ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2061–2080 of 2,422 studies

Chronic fatigue syndrome: chronic ciguatera poisoning as a differential diagnosis.

Pearn, J H·The Medical journal of Australia·1997

This study examines whether some people diagnosed with ME/CFS might actually have chronic ciguatera poisoning, a illness caused by eating contaminated seafood. The researchers suggest that certain ME/CFS cases could be misdiagnosed cases of ciguatera, which can cause similar long-lasting fatigue and other symptoms. The study calls for doctors to consider this possibility when evaluating patients with ME/CFS symptoms.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Demitrack, M A, Engleberg, N C·Current therapy in endocrinology and metabolism·1997

This is a review article that summarizes what was known about ME/CFS in 1997, focusing on endocrine and metabolic aspects of the illness. The authors examined how ME/CFS affects hormones and the body's energy systems. This paper provides an overview of medical understanding from that time period rather than presenting new research findings.

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome: relationships of self-ratings and actigraphy.

Jason, L A, Tryon, W W, Frankenberry, E et al.·Psychological reports·1997

This study looked at whether questionnaires people fill out about their fatigue match what activity monitors show about how much they actually move. Researchers tracked one patient with ME/CFS using both self-report scales and an actigraphy device. They found that activity levels were connected to things that predict fatigue, but were not directly related to how fatigued the person felt.

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for enteroviral persistence in humans.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1997

Researchers tested blood samples from 8 people with ME/CFS and found traces of enterovirus (a type of virus) in samples taken at least 5 months apart. In 4 of these individuals, the virus appeared to be the same virus persisting in their body over time, rather than a new infection. This suggests that some people with ME/CFS may have viruses that linger in their system rather than being cleared completely.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

Holland, P·The Journal of analytical psychology·1997

This study describes how one woman with ME/CFS improved over three years of talk therapy that focused on her emotions and relationships. The therapy helped her recognize patterns from her past—particularly how she swung between wanting closeness and withdrawing into isolation—which seemed connected to her physical exhaustion. As she worked through these patterns and built better relationships, including becoming pregnant, her fatigue improved.

E3 PreliminaryMechanismPEM not requiredMechanistic

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

See, D M, Broumand, N, Sahl, L et al.·Immunopharmacology·1997

This study tested whether two herbal supplements—echinacea and ginseng—could boost immune cells taken from healthy people and patients with ME/CFS or HIV/AIDS. Researchers found that both herbs increased the activity of natural killer cells and antibody-dependent immune responses in blood samples from all three groups. While the results suggest these herbs may help activate certain immune functions, this was a laboratory experiment using cells in a dish, not a study of people taking the supplements.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in young persons].

de Jong, L W, Prins, J B, Fiselier, T J et al.·Nederlands tijdschrift voor geneeskunde·1997

This study looked at ME/CFS in teenagers in the Netherlands, finding that about 10-20 out of every 100,000 teenagers have the condition. The researchers found that teenagers with ME/CFS often have long-term fatigue that significantly affects school attendance and daily life. They identified that how parents respond, a teenager's beliefs about their illness, and reduced physical activity can all make the condition last longer.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1997

This review examines three related conditions—fibromyalgia, ME/CFS, and myofascial pain syndrome—and discusses ongoing challenges in diagnosing and treating them. The study found that psychiatric conditions are not a core feature of these diseases, but rather reflect that people with these conditions are more likely to seek medical help. The researchers identified that a blood pressure problem called neurally mediated hypotension may play a role in ME/CFS, and that treating patients in multidisciplinary groups (rather than in isolation) showed more promise than traditional individual treatments.

Autonomic Nervous SystemDiagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic fatigue syndrome: a 20th century illness?

Wessely, S·Scandinavian journal of work, environment & health·1997

This article examines how ME/CFS became recognized as a medical illness in modern times. The condition was largely unknown and unnamed until the 1980s, when it emerged under various labels including 'chronic Epstein-Barr virus syndrome' and later 'chronic fatigue syndrome.' The author discusses how different countries use different names for the condition and explores connections between ME/CFS and the concept of somatization—when stress or psychological factors manifest as physical symptoms.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome and occupational health.

Mounstephen, A, Sharpe, M·Occupational medicine (Oxford, England)·1997

This article reviews what doctors who work in occupational health need to know about ME/CFS to help their patients. The authors discuss what ME/CFS is, what might cause it, how patients typically recover, and practical ways to diagnose and manage the condition. They argue that occupational health doctors are in a good position to help improve outcomes for people with ME/CFS, particularly by improving education, rehabilitation programs, and support for staying in or returning to work.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Gender differences in host defense mechanisms.

Cannon, J G, St Pierre, B A·Journal of psychiatric research·1997

This review looks at why the immune system works differently in women compared to men. Women generally have stronger immune responses, which helps them fight infections better, but also makes them more likely to develop autoimmune diseases where the immune system attacks the body. Because ME/CFS affects mostly women, researchers wondered if these gender differences in immune function might help explain why the illness is so much more common in women.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

Cannon, J G, Angel, J B, Abad, L W et al.·Journal of clinical immunology·1997

This study examined whether people with ME/CFS have abnormal levels of immune signaling molecules (called interleukins) in their blood compared to healthy people. Researchers collected blood samples from women with ME/CFS and matched healthy controls at different points in their menstrual cycles, and tested how their immune cells responded to physical activity. The findings suggest that ME/CFS may involve differences in how the immune system communicates, possibly related to hormonal changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome.

Plioplys, A V·Neurology·1997

Researchers investigated whether people with ME/CFS have antibodies (immune proteins) in their blood that attack muscles or the brain, which could explain fatigue and brain fog symptoms. They compared 10 ME/CFS patients with 10 healthy controls but did not find evidence of these harmful antibodies in either group.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach, J, Bac, P, Durlach, V et al.·Magnesium research·1997

This review discusses how low magnesium levels in the body can affect the nervous system and cause symptoms like fatigue, muscle twitching, heart palpitations, and breathing problems. The authors describe how magnesium deficiency can mimic or contribute to chronic fatigue syndrome and similar conditions, and they explain tests (like EMG and blood tests) that can help diagnose this problem. They also suggest that taking magnesium supplements by mouth at appropriate doses may help relieve these symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredCase-Control

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Dinan, T G, Majeed, T, Lavelle, E et al.·Psychoneuroendocrinology·1997

This study tested whether a specific brain chemical system called serotonin works properly in ME/CFS patients. Researchers gave patients and healthy people a medication that activates serotonin receptors, then measured how the body's stress-response system (the HPA axis) reacted. They found that ME/CFS patients had a weaker response than healthy people, suggesting this brain system doesn't function normally in ME/CFS.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

van der Meer, J W·Nederlands tijdschrift voor geneeskunde·1997

This review examines different theories about what causes ME/CFS, ranging from persistent infections and metabolic problems to psychiatric factors. While many potential causes have been proposed—including lingering infections, toxins, immune system problems, nervous system dysfunction, and hormone imbalances—none have been definitively proven. The authors note that psychological factors play an important role in how the illness develops and can be helpful in treating patients.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Definition of "chronic fatigue syndrome" (CFS)].

Heyll, U, Wachauf, P, Senger, V et al.·Medizinische Klinik (Munich, Germany : 1983)·1997

In 1988, doctors created an official definition for chronic fatigue syndrome (CFS) to help researchers study it consistently. However, this study found that the original definition didn't work as well as hoped—it didn't capture the condition accurately, and patients with CFS turned out to be quite different from each other. The authors suggest that CFS should be understood as a descriptive condition rather than a single disease with one cause.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue--'tired with 23 i's'].

van der Meer, J W, Elving, L D·Nederlands tijdschrift voor geneeskunde·1997

This study describes two patients with severe tiredness. One woman had chronic fatigue syndrome and improved slowly over time, while one man's exhaustion was caused by a treatable pituitary gland tumor that was removed surgically. The doctors emphasize that it's important to thoroughly examine patients to find out if something else is causing their tiredness before diagnosing chronic fatigue syndrome.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Elevated apoptotic cell population in patients with chronic fatigue syndrome: the pivotal role of protein kinase RNA.

Vojdani, A, Ghoneum, M, Choppa, P C et al.·Journal of internal medicine·1997

This study found that immune cells in ME/CFS patients are dying at higher rates than in healthy people. The researchers discovered that a molecule called PKR, which is produced in response to infections, is abnormally elevated in ME/CFS patients and may be triggering this excess cell death. When they blocked PKR in the lab, they were able to reduce cell death in about half of the ME/CFS samples, suggesting PKR might be a key player in ME/CFS disease.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Increased brain serotonin function in men with chronic fatigue syndrome.

Sharpe, M, Hawton, K, Clements, A et al.·BMJ (Clinical research ed.)·1997

This 1997 study examined whether people with ME/CFS have differences in serotonin activity in their brains. Serotonin is a chemical messenger that affects mood, sleep, and energy. The researchers found that men with ME/CFS showed increased brain serotonin function compared to healthy controls, which was unexpected since low serotonin is often associated with fatigue and depression.

Endocrine Disruption

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Chronic fatigue syndrome: chronic ciguatera poisoning as a differential diagnosis.

Chronic fatigue syndrome.

Chronic fatigue syndrome: relationships of self-ratings and actigraphy.

Evidence for enteroviral persistence in humans.

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

[Chronic fatigue syndrome in young persons].

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Chronic fatigue syndrome: a 20th century illness?

Chronic fatigue syndrome and occupational health.

Gender differences in host defense mechanisms.

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome.

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

[Chronic fatigue syndrome].

[Definition of "chronic fatigue syndrome" (CFS)].

[Chronic fatigue--'tired with 23 i's'].

Elevated apoptotic cell population in patients with chronic fatigue syndrome: the pivotal role of protein kinase RNA.

Increased brain serotonin function in men with chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research