Carlo-Stella, Nicoletta, Lorusso, Lorenzo, Candura, Stefano M et al. · Recenti progressi in medicina · 2004
ME/CFS is a serious illness that causes extreme tiredness and disability, but many doctors don't recognize or diagnose it properly. This review explains what we know about ME/CFS, including possible causes like infections and immune system problems, and describes a research effort to collect biological samples from patients to better understand the disease.
This review highlights the significant diagnostic and recognition gaps in ME/CFS in Italy and internationally during the early 2000s, establishing the clinical need for better understanding of disease mechanisms. The authors' effort to create a biological bank represents an important step toward investigating immunogenetic factors that may explain ME/CFS heterogeneity and pathology.
As a review article, this does not present original research data and therefore cannot prove causal relationships between proposed etiological factors and ME/CFS. The abstract does not specify which hypotheses have the strongest evidence, and conclusions about sickness behavior are not based on empirical findings presented here.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Carlo-Stella, Nicoletta, Lorusso, Lorenzo, Candura, Stefano M, & Cuccia, Mariaclara (2004). [Chronic fatigue syndrome: a review].. Recenti progressi in medicina. https://pubmed.ncbi.nlm.nih.gov/15598093/
BibTeX
@article{mecfsatlas-carlo-stella-2004-chronic-fatigue,
author = {Carlo-Stella, Nicoletta and Lorusso, Lorenzo and Candura, Stefano M and Cuccia, Mariaclara},
title = {[Chronic fatigue syndrome: a review].},
journal = {Recenti progressi in medicina},
year = {2004},
note = {PubMed: 15598093},
url = {https://www.mecfsatlas.com/evidence/carlo-stella-2004-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/carlo-stella-2004-chronic-fatigue
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