ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2041–2060 of 2,420 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Demitrack, M A, Engleberg, N C·Current therapy in endocrinology and metabolism·1997

This is a review article that summarizes what was known about ME/CFS in 1997, focusing on endocrine and metabolic aspects of the illness. The authors examined how ME/CFS affects hormones and the body's energy systems. This paper provides an overview of medical understanding from that time period rather than presenting new research findings.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.

Regland, B, Andersson, M, Abrahamsson, L et al.·Scandinavian journal of rheumatology·1997

Researchers tested the spinal fluid of 12 women who had both fibromyalgia and ME/CFS and found unusually high levels of a molecule called homocysteine in their brains and spinal cords. They also noticed that patients with lower vitamin B12 levels in their spinal fluid reported more severe fatigue. This suggests that a vitamin B12 deficiency might prevent the body from properly breaking down homocysteine, which could contribute to symptoms like exhaustion.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mood disorders in the female patient.

Redmond, G·International journal of fertility and women's medicine·1997

This paper discusses why women often experience mood changes and fatigue, and how doctors can help. The authors suggest that these symptoms are often related to depression rather than hormonal problems alone, and that SSRIs (a common type of antidepressant) can be helpful for many women. They also emphasize the importance of listening to patients about stress and life challenges.

E3 PreliminaryMechanismPEM not requiredMechanistic

Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.

Suhadolnik, R J, Peterson, D L, O'Brien, K et al.·Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·1997

This study examined a specific immune system protein called RNase L in people with ME/CFS. Researchers found that people with ME/CFS had unusual forms of this protein that were different sizes and worked differently than those in healthy people, suggesting their antiviral defense system may be malfunctioning in a previously unknown way.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach, J, Bac, P, Durlach, V et al.·Magnesium research·1997

This review discusses how low magnesium levels in the body can affect the nervous system and cause symptoms like fatigue, muscle twitching, heart palpitations, and breathing problems. The authors describe how magnesium deficiency can mimic or contribute to chronic fatigue syndrome and similar conditions, and they explain tests (like EMG and blood tests) that can help diagnose this problem. They also suggest that taking magnesium supplements by mouth at appropriate doses may help relieve these symptoms.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM unclear

Hypnosis in chronic fatigue syndrome.

Gregg, V H·Journal of the Royal Society of Medicine·1997

This study examined whether hypnosis might help people with ME/CFS. Researchers compared people with ME/CFS who received hypnosis treatment to those who did not. The study provides early information about whether this type of mind-body treatment might be beneficial for managing symptoms.

Interventions

E3 PreliminaryCohortPEM unclear

A 56-year-old woman with chronic fatigue syndrome.

Komaroff, A L·JAMA·1997

This case study describes one patient's experience with ME/CFS, detailing her symptoms, medical history, and clinical presentation. The study provides an in-depth look at how ME/CFS affects a real person and what doctors observed during evaluation. This type of detailed patient story can help both patients and doctors better understand the condition.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.

Dröge, W, Holm, E·FASEB journal : official publication of the Federation of American Societies for Experimental Biology·1997

This study proposes that several diseases—including ME/CFS, HIV, cancer, and inflammatory bowel disease—share a common pattern: low levels of certain amino acids (cysteine and glutamine), weakened immune cells called natural killer cells, and muscle weakness. The researchers suggest these low amino acid levels may be both a cause and a consequence of muscle wasting, and that boosting cysteine might help treatment when combined with disease-specific therapies.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Gupta, S, Aggarwal, S, See, D et al.·Journal of psychiatric research·1997

Researchers tested immune cells from people with ME/CFS to measure inflammation-related proteins called cytokines. They found that certain immune cells from ME/CFS patients produced higher levels of inflammatory proteins (TNF-alpha and IL-6) without any stimulation, but produced lower levels of a protective protein (IL-10) compared to healthy people. These imbalances might explain some of the symptoms people with ME/CFS experience.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Profile of patients with chemical injury and sensitivity.

Ziem, G, McTamney, J·Environmental health perspectives·1997

This study looked at people who react strongly to everyday chemicals—like cleaning products, pesticides, and new materials—at levels that don't bother most people. Researchers gave these patients questionnaires and ran medical tests to understand their symptoms. They found that chemical sensitivity often overlaps with ME/CFS and fibromyalgia, and that several body systems (liver, nervous system, immune system) appear to be affected in these patients.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Clements, A, Sharpe, M, Simkin, S et al.·Journal of psychosomatic research·1997

This study interviewed 66 people with ME/CFS to understand what they believe causes their illness and how they think they can manage it. Most patients believed their illness was primarily physical, though over half also thought stress played a role. Patients felt they could control symptoms by reducing activity, but believed they could not influence the underlying disease itself.

E3 PreliminaryCohortPEM unclearCross-Sectional

Cosmetic saline breast implants: a survey of satisfaction, breast-feeding experience, cancer screening, and health.

Strom, S S, Baldwin, B J, Sigurdson, A J et al.·Plastic and reconstructive surgery·1997

This study surveyed 292 women who had received saline breast implants to learn about their satisfaction and health outcomes. Most women were happy with their implants and reported getting regular mammograms. A small number of women reported health conditions including chronic fatigue syndrome, but the study was not designed to investigate whether implants caused these conditions.

E3 PreliminaryMechanismPEM not requiredMechanistic

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

See, D M, Broumand, N, Sahl, L et al.·Immunopharmacology·1997

This study tested whether two herbal supplements—echinacea and ginseng—could boost immune cells taken from healthy people and patients with ME/CFS or HIV/AIDS. Researchers found that both herbs increased the activity of natural killer cells and antibody-dependent immune responses in blood samples from all three groups. While the results suggest these herbs may help activate certain immune functions, this was a laboratory experiment using cells in a dish, not a study of people taking the supplements.

Immune System

E3 PreliminaryPEM unclear

Meeting the frustrations of chronic fatigue syndrome.

Plioplys, A V, Plioplys, S, Davis, J S·Hospital practice (1995)·1997

This article discusses the challenges that ME/CFS patients face, including long-lasting disability and doctors who may not understand or believe in the condition. The authors explain that while there are no blood tests that definitively prove ME/CFS, doctors can confidently diagnose it using established criteria and ruling out other diseases. They suggest that medications can help manage symptoms while patients work toward recovery.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCase-Control

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Dinan, T G, Majeed, T, Lavelle, E et al.·Psychoneuroendocrinology·1997

This study tested whether a specific brain chemical system called serotonin works properly in ME/CFS patients. Researchers gave patients and healthy people a medication that activates serotonin receptors, then measured how the body's stress-response system (the HPA axis) reacted. They found that ME/CFS patients had a weaker response than healthy people, suggesting this brain system doesn't function normally in ME/CFS.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1997

This review examines three related conditions—fibromyalgia, ME/CFS, and myofascial pain syndrome—and discusses ongoing challenges in diagnosing and treating them. The study found that psychiatric conditions are not a core feature of these diseases, but rather reflect that people with these conditions are more likely to seek medical help. The researchers identified that a blood pressure problem called neurally mediated hypotension may play a role in ME/CFS, and that treating patients in multidisciplinary groups (rather than in isolation) showed more promise than traditional individual treatments.

Autonomic Nervous SystemDiagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in young persons].

de Jong, L W, Prins, J B, Fiselier, T J et al.·Nederlands tijdschrift voor geneeskunde·1997

This study looked at ME/CFS in teenagers in the Netherlands, finding that about 10-20 out of every 100,000 teenagers have the condition. The researchers found that teenagers with ME/CFS often have long-term fatigue that significantly affects school attendance and daily life. They identified that how parents respond, a teenager's beliefs about their illness, and reduced physical activity can all make the condition last longer.

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for enteroviral persistence in humans.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1997

Researchers tested blood samples from 8 people with ME/CFS and found traces of enterovirus (a type of virus) in samples taken at least 5 months apart. In 4 of these individuals, the virus appeared to be the same virus persisting in their body over time, rather than a new infection. This suggests that some people with ME/CFS may have viruses that linger in their system rather than being cleared completely.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

van der Meer, J W·Nederlands tijdschrift voor geneeskunde·1997

This review examines different theories about what causes ME/CFS, ranging from persistent infections and metabolic problems to psychiatric factors. While many potential causes have been proposed—including lingering infections, toxins, immune system problems, nervous system dysfunction, and hormone imbalances—none have been definitively proven. The authors note that psychological factors play an important role in how the illness develops and can be helpful in treating patients.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

Holland, P·The Journal of analytical psychology·1997

This study describes how one woman with ME/CFS improved over three years of talk therapy that focused on her emotions and relationships. The therapy helped her recognize patterns from her past—particularly how she swung between wanting closeness and withdrawing into isolation—which seemed connected to her physical exhaustion. As she worked through these patterns and built better relationships, including becoming pregnant, her fatigue improved.

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Evidence browser

Chronic fatigue syndrome.

Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.

Mood disorders in the female patient.

Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Hypnosis in chronic fatigue syndrome.

A 56-year-old woman with chronic fatigue syndrome.

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Profile of patients with chemical injury and sensitivity.

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Cosmetic saline breast implants: a survey of satisfaction, breast-feeding experience, cancer screening, and health.

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

Meeting the frustrations of chronic fatigue syndrome.

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

[Chronic fatigue syndrome in young persons].

Evidence for enteroviral persistence in humans.

[Chronic fatigue syndrome].

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

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