ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2201–2220 of 2,420 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Sternon, J, Decaux, G, Hoffmann, G·Revue medicale de Bruxelles·1994

This paper describes how doctors can diagnose ME/CFS using specific criteria and discusses what might cause the condition. The authors note that viral infections may trigger ME/CFS, and that anxiety or depression can make symptoms worse. Importantly, they found that some patients improve on their own after a few years, though most don't respond well to available treatments.

SleepDiagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a defined unity?].

Rasmussen, A K, Andersen, V, Nielsen, H et al.·Ugeskrift for laeger·1994

This 1994 review examined what scientists knew about ME/CFS at that time, looking at whether a persistent virus or immune system problem caused the condition. The authors found that existing research did not consistently support either explanation, and that different studies often contradicted each other. They concluded that more careful research was needed to understand what actually causes ME/CFS and how to tell it apart from other illnesses.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome].

Artsimovich, N G, Chugunov, V S, Kornev, A V et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·1994

ME/CFS is a serious condition that causes extreme tiredness, brain fog, and flu-like symptoms that can last for months or years. The condition affects people of all ages, but is most common in women under 45. Researchers believe the immune system is not working properly in people with ME/CFS, though the exact problem is still unclear.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

Peterson, P K, Sirr, S A, Grammith, F C et al.·Clinical and diagnostic laboratory immunology·1994

Researchers tested whether light exercise (30 minutes of slow walking) would trigger abnormal immune and brain blood flow responses in ME/CFS patients compared to healthy people. They found that ME/CFS patients had higher levels of a specific immune protein (TGF-beta) both at rest and after exercise, and also showed changes in brain blood flow. These changes appeared larger in ME/CFS patients than in healthy controls, though the difference wasn't statistically significant.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome and psychiatric diseases].

Matsuno, T, Hikita, K, Matsuo, T·Nihon rinsho. Japanese journal of clinical medicine·1994

This 1994 commentary discusses whether ME/CFS is actually a form of depression or a separate condition. The authors argue that ME/CFS is genuinely different from depression because people with ME/CFS remain motivated and don't show the emotional numbness seen in depression. Instead, ME/CFS involves fatigue that fluctuates sharply, along with persistent physical symptoms like malaise and low fevers.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-7 (HHV-7).

Ablashi, D V, Berneman, Z N, Kramarsky, B et al.·In vivo (Athens, Greece)·1994

This review examines Human herpesvirus-7 (HHV-7), a common virus that infects most people in the United States. HHV-7 was first discovered in 1990 and was found in a ME/CFS patient in 1992, raising early questions about whether it might be involved in the illness. However, researchers have not yet found clear evidence that HHV-7 causes any specific disease.

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Lloyd, A, Gandevia, S, Brockman, A et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers asked whether a specific immune response causes the fatigue that ME/CFS patients experience after exercise. They had patients and healthy people do a 30-minute hand-grip exercise and checked their blood for immune chemicals (cytokines) before, during, and after exercise. Surprisingly, they found no changes in these immune chemicals in either group, and patients actually reported feeling less fatigued after the exercise—the opposite of what happens in real life.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Stealth viruses as neuropathogens.

Martin, W J·CAP today·1994

This article suggests that certain stealth viruses may damage the nervous system and contribute to various brain-related conditions, including ME/CFS. The authors note that diseases like ME/CFS, fibromyalgia, depression, and autism share overlapping symptoms—such as pain, mood changes, and cognitive problems—which may reflect a common underlying problem in how the brain responds to different triggers.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredObservational

Acylcarnitine deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Takahashi, M et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study found that people with ME/CFS have lower levels of acylcarnitine, a substance that helps muscles produce energy, in their blood. Because acylcarnitine plays an important role in how muscles use energy, this deficiency might explain why ME/CFS patients experience fatigue, muscle pain, and weakness. Importantly, acylcarnitine levels tended to improve as patients recovered, suggesting it could be useful for tracking disease severity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

MELISA-an in vitro tool for the study of metal allergy.

Stejskal, V D, Cederbrant, K, Lindvall, A et al.·Toxicology in vitro : an international journal published in association with BIBRA·1994

This study tested whether certain metals used in dental work and medical devices can trigger immune system reactions in people with chronic fatigue and mouth problems. Researchers used a laboratory test called MELISA to measure how immune cells from patients responded to metals like mercury, gold, and palladium. They found that people with symptoms had stronger immune reactions to these metals than healthy people without symptoms, suggesting a possible connection between metal exposure and their health problems.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Effort syndrome: hyperventilation and reduction of anaerobic threshold.

Nixon, P G·Biofeedback and self-regulation·1994

This study focuses on a condition called 'effort syndrome,' which causes people to feel exhausted during physical activity. The researchers found that patients with effort syndrome breathe too heavily (hyperventilate), which changes the chemistry of their blood and makes their muscles tire much earlier than normal. By measuring breathing patterns during exercise, doctors can identify how much work each patient can do before their body runs out of chemical buffers.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Rebora, A, Drago, F·Dermatology (Basel, Switzerland)·1994

This study describes skin problems that appear in some ME/CFS patients, occurring in about 10-35% of cases. Researchers found that patients sometimes develop mouth sores or skin rashes, possibly related to Epstein-Barr virus (EBV) infection. The study emphasizes that ME/CFS is diagnosed when someone has severe, disabling fatigue lasting at least 6 months with no other medical condition explaining it.

E3 PreliminaryCohortPEM not requiredCase-Control

Wegener's granuloma--presenting as a unilateral parotid swelling.

Benson-Mitchell, R, Tolley, N, Croft, C B et al.·The Journal of laryngology and otology·1994

This case study describes one patient who was initially diagnosed with ME/CFS but later found to have Wegener's granuloma, a serious autoimmune disease that causes inflammation in blood vessels. The patient presented with hearing loss and swelling in one salivary gland, which is an unusual way for this disease to appear. The case highlights how important it is for doctors to consider other diagnoses when patients have unexpected symptoms.

E3 PreliminaryCommentaryPEM unclearEditorial

The grey area of effort syndrome and hyperventilation: from Thomas Lewis to today.

Nixon, P G·Journal of the Royal College of Physicians of London·1993

This article reviews the historical concept of 'effort syndrome'—a condition where the body loses its ability to handle physical exertion due to chemical imbalances, particularly in how the body buffers acids produced during exercise. The author argues that this old diagnosis remains relevant today and should be considered when evaluating chronic fatigue and other unexplained illnesses, especially when emotional stress and overbreathing (hyperventilation) are present.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

Jason, L A·The journal of primary prevention·1993

This 1993 paper explores how the mind, nervous system, and immune system are connected in ME/CFS, and how community support might help with recovery. The authors use a real patient's story to show how understanding these connections and building supportive relationships could be helpful for people struggling with this illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothesis: the nasal fatigue reflex.

Chester, A C·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1993

This paper proposes a new theory: that extreme fatigue in ME/CFS and related conditions might be the body's protective reflex triggered by nasal or sinus problems. The idea is that in our evolutionary past, when a good sense of smell was crucial for survival, fatigue would have kept sick animals resting safely at home while their nose healed. The author suggests this ancient reflex may still be active in humans today.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is juvenile diabetes a viral disease?

Fohlman, J, Friman, G·Annals of medicine·1993

This review examines whether viruses—particularly enteroviruses like Coxsackie and ECHO viruses—might trigger type 1 diabetes in children. The authors suggest that a person can catch one of these viruses, and even though the initial infection may go unnoticed, the virus can persist in the body and potentially trigger the immune system to attack the insulin-producing cells in the pancreas. Interestingly, the authors mention that similar persistent viral infections might also play a role in chronic fatigue syndrome.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Society, mind and body in chronic fatigue syndrome: an anthropological view.

Ware, N C·Ciba Foundation symposium·1993

This study interviewed 50 people with chronic fatigue to understand how their daily lives, families, and work environments shaped their experience of illness. The researchers found that people often traced their illness to stressful life events and busy lifestyles, and that having ME/CFS sometimes led them to make positive changes by slowing down. The study also explains why ME/CFS patients often feel dismissed—society tends to separate 'mind' from 'body,' making psychological factors seem less real than physical ones.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, sleep disorder and chronic fatigue syndrome.

Moldofsky, H·Ciba Foundation symposium·1993

This study examined how sleep problems, tiredness, and muscle pain are connected in ME/CFS and fibromyalgia. Both conditions share similar unusual brain wave patterns during sleep that make sleep feel unrefreshing even though people sleep. The research suggests that problems with the immune system and sleep-wake cycle are linked, and interfering with either one can trigger the other and cause ME/CFS symptoms.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue in historical perspective.

Shorter, E·Ciba Foundation symposium·1993

This historical review examines how chronic fatigue as an illness has been understood and named over the past 150 years. The author traces how doctors have called similar conditions by different names—from 'neurasthenia' in the 1800s to 'myalgic encephalomyelitis,' 'chronic Epstein-Barr virus infection,' and 'fibromyalgia'—and explains how these separate medical concepts have recently begun to converge into what we now call chronic fatigue syndrome. The study shows that chronic fatigue became increasingly common in Europe and North America by the early 1900s, though it was rarely documented before the mid-1800s.

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[Chronic fatigue syndrome].

[Chronic fatigue syndrome--a defined unity?].

[The chronic fatigue syndrome].

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

[Chronic fatigue syndrome and psychiatric diseases].

Human herpesvirus-7 (HHV-7).

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Stealth viruses as neuropathogens.

Acylcarnitine deficiency in chronic fatigue syndrome.

MELISA-an in vitro tool for the study of metal allergy.

Effort syndrome: hyperventilation and reduction of anaerobic threshold.

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Wegener's granuloma--presenting as a unilateral parotid swelling.

The grey area of effort syndrome and hyperventilation: from Thomas Lewis to today.

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

Hypothesis: the nasal fatigue reflex.

Is juvenile diabetes a viral disease?

Society, mind and body in chronic fatigue syndrome: an anthropological view.

Fibromyalgia, sleep disorder and chronic fatigue syndrome.

Chronic fatigue in historical perspective.

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