ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2201–2220 of 2,423 studies

E3 PreliminaryCohortPEM not requiredCross-Sectional

The ocular signs and symptoms of chronic fatigue syndrome.

Caffery, B E, Josephson, J E, Samek, M J·Journal of the American Optometric Association·1994

This study looked at eye problems in 25 people with ME/CFS and found that all of them experienced some eye-related symptoms. The most common issues were problems with tears and the eye's surface, as well as difficulty focusing on close objects. Eye doctors should be aware of these issues when examining ME/CFS patients.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Sternon, J, Decaux, G, Hoffmann, G·Revue medicale de Bruxelles·1994

This paper describes how doctors can diagnose ME/CFS using specific criteria and discusses what might cause the condition. The authors note that viral infections may trigger ME/CFS, and that anxiety or depression can make symptoms worse. Importantly, they found that some patients improve on their own after a few years, though most don't respond well to available treatments.

SleepDiagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1994

This 1994 review examined three related conditions—fibromyalgia, ME/CFS, and myofascial pain syndrome—that often overlap and remain poorly understood. The author noted that these conditions frequently occur alongside Lyme disease and other medical or psychiatric illnesses. New research at that time suggested that problems with how the central nervous system (the brain and spinal cord) processes signals might play a role in fibromyalgia and ME/CFS.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Lloyd, A, Gandevia, S, Brockman, A et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers asked whether a specific immune response causes the fatigue that ME/CFS patients experience after exercise. They had patients and healthy people do a 30-minute hand-grip exercise and checked their blood for immune chemicals (cytokines) before, during, and after exercise. Surprisingly, they found no changes in these immune chemicals in either group, and patients actually reported feeling less fatigued after the exercise—the opposite of what happens in real life.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuropsychiatric status of patients with chronic fatigue syndrome: an overview.

Deluca, J, Johnson, S K, Natelson, B H·Toxicology and industrial health·1994

This review examines how ME/CFS affects thinking, memory, and mental health. Researchers compared people with ME/CFS to people with multiple sclerosis, depression, and healthy individuals to understand the neuropsychiatric symptoms (brain and mental health effects) that often accompany the chronic fatigue. The study suggests that cognitive problems in ME/CFS are a real biological feature of the illness, not simply depression.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Viral studies of chronic fatigue syndrome.

Ablashi, D V·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This review article examines whether viruses play a role in causing ME/CFS by looking at existing research on viral infections in patients with this condition. The author analyzes studies investigating connections between various viruses and ME/CFS symptoms. The review helps summarize what scientists knew in 1994 about potential viral causes of the illness.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Acylcarnitine deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Takahashi, M et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study found that people with ME/CFS have lower levels of acylcarnitine, a substance that helps muscles produce energy, in their blood. Because acylcarnitine plays an important role in how muscles use energy, this deficiency might explain why ME/CFS patients experience fatigue, muscle pain, and weakness. Importantly, acylcarnitine levels tended to improve as patients recovered, suggesting it could be useful for tracking disease severity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryBehavioralPEM unclearCase-Control

Chronic fatigue syndrome or affective disorder? Implications of the diagnosis on management.

Giannopoulou, Joanna, Marriott, Sarah·European child & adolescent psychiatry·1994

This case study describes a teenage boy who was initially thought to have post-viral fatigue syndrome (a condition similar to ME/CFS that follows infections) but was actually diagnosed with bipolar disorder, a mental health condition involving extreme mood swings. The doctors discuss how difficult it can be to tell the difference between these two conditions in young people, and how getting the diagnosis wrong can seriously affect their treatment and development.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Rebora, A, Drago, F·Dermatology (Basel, Switzerland)·1994

This study describes skin problems that appear in some ME/CFS patients, occurring in about 10-35% of cases. Researchers found that patients sometimes develop mouth sores or skin rashes, possibly related to Epstein-Barr virus (EBV) infection. The study emphasizes that ME/CFS is diagnosed when someone has severe, disabling fatigue lasting at least 6 months with no other medical condition explaining it.

E3 PreliminaryCohortPEM unclearCase-Control

Refractory chronic fatigue syndrome in adolescence.

Sidebotham, P D, Skeldon, I, Chambers, T L et al.·British journal of hospital medicine·1994

This study looked at young people with severe, long-lasting fatigue that didn't improve with standard treatments. The researchers compared adolescents who had ME/CFS that was difficult to manage with those who responded better to care. The findings help doctors understand which young patients may need different or more intensive approaches to treatment.

E3 PreliminaryReviewPEM unclearReview-Narrative

Stealth viruses as neuropathogens.

Martin, W J·CAP today·1994

This article suggests that certain stealth viruses may damage the nervous system and contribute to various brain-related conditions, including ME/CFS. The authors note that diseases like ME/CFS, fibromyalgia, depression, and autism share overlapping symptoms—such as pain, mood changes, and cognitive problems—which may reflect a common underlying problem in how the brain responds to different triggers.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearCross-Sectional

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

Peterson, P K, Sirr, S A, Grammith, F C et al.·Clinical and diagnostic laboratory immunology·1994

Researchers tested whether light exercise (30 minutes of slow walking) would trigger abnormal immune and brain blood flow responses in ME/CFS patients compared to healthy people. They found that ME/CFS patients had higher levels of a specific immune protein (TGF-beta) both at rest and after exercise, and also showed changes in brain blood flow. These changes appeared larger in ME/CFS patients than in healthy controls, though the difference wasn't statistically significant.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression.

Patarca, R, Klimas, N G, Lugtendorf, S et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study tested blood samples from 70 ME/CFS patients and compared them to healthy people. Researchers found that about 60% of ME/CFS patients had unusually high levels of immune chemicals called cytokines, particularly two types called TNF-alpha and TNF-beta. These chemicals are normally released by the body to fight infections, but in ME/CFS patients they appeared to be abnormally activated even without an active infection.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Effort syndrome: hyperventilation and reduction of anaerobic threshold.

Nixon, P G·Biofeedback and self-regulation·1994

This study focuses on a condition called 'effort syndrome,' which causes people to feel exhausted during physical activity. The researchers found that patients with effort syndrome breathe too heavily (hyperventilate), which changes the chemistry of their blood and makes their muscles tire much earlier than normal. By measuring breathing patterns during exercise, doctors can identify how much work each patient can do before their body runs out of chemical buffers.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome and psychiatric diseases].

Matsuno, T, Hikita, K, Matsuo, T·Nihon rinsho. Japanese journal of clinical medicine·1994

This 1994 commentary discusses whether ME/CFS is actually a form of depression or a separate condition. The authors argue that ME/CFS is genuinely different from depression because people with ME/CFS remain motivated and don't show the emotional numbness seen in depression. Instead, ME/CFS involves fatigue that fluctuates sharply, along with persistent physical symptoms like malaise and low fevers.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Women's health issues: a review of the current literature in the social work journals, 1985-1992.

Millner, L, Widerman, E·Social work in health care·1994

This study reviewed social work journal articles published between 1985-1992 to see how the profession was addressing women's health issues. Researchers found 36 articles, most focusing on reproduction and pregnancy, with fewer articles on illnesses like chronic fatigue syndrome. The study concluded that social work was overlooking important structural factors that affect women's health, such as employment and childcare access.

E3 PreliminaryMechanismPEM not requiredMechanistic

Infection of natural killer cells by human herpesvirus 6.

Lusso, P, Malnati, M S, Garzino-Demo, A et al.·Nature·1993

This study found that a virus called HHV-6 can directly infect and damage natural killer cells, which are important immune cells that normally fight viruses. When HHV-6 infects these cells, it kills them and also causes them to express a protein that makes them vulnerable to HIV infection. This suggests that HHV-6 might be a way the body's natural antiviral defenses get weakened.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is juvenile diabetes a viral disease?

Fohlman, J, Friman, G·Annals of medicine·1993

This review examines whether viruses—particularly enteroviruses like Coxsackie and ECHO viruses—might trigger type 1 diabetes in children. The authors suggest that a person can catch one of these viruses, and even though the initial infection may go unnoticed, the virus can persist in the body and potentially trigger the immune system to attack the insulin-producing cells in the pancreas. Interestingly, the authors mention that similar persistent viral infections might also play a role in chronic fatigue syndrome.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

Jason, L A·The journal of primary prevention·1993

This 1993 paper explores how the mind, nervous system, and immune system are connected in ME/CFS, and how community support might help with recovery. The authors use a real patient's story to show how understanding these connections and building supportive relationships could be helpful for people struggling with this illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothesis: the nasal fatigue reflex.

Chester, A C·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1993

This paper proposes a new theory: that extreme fatigue in ME/CFS and related conditions might be the body's protective reflex triggered by nasal or sinus problems. The idea is that in our evolutionary past, when a good sense of smell was crucial for survival, fatigue would have kept sick animals resting safely at home while their nose healed. The author suggests this ancient reflex may still be active in humans today.

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The ocular signs and symptoms of chronic fatigue syndrome.

[Chronic fatigue syndrome].

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Neuropsychiatric status of patients with chronic fatigue syndrome: an overview.

Viral studies of chronic fatigue syndrome.

Acylcarnitine deficiency in chronic fatigue syndrome.

Chronic fatigue syndrome or affective disorder? Implications of the diagnosis on management.

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Refractory chronic fatigue syndrome in adolescence.

Stealth viruses as neuropathogens.

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression.

Effort syndrome: hyperventilation and reduction of anaerobic threshold.

[Chronic fatigue syndrome and psychiatric diseases].

Women's health issues: a review of the current literature in the social work journals, 1985-1992.

Infection of natural killer cells by human herpesvirus 6.

Is juvenile diabetes a viral disease?

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

Hypothesis: the nasal fatigue reflex.

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