ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2201–2220 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurobiological aspects of the chronic fatigue syndrome.

Bearn, J, Wessely, S·European journal of clinical investigation·1994

This study looked at how the brain and nervous system may be involved in chronic fatigue syndrome (ME/CFS). Researchers examined the biological mechanisms that might explain why people with ME/CFS experience persistent tiredness and other symptoms. The review helps identify which parts of the nervous system could be affected in this condition.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuropsychiatric status of patients with chronic fatigue syndrome: an overview.

Deluca, J, Johnson, S K, Natelson, B H·Toxicology and industrial health·1994

This review examines how ME/CFS affects thinking, memory, and mental health. Researchers compared people with ME/CFS to people with multiple sclerosis, depression, and healthy individuals to understand the neuropsychiatric symptoms (brain and mental health effects) that often accompany the chronic fatigue. The study suggests that cognitive problems in ME/CFS are a real biological feature of the illness, not simply depression.

Cognitive Impairment

E3 PreliminaryCommentaryPEM not requiredEditorial

Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome.

Gray, J B, Martinovic, A M·Medical hypotheses·1994

This study proposes that ME/CFS may involve problems with how the body processes essential fatty acids—nutrients found in foods like fish and seeds. When stress is constant or too intense, the body's ability to use these fatty acids becomes sluggish, which can trigger ongoing immune system problems and exhaustion. The researchers suggest that changing your diet to better balance these fatty acids might help restore normal immune function and improve symptoms.

Energy MetabolismImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Professional and popular views of chronic fatigue syndrome.

MacLean, G, Wessely, S·BMJ (Clinical research ed.)·1994

This study looked at how ME/CFS was covered in different types of media between 1980 and 1994. Researchers found that scientific journals were skeptical about whether ME/CFS had physical causes, while newspapers and magazines tended to present it as a real medical illness. This difference in coverage may have confused the public and healthcare providers about what ME/CFS actually is.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome. Clinical, social psychological problems and management].

Wessely, S·L'Encephale·1994

This review examines ME/CFS by comparing it to an older condition called neurasthenia and explores what causes the illness. The authors suggest that ME/CFS likely involves multiple factors including brain chemistry changes, difficulty perceiving effort, mood problems, and reduced physical activity—rather than being purely psychological or a muscle problem. They recommend cognitive-behavioral therapy (gradual activity increase) and antidepressants as the main treatments, while warning that too much rest can actually make the condition worse long-term.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Stealth viruses as neuropathogens.

Martin, W J·CAP today·1994

This article suggests that certain stealth viruses may damage the nervous system and contribute to various brain-related conditions, including ME/CFS. The authors note that diseases like ME/CFS, fibromyalgia, depression, and autism share overlapping symptoms—such as pain, mood changes, and cognitive problems—which may reflect a common underlying problem in how the brain responds to different triggers.

Neuroinflammation

E3 PreliminaryCohortPEM not requiredCase-Control

Wegener's granuloma--presenting as a unilateral parotid swelling.

Benson-Mitchell, R, Tolley, N, Croft, C B et al.·The Journal of laryngology and otology·1994

This case study describes one patient who was initially diagnosed with ME/CFS but later found to have Wegener's granuloma, a serious autoimmune disease that causes inflammation in blood vessels. The patient presented with hearing loss and swelling in one salivary gland, which is an unusual way for this disease to appear. The case highlights how important it is for doctors to consider other diagnoses when patients have unexpected symptoms.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a defined unity?].

Rasmussen, A K, Andersen, V, Nielsen, H et al.·Ugeskrift for laeger·1994

This 1994 review examined what scientists knew about ME/CFS at that time, looking at whether a persistent virus or immune system problem caused the condition. The authors found that existing research did not consistently support either explanation, and that different studies often contradicted each other. They concluded that more careful research was needed to understand what actually causes ME/CFS and how to tell it apart from other illnesses.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome].

Artsimovich, N G, Chugunov, V S, Kornev, A V et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·1994

ME/CFS is a serious condition that causes extreme tiredness, brain fog, and flu-like symptoms that can last for months or years. The condition affects people of all ages, but is most common in women under 45. Researchers believe the immune system is not working properly in people with ME/CFS, though the exact problem is still unclear.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Viral studies of chronic fatigue syndrome.

Ablashi, D V·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This review article examines whether viruses play a role in causing ME/CFS by looking at existing research on viral infections in patients with this condition. The author analyzes studies investigating connections between various viruses and ME/CFS symptoms. The review helps summarize what scientists knew in 1994 about potential viral causes of the illness.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Corticospinal excitability in patients diagnosed with chronic fatigue syndrome.

Brouwer, B, Packer, T·Muscle & nerve·1994

This 1994 study examined how the nervous system controls muscle movement in people with ME/CFS by measuring a specific type of nerve signal called corticospinal excitability. Researchers looked at whether the connection between the brain and muscles works differently in ME/CFS patients compared to healthy controls. The study explored whether abnormalities in this nerve-to-muscle communication might explain some of the muscle-related symptoms in ME/CFS.

E3 PreliminaryBehavioralPEM unclearCase-Control

Chronic fatigue syndrome or affective disorder? Implications of the diagnosis on management.

Giannopoulou, Joanna, Marriott, Sarah·European child & adolescent psychiatry·1994

This case study describes a teenage boy who was initially thought to have post-viral fatigue syndrome (a condition similar to ME/CFS that follows infections) but was actually diagnosed with bipolar disorder, a mental health condition involving extreme mood swings. The doctors discuss how difficult it can be to tell the difference between these two conditions in young people, and how getting the diagnosis wrong can seriously affect their treatment and development.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Trinidad, E E, Ramírez-Ronda, C·Boletin de la Asociacion Medica de Puerto Rico·1994

Chronic Fatigue Syndrome (ME/CFS) is a long-lasting illness that causes extreme tiredness and affects an estimated 24% of people. It was officially defined as a medical condition in 1988 after doctors recognized increasing numbers of patients with similar symptoms. The condition is more common in women aged 20-50 and is currently treated with supportive care to help manage symptoms.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Lloyd, A, Gandevia, S, Brockman, A et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers asked whether a specific immune response causes the fatigue that ME/CFS patients experience after exercise. They had patients and healthy people do a 30-minute hand-grip exercise and checked their blood for immune chemicals (cytokines) before, during, and after exercise. Surprisingly, they found no changes in these immune chemicals in either group, and patients actually reported feeling less fatigued after the exercise—the opposite of what happens in real life.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

A brief history of chronic fatigue syndrome.

Kim, E·JAMA·1994

This is a historical review article that traces how chronic fatigue syndrome (ME/CFS) has been understood and described over time. The article examines the evolution of the condition from early medical descriptions through the modern era, helping readers understand how our knowledge of ME/CFS has changed. It provides context for why ME/CFS was named and recognized as a legitimate medical condition.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: a critical review].

Cathébras, P, Bouchou, K, Charmion, S et al.·La Revue de medecine interne·1993

ME/CFS is a debilitating condition characterized mainly by extreme tiredness of unknown cause. Current diagnostic criteria don't clearly identify a single uniform group of patients, and no clear infectious or immune cause has been definitively proven, though some viruses and immune changes may play a role in some cases. Treatment options are limited but may include antidepressants and cognitive-behavioral therapy.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

From the Centers for Disease Control and Prevention. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

JAMA·1993

In the early 1990s, researchers tested whether retroviruses (a type of virus) could be identified in people with ME/CFS using available blood tests. The CDC study found that these retroviral tests could not reliably identify or confirm ME/CFS in patients. This helped clarify that ME/CFS was not caused by the retroviruses being tested at that time.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome].

Ewig, S·Deutsche medizinische Wochenschrift (1946)·1993

This is a review article about chronic fatigue syndrome (ME/CFS) published in a German medical journal. The author summarizes existing knowledge about the condition to help doctors and patients understand what was known about this illness in the early 1990s.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Barnes, P R, Taylor, D J, Kemp, G J et al.·Journal of neurology, neurosurgery, and psychiatry·1993

Researchers used a special type of MRI scan to measure how muscles use energy in ME/CFS patients compared to healthy people. They found that most patients had normal muscle energy use, but about a quarter showed unusual patterns in how their muscles handled acid buildup during exercise. This suggests muscle metabolism problems may exist in some, but not all, ME/CFS patients.

Biomarkers

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome. A fresh look at an old problem.

McSherry, J·Canadian family physician Medecin de famille canadien·1993

This editorial discusses chronic fatigue syndrome (ME/CFS) as a real medical condition affecting about 3 in 100,000 people. Most patients experience symptoms for approximately 2.5 years before recovering to normal health. Since there is no single definitive test, doctors diagnose ME/CFS by ruling out other diseases, and currently no one treatment works for everyone.

Diagnostics

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Evidence browser

Neurobiological aspects of the chronic fatigue syndrome.

Neuropsychiatric status of patients with chronic fatigue syndrome: an overview.

Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome.

Professional and popular views of chronic fatigue syndrome.

[Chronic fatigue syndrome. Clinical, social psychological problems and management].

Stealth viruses as neuropathogens.

Wegener's granuloma--presenting as a unilateral parotid swelling.

[Chronic fatigue syndrome--a defined unity?].

[The chronic fatigue syndrome].

Viral studies of chronic fatigue syndrome.

Corticospinal excitability in patients diagnosed with chronic fatigue syndrome.

Chronic fatigue syndrome or affective disorder? Implications of the diagnosis on management.

[Chronic fatigue syndrome].

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

A brief history of chronic fatigue syndrome.

[Chronic fatigue syndrome: a critical review].

From the Centers for Disease Control and Prevention. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

[The chronic fatigue syndrome].

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Chronic fatigue syndrome. A fresh look at an old problem.

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