Onouchi, H, Muro, Y, Tomita, Y · Journal of autoimmunity · 1999 · DOI
Researchers tested blood samples from 365 Japanese patients and found 11 with unusual antibodies called anti-p80-coilin antibodies. All 11 were young women experiencing fatigue, joint pain, headaches, and other symptoms similar to ME/CFS. The study found that these antibodies come in different types, and one type (IgG2) might be a marker for autoimmune disease.
This study identifies anti-p80-coilin antibodies in young women presenting with CFS-like symptoms, suggesting a potential autoimmune biomarker for this patient population. Understanding antibody signatures in ME/CFS may help distinguish this condition from other rheumatic diseases and could guide future diagnostic and therapeutic approaches.
This study does not establish that anti-p80-coilin antibodies cause ME/CFS or are diagnostic of it, as only one patient fulfilled ME/CFS criteria. The cross-sectional design cannot determine whether these antibodies precede, accompany, or result from illness. The small sample size and lack of healthy controls limit generalizability beyond the Japanese population studied.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Onouchi, H, Muro, Y, & Tomita, Y (1999). Clinical features and IgG subclass distribution of anti-p80 coilin antibodies.. Journal of autoimmunity. https://doi.org/10.1006/jaut.1999.0318
BibTeX
@article{mecfsatlas-onouchi-1999-clinical-features,
author = {Onouchi, H and Muro, Y and Tomita, Y},
title = {Clinical features and IgG subclass distribution of anti-p80 coilin antibodies.},
journal = {Journal of autoimmunity},
year = {1999},
doi = {10.1006/jaut.1999.0318},
note = {PubMed: 10479391},
url = {https://www.mecfsatlas.com/evidence/onouchi-1999-clinical-features},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/onouchi-1999-clinical-features
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