ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2181–2200 of 2,422 studies

E3 PreliminaryCohortPEM unclearCase-Control

Refractory chronic fatigue syndrome in adolescence.

Sidebotham, P D, Skeldon, I, Chambers, T L et al.·British journal of hospital medicine·1994

This study looked at young people with severe, long-lasting fatigue that didn't improve with standard treatments. The researchers compared adolescents who had ME/CFS that was difficult to manage with those who responded better to care. The findings help doctors understand which young patients may need different or more intensive approaches to treatment.

E3 PreliminaryMechanismPEM not requiredMechanistic

MELISA-an in vitro tool for the study of metal allergy.

Stejskal, V D, Cederbrant, K, Lindvall, A et al.·Toxicology in vitro : an international journal published in association with BIBRA·1994

This study tested whether certain metals used in dental work and medical devices can trigger immune system reactions in people with chronic fatigue and mouth problems. Researchers used a laboratory test called MELISA to measure how immune cells from patients responded to metals like mercury, gold, and palladium. They found that people with symptoms had stronger immune reactions to these metals than healthy people without symptoms, suggesting a possible connection between metal exposure and their health problems.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome and psychiatric diseases].

Matsuno, T, Hikita, K, Matsuo, T·Nihon rinsho. Japanese journal of clinical medicine·1994

This 1994 commentary discusses whether ME/CFS is actually a form of depression or a separate condition. The authors argue that ME/CFS is genuinely different from depression because people with ME/CFS remain motivated and don't show the emotional numbness seen in depression. Instead, ME/CFS involves fatigue that fluctuates sharply, along with persistent physical symptoms like malaise and low fevers.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression.

Patarca, R, Klimas, N G, Lugtendorf, S et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study tested blood samples from 70 ME/CFS patients and compared them to healthy people. Researchers found that about 60% of ME/CFS patients had unusually high levels of immune chemicals called cytokines, particularly two types called TNF-alpha and TNF-beta. These chemicals are normally released by the body to fight infections, but in ME/CFS patients they appeared to be abnormally activated even without an active infection.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Sternon, J, Decaux, G, Hoffmann, G·Revue medicale de Bruxelles·1994

This paper describes how doctors can diagnose ME/CFS using specific criteria and discusses what might cause the condition. The authors note that viral infections may trigger ME/CFS, and that anxiety or depression can make symptoms worse. Importantly, they found that some patients improve on their own after a few years, though most don't respond well to available treatments.

SleepDiagnostics

E3 PreliminaryCohortPEM not requiredCross-Sectional

The ocular signs and symptoms of chronic fatigue syndrome.

Caffery, B E, Josephson, J E, Samek, M J·Journal of the American Optometric Association·1994

This study looked at eye problems in 25 people with ME/CFS and found that all of them experienced some eye-related symptoms. The most common issues were problems with tears and the eye's surface, as well as difficulty focusing on close objects. Eye doctors should be aware of these issues when examining ME/CFS patients.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredObservational

Acylcarnitine deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Takahashi, M et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study found that people with ME/CFS have lower levels of acylcarnitine, a substance that helps muscles produce energy, in their blood. Because acylcarnitine plays an important role in how muscles use energy, this deficiency might explain why ME/CFS patients experience fatigue, muscle pain, and weakness. Importantly, acylcarnitine levels tended to improve as patients recovered, suggesting it could be useful for tracking disease severity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

A brief history of chronic fatigue syndrome.

Kim, E·JAMA·1994

This is a historical review article that traces how chronic fatigue syndrome (ME/CFS) has been understood and described over time. The article examines the evolution of the condition from early medical descriptions through the modern era, helping readers understand how our knowledge of ME/CFS has changed. It provides context for why ME/CFS was named and recognized as a legitimate medical condition.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents.

Priori, R, Conti, F, Luan, F L et al.·European journal of pediatrics·1994

This study describes four teenagers in Italy who developed severe, persistent fatigue after taking L-tryptophan supplements. Before the fatigue developed, they experienced eosinophilia myalgia syndrome (EMS)—a condition with high levels of certain white blood cells and severe muscle pain. The researchers found that these teenagers' symptoms looked very similar to chronic fatigue syndrome (ME/CFS).

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Human herpesvirus 6. General overview].

Tîrdei, G, Ruţă, S M, Popescu, A E·Revue roumaine de virologie (Bucharest, Romania : 1990)·1994

Human herpesvirus 6 (HHV6) is a common virus that infects most people before age three, usually causing no symptoms or only mild illness. Researchers have good understanding of how the virus works and spreads, but it remains unclear whether HHV6 plays a role in chronic fatigue syndrome and some other long-term illnesses. This review summarizes what we know and don't know about this virus.

Immune System

E3 PreliminaryPEM not required

Cytomegalovirus-related sequence in an atypical cytopathic virus repeatedly isolated from a patient with chronic fatigue syndrome.

Martin, W J, Zeng, L C, Ahmed, K et al.·The American journal of pathology·1994

Researchers found an unusual virus in a patient with chronic fatigue syndrome that looked similar to cytomegalovirus (CMV) under a microscope but behaved differently. The virus had genetic material that partially matched CMV, but it didn't react to standard tests for known viruses. This suggests it may be a previously unknown type of virus that can establish a long-term infection in humans.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a diagnostic challenge for the laboratory.

Lanham, R J·Clinical laboratory science : journal of the American Society for Medical Technology·1994

This review examined what we know about ME/CFS, a condition characterized by extreme tiredness, pain, and thinking difficulties that come and go in cycles. While researchers don't yet know what causes ME/CFS, studies show that people with this condition often have unusual immune system test results. Currently, there is no single blood test or marker that can definitively diagnose ME/CFS, so doctors treat symptoms based on what each patient experiences.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Viral studies of chronic fatigue syndrome.

Ablashi, D V·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This review article examines whether viruses play a role in causing ME/CFS by looking at existing research on viral infections in patients with this condition. The author analyzes studies investigating connections between various viruses and ME/CFS symptoms. The review helps summarize what scientists knew in 1994 about potential viral causes of the illness.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a defined unity?].

Rasmussen, A K, Andersen, V, Nielsen, H et al.·Ugeskrift for laeger·1994

This 1994 review examined what scientists knew about ME/CFS at that time, looking at whether a persistent virus or immune system problem caused the condition. The authors found that existing research did not consistently support either explanation, and that different studies often contradicted each other. They concluded that more careful research was needed to understand what actually causes ME/CFS and how to tell it apart from other illnesses.

Immune SystemPost-Exertional Malaise

E3 PreliminaryGuidelinePEM unclearGuideline

[Therapeutic guidelines in chronic fatigue syndrome].

Bertolín Guillén, J M, Bedate Villar, J·Actas luso-espanolas de neurologia, psiquiatria y ciencias afines·1994

This article reviews different treatment approaches for ME/CFS, which currently lacks a definitive cure. Researchers found that antidepressant medications—particularly amfebutamone and selective serotonin reuptake inhibitors—showed the most promise, while other medications (antivirals, immune boosters, anti-inflammatory drugs) had limited success. A combination of cognitive behavioral therapy and comprehensive psychiatric management tailored to each patient's needs also appeared helpful.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Rebora, A, Drago, F·Dermatology (Basel, Switzerland)·1994

This study describes skin problems that appear in some ME/CFS patients, occurring in about 10-35% of cases. Researchers found that patients sometimes develop mouth sores or skin rashes, possibly related to Epstein-Barr virus (EBV) infection. The study emphasizes that ME/CFS is diagnosed when someone has severe, disabling fatigue lasting at least 6 months with no other medical condition explaining it.

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Lloyd, A, Gandevia, S, Brockman, A et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers asked whether a specific immune response causes the fatigue that ME/CFS patients experience after exercise. They had patients and healthy people do a 30-minute hand-grip exercise and checked their blood for immune chemicals (cytokines) before, during, and after exercise. Surprisingly, they found no changes in these immune chemicals in either group, and patients actually reported feeling less fatigued after the exercise—the opposite of what happens in real life.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Effort syndrome: hyperventilation and reduction of anaerobic threshold.

Nixon, P G·Biofeedback and self-regulation·1994

This study focuses on a condition called 'effort syndrome,' which causes people to feel exhausted during physical activity. The researchers found that patients with effort syndrome breathe too heavily (hyperventilate), which changes the chemistry of their blood and makes their muscles tire much earlier than normal. By measuring breathing patterns during exercise, doctors can identify how much work each patient can do before their body runs out of chemical buffers.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.

Suhadolnik, R J, Reichenbach, N L, Hitzges, P et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study found that people with ME/CFS have overactive immune signaling molecules called the 2-5A pathway in their blood cells, which normally fight viral infections. When patients received an experimental treatment, this overactive pathway calmed down and they improved clinically, and the researchers also found signs of a herpesvirus in almost all CFS patients tested.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Stealth viruses as neuropathogens.

Martin, W J·CAP today·1994

This article suggests that certain stealth viruses may damage the nervous system and contribute to various brain-related conditions, including ME/CFS. The authors note that diseases like ME/CFS, fibromyalgia, depression, and autism share overlapping symptoms—such as pain, mood changes, and cognitive problems—which may reflect a common underlying problem in how the brain responds to different triggers.

Neuroinflammation

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Evidence browser

Refractory chronic fatigue syndrome in adolescence.

MELISA-an in vitro tool for the study of metal allergy.

[Chronic fatigue syndrome and psychiatric diseases].

Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression.

[Chronic fatigue syndrome].

The ocular signs and symptoms of chronic fatigue syndrome.

Acylcarnitine deficiency in chronic fatigue syndrome.

A brief history of chronic fatigue syndrome.

Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents.

[Human herpesvirus 6. General overview].

Cytomegalovirus-related sequence in an atypical cytopathic virus repeatedly isolated from a patient with chronic fatigue syndrome.

Chronic fatigue syndrome: a diagnostic challenge for the laboratory.

Viral studies of chronic fatigue syndrome.

[Chronic fatigue syndrome--a defined unity?].

[Therapeutic guidelines in chronic fatigue syndrome].

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Effort syndrome: hyperventilation and reduction of anaerobic threshold.

Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.

Stealth viruses as neuropathogens.

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