ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1721–1740 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

The concepts of fatigue and depression in cancer.

Reuter, K, Härter, M·European journal of cancer care·2004

This paper examines why fatigue and depression often occur together in cancer patients and look so similar. The authors compare the symptoms of fatigue and depression to see what's the same and what's different, finding that while they share many symptoms, depression has specific psychological features that fatigue doesn't. They suggest that better tools are needed to help doctors tell the two conditions apart.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia syndrome in women.

Shaver, Joan L·The Nursing clinics of North America·2004

This article reviews fibromyalgia syndrome (FMS), a condition causing chronic pain and fatigue that affects far more women than men. The authors describe common symptoms and discuss research into what might cause FMS and related conditions like ME/CFS, IBS, and TMD, as well as current treatment options.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Dysautonomia in chronic fatigue syndrome: facts, hypotheses, implications.

Naschitz, Jochanan E, Yeshurun, Daniel, Rosner, Itzhak·Medical hypotheses·2004

This study looked at whether people with ME/CFS have problems with their autonomic nervous system—the part that automatically controls heart rate and blood pressure. Researchers found a distinctive pattern of dysautonomia (autonomic dysfunction) in ME/CFS patients that differs from other conditions, and they developed two scoring systems to help identify it. A small pilot study suggested that treating this dysautonomia with a medication called midodrine improved both the autonomic problems and fatigue symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearMechanistic

Altered central nervous system signal during motor performance in chronic fatigue syndrome.

Siemionow, Vlodek, Fang, Yin, Calabrese, Leonard et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2004

This study measured brain electrical activity in ME/CFS patients and healthy people while they performed repeated hand-squeezing exercises. The researchers found that ME/CFS patients showed different brain activity patterns—particularly increased slower brain waves and larger electrical signals related to movement control—especially when the exercises became tiring. These brain activity differences might help doctors develop better ways to diagnose ME/CFS.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredMechanistic

Exercise lowers pain threshold in chronic fatigue syndrome.

Whiteside, Alan, Hansen, Stig, Chaudhuri, Abhijit·Pain·2004

This study looked at how exercise affects pain sensitivity in people with ME/CFS compared to healthy people. When healthy volunteers exercised, their pain threshold (the point at which they felt pain) went up, making them less sensitive to pain. However, in ME/CFS patients, the pain threshold actually decreased after exercise, meaning they became more sensitive to pain. This suggests that the body's natural pain-blocking system may not work properly in ME/CFS.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of Kuibitang on lipopolysaccharide-induced cytokine production in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

Shin, Hye-Young, An, Nyeon-Hyoung, Cha, Yun-Jin et al.·Journal of ethnopharmacology·2004

This study tested whether Kuibitang (KBT), a traditional herbal treatment used in South Korea, could affect immune system chemicals in people with ME/CFS. Researchers added KBT to blood cells from CFS patients and healthy people, then stimulated those cells to see how they responded. They found that KBT reduced some inflammatory chemicals but increased others, suggesting it might help balance the abnormal immune responses seen in CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Acetylcholine mediated vasodilatation in the microcirculation of patients with chronic fatigue syndrome.

Spence, V A, Khan, F, Kennedy, G et al.·Prostaglandins, leukotrienes, and essential fatty acids·2004

This study looked at how blood vessels in ME/CFS patients respond to acetylcholine, a chemical messenger in the body. Normally, blood vessels become less responsive to acetylcholine in disease, but researchers found the opposite in ME/CFS patients—their blood vessels were unusually sensitive to it. This unusual sensitivity might help explain why many ME/CFS patients experience problems with blood flow and circulation.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in a cognitive perspective. A therapeutic model].

d'Elia, Giacomo·Lakartidningen·2004

This paper describes how cognitive therapy—a type of talk therapy focused on thoughts and beliefs—can help people with ME/CFS. The approach recognizes that unhelpful thoughts about the illness (like believing symptoms mean serious physical harm) can interact with real physical problems and low mood, creating a cycle that keeps people tired and inactive. A therapist works with the patient to gently challenge these beliefs and plan small increases in activity to show that feared outcomes don't happen.

E3 PreliminaryMechanismPEM not requiredMechanistic

Neural correlates of the chronic fatigue syndrome--an fMRI study.

de Lange, Floris P, Kalkman, Joke S, Bleijenberg, Gijs et al.·Brain : a journal of neurology·2004

This study used brain imaging to compare how people with ME/CFS and healthy people perform simple mental tasks involving imagining movements. People with ME/CFS were slower at these tasks, but their brains showed some differences in how they used certain regions, particularly areas involved in vision and error detection. The findings suggest that ME/CFS may involve problems with how the brain plans movements and processes mistakes.

E3 PreliminaryCohortPEM not requiredCase-Control

Midodrine treatment for chronic fatigue syndrome.

Naschitz, J, Dreyfuss, D, Yeshurun, D et al.·Postgraduate medical journal·2004

This study reports on one patient with severe ME/CFS who was treated with midodrine, a medication that helps regulate blood pressure and heart rate control. The patient's symptoms of dysautonomia (problems with the autonomic nervous system that controls automatic body functions) improved with this treatment, and their fatigue also improved. This suggests that treating the autonomic nervous system dysfunction may help some people with ME/CFS feel better.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome.

Puri, B K·Prostaglandins, leukotrienes, and essential fatty acids·2004

This study looked at whether a supplement containing high amounts of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid found in fish oil, could help people with ME/CFS. A small group of patients took this supplement and most reported feeling better within 8-12 weeks. The researchers suggest that EPA might be a helpful treatment option for some people with this condition.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome: a review].

Carlo-Stella, Nicoletta, Lorusso, Lorenzo, Candura, Stefano M et al.·Recenti progressi in medicina·2004

ME/CFS is a serious illness that causes extreme tiredness and disability, but many doctors don't recognize or diagnose it properly. This review explains what we know about ME/CFS, including possible causes like infections and immune system problems, and describes a research effort to collect biological samples from patients to better understand the disease.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Physiopathologic relationship between interstitial cystitis and rheumatic, autoimmune, and chronic inflammatory diseases].

Lorenzo Gómez, María Fernanda, Gómez Castro, Susana·Archivos espanoles de urologia·2004

This review examined whether interstitial cystitis (a chronic bladder pain condition) shares common causes with autoimmune and inflammatory diseases like lupus, Sjögren's syndrome, and fibromyalgia. Researchers found that many patients with these conditions have similar symptoms and immune system abnormalities, and that some interstitial cystitis patients improve with anti-inflammatory medications. The study suggests these disorders may share underlying mechanisms, though the exact causes remain unknown.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Manual-based cognitive behaviour therapy for chronic fatigue syndrome: therapists' adherence and perceptions.

Bazelmans, Ellen, Prins, Judith B, Hoogveld, Sigrid et al.·Cognitive behaviour therapy·2004

This study looked at how well therapists followed a standardized treatment manual when using cognitive behavior therapy (CBT) to treat ME/CFS patients. Researchers recorded therapy sessions and asked therapists about their experiences. They found that therapists generally stuck to the treatment plan, but many found ME/CFS patients harder to treat than patients with other conditions, mostly because of difficulty building patient confidence and motivation.

E3 PreliminaryBehavioralPEM unclearObservational

Chronic Fatigue: A Survey, Outcome Study and Proposals.

Lines, Sharon·Child and adolescent mental health·2004

This study followed 20 children with chronic fatigue at a major hospital in London using a talk-based therapy approach adapted for children. Most children (87%) improved over time, with more attending school and having fewer symptoms. The children who did best were those whose fatigue had lasted less than a year and who gradually increased their activities at home.

E3 PreliminaryReviewPEM unclearReview-Narrative

Physiology and pathophysiology of the 5-HT3 receptor.

Färber, L, Haus, U, Späth, M et al.·Scandinavian journal of rheumatology. Supplement·2004

This review examines how a specific brain chemical receptor called 5-HT3 works in the body and what happens when it malfunctions. The researchers found that blocking this receptor with certain medications may help treat several conditions, including ME/CFS, by reducing symptoms like nausea, pain, and anxiety. However, scientists still don't fully understand exactly how this receptor causes problems in these different illnesses.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryCohortPEM not requiredObservational

Neuropsychiatric sequelae of Nipah virus encephalitis.

Ng, Beng-Yeong, Lim, C C Tchoyoson, Yeoh, Alice et al.·The Journal of neuropsychiatry and clinical neurosciences·2004

This study followed 9 people who had Nipah virus brain inflammation for 2 years to see what happened to them afterward. Most developed psychiatric symptoms like depression or personality changes, and nearly all showed memory and attention problems. Interestingly, two patients developed chronic fatigue syndrome after their initial illness recovered.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue in neurological disorders.

Chaudhuri, Abhijit, Behan, Peter O·Lancet (London, England)·2004

This review examines fatigue in various neurological diseases, including ME/CFS. The authors explain that fatigue can result from problems in muscle function (where muscles can't sustain effort) or problems in the brain and nervous system (where the brain perceives activities as requiring excessive effort). They suggest that imbalances in stress hormones and disrupted communication between key brain regions may underlie persistent fatigue.

Endocrine Disruption

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome.

Ohashi, K, Bleijenberg, G, van der Werf, S et al.·Methods of information in medicine·2004

This study looked at how physical activity patterns differ between people with ME/CFS and healthy people throughout the day. Researchers used special mathematical tools to analyze activity data and found that people with ME/CFS have more sudden, abrupt stops in their activities during the day—possibly because fatigue forces them to rest unexpectedly. This pattern was not seen in healthy control subjects.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Q fever as a biological weapon.

Kagawa, Frank T, Wehner, John H, Mohindra, Vibha·Seminars in respiratory infections·2003

Q fever is a rare bacterial infection that can be caught from animals and is highly contagious. Most people who catch it have no symptoms or mild flu-like illness, but some develop serious complications like pneumonia or inflammation of the heart. Importantly, a small number of people develop chronic Q fever, which can cause long-term fatigue similar to ME/CFS.

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Evidence browser

The concepts of fatigue and depression in cancer.

Fibromyalgia syndrome in women.

Dysautonomia in chronic fatigue syndrome: facts, hypotheses, implications.

Altered central nervous system signal during motor performance in chronic fatigue syndrome.

Exercise lowers pain threshold in chronic fatigue syndrome.

Effect of Kuibitang on lipopolysaccharide-induced cytokine production in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

Acetylcholine mediated vasodilatation in the microcirculation of patients with chronic fatigue syndrome.

[Chronic fatigue syndrome in a cognitive perspective. A therapeutic model].

Neural correlates of the chronic fatigue syndrome--an fMRI study.

Midodrine treatment for chronic fatigue syndrome.

The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome.

[Chronic fatigue syndrome: a review].

[Physiopathologic relationship between interstitial cystitis and rheumatic, autoimmune, and chronic inflammatory diseases].

Manual-based cognitive behaviour therapy for chronic fatigue syndrome: therapists' adherence and perceptions.

Chronic Fatigue: A Survey, Outcome Study and Proposals.

Physiology and pathophysiology of the 5-HT3 receptor.

Neuropsychiatric sequelae of Nipah virus encephalitis.

Fatigue in neurological disorders.

Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome.

Q fever as a biological weapon.

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