ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2021–2040 of 2,423 studies

E3 PreliminaryBehavioralPEM unclearCase-Control

Childhood abuse, personality disorder and chronic fatigue syndrome.

Cuykx, V, Van Houdenhove, B, Neerinckx, E·General hospital psychiatry·1998

This study looked at whether people with ME/CFS were more likely to have experienced childhood abuse or have certain personality patterns compared to healthy controls. The researchers compared groups of ME/CFS patients with people without the condition to explore possible connections between early life experiences and the development of ME/CFS.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Parallels between post-polio fatigue and chronic fatigue syndrome: a common pathophysiology?

Bruno, R L, Creange, S J, Frick, N M·The American journal of medicine·1998

This review examines similarities between fatigue experienced by polio survivors and people with ME/CFS, suggesting they may share common underlying brain problems. Both conditions involve difficulty concentrating, staying awake, and severe fatigue. The researchers propose that reduced dopamine (a brain chemical) and problems with specific brain systems might explain fatigue in both diseases.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome.

Demitrack, M A, Crofford, L J·Annals of the New York Academy of Sciences·1998

This study found that people with ME/CFS have reduced activity in their stress-response system—a network in the brain called the HPA axis that normally helps the body cope with physical and emotional challenges. The researchers discovered that this underactive response pattern is different from what happens in depression, and it may explain why stress and exertion worsen ME/CFS symptoms. The findings suggest that problems with specific brain chemicals involved in stress regulation may contribute to the condition.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and chronic fatigue: the holistic perspective.

Kenner, C·Holistic nursing practice·1998

This article discusses fibromyalgia syndrome and chronic fatigue syndrome (CFS), two conditions that affect mostly women and can significantly impact physical and emotional health. The authors argue that treating these conditions effectively requires a comprehensive, team-based approach that includes both conventional medical care and complementary therapies. They emphasize that patients and families need support strategies tailored to their individual situations to manage these long-term illnesses.

E3 PreliminaryCohortPEM not requiredCase-Control

The case history of an elite ultra-endurance cyclist who developed chronic fatigue syndrome.

Rowbottom, D G, Keast, D, Green, S et al.·Medicine and science in sports and exercise·1998

Researchers studied an elite cyclist who developed ME/CFS and tested his fitness before, during, and after his illness. His oxygen capacity and exercise performance dropped significantly during illness, but surprisingly remained low even after he felt clinically better. The authors suggest these fitness losses were due to prolonged inactivity from being sick rather than damage to his muscles' ability to use oxygen.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review.

Newman, Michael E., Shapira, Baruch, Lerer, Bernard·The international journal of neuropsychopharmacology·1998

This review examines a test called the fenfluramine challenge test, which measures how well the brain's serotonin system is working by looking at prolactin levels after taking fenfluramine. The researchers found that people with depression typically had a blunted (reduced) prolactin response, and that some people with chronic fatigue syndrome might have had an enhanced response, though not many studies existed in this group.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic orofacial muscle pain: a new approach to diagnosis and management.

Klineberg, I, McGregor, N, Butt, H et al.·The Alpha omegan·1998

This study looked at different types of muscle pain conditions, including fibromyalgia and jaw pain, and found they affect men and women differently. The researchers suggest that some people may be genetically vulnerable to chronic pain, and that infections at the start of illness might play a role. They found links between abnormal fat levels, muscle metabolism problems, and fibromyalgia, which may also be connected to chronic fatigue syndrome.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Illness from low levels of environmental chemicals: relevance to chronic fatigue syndrome and fibromyalgia.

Bell, I R, Baldwin, C M, Schwartz, G E·The American journal of medicine·1998

Some people with ME/CFS and fibromyalgia react strongly to small amounts of everyday chemicals (like fragrances or pesticides) that don't normally harm others. This paper reviews evidence suggesting that the brain's limbic system—which controls emotions and basic body functions—may become overly sensitive to these chemicals, creating a chain reaction that affects multiple body systems. The authors propose that certain people are born with or develop a heightened sensitivity to this kind of stimulation, which could explain why some ME/CFS patients feel sick from exposure to low levels of chemicals.

Endocrine DisruptionPain and Sensitization

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome].

Litzman, J, Lokaj, J, Fucíková, T·Casopis lekaru ceskych·1998

This article discusses chronic fatigue syndrome as a growing health concern in the Czech Republic. The authors explain that doctors cannot yet identify what causes the disease or how it develops in the body, and no single blood test can diagnose it. While some doctors suggest counseling or antidepressants to help with symptoms, treatments targeting the immune system or viruses have not proven effective in rigorous studies.

E3 PreliminaryMechanismPEM unclearObservational

Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome.

Evengard, B, Nilsson, C G, Lindh, G et al.·Pain·1998

Researchers measured a pain-signaling chemical called substance P in the spinal fluid of 15 people with ME/CFS. They found that all the ME/CFS patients had normal levels of this chemical. This is important because fibromyalgia—a condition with similar symptoms—typically shows elevated substance P levels. This finding suggests that ME/CFS and fibromyalgia may be caused by different biological problems, even though patients experience some overlapping symptoms.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

The connection between chronic fatigue syndrome and neurally mediated hypotension.

Wilke, W S, Fouad-Tarazi, F M, Cash, J M et al.·Cleveland Clinic journal of medicine·1998

Some ME/CFS patients experience a problem where their blood pressure drops abnormally when they stand up, a condition called neurally mediated hypotension. This review examines research showing that this blood pressure response may be linked to ME/CFS symptoms. Understanding this connection could help explain why some patients feel worse with certain activities and may guide treatment options.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The psychotherapeutic effects of estrogens.

Panay, N, Studd, J W·Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·1998

This review examines how estrogen, a hormone in women's bodies, may affect mood, thinking ability, and symptoms of depression. The authors found that estrogen therapy can help treat depression and improve memory in some women, and that early research suggests it might also help with fatigue and mood in women with chronic fatigue syndrome (ME/CFS).

E3 PreliminaryReviewPEM unclearReview-Narrative

[The non-specific environmental syndromes MCS (Multiple Chemical Sensitivity), IEI (Idiopathic Environmental Intolerance) and SBS (Sick Building Syndrome)].

Csef, H·Fortschritte der Medizin·1998

This review examines three similar conditions—Multiple Chemical Sensitivity (MCS), Idiopathic Environmental Intolerance (IEI), and Sick Building Syndrome (SBS)—that cause people to feel sick when exposed to ordinary environmental triggers like chemicals or buildings. The authors note these conditions share important similarities with ME/CFS and fibromyalgia, and discuss different treatment approaches. The review highlights how controversial these conditions are, with some doctors accepting them while others remain skeptical.

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia and chronic fatigue syndrome: an update for athletic trainers.

Cramer, C R·Journal of athletic training·1998

This article reviews what we know about ME/CFS and fibromyalgia, two conditions that cause severe fatigue, muscle pain, and sleep problems. The authors looked at medical research and government health information to summarize how these conditions affect people, especially athletes. They discuss various treatments being tested, including exercise, relaxation therapy, and medications, and emphasize the importance of careful medical evaluation and psychological support during diagnosis and treatment.

Pain and SensitizationSleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome.

Ogawa, M, Nishiura, T, Yoshimura, M et al.·European journal of clinical investigation·1998

This study looked at how a common amino acid called L-arginine affects immune cells called natural killer cells in ME/CFS patients compared to healthy people. The researchers found that L-arginine boosted natural killer cell activity in healthy volunteers, but this boost didn't happen in ME/CFS patients. The difference appears to be related to how the body produces nitric oxide, a chemical messenger involved in immune function.

Immune System

E3 PreliminaryCohortPEM unclear

Normal gastric emptying time and myoelectrical activity in an adolescent with chronic fatigue syndrome.

Corrado, G, Riezzo, G, Rea, P et al.·Italian journal of gastroenterology and hepatology·1998

This study looked at stomach function in a teenager with ME/CFS by measuring how quickly food moves through the stomach and checking the electrical signals that control stomach contractions. The researchers found that this patient's stomach was working normally in both measures, suggesting that stomach problems may not be the cause of ME/CFS symptoms in this case.

E3 PreliminaryMechanismPEM not requiredMechanistic

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

See, D M, Broumand, N, Sahl, L et al.·Immunopharmacology·1997

This study tested whether two herbal supplements—echinacea and ginseng—could boost immune cells taken from healthy people and patients with ME/CFS or HIV/AIDS. Researchers found that both herbs increased the activity of natural killer cells and antibody-dependent immune responses in blood samples from all three groups. While the results suggest these herbs may help activate certain immune functions, this was a laboratory experiment using cells in a dish, not a study of people taking the supplements.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach, J, Bac, P, Durlach, V et al.·Magnesium research·1997

This review discusses how low magnesium levels in the body can affect the nervous system and cause symptoms like fatigue, muscle twitching, heart palpitations, and breathing problems. The authors describe how magnesium deficiency can mimic or contribute to chronic fatigue syndrome and similar conditions, and they explain tests (like EMG and blood tests) that can help diagnose this problem. They also suggest that taking magnesium supplements by mouth at appropriate doses may help relieve these symptoms.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

Evengård, B, Lipkin, W I·Lakartidningen·1997

This review examines Borna disease virus (BDV), a virus found in animals worldwide that can affect the nervous system. Researchers have wondered whether BDV might also infect humans and contribute to conditions like ME/CFS, depression, and schizophrenia. This article summarizes what scientists know about BDV and discusses how it might cause illness in people.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

van der Meer, J W·Nederlands tijdschrift voor geneeskunde·1997

This review examines different theories about what causes ME/CFS, ranging from persistent infections and metabolic problems to psychiatric factors. While many potential causes have been proposed—including lingering infections, toxins, immune system problems, nervous system dysfunction, and hormone imbalances—none have been definitively proven. The authors note that psychological factors play an important role in how the illness develops and can be helpful in treating patients.

Diagnostics

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Evidence browser

Childhood abuse, personality disorder and chronic fatigue syndrome.

Parallels between post-polio fatigue and chronic fatigue syndrome: a common pathophysiology?

Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome.

Fibromyalgia and chronic fatigue: the holistic perspective.

The case history of an elite ultra-endurance cyclist who developed chronic fatigue syndrome.

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review.

Chronic orofacial muscle pain: a new approach to diagnosis and management.

Illness from low levels of environmental chemicals: relevance to chronic fatigue syndrome and fibromyalgia.

[Chronic fatigue syndrome].

Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome.

The connection between chronic fatigue syndrome and neurally mediated hypotension.

The psychotherapeutic effects of estrogens.

[The non-specific environmental syndromes MCS (Multiple Chemical Sensitivity), IEI (Idiopathic Environmental Intolerance) and SBS (Sick Building Syndrome)].

Fibromyalgia and chronic fatigue syndrome: an update for athletic trainers.

Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome.

Normal gastric emptying time and myoelectrical activity in an adolescent with chronic fatigue syndrome.

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

[Chronic fatigue syndrome].

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