ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2061–2080 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Myasthenia gravis.

Pourmand, R·Disease-a-month : DM·1997

This article discusses myasthenia gravis, a different disease from ME/CFS in which the immune system attacks the connection between nerves and muscles, causing weakness and fatigue that worsen with activity. The authors explain how doctors diagnose this condition and review improved treatments that have made it less serious than it used to be. While myasthenia gravis can sometimes look like ME/CFS or depression, it is a distinct autoimmune disorder with specific antibodies in the blood.

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for enteroviral persistence in humans.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1997

Researchers tested blood samples from 8 people with ME/CFS and found traces of enterovirus (a type of virus) in samples taken at least 5 months apart. In 4 of these individuals, the virus appeared to be the same virus persisting in their body over time, rather than a new infection. This suggests that some people with ME/CFS may have viruses that linger in their system rather than being cleared completely.

E3 PreliminaryMechanismPEM not requiredCase-Control

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Dinan, T G, Majeed, T, Lavelle, E et al.·Psychoneuroendocrinology·1997

This study tested whether a specific brain chemical system called serotonin works properly in ME/CFS patients. Researchers gave patients and healthy people a medication that activates serotonin receptors, then measured how the body's stress-response system (the HPA axis) reacted. They found that ME/CFS patients had a weaker response than healthy people, suggesting this brain system doesn't function normally in ME/CFS.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

See, D M, Broumand, N, Sahl, L et al.·Immunopharmacology·1997

This study tested whether two herbal supplements—echinacea and ginseng—could boost immune cells taken from healthy people and patients with ME/CFS or HIV/AIDS. Researchers found that both herbs increased the activity of natural killer cells and antibody-dependent immune responses in blood samples from all three groups. While the results suggest these herbs may help activate certain immune functions, this was a laboratory experiment using cells in a dish, not a study of people taking the supplements.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mood disorders in the female patient.

Redmond, G·International journal of fertility and women's medicine·1997

This paper discusses why women often experience mood changes and fatigue, and how doctors can help. The authors suggest that these symptoms are often related to depression rather than hormonal problems alone, and that SSRIs (a common type of antidepressant) can be helpful for many women. They also emphasize the importance of listening to patients about stress and life challenges.

E3 PreliminaryMechanismPEM not requiredObservational

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

Cannon, J G, Angel, J B, Abad, L W et al.·Journal of clinical immunology·1997

This study examined whether people with ME/CFS have abnormal levels of immune signaling molecules (called interleukins) in their blood compared to healthy people. Researchers collected blood samples from women with ME/CFS and matched healthy controls at different points in their menstrual cycles, and tested how their immune cells responded to physical activity. The findings suggest that ME/CFS may involve differences in how the immune system communicates, possibly related to hormonal changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

Evengård, B, Lipkin, W I·Lakartidningen·1997

This review examines Borna disease virus (BDV), a virus found in animals worldwide that can affect the nervous system. Researchers have wondered whether BDV might also infect humans and contribute to conditions like ME/CFS, depression, and schizophrenia. This article summarizes what scientists know about BDV and discusses how it might cause illness in people.

E3 PreliminaryGuidelinePEM not requiredGuideline

[Indications for management in long-term, physically unexplained fatigue symptoms].

van der Meer, J W, Rijken, P M, Bleijenberg, G et al.·Nederlands tijdschrift voor geneeskunde·1997

This guideline, developed by Dutch doctors and health officials, suggests that chronic fatigue lasting more than 6 months without a clear medical cause should be managed differently depending on how long someone has had it. Rather than continuously searching for hidden causes, patients are encouraged to gradually rebuild activity using a structured schedule and focus on overall health promotion.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome and occupational health.

Mounstephen, A, Sharpe, M·Occupational medicine (Oxford, England)·1997

This article reviews what doctors who work in occupational health need to know about ME/CFS to help their patients. The authors discuss what ME/CFS is, what might cause it, how patients typically recover, and practical ways to diagnose and manage the condition. They argue that occupational health doctors are in a good position to help improve outcomes for people with ME/CFS, particularly by improving education, rehabilitation programs, and support for staying in or returning to work.

Diagnostics

E3 PreliminaryPEM unclear

Meeting the frustrations of chronic fatigue syndrome.

Plioplys, A V, Plioplys, S, Davis, J S·Hospital practice (1995)·1997

This article discusses the challenges that ME/CFS patients face, including long-lasting disability and doctors who may not understand or believe in the condition. The authors explain that while there are no blood tests that definitively prove ME/CFS, doctors can confidently diagnose it using established criteria and ruling out other diseases. They suggest that medications can help manage symptoms while patients work toward recovery.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.

Dröge, W, Holm, E·FASEB journal : official publication of the Federation of American Societies for Experimental Biology·1997

This study proposes that several diseases—including ME/CFS, HIV, cancer, and inflammatory bowel disease—share a common pattern: low levels of certain amino acids (cysteine and glutamine), weakened immune cells called natural killer cells, and muscle weakness. The researchers suggest these low amino acid levels may be both a cause and a consequence of muscle wasting, and that boosting cysteine might help treatment when combined with disease-specific therapies.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Clements, A, Sharpe, M, Simkin, S et al.·Journal of psychosomatic research·1997

This study interviewed 66 people with ME/CFS to understand what they believe causes their illness and how they think they can manage it. Most patients believed their illness was primarily physical, though over half also thought stress played a role. Patients felt they could control symptoms by reducing activity, but believed they could not influence the underlying disease itself.

E3 PreliminaryCohortPEM unclearCross-Sectional

Cosmetic saline breast implants: a survey of satisfaction, breast-feeding experience, cancer screening, and health.

Strom, S S, Baldwin, B J, Sigurdson, A J et al.·Plastic and reconstructive surgery·1997

This study surveyed 292 women who had received saline breast implants to learn about their satisfaction and health outcomes. Most women were happy with their implants and reported getting regular mammograms. A small number of women reported health conditions including chronic fatigue syndrome, but the study was not designed to investigate whether implants caused these conditions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach, J, Bac, P, Durlach, V et al.·Magnesium research·1997

This review discusses how low magnesium levels in the body can affect the nervous system and cause symptoms like fatigue, muscle twitching, heart palpitations, and breathing problems. The authors describe how magnesium deficiency can mimic or contribute to chronic fatigue syndrome and similar conditions, and they explain tests (like EMG and blood tests) that can help diagnose this problem. They also suggest that taking magnesium supplements by mouth at appropriate doses may help relieve these symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome.

Plioplys, A V·Neurology·1997

Researchers investigated whether people with ME/CFS have antibodies (immune proteins) in their blood that attack muscles or the brain, which could explain fatigue and brain fog symptoms. They compared 10 ME/CFS patients with 10 healthy controls but did not find evidence of these harmful antibodies in either group.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: an update for clinicians in primary care.

Houde, S C, Kampfe-Leacher, R·The Nurse practitioner·1997

This article explains what ME/CFS is and how doctors can recognize it. The main challenge is that ME/CFS doesn't show up on standard tests, so doctors need to rule out other conditions first. Treatment works best when it's tailored to each person's specific symptoms and needs.

InterventionsDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome--aetiological aspects.

Dickinson, C J·European journal of clinical investigation·1997

This review examines why ME/CFS develops, looking at evidence from 40 years of research. The author discusses how ME/CFS may involve damage to the brain stem (the oldest part of the brain that controls basic functions like sleep and alertness), possibly from a previous viral infection. Brain imaging studies have found small patches of damage in the brain stems of some ME/CFS patients, similar to what is seen in other conditions like post-polio fatigue.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

Holland, P·The Journal of analytical psychology·1997

This study describes how one woman with ME/CFS improved over three years of talk therapy that focused on her emotions and relationships. The therapy helped her recognize patterns from her past—particularly how she swung between wanting closeness and withdrawing into isolation—which seemed connected to her physical exhaustion. As she worked through these patterns and built better relationships, including becoming pregnant, her fatigue improved.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Profile of patients with chemical injury and sensitivity.

Ziem, G, McTamney, J·Environmental health perspectives·1997

This study looked at people who react strongly to everyday chemicals—like cleaning products, pesticides, and new materials—at levels that don't bother most people. Researchers gave these patients questionnaires and ran medical tests to understand their symptoms. They found that chemical sensitivity often overlaps with ME/CFS and fibromyalgia, and that several body systems (liver, nervous system, immune system) appear to be affected in these patients.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in young persons].

de Jong, L W, Prins, J B, Fiselier, T J et al.·Nederlands tijdschrift voor geneeskunde·1997

This study looked at ME/CFS in teenagers in the Netherlands, finding that about 10-20 out of every 100,000 teenagers have the condition. The researchers found that teenagers with ME/CFS often have long-term fatigue that significantly affects school attendance and daily life. They identified that how parents respond, a teenager's beliefs about their illness, and reduced physical activity can all make the condition last longer.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Myasthenia gravis.

Evidence for enteroviral persistence in humans.

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

Mood disorders in the female patient.

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

[Indications for management in long-term, physically unexplained fatigue symptoms].

Chronic fatigue syndrome and occupational health.

Meeting the frustrations of chronic fatigue syndrome.

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Cosmetic saline breast implants: a survey of satisfaction, breast-feeding experience, cancer screening, and health.

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome.

Chronic fatigue syndrome: an update for clinicians in primary care.

Chronic fatigue syndrome--aetiological aspects.

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

Profile of patients with chemical injury and sensitivity.

[Chronic fatigue syndrome in young persons].

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research