ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1961–1980 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

The effects on siblings in families with a child with chronic fatigue syndrome.

Jackson, E L·Journal of child health care : for professionals working with children in the hospital and community·1999

When a child has ME/CFS, it affects the entire family, not just the sick child. This review looked at how brothers and sisters of children with ME/CFS are impacted and how they cope with the situation. The authors found that healthy siblings often don't get enough attention and support because the focus is on caring for the ill child.

E3 PreliminaryCohortPEM unclearCase-Control

Detailed description of a pregnancy associated with severe chronic fatigue syndrome.

Jha, R R, Masson, E A, Lindow, S W·Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·1999

This is a detailed case report describing one woman's experience with severe ME/CFS during pregnancy. The report documents how her condition changed during pregnancy and what medical care she received. While this is just one person's story rather than a study comparing many patients, it provides valuable insight into what pregnancy can be like for someone with severe ME/CFS.

E3 PreliminaryCohortPEM unclearCase-Control

[Autoimmune fatigue syndrome and fibromyalgia syndrome].

Itoh, Y, Igarashi, T, Tatsuma, N et al.·Nihon Ika Daigaku zasshi·1999

This study looked at two patients who were initially thought to have autoimmune fatigue syndrome (a condition where the immune system may attack the body and cause tiredness) but were later found to have fibromyalgia (widespread muscle pain and tender points). The researchers wondered if these two conditions might be related, so they checked how many tender points fibromyalgia patients had and looked at their immune markers. They found that patients with certain immune patterns had more tender points, suggesting autoimmunity might play a role in both conditions.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Functional somatic syndromes.

Barsky, A J, Borus, J F·Annals of internal medicine·1999

This 1999 editorial discusses how several chronic conditions—including ME/CFS, fibromyalgia, and irritable bowel syndrome—share common features: they cause real suffering and disability, but standard medical tests often don't find clear tissue damage. The authors suggest that a self-reinforcing cycle develops where patients become convinced they have a serious disease, their symptoms worsen over time, and this belief itself amplifies their suffering, even when psychological and social factors play a role.

E3 PreliminaryMechanismPEM not requiredMechanistic

Stealth adaptation of an African green monkey simian cytomegalovirus.

Martin, W J·Experimental and molecular pathology·1999

Researchers found genetic material from a virus in a patient with chronic fatigue syndrome that resembles human cytomegalovirus (a common virus). Interestingly, the virus was missing genes that the immune system normally recognizes and attacks, which might allow it to hide from immune defenses. Genetic analysis showed this virus actually came from African green monkeys, not humans.

Immune System

E3 PreliminaryPEM not required

Fatigue that doesn't go away.

Propsner, N M·New Jersey medicine : the journal of the Medical Society of New Jersey·1999

This article describes chronic fatigue syndrome (ME/CFS), a condition where people experience extreme tiredness that doesn't improve with rest. The fatigue often begins after a viral infection and is more commonly seen in middle-aged women. While current treatments can help manage symptoms, researchers are working to better understand the condition and develop more effective approaches.

Interventions

E3 PreliminaryPEM not requiredRegistry-Resource

The Chronic Fatigue Twin Registry: method of construction, composition, and zygosity assignment.

Buchwald, D, Herrell, R, Ashton, S et al.·Twin research : the official journal of the International Society for Twin Studies·1999

Researchers created a registry of twin pairs where at least one person had chronic fatigue to better understand the condition. They recruited 204 twin pairs through support groups, doctors, and other sources, and had 177 complete their detailed questionnaires and phone interviews. This registry was designed to help scientists study what causes chronic fatigue and whether genetics or life circumstances play a bigger role.

Diagnostics

E3 PreliminaryGuidelinePEM not requiredGuideline

Investigating fatigue of less than 6 months' duration. Guidelines for family physicians.

Godwin, M, Delva, D, Miller, K et al.·Canadian family physician Medecin de famille canadien·1999

This guideline helps family doctors systematically evaluate adults who come to them complaining of fatigue lasting less than 6 months. Rather than ordering many expensive tests, the guidelines recommend doctors first talk with patients about their symptoms and do a physical exam, paying special attention to psychological and social factors that might cause tiredness. The guideline then tells doctors which tests to consider based on what they find.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cortical motor potential alterations in chronic fatigue syndrome.

Gordon, R, Michalewski, H J, Nguyen, T et al.·International journal of molecular medicine·1999

Researchers measured electrical brain activity in people with ME/CFS while they performed tasks like responding to targets, remembering information, and moving on command. They found that people with ME/CFS were slower at these tasks and showed weaker brain signals before moving, suggesting their brains may prepare for movement differently. However, their brains processed sensory information and made decisions normally.

Cognitive Impairment

E3 PreliminaryBehavioralPEM not requiredCase-Control

Cognitive behavior therapy for chronic fatigue syndrome: a case study.

Prins, J B, Bleijenberg, G·Journal of behavior therapy and experimental psychiatry·1999

This study followed one 26-year-old woman with ME/CFS who received cognitive behavior therapy (CBT)—a type of talk therapy focused on changing unhelpful thinking patterns and behaviors. Over 33 months, she worked with therapists on topics like building a sense of control, managing physical activity carefully, and reducing worry about her body. By the end, her fatigue and ability to function improved significantly, moving from very severe to levels similar to healthy people.

E3 PreliminaryCohortPEM not requiredObservational

Acute effects of thirty minutes of light-intensity, intermittent exercise on patients with chronic fatigue syndrome.

Clapp, L L, Richardson, M T, Smith, J F et al.·Physical therapy·1999

This study looked at whether 30 minutes of light, on-and-off walking on a treadmill would make symptoms worse in people with ME/CFS. Ten participants did 10 short 3-minute walks with 3-minute rest breaks in between. The researchers found that this type of gentle, intermittent exercise did not worsen symptoms immediately or up to a week afterward.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

Clinical features and IgG subclass distribution of anti-p80 coilin antibodies.

Onouchi, H, Muro, Y, Tomita, Y·Journal of autoimmunity·1999

Researchers tested blood samples from 365 Japanese patients and found 11 with unusual antibodies called anti-p80-coilin antibodies. All 11 were young women experiencing fatigue, joint pain, headaches, and other symptoms similar to ME/CFS. The study found that these antibodies come in different types, and one type (IgG2) might be a marker for autoimmune disease.

Immune System

E3 PreliminaryPEM unclear

Case of chronic fatigue syndrome after Crimean war and Indian mutiny.

Jones, E, Wessely, S·BMJ (Clinical research ed.)·1999

This historical research paper examines cases of chronic fatigue syndrome (then called different names) that occurred in soldiers during the Crimean War and Indian Mutiny in the 1800s. The authors looked back at medical records from these time periods to document how fatigue illnesses affected military personnel. This work shows that ME/CFS-like conditions are not new to modern times but have been documented for well over a century.

E3 PreliminaryReviewPEM unclearReview-Narrative

Report of a workshop on the epidemiology, natural history, and pathogenesis of chronic fatigue syndrome in adolescents.

Marshall, G S·The Journal of pediatrics·1999

This 1999 workshop report brought together experts to discuss what was known about ME/CFS in teenagers. The report summarized information about how common the illness is, how it develops over time, and what might cause it in young people. It served as an important step in recognizing that ME/CFS affects adolescents and that they needed specialized attention.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Similarities of chronic fatigue syndrome, fibromyalgia and multiple chemical sensitivity].

Csef, H·Deutsche medizinische Wochenschrift (1946)·1999

This study looked at three conditions—chronic fatigue syndrome (ME/CFS), fibromyalgia, and multiple chemical sensitivity—to see if they share similarities. The researchers examined how these conditions might be related to each other based on their common features. Understanding these connections could help doctors better recognize and treat patients who experience overlapping symptoms across these conditions.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

Chronic Chlamydia pneumoniae infection: a treatable cause of chronic fatigue syndrome.

Chia, J K, Chia, L Y·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1999

This study examined whether a common bacterial infection called Chlamydia pneumoniae might be a treatable cause of ME/CFS. Researchers looked at patients with ME/CFS and tested whether treating this infection with antibiotics could improve their symptoms. The authors suggest that some cases of ME/CFS might be linked to this persistent bacterial infection.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The development of the Chronic Fatigue Syndrome Attitudes Test. A psychometric analysis.

Shlaes, J L, Jason, L A, Ferrari, J R·Evaluation & the health professions·1999

This study created a new tool called the Chronic Fatigue Syndrome Attitudes Test (CAT) to measure how people feel about ME/CFS and those who have it. Researchers designed a 13-question survey based on common negative attitudes people hold toward the illness. The tool was tested to make sure it works reliably and accurately captures these attitudes.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Carnitine as a vitamin-like biofactor].

Saheki, T·Nihon rinsho. Japanese journal of clinical medicine·1999

Carnitine is a natural substance in the body that helps cells produce energy by breaking down fats. This review discusses how carnitine performs multiple important functions beyond energy production, including supporting brain health and helping the body eliminate waste products. The authors suggest carnitine may play a role in chronic fatigue syndrome and other conditions involving energy metabolism.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.

Wessely, S, Hotopf, M·Bailliere's best practice & research. Clinical rheumatology·1999

This research article examines whether fibromyalgia is truly a separate disease or whether it's actually similar to other conditions like ME/CFS, irritable bowel syndrome, and chronic chest pain. The authors reviewed historical records, clinical observations, and population-level data and concluded that fibromyalgia shares many features with other unexplained illnesses rather than being completely distinct.

E3 PreliminaryMechanismPEM unclearCase-Control

Immunological response in chronic fatigue syndrome following a graded exercise test to exhaustion.

LaManca, J J, Sisto, S A, Zhou, X D et al.·Journal of clinical immunology·1999

Researchers tested whether people with ME/CFS have an unusual immune system response to hard exercise compared to healthy people who don't exercise regularly. They had 20 women with ME/CFS and 14 healthy women do an exhausting treadmill test, then checked their blood for immune cells and immune chemicals at several time points. While people with ME/CFS reported much worse fatigue 24 hours later, their immune systems actually responded to the exercise in the same way as the healthy controls.

Immune SystemPost-Exertional Malaise

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The effects on siblings in families with a child with chronic fatigue syndrome.

Detailed description of a pregnancy associated with severe chronic fatigue syndrome.

[Autoimmune fatigue syndrome and fibromyalgia syndrome].

Functional somatic syndromes.

Stealth adaptation of an African green monkey simian cytomegalovirus.

Fatigue that doesn't go away.

The Chronic Fatigue Twin Registry: method of construction, composition, and zygosity assignment.

Investigating fatigue of less than 6 months' duration. Guidelines for family physicians.

Cortical motor potential alterations in chronic fatigue syndrome.

Cognitive behavior therapy for chronic fatigue syndrome: a case study.

Acute effects of thirty minutes of light-intensity, intermittent exercise on patients with chronic fatigue syndrome.

Clinical features and IgG subclass distribution of anti-p80 coilin antibodies.

Case of chronic fatigue syndrome after Crimean war and Indian mutiny.

Report of a workshop on the epidemiology, natural history, and pathogenesis of chronic fatigue syndrome in adolescents.

[Similarities of chronic fatigue syndrome, fibromyalgia and multiple chemical sensitivity].

Chronic Chlamydia pneumoniae infection: a treatable cause of chronic fatigue syndrome.

The development of the Chronic Fatigue Syndrome Attitudes Test. A psychometric analysis.

[Carnitine as a vitamin-like biofactor].

Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.

Immunological response in chronic fatigue syndrome following a graded exercise test to exhaustion.

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