Kuratsune, H · Ryoikibetsu shokogun shirizu · 2000
This is a review article that summarizes what was known about chronic fatigue syndrome (ME/CFS) around the year 2000. Rather than conducting a new experiment, the author examined existing research to provide an overview of the condition. It helps explain what ME/CFS is and what scientists understood about it at that time.
Review articles serve an important function in synthesizing scattered research findings into coherent frameworks that help both patients and clinicians understand a complex condition. Early reviews of ME/CFS were particularly valuable as the condition was still being characterized and differentiated from other illnesses, helping establish foundational knowledge in the field.
As a narrative review without original data, this study does not prove any new mechanisms, treatments, or diagnostic criteria. It cannot establish causation or provide evidence stronger than the individual studies it reviews. The conclusions reflect knowledge available in 2000 and do not represent current understanding of ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Kuratsune, H (2000). [Chronic fatigue syndrome].. Ryoikibetsu shokogun shirizu. https://pubmed.ncbi.nlm.nih.gov/11212796/
BibTeX
@article{mecfsatlas-kuratsune-2000-chronic-fatigue,
author = {Kuratsune, H},
title = {[Chronic fatigue syndrome].},
journal = {Ryoikibetsu shokogun shirizu},
year = {2000},
note = {PubMed: 11212796},
url = {https://www.mecfsatlas.com/evidence/kuratsune-2000-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/kuratsune-2000-chronic-fatigue
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