ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1921–1940 of 2,422 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Feminist perspectives on the social construction of chronic fatigue syndrome.

Richman, J A, Jason, L A, Taylor, R R et al.·Health care for women international·2000

This study compares how doctors have historically viewed ME/CFS with how patients themselves understand the illness. The researchers found that when medical science couldn't find a viral cause for ME/CFS, doctors increasingly blamed psychiatric or social factors instead of looking for biological explanations. The authors argue that discovering biological markers (measurable signs of disease) could help restore ME/CFS's credibility as a real medical condition, similar to how multiple sclerosis gained recognition.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Nutritional strategies for treating chronic fatigue syndrome.

Werbach, M R·Alternative medicine review : a journal of clinical therapeutic·2000

This review examines whether nutritional deficiencies might play a role in ME/CFS and suggests that patients may benefit from supplementation. The authors identified several nutrients—including B vitamins, vitamin C, magnesium, and others—that appear to be lower in ME/CFS patients, likely due to the illness itself rather than poor diet. They recommend considering vitamin and mineral supplements as a trial treatment, since these supplements are generally safe and may help with both symptoms and recovery.

Energy Metabolism

E3 PreliminaryCommentaryPEM not requiredEditorial

The biopsychosocial model--a tool for rheumatologists.

Ferrari, R·Bailliere's best practice & research. Clinical rheumatology·2000

This article discusses how doctors can better understand and treat ME/CFS and similar conditions by moving away from the traditional debate of whether symptoms are 'all in your head' or entirely physical. Instead, it suggests using the biopsychosocial model, which recognizes that physical symptoms, thoughts, emotions, and life circumstances all play a role. The article explains how doctors can use patient education and help patients change unhelpful illness behaviors to improve treatment outcomes.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion.

Stewart, J M·Pediatric research·2000

This study looked at how the nervous system controls heart rate and blood pressure in adolescents with ME/CFS and POTS when they stand up or tilt their head upward. Researchers found that both groups had similar problems: their bodies couldn't properly regulate heart rate through the vagus nerve (which normally helps calm the heart), and their blood vessels were overly tense. This mismatch may explain why these patients experience dizziness, rapid heartbeat, and fatigue when standing.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

Does severe nutcracker phenomenon cause pediatric chronic fatigue?

Takahashi, Y, Ohta, S, Sano, A et al.·Clinical nephrology·2000

Researchers found that 9 children with chronic fatigue all had a rare blood vessel condition called nutcracker phenomenon, where a vein gets compressed and restricts blood flow. These children also had symptoms of autonomic dysfunction (problems with automatic body functions like heart rate and blood pressure) and were originally thought to have psychological problems. The study suggests that this vascular compression might be connected to their fatigue and other symptoms.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Sympathetic nervous system function in fibromyalgia.

Petzke, F, Clauw, D J·Current rheumatology reports·2000

This review examines how the sympathetic nervous system—the part that controls your 'fight or flight' stress response—works differently in fibromyalgia patients. Researchers looked at various ways to measure sympathetic function, including heart rate changes, stress hormone levels, and physical responses to stress. The authors also compared findings in fibromyalgia to similar conditions like ME/CFS, irritable bowel syndrome, and migraine to identify common patterns.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearMechanistic

Chronic fatigue syndrome is not associated with expression of endogenous retroviral p15E.

Gelman, I H, Unger, E R, Mawle, A C et al.·Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology·2000

Researchers investigated whether a virus called endogenous retroviral p15E might be involved in causing ME/CFS. They tested blood samples from people with ME/CFS and compared them to healthy controls. The study found no evidence that this viral protein was present in higher amounts in ME/CFS patients, suggesting it is not responsible for the disease.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Genioglossal advancement in the surgical treatment of obstructive sleep apnea syndrome in adults].

Foltán, R, Sonka, K·Sbornik lekarsky·2000

This case report describes a 68-year-old woman with severe sleep apnea (a condition where breathing repeatedly stops during sleep) who also had symptoms of chronic fatigue, daytime sleepiness, and morning headaches. Because she couldn't tolerate the standard breathing mask treatment due to anxiety, she had surgery to widen her airway. After surgery, her sleep apnea improved significantly and her fatigue and other symptoms improved.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--the disease and approaches to treatment].

Apel-Paz, M, Lior, B, Shemesh-Kigli, R·Harefuah·2000

This review article examines ME/CFS, describing what the disease is and discussing different treatment approaches. The authors provide an overview of the condition and explore various ways doctors have tried to help patients manage their symptoms. This type of review helps bring together existing knowledge about the illness and its management.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Controversies in neurological infectious diseases.

Greenlee, J E, Rose, J W·Seminars in neurology·2000

This is a review article that discusses six controversial topics in infections affecting the nervous system. One of these topics is whether viruses might play a role in chronic fatigue syndrome (ME/CFS). The authors examine what scientists know and disagree about regarding these infections and their treatments.

E3 PreliminaryCohortPEM unclearCase-Control

An effective "transluminal balloon angioplasty" therapy for pediatric chronic fatigue syndrome with nutcracker phenomenon.

Takahashi, Y, Sano, A, Matsuo, M·Clinical nephrology·2000

This case report describes a small number of children with chronic fatigue syndrome who also had a rare blood vessel condition called 'nutcracker phenomenon,' where a vein becomes compressed. The researchers tried a procedure called balloon angioplasty (widening the compressed vessel) to see if it could help reduce fatigue symptoms. The study suggests this treatment may have helped some patients, but it involved only a few cases.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Sleep and circadian rhythm disorders in fibromyalgia.

Korszun, A·Current rheumatology reports·2000

Fibromyalgia is a condition causing widespread muscle pain along with sleep problems and extreme tiredness. This review examines how broken sleep patterns and disrupted body clocks (which control things like stress hormones) play a role in fibromyalgia. The authors suggest that treating sleep disorders, depression, and improving sleep habits—along with careful use of medications—may help relieve symptoms.

Sleep

E3 PreliminaryCommentaryPEM not requiredEditorial

Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.

Visser, J T, De Kloet, E R, Nagelkerken, L·Annals of the New York Academy of Sciences·2000

This study explores how stress hormones called glucocorticoids affect the immune system in ME/CFS patients. The researchers found evidence suggesting that in ME/CFS, these stress hormones may be shifting the immune system's balance in an unhelpful way—boosting certain types of immune responses while weakening others. This could help explain why ME/CFS patients experience ongoing immune system problems.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome].

Kuratsune, H·Ryoikibetsu shokogun shirizu·2000

This is a review article that summarizes what was known about chronic fatigue syndrome (ME/CFS) around the year 2000. Rather than conducting a new experiment, the author examined existing research to provide an overview of the condition. It helps explain what ME/CFS is and what scientists understood about it at that time.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The challenge of evaluating fatigue.

Rodriguez, T·Journal of the American Academy of Nurse Practitioners·2000

This article helps doctors and nurse practitioners understand how to properly evaluate fatigue in patients. It explains that fatigue can have many different causes and can be either short-term or long-term, and it's important to distinguish chronic fatigue from ME/CFS. The article suggests using specific tools and checklists to help identify what might be causing someone's fatigue so it can be properly treated.

Diagnostics

E3 PreliminaryCohortPEM not requiredObservational

Treatment of chronic fatigue syndrome with 5-HT3 receptor antagonists--preliminary results.

Späth, M, Welzel, D, Färber, L·Scandinavian journal of rheumatology. Supplement·2000

Researchers tested whether two medications that block serotonin receptors (tropisetron and ondansetron) might help ME/CFS patients feel less fatigued. About one third of the patients who took these medications reported meaningful improvement in fatigue and energy levels over 15 days, with no serious side effects reported.

Interventions

E3 PreliminaryCohortPEM unclearCase-Control

Detailed description of a pregnancy associated with severe chronic fatigue syndrome.

Jha, R R, Masson, E A, Lindow, S W·Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·1999

This is a detailed case report describing one woman's experience with severe ME/CFS during pregnancy. The report documents how her condition changed during pregnancy and what medical care she received. While this is just one person's story rather than a study comparing many patients, it provides valuable insight into what pregnancy can be like for someone with severe ME/CFS.

E3 PreliminaryCohortPEM not requiredCase-Control

Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome.

Rowe, P C, Barron, D F, Calkins, H et al.·The Journal of pediatrics·1999

This study looked at 12 teenagers who had both ME/CFS and a connective tissue condition called Ehlers-Danlos syndrome (EDS). All of them also experienced problems with blood pressure and heart rate when standing up (orthostatic intolerance). The researchers found that abnormal connective tissue in blood vessels may cause blood to pool in the legs when standing, which could explain why these conditions often occur together.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

The neuroendocrinology of chronic fatigue syndrome: focus on the hypothalamic-pituitary-adrenal axis.

Scott, L V, Dinan, T G·Functional neurology·1999

This study examined how the stress-response system in the brain works differently in people with ME/CFS. The researchers focused on the hypothalamic-pituitary-adrenal (HPA) axis, which is the body's main system for managing stress and producing cortisol. The study reviewed evidence suggesting this system may not function normally in ME/CFS patients, potentially contributing to their symptoms.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.

Wessely, S, Hotopf, M·Bailliere's best practice & research. Clinical rheumatology·1999

This research article examines whether fibromyalgia is truly a separate disease or whether it's actually similar to other conditions like ME/CFS, irritable bowel syndrome, and chronic chest pain. The authors reviewed historical records, clinical observations, and population-level data and concluded that fibromyalgia shares many features with other unexplained illnesses rather than being completely distinct.

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Feminist perspectives on the social construction of chronic fatigue syndrome.

Nutritional strategies for treating chronic fatigue syndrome.

The biopsychosocial model--a tool for rheumatologists.

Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion.

Does severe nutcracker phenomenon cause pediatric chronic fatigue?

Sympathetic nervous system function in fibromyalgia.

Chronic fatigue syndrome is not associated with expression of endogenous retroviral p15E.

[Genioglossal advancement in the surgical treatment of obstructive sleep apnea syndrome in adults].

[Chronic fatigue syndrome--the disease and approaches to treatment].

Controversies in neurological infectious diseases.

An effective "transluminal balloon angioplasty" therapy for pediatric chronic fatigue syndrome with nutcracker phenomenon.

Sleep and circadian rhythm disorders in fibromyalgia.

Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.

[Chronic fatigue syndrome].

The challenge of evaluating fatigue.

Treatment of chronic fatigue syndrome with 5-HT3 receptor antagonists--preliminary results.

Detailed description of a pregnancy associated with severe chronic fatigue syndrome.

Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome.

The neuroendocrinology of chronic fatigue syndrome: focus on the hypothalamic-pituitary-adrenal axis.

Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.

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