ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2021–2040 of 2,422 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a literature review from a physiatric perspective.

Jain, S S, DeLisa, J A·American journal of physical medicine & rehabilitation·1998

This review examined over 200 scientific studies about ME/CFS to understand what we know about the condition, particularly focusing on thinking problems and exercise. The authors found that while patients often report cognitive difficulties, actual measured problems are subtle and mainly affect how quickly the brain processes complex information. Brain imaging studies suggest changes may occur in the white matter of the brain rather than in the muscles themselves.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Fibromyalgia. A critical review].

Cathébras, P, Lauwers, A, Rousset, H·Annales de medecine interne·1998

Fibromyalgia is a chronic pain condition that affects about 2% of the general population, with symptoms including widespread pain, fatigue, and sleep problems. This review examines how fibromyalgia overlaps with other conditions like ME/CFS and depression, and discusses why current treatments like antidepressants and therapy have limited effectiveness. The authors suggest that fibromyalgia may develop through interconnected factors rather than a single cause.

SleepDiagnostics

E3 PreliminaryCohortPEM unclear

Normal gastric emptying time and myoelectrical activity in an adolescent with chronic fatigue syndrome.

Corrado, G, Riezzo, G, Rea, P et al.·Italian journal of gastroenterology and hepatology·1998

This study looked at stomach function in a teenager with ME/CFS by measuring how quickly food moves through the stomach and checking the electrical signals that control stomach contractions. The researchers found that this patient's stomach was working normally in both measures, suggesting that stomach problems may not be the cause of ME/CFS symptoms in this case.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuroimaging in chronic fatigue syndrome.

Lange, G, Wang, S, DeLuca, J et al.·The American journal of medicine·1998

This review examines how brain imaging scans can help understand ME/CFS. Researchers looked at two main types of scans: MRI scans that show the structure of the brain, and SPECT scans that show blood flow in the brain. The article discusses what these imaging techniques have revealed so far and what challenges doctors face in using them to diagnose ME/CFS.

Biomarkers

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome.

Stewart, J, Weldon, A, Arlievsky, N et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1998

This study looked at how the nervous system controls heart rate in children with ME/CFS during a tilt test (where patients lie flat then are gradually tilted upright). Researchers found that children with ME/CFS had much lower heart rate variability—a measure of how well the nervous system adjusts the heart—compared to children who faint from other causes and healthy controls. When tilted, children with ME/CFS did not show the normal nervous system adjustments that other groups showed, suggesting their autonomic nervous system (which controls involuntary functions) may not be working properly.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Reviewing the reviews: the example of chronic fatigue syndrome.

Joyce, J, Rabe-Hesketh, S, Wessely, S·JAMA·1998

This study examined how researchers write review articles about ME/CFS and found that what gets included depends heavily on the author's background and where they're from. Scientists with laboratory training tend to focus on lab-based research, while psychiatrists tend to focus on psychiatric research. Authors also tend to cite papers from their own country much more often than papers from other countries.

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurobehavioral properties of chemical sensitivity syndromes.

Weiss, B·Neurotoxicology·1998

This review examines four conditions that involve chemical sensitivity and fatigue-like symptoms: Multiple Chemical Sensitivity Syndrome, Sick Building Syndrome, Chronic Fatigue Syndrome, and Gulf War Syndrome. The authors explore different theories about why people develop these conditions, including psychiatric factors, learned behavioral responses, changes in how the nervous system works, and problems with the immune system's stress response. The review suggests that laboratory studies and controlled clinical trials could help determine which explanations are correct.

Endocrine DisruptionPain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Sawada, M et al.·International journal of molecular medicine·1998

This study found that most ME/CFS patients in Japan had lower-than-normal levels of a hormone called DHEA-S, which is made by the adrenal glands. DHEA-S helps regulate mood, memory, stress response, sleep, and anxiety. The researchers suggest that low DHEA-S levels might explain some of the brain-related symptoms ME/CFS patients experience, like depression and cognitive problems.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Mouse running activity is lowered by Brucella abortus treatment: a potential model to study chronic fatigue.

Ottenweller, J E, Natelson, B H, Gause, W C et al.·Physiology & behavior·1998

Researchers infected mice with a killed bacterium to see if it would create a model similar to ME/CFS. The mice immediately stopped running and grooming after infection, then slowly recovered over 2-4 weeks—though some mice recovered faster than others. Interestingly, during recovery, the mice could only run for short periods at first before becoming exhausted, gradually building up their endurance over time.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome].

Litzman, J, Lokaj, J, Fucíková, T·Casopis lekaru ceskych·1998

This article discusses chronic fatigue syndrome as a growing health concern in the Czech Republic. The authors explain that doctors cannot yet identify what causes the disease or how it develops in the body, and no single blood test can diagnose it. While some doctors suggest counseling or antidepressants to help with symptoms, treatments targeting the immune system or viruses have not proven effective in rigorous studies.

E3 PreliminaryMechanismPEM not requiredMechanistic

The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

See, D M, Cimoch, P, Chou, S et al.·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1998

This study tested whether a supplement containing eight specific sugars (called glyconutrients) could help fix immune system problems in ME/CFS patients. Researchers added the supplement to immune cells from ME/CFS patients and healthy controls in a laboratory dish and measured whether it improved immune function. The supplement appeared to increase the activity of several types of immune cells and reduce cell death in ME/CFS patients' immune cells.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome.

Ogawa, M, Nishiura, T, Yoshimura, M et al.·European journal of clinical investigation·1998

This study looked at how a common amino acid called L-arginine affects immune cells called natural killer cells in ME/CFS patients compared to healthy people. The researchers found that L-arginine boosted natural killer cell activity in healthy volunteers, but this boost didn't happen in ME/CFS patients. The difference appears to be related to how the body produces nitric oxide, a chemical messenger involved in immune function.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Future directions in exercise and immunology: regulation and integration.

Mackinnon, L T·International journal of sports medicine·1998

This editorial discusses how exercise affects the immune system and raises important questions for future research. It explores whether athletes' bodies are actually fighting infections less effectively, whether reducing certain immune responses might sometimes be helpful, and how exercise training might help people with conditions like chronic fatigue syndrome improve their immune function.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome.

Crofford, L J·Zeitschrift fur Rheumatologie·1998

This review examines the stress response system (HPA axis) in fibromyalgia and chronic fatigue syndrome. The authors suggest that problems with this stress system may be connected to common symptoms like pain, exhaustion, sleep problems, and mood changes. Several treatments that help patients—including exercise and certain antidepressants—appear to work partly by affecting this stress response system.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

The psychotherapeutic effects of estrogens.

Panay, N, Studd, J W·Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·1998

This review examines how estrogen, a hormone in women's bodies, may affect mood, thinking ability, and symptoms of depression. The authors found that estrogen therapy can help treat depression and improve memory in some women, and that early research suggests it might also help with fatigue and mood in women with chronic fatigue syndrome (ME/CFS).

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome: relationships of self-ratings and actigraphy.

Jason, L A, Tryon, W W, Frankenberry, E et al.·Psychological reports·1997

This study looked at whether questionnaires people fill out about their fatigue match what activity monitors show about how much they actually move. Researchers tracked one patient with ME/CFS using both self-report scales and an actigraphy device. They found that activity levels were connected to things that predict fatigue, but were not directly related to how fatigued the person felt.

E3 PreliminaryMechanismPEM not requiredCase-Control

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Dinan, T G, Majeed, T, Lavelle, E et al.·Psychoneuroendocrinology·1997

This study tested whether a specific brain chemical system called serotonin works properly in ME/CFS patients. Researchers gave patients and healthy people a medication that activates serotonin receptors, then measured how the body's stress-response system (the HPA axis) reacted. They found that ME/CFS patients had a weaker response than healthy people, suggesting this brain system doesn't function normally in ME/CFS.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach, J, Bac, P, Durlach, V et al.·Magnesium research·1997

This review discusses how low magnesium levels in the body can affect the nervous system and cause symptoms like fatigue, muscle twitching, heart palpitations, and breathing problems. The authors describe how magnesium deficiency can mimic or contribute to chronic fatigue syndrome and similar conditions, and they explain tests (like EMG and blood tests) that can help diagnose this problem. They also suggest that taking magnesium supplements by mouth at appropriate doses may help relieve these symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for enteroviral persistence in humans.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1997

Researchers tested blood samples from 8 people with ME/CFS and found traces of enterovirus (a type of virus) in samples taken at least 5 months apart. In 4 of these individuals, the virus appeared to be the same virus persisting in their body over time, rather than a new infection. This suggests that some people with ME/CFS may have viruses that linger in their system rather than being cleared completely.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Gupta, S, Aggarwal, S, See, D et al.·Journal of psychiatric research·1997

Researchers tested immune cells from people with ME/CFS to measure inflammation-related proteins called cytokines. They found that certain immune cells from ME/CFS patients produced higher levels of inflammatory proteins (TNF-alpha and IL-6) without any stimulation, but produced lower levels of a protective protein (IL-10) compared to healthy people. These imbalances might explain some of the symptoms people with ME/CFS experience.

Immune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Chronic fatigue syndrome: a literature review from a physiatric perspective.

[Fibromyalgia. A critical review].

Normal gastric emptying time and myoelectrical activity in an adolescent with chronic fatigue syndrome.

Neuroimaging in chronic fatigue syndrome.

Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome.

Reviewing the reviews: the example of chronic fatigue syndrome.

Neurobehavioral properties of chemical sensitivity syndromes.

Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.

Mouse running activity is lowered by Brucella abortus treatment: a potential model to study chronic fatigue.

[Chronic fatigue syndrome].

The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome.

Future directions in exercise and immunology: regulation and integration.

The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome.

The psychotherapeutic effects of estrogens.

Chronic fatigue syndrome: relationships of self-ratings and actigraphy.

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Evidence for enteroviral persistence in humans.

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research