ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2181–2200 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a diagnostic challenge for the laboratory.

Lanham, R J·Clinical laboratory science : journal of the American Society for Medical Technology·1994

This review examined what we know about ME/CFS, a condition characterized by extreme tiredness, pain, and thinking difficulties that come and go in cycles. While researchers don't yet know what causes ME/CFS, studies show that people with this condition often have unusual immune system test results. Currently, there is no single blood test or marker that can definitively diagnose ME/CFS, so doctors treat symptoms based on what each patient experiences.

Immune SystemPost-Exertional Malaise

E3 PreliminaryPEM not required

Cytomegalovirus-related sequence in an atypical cytopathic virus repeatedly isolated from a patient with chronic fatigue syndrome.

Martin, W J, Zeng, L C, Ahmed, K et al.·The American journal of pathology·1994

Researchers found an unusual virus in a patient with chronic fatigue syndrome that looked similar to cytomegalovirus (CMV) under a microscope but behaved differently. The virus had genetic material that partially matched CMV, but it didn't react to standard tests for known viruses. This suggests it may be a previously unknown type of virus that can establish a long-term infection in humans.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Viral studies of chronic fatigue syndrome.

Levy, J A·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This review explores whether viruses might cause ME/CFS. Researchers found that while many different viruses have been suspected, no single virus has been proven to be the cause. However, studies show that people with ME/CFS have immune system abnormalities—particularly problems with cells that fight infection—suggesting their body may be stuck in an overactive response to a virus they once had or still have.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Trinidad, E E, Ramírez-Ronda, C·Boletin de la Asociacion Medica de Puerto Rico·1994

Chronic Fatigue Syndrome (ME/CFS) is a long-lasting illness that causes extreme tiredness and affects an estimated 24% of people. It was officially defined as a medical condition in 1988 after doctors recognized increasing numbers of patients with similar symptoms. The condition is more common in women aged 20-50 and is currently treated with supportive care to help manage symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuropsychiatric status of patients with chronic fatigue syndrome: an overview.

Deluca, J, Johnson, S K, Natelson, B H·Toxicology and industrial health·1994

This review examines how ME/CFS affects thinking, memory, and mental health. Researchers compared people with ME/CFS to people with multiple sclerosis, depression, and healthy individuals to understand the neuropsychiatric symptoms (brain and mental health effects) that often accompany the chronic fatigue. The study suggests that cognitive problems in ME/CFS are a real biological feature of the illness, not simply depression.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome. Clinical, social psychological problems and management].

Wessely, S·L'Encephale·1994

This review examines ME/CFS by comparing it to an older condition called neurasthenia and explores what causes the illness. The authors suggest that ME/CFS likely involves multiple factors including brain chemistry changes, difficulty perceiving effort, mood problems, and reduced physical activity—rather than being purely psychological or a muscle problem. They recommend cognitive-behavioral therapy (gradual activity increase) and antidepressants as the main treatments, while warning that too much rest can actually make the condition worse long-term.

Sleep

E3 PreliminaryCommentaryPEM not requiredEditorial

Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome.

Gray, J B, Martinovic, A M·Medical hypotheses·1994

This study proposes that ME/CFS may involve problems with how the body processes essential fatty acids—nutrients found in foods like fish and seeds. When stress is constant or too intense, the body's ability to use these fatty acids becomes sluggish, which can trigger ongoing immune system problems and exhaustion. The researchers suggest that changing your diet to better balance these fatty acids might help restore normal immune function and improve symptoms.

Energy MetabolismImmune System

E3 PreliminaryBehavioralPEM unclearCase-Control

Chronic fatigue syndrome or affective disorder? Implications of the diagnosis on management.

Giannopoulou, Joanna, Marriott, Sarah·European child & adolescent psychiatry·1994

This case study describes a teenage boy who was initially thought to have post-viral fatigue syndrome (a condition similar to ME/CFS that follows infections) but was actually diagnosed with bipolar disorder, a mental health condition involving extreme mood swings. The doctors discuss how difficult it can be to tell the difference between these two conditions in young people, and how getting the diagnosis wrong can seriously affect their treatment and development.

Diagnostics

E3 PreliminaryMechanismPEM unclearCross-Sectional

Corticospinal excitability in patients diagnosed with chronic fatigue syndrome.

Brouwer, B, Packer, T·Muscle & nerve·1994

This 1994 study examined how the nervous system controls muscle movement in people with ME/CFS by measuring a specific type of nerve signal called corticospinal excitability. Researchers looked at whether the connection between the brain and muscles works differently in ME/CFS patients compared to healthy controls. The study explored whether abnormalities in this nerve-to-muscle communication might explain some of the muscle-related symptoms in ME/CFS.

E3 PreliminaryCohortPEM not requiredCross-Sectional

The ocular signs and symptoms of chronic fatigue syndrome.

Caffery, B E, Josephson, J E, Samek, M J·Journal of the American Optometric Association·1994

This study looked at eye problems in 25 people with ME/CFS and found that all of them experienced some eye-related symptoms. The most common issues were problems with tears and the eye's surface, as well as difficulty focusing on close objects. Eye doctors should be aware of these issues when examining ME/CFS patients.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cognitive functioning of patients with chronic fatigue syndrome.

Johnson, S K, DeLuca, J, Fiedler, N et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Many people with ME/CFS experience brain fog and difficulty thinking clearly, which can be just as disabling as physical symptoms. This review examined research on these cognitive problems and found that the issue may not be with memory itself, but rather with how the brain processes information—like a computer that struggles to handle incoming data quickly enough. Understanding this difference is important for developing better treatments and support strategies.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredObservational

Acylcarnitine deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Takahashi, M et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study found that people with ME/CFS have lower levels of acylcarnitine, a substance that helps muscles produce energy, in their blood. Because acylcarnitine plays an important role in how muscles use energy, this deficiency might explain why ME/CFS patients experience fatigue, muscle pain, and weakness. Importantly, acylcarnitine levels tended to improve as patients recovered, suggesting it could be useful for tracking disease severity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Rebora, A, Drago, F·Dermatology (Basel, Switzerland)·1994

This study describes skin problems that appear in some ME/CFS patients, occurring in about 10-35% of cases. Researchers found that patients sometimes develop mouth sores or skin rashes, possibly related to Epstein-Barr virus (EBV) infection. The study emphasizes that ME/CFS is diagnosed when someone has severe, disabling fatigue lasting at least 6 months with no other medical condition explaining it.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

Peterson, P K, Sirr, S A, Grammith, F C et al.·Clinical and diagnostic laboratory immunology·1994

Researchers tested whether light exercise (30 minutes of slow walking) would trigger abnormal immune and brain blood flow responses in ME/CFS patients compared to healthy people. They found that ME/CFS patients had higher levels of a specific immune protein (TGF-beta) both at rest and after exercise, and also showed changes in brain blood flow. These changes appeared larger in ME/CFS patients than in healthy controls, though the difference wasn't statistically significant.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a defined unity?].

Rasmussen, A K, Andersen, V, Nielsen, H et al.·Ugeskrift for laeger·1994

This 1994 review examined what scientists knew about ME/CFS at that time, looking at whether a persistent virus or immune system problem caused the condition. The authors found that existing research did not consistently support either explanation, and that different studies often contradicted each other. They concluded that more careful research was needed to understand what actually causes ME/CFS and how to tell it apart from other illnesses.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredObservational

Human adjuvant disease revisited: a review of eleven post-augmentation mammoplasty patients.

Fenske, T K, Davis, P, Aaron, S L·Clinical and experimental rheumatology·1994

This study examined 11 women who developed widespread pain, fatigue, and joint symptoms after receiving silicone breast implants. The researchers found that 6 patients met criteria for fibromyalgia and 5 had chronic fatigue syndrome symptoms, but none had evidence of a traditional autoimmune disease. The authors suggest these cases should be classified as CFS or fibromyalgia rather than a unique implant-related disease.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Human herpesvirus 6. General overview].

Tîrdei, G, Ruţă, S M, Popescu, A E·Revue roumaine de virologie (Bucharest, Romania : 1990)·1994

Human herpesvirus 6 (HHV6) is a common virus that infects most people before age three, usually causing no symptoms or only mild illness. Researchers have good understanding of how the virus works and spreads, but it remains unclear whether HHV6 plays a role in chronic fatigue syndrome and some other long-term illnesses. This review summarizes what we know and don't know about this virus.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Lloyd, A, Gandevia, S, Brockman, A et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers asked whether a specific immune response causes the fatigue that ME/CFS patients experience after exercise. They had patients and healthy people do a 30-minute hand-grip exercise and checked their blood for immune chemicals (cytokines) before, during, and after exercise. Surprisingly, they found no changes in these immune chemicals in either group, and patients actually reported feeling less fatigued after the exercise—the opposite of what happens in real life.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearCommentary

Coming to terms with ME.

Hoad, A·Health visitor·1994

This article shares the personal story of Anne Hoad, a former health visitor who was diagnosed with ME in her mid-50s. She describes how difficult it was to accept the severe limitations ME placed on her life and how little understanding exists about this debilitating condition. Her account highlights common misconceptions about ME and the emotional challenge of coming to terms with a chronic illness that is poorly recognized by society.

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome and psychiatric diseases].

Matsuno, T, Hikita, K, Matsuo, T·Nihon rinsho. Japanese journal of clinical medicine·1994

This 1994 commentary discusses whether ME/CFS is actually a form of depression or a separate condition. The authors argue that ME/CFS is genuinely different from depression because people with ME/CFS remain motivated and don't show the emotional numbness seen in depression. Instead, ME/CFS involves fatigue that fluctuates sharply, along with persistent physical symptoms like malaise and low fevers.

Diagnostics

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Evidence browser

Chronic fatigue syndrome: a diagnostic challenge for the laboratory.

Cytomegalovirus-related sequence in an atypical cytopathic virus repeatedly isolated from a patient with chronic fatigue syndrome.

Viral studies of chronic fatigue syndrome.

[Chronic fatigue syndrome].

Neuropsychiatric status of patients with chronic fatigue syndrome: an overview.

[Chronic fatigue syndrome. Clinical, social psychological problems and management].

Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome.

Chronic fatigue syndrome or affective disorder? Implications of the diagnosis on management.

Corticospinal excitability in patients diagnosed with chronic fatigue syndrome.

The ocular signs and symptoms of chronic fatigue syndrome.

Cognitive functioning of patients with chronic fatigue syndrome.

Acylcarnitine deficiency in chronic fatigue syndrome.

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

[Chronic fatigue syndrome--a defined unity?].

Human adjuvant disease revisited: a review of eleven post-augmentation mammoplasty patients.

[Human herpesvirus 6. General overview].

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Coming to terms with ME.

[Chronic fatigue syndrome and psychiatric diseases].

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