ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1721–1740 of 2,423 studies

E3 PreliminaryMechanismPEM not requiredCross-Sectional

High levels of type 2 cytokine-producing cells in chronic fatigue syndrome.

Skowera, A, Cleare, A, Blair, D et al.·Clinical and experimental immunology·2004

This study looked at immune cells in the blood of ME/CFS patients to see if they respond differently than in healthy people. Researchers found that ME/CFS patients had higher levels of immune cells that produce type 2 cytokines—signaling molecules associated with a particular type of immune response. This suggests the immune system in ME/CFS may be stuck in an unusual activation pattern.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.

Wang, Xin Q, Takahashi, Takashi, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2004

Researchers tested a Japanese herbal medicine called Hochu-ekki-to (TJ-41) in mice with an experimentally induced condition similar to ME/CFS. Mice treated with the herb showed better activity levels and survived longer than untreated mice, suggesting the herb may help reduce activity loss associated with chronic fatigue-like conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Muscle metabolism with blood flow restriction in chronic fatigue syndrome.

McCully, Kevin K, Smith, Sinclair, Rajaei, Sheeva et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2004

This study looked at whether ME/CFS patients have problems with blood flow and how their muscles use oxygen during recovery from exercise. Researchers compared 19 ME/CFS patients to 11 healthy people and found that ME/CFS patients had reduced blood flow to muscles during recovery, but this did not actually impair how well their muscles worked or used oxygen.

E3 PreliminaryMechanismPEM not requiredObservational

Learning and memorization impairment in childhood chronic fatigue syndrome manifesting as school phobia in Japan.

Miike, Teruhisa, Tomoda, Akemi, Jhodoi, Takako et al.·Brain & development·2004

This study followed children with chronic fatigue syndrome (CFS) in Japan over 15 years to understand why they experience severe tiredness and difficulty learning and remembering information. The researchers found that these children had problems with their autonomic nervous system (the automatic system controlling heart rate, temperature, and digestion), disrupted sleep-wake cycles similar to jet lag, and reduced blood flow to certain brain areas. Understanding these patterns may help explain why learning becomes so difficult for children with CFS.

SleepCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

In vivo magnetic resonance spectroscopy in chronic fatigue syndrome.

Chaudhuri, A, Behan, P O·Prostaglandins, leukotrienes, and essential fatty acids·2004

This study used a special type of MRI scan called magnetic resonance spectroscopy (MRS) to look at how cells work in ME/CFS patients. The scans showed that muscle cells may become too acidic during exercise, and brain cells may have signs of stress. These findings suggest that ME/CFS involves problems with how cells produce and use energy.

E3 PreliminaryMechanismPEM requiredMechanistic

Exercise lowers pain threshold in chronic fatigue syndrome.

Whiteside, Alan, Hansen, Stig, Chaudhuri, Abhijit·Pain·2004

This study looked at how exercise affects pain sensitivity in people with ME/CFS compared to healthy people. When healthy volunteers exercised, their pain threshold (the point at which they felt pain) went up, making them less sensitive to pain. However, in ME/CFS patients, the pain threshold actually decreased after exercise, meaning they became more sensitive to pain. This suggests that the body's natural pain-blocking system may not work properly in ME/CFS.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Developing and evaluating community-based services through participatory action research: two case examples.

Taylor, Renée R, Braveman, Brent, Hammel, Joy·The American journal of occupational therapy : official publication of the American Occupational Therapy Association·2004

This study shows how occupational therapists can work together with ME/CFS patients and their communities to design better support services. Instead of experts telling people what they need, this approach lets patients and community members have a real voice in deciding what services should be created and how they should work. The researchers used two real-world examples—one with ME/CFS patients and one with AIDS patients—to show how this partnership approach can lead to more helpful and empowering services.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Manual-based cognitive behaviour therapy for chronic fatigue syndrome: therapists' adherence and perceptions.

Bazelmans, Ellen, Prins, Judith B, Hoogveld, Sigrid et al.·Cognitive behaviour therapy·2004

This study looked at how well therapists followed a standardized treatment manual when using cognitive behavior therapy (CBT) to treat ME/CFS patients. Researchers recorded therapy sessions and asked therapists about their experiences. They found that therapists generally stuck to the treatment plan, but many found ME/CFS patients harder to treat than patients with other conditions, mostly because of difficulty building patient confidence and motivation.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fatigue in neuromuscular disease].

Van Engelen, B G M, Kalkman, J S, Schillings, M L et al.·Nederlands tijdschrift voor geneeskunde·2004

Fatigue is a common symptom in many diseases, including neuromuscular disorders like post-polio syndrome and myasthenia gravis. This review found that about 64% of neuromuscular patients experience severe fatigue—a rate similar to multiple sclerosis patients. The authors suggest that using reliable measurement tools and combining different medical specialties could help researchers understand why fatigue happens and develop better treatments.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue in neurological disorders.

Chaudhuri, Abhijit, Behan, Peter O·Lancet (London, England)·2004

This review examines fatigue in various neurological diseases, including ME/CFS. The authors explain that fatigue can result from problems in muscle function (where muscles can't sustain effort) or problems in the brain and nervous system (where the brain perceives activities as requiring excessive effort). They suggest that imbalances in stress hormones and disrupted communication between key brain regions may underlie persistent fatigue.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Unloading the trunk: neurasthenia, CFS and race.

Luthra, A, Wessely, S·Social science & medicine (1982)·2004

This study examines how ME/CFS and its historical predecessor neurasthenia have been discussed in terms of race and ethnicity over the past century. The authors found that there is a pattern of thinking that associates fatigue illnesses with technological 'development' in white countries, and they explore why far fewer non-white patients appear in specialist ME/CFS clinics compared to what you might expect from the general population.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome.

Okada, Tomohisa, Tanaka, Masaaki, Kuratsune, Hirohiko et al.·BMC neurology·2004

This study used brain imaging to compare the brains of people with ME/CFS to healthy individuals. Researchers found that people with ME/CFS had smaller gray matter (the thinking part of the brain) in specific areas of the prefrontal cortex, which is the region responsible for decision-making and regulating sensations. Importantly, the amount of shrinkage in one area of the prefrontal cortex matched how severe each person's fatigue was, suggesting this brain region may play a key role in how our bodies experience and manage fatigue.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fainting freshmen and sinking sophomores: cardiovascular issues of the adolescent.

DiVasta, Amy Desrochers, Alexander, Mark E·Current opinion in pediatrics·2004

This review article explains that fainting is common in teenagers, but most cases are not caused by serious heart problems. Doctors can identify the few teenagers with real heart disease using a detailed patient history, physical examination, and an electrocardiogram (ECG). The article emphasizes that teenagers with certain conditions—including chronic fatigue syndrome, eating disorders, and exercise-related fainting—need extra careful evaluation because their heart problems may be more serious or harder to manage.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry?

Staines, Donald R·Medical hypotheses·2004

This paper proposes that ME/CFS may develop when the immune system mistakenly attacks natural signaling chemicals in the body called vasoactive neuropeptides, which are crucial for nerve function, blood flow, temperature regulation, and immune balance. The author suggests this autoimmune attack could be triggered by infection, intense exercise, or occur on its own, and explains how damage to these chemicals could cause the main symptoms of ME/CFS including fatigue, muscle pain, brain fog, and chemical sensitivity.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome.

Ohashi, K, Bleijenberg, G, van der Werf, S et al.·Methods of information in medicine·2004

This study looked at how physical activity patterns differ between people with ME/CFS and healthy people throughout the day. Researchers used special mathematical tools to analyze activity data and found that people with ME/CFS have more sudden, abrupt stops in their activities during the day—possibly because fatigue forces them to rest unexpectedly. This pattern was not seen in healthy control subjects.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in a cognitive perspective. A therapeutic model].

d'Elia, Giacomo·Lakartidningen·2004

This paper describes how cognitive therapy—a type of talk therapy focused on thoughts and beliefs—can help people with ME/CFS. The approach recognizes that unhelpful thoughts about the illness (like believing symptoms mean serious physical harm) can interact with real physical problems and low mood, creating a cycle that keeps people tired and inactive. A therapist works with the patient to gently challenge these beliefs and plan small increases in activity to show that feared outcomes don't happen.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Kapfhammer, H P, Rothenhäusler, H B·MMW Fortschritte der Medizin·2004

ME/CFS involves fatigue and exhaustion that can look different from person to person. These symptoms can happen after infections like viruses or alongside mood and anxiety problems. The authors suggest that cognitive-behavioral therapy (a type of talk therapy focused on thoughts and behaviors) combined with antidepressant medication may help some patients.

E3 PreliminaryReviewPEM unclearReview-Narrative

Physiology and pathophysiology of the 5-HT3 receptor.

Färber, L, Haus, U, Späth, M et al.·Scandinavian journal of rheumatology. Supplement·2004

This review examines how a specific brain chemical receptor called 5-HT3 works in the body and what happens when it malfunctions. The researchers found that blocking this receptor with certain medications may help treat several conditions, including ME/CFS, by reducing symptoms like nausea, pain, and anxiety. However, scientists still don't fully understand exactly how this receptor causes problems in these different illnesses.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia syndrome in women.

Shaver, Joan L·The Nursing clinics of North America·2004

This article reviews fibromyalgia syndrome (FMS), a condition causing chronic pain and fatigue that affects far more women than men. The authors describe common symptoms and discuss research into what might cause FMS and related conditions like ME/CFS, IBS, and TMD, as well as current treatment options.

Pain and Sensitization

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Patient power and control: a study of women with uncertain illness trajectories.

Asbring, Pia, Närvänen, Anna-Liisa·Qualitative health research·2004

This study interviewed 25 women with ME/CFS or fibromyalgia to understand how they try to take control of their health and interact with doctors. The women described learning about their illness, talking with caregivers, and using different strategies like being firm about their needs or sometimes stepping back from medical care to manage their conditions better.

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Evidence browser

High levels of type 2 cytokine-producing cells in chronic fatigue syndrome.

Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.

Muscle metabolism with blood flow restriction in chronic fatigue syndrome.

Learning and memorization impairment in childhood chronic fatigue syndrome manifesting as school phobia in Japan.

In vivo magnetic resonance spectroscopy in chronic fatigue syndrome.

Exercise lowers pain threshold in chronic fatigue syndrome.

Developing and evaluating community-based services through participatory action research: two case examples.

Manual-based cognitive behaviour therapy for chronic fatigue syndrome: therapists' adherence and perceptions.

[Fatigue in neuromuscular disease].

Fatigue in neurological disorders.

Unloading the trunk: neurasthenia, CFS and race.

Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome.

Fainting freshmen and sinking sophomores: cardiovascular issues of the adolescent.

Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry?

Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome.

[Chronic fatigue syndrome in a cognitive perspective. A therapeutic model].

[Chronic fatigue syndrome].

Physiology and pathophysiology of the 5-HT3 receptor.

Fibromyalgia syndrome in women.

Patient power and control: a study of women with uncertain illness trajectories.

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