ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1961–1980 of 2,423 studies

E3 PreliminaryCohortPEM not requiredCase-Control

Monitoring and assessing symptoms of chronic fatigue syndrome: use of time series regression.

Jason, L A, Tryon, W W, Taylor, R R et al.·Psychological reports·1999

This study asked one person with ME/CFS to track their symptoms hourly and daily to understand what makes fatigue better or worse. Researchers found that energy levels, physical activity, and mental effort were closely connected to how tired the person felt. This detailed tracking method could help doctors and researchers better understand ME/CFS patterns.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The development of the Chronic Fatigue Syndrome Attitudes Test. A psychometric analysis.

Shlaes, J L, Jason, L A, Ferrari, J R·Evaluation & the health professions·1999

This study created a new tool called the Chronic Fatigue Syndrome Attitudes Test (CAT) to measure how people feel about ME/CFS and those who have it. Researchers designed a 13-question survey based on common negative attitudes people hold toward the illness. The tool was tested to make sure it works reliably and accurately captures these attitudes.

E3 PreliminaryMechanismPEM unclearMechanistic

Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.

Berg, D, Berg, L H, Couvaras, J et al.·Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·1999

This study proposes that ME/CFS and fibromyalgia may be caused by low-level blood clotting activation triggered by certain antibodies in the immune system. Researchers used five specific blood tests to detect signs of abnormal clotting in patients with these conditions. If confirmed, this finding could help doctors diagnose these diseases and monitor treatment with blood-thinning medications.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome.

Paul, L, Wood, L, Behan, W M et al.·European journal of neurology·1999

This study tested whether people with ME/CFS recover more slowly from exercise than healthy people. Researchers had both patients and control subjects perform intense leg muscle contractions, then measured how quickly their muscle strength returned to normal. The results confirmed that while both groups got tired similarly during exercise, people with ME/CFS took much longer to recover their muscle strength afterward—even 24 hours later.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredCase-Control

Chronic fatigue syndrome: assessing symptoms and activity level.

Jason, L A, King, C P, Frankenberry, E L et al.·Journal of clinical psychology·1999

This study looked at better ways to measure ME/CFS by tracking both symptoms and daily activity over time. Instead of just asking whether someone has symptoms, the researchers used rating scales and special devices to measure how severe symptoms are and how they change day-to-day. Two detailed case examples showed that this combined approach reveals important patterns that standard symptom checklists miss.

E3 PreliminaryMechanismPEM not requiredMechanistic

Impaired oxygen delivery to muscle in chronic fatigue syndrome.

McCully, K K, Natelson, B H·Clinical science (London, England : 1979)·1999

This study found that muscles in people with ME/CFS are not receiving oxygen as quickly and efficiently as they should after exercise or when blood flow is temporarily stopped. The researchers measured how fast oxygen returns to calf muscles and found it took significantly longer in ME/CFS patients compared to healthy people. They also found that the muscles' ability to use oxygen for energy was reduced by about 20% in ME/CFS patients.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome: new insights and old ignorance.

Evengård, B, Schacterle, R S, Komaroff, A L·Journal of internal medicine·1999

ME/CFS is a complex condition that affects thinking, sleep quality, and causes physical symptoms like sore throats, muscle pain, and exhaustion after activity. While many patients report that their illness began with an infection, scientists still don't fully understand how infections connect to ME/CFS. Research shows the immune system is overactive and certain brain systems aren't working normally, suggesting ME/CFS involves multiple body systems.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Acute phase responses and cytokine secretion in chronic fatigue syndrome.

Cannon, J G, Angel, J B, Ball, R W et al.·Journal of clinical immunology·1999

This study tested whether people with ME/CFS have abnormal levels of immune signaling molecules called cytokines, which could explain their symptoms. Researchers compared 10 ME/CFS patients with 11 healthy controls at rest and after 15 minutes of stepping exercise, measuring immune markers in their blood. They found that ME/CFS patients had higher baseline levels of certain inflammatory markers, but exercise responses were similar between groups.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Small adrenal glands in chronic fatigue syndrome: a preliminary computer tomography study.

Scott, L V, Teh, J, Reznek, R et al.·Psychoneuroendocrinology·1999

This study looked at whether the adrenal glands (small organs that help manage stress and energy) are physically smaller in people with ME/CFS. Researchers used CT scans to measure adrenal gland size in 8 ME/CFS patients who showed signs of adrenal underfunction and compared them to 55 healthy people. They found that the adrenal glands in ME/CFS patients were about 50% smaller than in healthy controls, suggesting that adrenal shrinkage may occur in some ME/CFS patients.

Endocrine Disruption

E3 PreliminaryCommentaryPEM not requiredEditorial

Functional somatic syndromes.

Barsky, A J, Borus, J F·Annals of internal medicine·1999

This 1999 editorial discusses how several chronic conditions—including ME/CFS, fibromyalgia, and irritable bowel syndrome—share common features: they cause real suffering and disability, but standard medical tests often don't find clear tissue damage. The authors suggest that a self-reinforcing cycle develops where patients become convinced they have a serious disease, their symptoms worsen over time, and this belief itself amplifies their suffering, even when psychological and social factors play a role.

E3 PreliminaryReviewPEM unclearReview-Narrative

The effects on siblings in families with a child with chronic fatigue syndrome.

Jackson, E L·Journal of child health care : for professionals working with children in the hospital and community·1999

When a child has ME/CFS, it affects the entire family, not just the sick child. This review looked at how brothers and sisters of children with ME/CFS are impacted and how they cope with the situation. The authors found that healthy siblings often don't get enough attention and support because the focus is on caring for the ill child.

E3 PreliminaryPEM not requiredRegistry-Resource

The Chronic Fatigue Twin Registry: method of construction, composition, and zygosity assignment.

Buchwald, D, Herrell, R, Ashton, S et al.·Twin research : the official journal of the International Society for Twin Studies·1999

Researchers created a registry of twin pairs where at least one person had chronic fatigue to better understand the condition. They recruited 204 twin pairs through support groups, doctors, and other sources, and had 177 complete their detailed questionnaires and phone interviews. This registry was designed to help scientists study what causes chronic fatigue and whether genetics or life circumstances play a bigger role.

Diagnostics

E3 PreliminaryGuidelinePEM not requiredGuideline

Investigating fatigue of less than 6 months' duration. Guidelines for family physicians.

Godwin, M, Delva, D, Miller, K et al.·Canadian family physician Medecin de famille canadien·1999

This guideline helps family doctors systematically evaluate adults who come to them complaining of fatigue lasting less than 6 months. Rather than ordering many expensive tests, the guidelines recommend doctors first talk with patients about their symptoms and do a physical exam, paying special attention to psychological and social factors that might cause tiredness. The guideline then tells doctors which tests to consider based on what they find.

E3 PreliminaryCohortPEM unclearCase-Control

[Autoimmune fatigue syndrome and fibromyalgia syndrome].

Itoh, Y, Igarashi, T, Tatsuma, N et al.·Nihon Ika Daigaku zasshi·1999

This study looked at two patients who were initially thought to have autoimmune fatigue syndrome (a condition where the immune system may attack the body and cause tiredness) but were later found to have fibromyalgia (widespread muscle pain and tender points). The researchers wondered if these two conditions might be related, so they checked how many tender points fibromyalgia patients had and looked at their immune markers. They found that patients with certain immune patterns had more tender points, suggesting autoimmunity might play a role in both conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cortical motor potential alterations in chronic fatigue syndrome.

Gordon, R, Michalewski, H J, Nguyen, T et al.·International journal of molecular medicine·1999

Researchers measured electrical brain activity in people with ME/CFS while they performed tasks like responding to targets, remembering information, and moving on command. They found that people with ME/CFS were slower at these tasks and showed weaker brain signals before moving, suggesting their brains may prepare for movement differently. However, their brains processed sensory information and made decisions normally.

Cognitive Impairment

E3 PreliminaryPEM not required

Fatigue that doesn't go away.

Propsner, N M·New Jersey medicine : the journal of the Medical Society of New Jersey·1999

This article describes chronic fatigue syndrome (ME/CFS), a condition where people experience extreme tiredness that doesn't improve with rest. The fatigue often begins after a viral infection and is more commonly seen in middle-aged women. While current treatments can help manage symptoms, researchers are working to better understand the condition and develop more effective approaches.

Interventions

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dehydroepiandrosterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome.

De Becker, P, De Meirleir, K, Joos, E et al.·Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·1999

This study tested how the adrenal glands respond to a hormone signal in ME/CFS patients compared to healthy people. Researchers gave a hormone called ACTH to 22 ME/CFS patients and 14 healthy controls, then measured DHEA levels over an hour. While starting DHEA levels were normal, ME/CFS patients showed a weaker increase in DHEA after the hormone injection compared to healthy controls.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Cognitive behavior therapy for chronic fatigue syndrome: a case study.

Prins, J B, Bleijenberg, G·Journal of behavior therapy and experimental psychiatry·1999

This study followed one 26-year-old woman with ME/CFS who received cognitive behavior therapy (CBT)—a type of talk therapy focused on changing unhelpful thinking patterns and behaviors. Over 33 months, she worked with therapists on topics like building a sense of control, managing physical activity carefully, and reducing worry about her body. By the end, her fatigue and ability to function improved significantly, moving from very severe to levels similar to healthy people.

E3 PreliminaryCommentaryPEM unclearEditorial

[Fibromyalgia syndrome].

Matsumoto, Y·Nihon rinsho. Japanese journal of clinical medicine·1999

This paper discusses fibromyalgia syndrome (FMS), a condition characterized by widespread pain, fatigue, sleep problems, and mood changes without visible inflammation or damage on tests. The author explains that while fibromyalgia is recognized as real, some doctors still debate whether it is truly distinct from other conditions. Many people with ME/CFS also meet the criteria for fibromyalgia, but there are some differences between the two conditions—such as signs of viral triggers and low blood chemical levels found in ME/CFS but not usually in fibromyalgia.

Pain and SensitizationSleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Stealth adaptation of an African green monkey simian cytomegalovirus.

Martin, W J·Experimental and molecular pathology·1999

Researchers found genetic material from a virus in a patient with chronic fatigue syndrome that resembles human cytomegalovirus (a common virus). Interestingly, the virus was missing genes that the immune system normally recognizes and attacks, which might allow it to hide from immune defenses. Genetic analysis showed this virus actually came from African green monkeys, not humans.

Immune System

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Monitoring and assessing symptoms of chronic fatigue syndrome: use of time series regression.

The development of the Chronic Fatigue Syndrome Attitudes Test. A psychometric analysis.

Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.

Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome.

Chronic fatigue syndrome: assessing symptoms and activity level.

Impaired oxygen delivery to muscle in chronic fatigue syndrome.

Chronic fatigue syndrome: new insights and old ignorance.

Acute phase responses and cytokine secretion in chronic fatigue syndrome.

Small adrenal glands in chronic fatigue syndrome: a preliminary computer tomography study.

Functional somatic syndromes.

The effects on siblings in families with a child with chronic fatigue syndrome.

The Chronic Fatigue Twin Registry: method of construction, composition, and zygosity assignment.

Investigating fatigue of less than 6 months' duration. Guidelines for family physicians.

[Autoimmune fatigue syndrome and fibromyalgia syndrome].

Cortical motor potential alterations in chronic fatigue syndrome.

Fatigue that doesn't go away.

Dehydroepiandrosterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome.

Cognitive behavior therapy for chronic fatigue syndrome: a case study.

[Fibromyalgia syndrome].

Stealth adaptation of an African green monkey simian cytomegalovirus.

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