ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2041–2060 of 2,423 studies

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue--'tired with 23 i's'].

van der Meer, J W, Elving, L D·Nederlands tijdschrift voor geneeskunde·1997

This study describes two patients with severe tiredness. One woman had chronic fatigue syndrome and improved slowly over time, while one man's exhaustion was caused by a treatable pituitary gland tumor that was removed surgically. The doctors emphasize that it's important to thoroughly examine patients to find out if something else is causing their tiredness before diagnosing chronic fatigue syndrome.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1997

This review examines three related conditions—fibromyalgia, ME/CFS, and myofascial pain syndrome—and discusses ongoing challenges in diagnosing and treating them. The study found that psychiatric conditions are not a core feature of these diseases, but rather reflect that people with these conditions are more likely to seek medical help. The researchers identified that a blood pressure problem called neurally mediated hypotension may play a role in ME/CFS, and that treating patients in multidisciplinary groups (rather than in isolation) showed more promise than traditional individual treatments.

Autonomic Nervous SystemDiagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: an update for clinicians in primary care.

Houde, S C, Kampfe-Leacher, R·The Nurse practitioner·1997

This article explains what ME/CFS is and how doctors can recognize it. The main challenge is that ME/CFS doesn't show up on standard tests, so doctors need to rule out other conditions first. Treatment works best when it's tailored to each person's specific symptoms and needs.

InterventionsDiagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome: relationships of self-ratings and actigraphy.

Jason, L A, Tryon, W W, Frankenberry, E et al.·Psychological reports·1997

This study looked at whether questionnaires people fill out about their fatigue match what activity monitors show about how much they actually move. Researchers tracked one patient with ME/CFS using both self-report scales and an actigraphy device. They found that activity levels were connected to things that predict fatigue, but were not directly related to how fatigued the person felt.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Gender differences in host defense mechanisms.

Cannon, J G, St Pierre, B A·Journal of psychiatric research·1997

This review looks at why the immune system works differently in women compared to men. Women generally have stronger immune responses, which helps them fight infections better, but also makes them more likely to develop autoimmune diseases where the immune system attacks the body. Because ME/CFS affects mostly women, researchers wondered if these gender differences in immune function might help explain why the illness is so much more common in women.

Immune System

E3 PreliminaryPEM unclear

Meeting the frustrations of chronic fatigue syndrome.

Plioplys, A V, Plioplys, S, Davis, J S·Hospital practice (1995)·1997

This article discusses the challenges that ME/CFS patients face, including long-lasting disability and doctors who may not understand or believe in the condition. The authors explain that while there are no blood tests that definitively prove ME/CFS, doctors can confidently diagnose it using established criteria and ruling out other diseases. They suggest that medications can help manage symptoms while patients work toward recovery.

Diagnostics

E3 PreliminaryCohortPEM not requiredCross-Sectional

Profile of patients with chemical injury and sensitivity.

Ziem, G, McTamney, J·Environmental health perspectives·1997

This study looked at people who react strongly to everyday chemicals—like cleaning products, pesticides, and new materials—at levels that don't bother most people. Researchers gave these patients questionnaires and ran medical tests to understand their symptoms. They found that chemical sensitivity often overlaps with ME/CFS and fibromyalgia, and that several body systems (liver, nervous system, immune system) appear to be affected in these patients.

Immune System

E3 PreliminaryGuidelinePEM not requiredGuideline

[Indications for management in long-term, physically unexplained fatigue symptoms].

van der Meer, J W, Rijken, P M, Bleijenberg, G et al.·Nederlands tijdschrift voor geneeskunde·1997

This guideline, developed by Dutch doctors and health officials, suggests that chronic fatigue lasting more than 6 months without a clear medical cause should be managed differently depending on how long someone has had it. Rather than continuously searching for hidden causes, patients are encouraged to gradually rebuild activity using a structured schedule and focus on overall health promotion.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.

Dröge, W, Holm, E·FASEB journal : official publication of the Federation of American Societies for Experimental Biology·1997

This study proposes that several diseases—including ME/CFS, HIV, cancer, and inflammatory bowel disease—share a common pattern: low levels of certain amino acids (cysteine and glutamine), weakened immune cells called natural killer cells, and muscle weakness. The researchers suggest these low amino acid levels may be both a cause and a consequence of muscle wasting, and that boosting cysteine might help treatment when combined with disease-specific therapies.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome--aetiological aspects.

Dickinson, C J·European journal of clinical investigation·1997

This review examines why ME/CFS develops, looking at evidence from 40 years of research. The author discusses how ME/CFS may involve damage to the brain stem (the oldest part of the brain that controls basic functions like sleep and alertness), possibly from a previous viral infection. Brain imaging studies have found small patches of damage in the brain stems of some ME/CFS patients, similar to what is seen in other conditions like post-polio fatigue.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Myasthenia gravis.

Pourmand, R·Disease-a-month : DM·1997

This article discusses myasthenia gravis, a different disease from ME/CFS in which the immune system attacks the connection between nerves and muscles, causing weakness and fatigue that worsen with activity. The authors explain how doctors diagnose this condition and review improved treatments that have made it less serious than it used to be. While myasthenia gravis can sometimes look like ME/CFS or depression, it is a distinct autoimmune disorder with specific antibodies in the blood.

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome and occupational health.

Mounstephen, A, Sharpe, M·Occupational medicine (Oxford, England)·1997

This article reviews what doctors who work in occupational health need to know about ME/CFS to help their patients. The authors discuss what ME/CFS is, what might cause it, how patients typically recover, and practical ways to diagnose and manage the condition. They argue that occupational health doctors are in a good position to help improve outcomes for people with ME/CFS, particularly by improving education, rehabilitation programs, and support for staying in or returning to work.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Gupta, S, Aggarwal, S, See, D et al.·Journal of psychiatric research·1997

Researchers tested immune cells from people with ME/CFS to measure inflammation-related proteins called cytokines. They found that certain immune cells from ME/CFS patients produced higher levels of inflammatory proteins (TNF-alpha and IL-6) without any stimulation, but produced lower levels of a protective protein (IL-10) compared to healthy people. These imbalances might explain some of the symptoms people with ME/CFS experience.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

Holland, P·The Journal of analytical psychology·1997

This study describes how one woman with ME/CFS improved over three years of talk therapy that focused on her emotions and relationships. The therapy helped her recognize patterns from her past—particularly how she swung between wanting closeness and withdrawing into isolation—which seemed connected to her physical exhaustion. As she worked through these patterns and built better relationships, including becoming pregnant, her fatigue improved.

E3 PreliminaryMechanismPEM not requiredCase-Control

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Dinan, T G, Majeed, T, Lavelle, E et al.·Psychoneuroendocrinology·1997

This study tested whether a specific brain chemical system called serotonin works properly in ME/CFS patients. Researchers gave patients and healthy people a medication that activates serotonin receptors, then measured how the body's stress-response system (the HPA axis) reacted. They found that ME/CFS patients had a weaker response than healthy people, suggesting this brain system doesn't function normally in ME/CFS.

Endocrine Disruption

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic parvovirus B19 infection resulting in chronic fatigue syndrome: case history and review.

Jacobson, S K, Daly, J S, Thorne, G M et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1997

This case study describes a young woman whose severe fatigue, fever, and other symptoms resembled ME/CFS, but were traced to a persistent parvovirus B19 infection. Doctors detected the virus in her blood using sensitive testing methods, even though her body had produced antibodies against it. When she received intravenous immunoglobulin treatment, her fever improved.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mood disorders in the female patient.

Redmond, G·International journal of fertility and women's medicine·1997

This paper discusses why women often experience mood changes and fatigue, and how doctors can help. The authors suggest that these symptoms are often related to depression rather than hormonal problems alone, and that SSRIs (a common type of antidepressant) can be helpful for many women. They also emphasize the importance of listening to patients about stress and life challenges.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

Evengård, B, Lipkin, W I·Lakartidningen·1997

This review examines Borna disease virus (BDV), a virus found in animals worldwide that can affect the nervous system. Researchers have wondered whether BDV might also infect humans and contribute to conditions like ME/CFS, depression, and schizophrenia. This article summarizes what scientists know about BDV and discusses how it might cause illness in people.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach, J, Bac, P, Durlach, V et al.·Magnesium research·1997

This review discusses how low magnesium levels in the body can affect the nervous system and cause symptoms like fatigue, muscle twitching, heart palpitations, and breathing problems. The authors describe how magnesium deficiency can mimic or contribute to chronic fatigue syndrome and similar conditions, and they explain tests (like EMG and blood tests) that can help diagnose this problem. They also suggest that taking magnesium supplements by mouth at appropriate doses may help relieve these symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredObservational

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

Cannon, J G, Angel, J B, Abad, L W et al.·Journal of clinical immunology·1997

This study examined whether people with ME/CFS have abnormal levels of immune signaling molecules (called interleukins) in their blood compared to healthy people. Researchers collected blood samples from women with ME/CFS and matched healthy controls at different points in their menstrual cycles, and tested how their immune cells responded to physical activity. The findings suggest that ME/CFS may involve differences in how the immune system communicates, possibly related to hormonal changes.

Immune SystemPost-Exertional Malaise

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[Chronic fatigue--'tired with 23 i's'].

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Chronic fatigue syndrome: an update for clinicians in primary care.

Chronic fatigue syndrome: relationships of self-ratings and actigraphy.

Gender differences in host defense mechanisms.

Meeting the frustrations of chronic fatigue syndrome.

Profile of patients with chemical injury and sensitivity.

[Indications for management in long-term, physically unexplained fatigue symptoms].

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.

Chronic fatigue syndrome--aetiological aspects.

Myasthenia gravis.

Chronic fatigue syndrome and occupational health.

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Chronic parvovirus B19 infection resulting in chronic fatigue syndrome: case history and review.

Mood disorders in the female patient.

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

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