ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1921–1940 of 2,420 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Physical activity for the chronically ill and disabled.

Durstine, J L, Painter, P, Franklin, B A et al.·Sports medicine (Auckland, N.Z.)·2000

This review article examines how exercise should be prescribed differently for people with chronic illnesses and disabilities compared to healthy people. The authors note that while exercise guidelines exist for conditions like heart disease, many chronic conditions—including ME/CFS—have received little scientific attention regarding safe and effective exercise recommendations. The key idea is that exercise plans need to be customized based on each person's individual health status rather than using one-size-fits-all approaches.

E3 PreliminaryMechanismPEM unclearMechanistic

Chronic fatigue syndrome is not associated with expression of endogenous retroviral p15E.

Gelman, I H, Unger, E R, Mawle, A C et al.·Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology·2000

Researchers investigated whether a virus called endogenous retroviral p15E might be involved in causing ME/CFS. They tested blood samples from people with ME/CFS and compared them to healthy controls. The study found no evidence that this viral protein was present in higher amounts in ME/CFS patients, suggesting it is not responsible for the disease.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Does severe nutcracker phenomenon cause pediatric chronic fatigue?

Takahashi, Y, Ohta, S, Sano, A et al.·Clinical nephrology·2000

Researchers found that 9 children with chronic fatigue all had a rare blood vessel condition called nutcracker phenomenon, where a vein gets compressed and restricts blood flow. These children also had symptoms of autonomic dysfunction (problems with automatic body functions like heart rate and blood pressure) and were originally thought to have psychological problems. The study suggests that this vascular compression might be connected to their fatigue and other symptoms.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome.

Neeck, G, Crofford, L J·Rheumatic diseases clinics of North America·2000

This review examines how hormone systems work differently in people with ME/CFS and fibromyalgia. In ME/CFS, the stress hormone system appears to be underactive, possibly due to problems in the brain. In fibromyalgia, the opposite seems true—the stress hormone system appears overactive, likely as the body's response to chronic pain. Understanding these differences could help explain why these conditions feel so different and might guide better treatments.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome.

Korszun, A, Young, E A, Engleberg, N C et al.·The Journal of rheumatology·2000

Researchers tested whether women with fibromyalgia (FM) and chronic fatigue syndrome (CFS) have imbalances in hormones related to reproduction and the menstrual cycle. They collected blood samples every 10 minutes over 12 hours from women with FM, women with CFS, and healthy controls during the first part of the menstrual cycle. They found no significant differences in hormone levels or patterns between the patient groups and healthy women.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome].

Kuratsune, H·Ryoikibetsu shokogun shirizu·2000

This is a review article that summarizes what was known about chronic fatigue syndrome (ME/CFS) around the year 2000. Rather than conducting a new experiment, the author examined existing research to provide an overview of the condition. It helps explain what ME/CFS is and what scientists understood about it at that time.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report.

Redman, D A·Journal of alternative and complementary medicine (New York, N.Y.)·2000

Many people with ME/CFS experience orthostatic hypotension—a sudden drop in blood pressure when standing up—which can be severely disabling. This paper reviews why existing medications for this condition often don't work well and proposes that Ruscus aculeatus (butcher's broom), a plant-based supplement used in Europe, might help by improving blood vessel function and preventing blood from pooling in the legs.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCross-Sectional

"I could not lift my arm holding the fork...". Living with chronic fatigue syndrome.

Söderlund, A, Skoge, A M, Malterud, K·Scandinavian journal of primary health care·2000

This study asked 12 people with ME/CFS to describe what living with the illness is really like. They reported extreme exhaustion that goes far beyond normal tiredness, along with muscle weakness, pain, memory problems, sleep issues, and heightened sensitivity to light, sound, and smells. These symptoms made everyday activities like cooking, talking, and housework unpredictably difficult, which disrupted their social lives and relationships.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredObservational

Fatigue in chronic fatigue syndrome: a discourse analysis of women's experiential narratives.

Hart, B, Grace, V M·Health care for women international·2000

This study interviewed 11 women with ME/CFS in New Zealand to understand how they experience and describe fatigue. The women often talked about fatigue as something missing or absent—a lack of energy or ability—rather than as a specific physical symptom doctors could identify. The researchers suggest that healthcare approaches need to recognize how complex and personal the experience of fatigue is for each person.

E3 PreliminaryCommentaryPEM unclearEditorial

Traumatic stress disorders: a classification with implications for prevention and management.

Pearn, J·Military medicine·2000

This article reviews different types of stress disorders that can develop after traumatic events, particularly in military personnel. It describes how these conditions are classified and discusses different ways they can be prevented and treated. The article notes that chronic fatigue syndrome is mentioned as one potential long-term stress-related condition that may develop after trauma.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Physical activity for mental health].

Martinsen, E W·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2000

This review examined whether exercise can help treat mental health conditions like depression and anxiety. The research found that exercise works best for mild to moderate depression and chronic fatigue syndrome, and may also help with panic disorder, anxiety, and other conditions. Exercise appears to be a useful, affordable alternative or addition to standard treatments like medication and therapy.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Aspects of occupational disability in psychosomatic disorders].

Huber, M·Versicherungsmedizin·2000

This 2000 review describes how psychosomatic illnesses—conditions where physical and emotional health are closely connected—were a major reason people went on disability leave in the 1990s. The article discusses several conditions including chronic fatigue syndrome, fibromyalgia, and chronic pain disorders, and suggests that the best approach to help these patients is through teamwork between physical medicine doctors and mental health professionals early in the illness.

E3 PreliminaryReviewPEM unclearReview-Narrative

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.

Bradley, L A, McKendree-Smith, N L, Alarcón, G S·Current review of pain·2000

Both fibromyalgia (FM) and ME/CFS cause muscle and joint pain, but the underlying reasons differ between these conditions. People with FM alone have unusually sensitive pain responses to light touch or mild pressure (called allodynia), while people with ME/CFS do not typically show this. This study examined what brain and hormone system differences might explain why these two conditions cause pain in different ways.

Pain and Sensitization

E3 PreliminaryMechanismPEM unclearMechanistic

Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.

Fulle, S, Mecocci, P, Fanó, G et al.·Free radical biology & medicine·2000

Researchers examined muscle tissue from ME/CFS patients and found signs of oxidative damage—a type of cellular wear and tear similar to rust forming on metal. The patients' muscles showed damage to DNA and fats in cells, and their bodies had ramped up production of protective chemicals called antioxidants to fight back against this damage. This suggests ME/CFS may cause real, measurable changes in how muscle cells function at a chemical level.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

Clinical features and IgG subclass distribution of anti-p80 coilin antibodies.

Onouchi, H, Muro, Y, Tomita, Y·Journal of autoimmunity·1999

Researchers tested blood samples from 365 Japanese patients and found 11 with unusual antibodies called anti-p80-coilin antibodies. All 11 were young women experiencing fatigue, joint pain, headaches, and other symptoms similar to ME/CFS. The study found that these antibodies come in different types, and one type (IgG2) might be a marker for autoimmune disease.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.

Berg, D, Berg, L H, Couvaras, J et al.·Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·1999

This study proposes that ME/CFS and fibromyalgia may be caused by low-level blood clotting activation triggered by certain antibodies in the immune system. Researchers used five specific blood tests to detect signs of abnormal clotting in patients with these conditions. If confirmed, this finding could help doctors diagnose these diseases and monitor treatment with blood-thinning medications.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Nefazodone for patients with chronic fatigue syndrome.

Hickie, I·The Australian and New Zealand journal of psychiatry·1999

This small study looked at whether a medication called nefazodone could help ME/CFS patients feel better. Ten patients took the drug and also received advice about sleep and behavioral strategies. Most patients reported some improvement in tiredness, sleep problems, and mood, and half were able to return to work or their normal activities.

Sleep

E3 PreliminaryCohortPEM not requiredCase-Control

Borna disease virus infection in two family clusters of patients with chronic fatigue syndrome.

Nakaya, T, Takahashi, H, Nakamur, Y et al.·Microbiology and immunology·1999

This study examined two families where multiple members had ME/CFS and looked for evidence of Borna disease virus (BDV) infection. Researchers found that family members diagnosed with ME/CFS had signs of BDV infection (antibodies and viral RNA), while most healthy family members did not. This suggests a possible link between this virus and ME/CFS, and raises the question of whether the virus might spread within families.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Acute phase responses and cytokine secretion in chronic fatigue syndrome.

Cannon, J G, Angel, J B, Ball, R W et al.·Journal of clinical immunology·1999

This study tested whether people with ME/CFS have abnormal levels of immune signaling molecules called cytokines, which could explain their symptoms. Researchers compared 10 ME/CFS patients with 11 healthy controls at rest and after 15 minutes of stepping exercise, measuring immune markers in their blood. They found that ME/CFS patients had higher baseline levels of certain inflammatory markers, but exercise responses were similar between groups.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome.

Paul, L, Wood, L, Behan, W M et al.·European journal of neurology·1999

This study tested whether people with ME/CFS recover more slowly from exercise than healthy people. Researchers had both patients and control subjects perform intense leg muscle contractions, then measured how quickly their muscle strength returned to normal. The results confirmed that while both groups got tired similarly during exercise, people with ME/CFS took much longer to recover their muscle strength afterward—even 24 hours later.

Post-Exertional Malaise

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Evidence browser

Physical activity for the chronically ill and disabled.

Chronic fatigue syndrome is not associated with expression of endogenous retroviral p15E.

Does severe nutcracker phenomenon cause pediatric chronic fatigue?

Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome.

Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome.

[Chronic fatigue syndrome].

Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report.

"I could not lift my arm holding the fork...". Living with chronic fatigue syndrome.

Fatigue in chronic fatigue syndrome: a discourse analysis of women's experiential narratives.

Traumatic stress disorders: a classification with implications for prevention and management.

[Physical activity for mental health].

[Aspects of occupational disability in psychosomatic disorders].

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.

Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.

Clinical features and IgG subclass distribution of anti-p80 coilin antibodies.

Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.

Nefazodone for patients with chronic fatigue syndrome.

Borna disease virus infection in two family clusters of patients with chronic fatigue syndrome.

Acute phase responses and cytokine secretion in chronic fatigue syndrome.

Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome.

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