue, pain, sleep problems, and fever. They continued the therapy once or twice a week for a year and did not get worse, even after stopping their previous medication.

Pain and SensitizationSleep

E3 PreliminaryCohortPEM not requiredObservational

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Fernández-Solà, Joaquim, Lluís Padierna, Meritxell, Nogué Xarau, Santiago et al.·Medicina clinica·2005

This study followed 26 people who developed ME/CFS after being exposed to insecticide sprays at their workplace. Most patients were women who first experienced airway inflammation and digestive problems, followed by brain fog, muscle pain, and fatigue. About one-third also developed chemical sensitivity. The researchers emphasize that proper ventilation and safety precautions during and after insecticide use are crucial to prevent these illnesses.

Pain and Sensitization

E3 PreliminaryCommentaryPEM unclearEditorial

Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.

Durlach, J, Pagès, N, Bac, P et al.·Magnesium research·2005

This paper proposes that low magnesium levels combined with disrupted biological clocks (your body's natural 24-hour rhythm) may contribute to asthma that gets worse at night. The authors suggest that magnesium depletion is different from simple magnesium deficiency—it involves a deeper dysregulation that cannot be fixed by supplements alone. They propose two subtypes based on whether the biological clock is overactive (linked to nighttime asthma) or underactive (linked to daytime symptoms).

Sleep

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Chronic fatigue syndrome is associated with diminished intracellular perforin.

Maher, K J, Klimas, N G, Fletcher, M A·Clinical and experimental immunology·2005

This study found that people with ME/CFS have lower levels of a protein called perforin in their immune cells, particularly in natural killer cells. Perforin is a weapon that immune cells use to fight off infections and abnormal cells. The researchers suggest this deficiency might help explain why people with ME/CFS often have weakened immune function.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neuropathology in rhinosinusitis.

Baraniuk, James N, Petrie, Kristina Naranch, Le, Uyenphuong et al.·American journal of respiratory and critical care medicine·2005

Researchers tested how the nasal passages of people with ME/CFS, sinusitis, allergies, and healthy controls responded to salt water spray. They found that people with ME/CFS experienced unusual nerve sensitivity (feeling more pain) but their mucus-producing glands didn't respond normally to the stimulus. This suggests that ME/CFS involves a different pattern of how nerves and mucus glands work in the nose compared to other nasal conditions.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Staines, Donald R·Medical hypotheses·2005

This paper proposes that ME/CFS and similar fatigue disorders may be caused by the immune system attacking special messenger molecules in the body called vasoactive neuropeptides. These molecules normally help control energy metabolism, nerve function, and immune responses. The authors suggest that when antibodies damage these molecules, it could explain the severe fatigue and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Are attention deficit hyperactivity disorder and chronic fatigue syndrome allergy related? what is fibromyalgia?

Bellanti, Joseph A, Sabra, Aderbal, Castro, Henry J et al.·Allergy and asthma proceedings·2005

This review article explores whether allergies and immune system problems might play a role in three conditions: ADHD, chronic fatigue syndrome (CFS), and fibromyalgia. The authors suggest that while the exact causes of these disorders remain unknown, allergic reactions—including reactions to foods—may trigger or worsen symptoms in all three conditions. They propose that problems in the body's neuroendocrine-immune system (the network connecting the brain, hormones, and immune function) are central to understanding these illnesses.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

A patient's journey with myalgic encephalomyelitis.

Ong, Bie Nio, Evans, Daphne, Bartlam, Andrew·BMJ (Clinical research ed.)·2005

This study tells the personal story of one patient's experience living with ME/CFS, documenting how the illness affected their daily life, symptoms, and journey seeking medical care. Through this individual's account, the researchers highlight the real challenges people with ME/CFS face in their everyday activities and interactions with healthcare providers. The patient's narrative shows how ME/CFS impacts not just physical health, but also emotional wellbeing and social relationships.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The role of enterovirus in chronic fatigue syndrome.

Chia, J K S·Journal of clinical pathology·2005

This review examines whether enteroviruses—common viruses that cause respiratory and stomach infections—might play a role in ME/CFS. Researchers found that these viruses can sometimes persist in the body long-term and produce symptoms similar to ME/CFS. Laboratory and animal studies showed that viral RNA (genetic material) can remain in muscles and cause ongoing inflammation, which matches what has been seen in tissue samples from ME/CFS patients.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders.

Staines, Donald R·Medical hypotheses·2005

This article explores a theory that ME/CFS and related conditions like fibromyalgia might be caused by problems with special chemical messengers in the body called vasoactive neuropeptides. These chemicals normally help control blood vessels, inflammation, and immune function. The authors suggest that if this theory is correct, several treatments might help—including replacing these chemicals, using certain medications, or modifying genes—though they emphasize this is still speculative and unproven.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

Nijs, Jo, De Meirleir, Kenny·In vivo (Athens, Greece)·2005

This study looks at a specific immune system pathway called the 2-5A synthetase/RNase L pathway that may be broken in ME/CFS patients. Researchers found that in ME/CFS, this pathway is overactive but also working improperly—it's being broken down into unusual pieces instead of functioning normally. This abnormal pathway appears connected to reduced natural killer cell function and problems with how cells die when they should.

Immune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Characterization of virus isolates by particle-associated nucleic acid PCR.

A new view on hypocortisolism.

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.

Chronic fatigue syndrome is associated with diminished intracellular perforin.

Neuropathology in rhinosinusitis.

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Are attention deficit hyperactivity disorder and chronic fatigue syndrome allergy related? what is fibromyalgia?

A patient's journey with myalgic encephalomyelitis.

The role of enterovirus in chronic fatigue syndrome.

Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders.

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research