ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2241–2260 of 2,420 studies

E3 PreliminaryCohortPEM unclearCase-Control

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Bojić, I, Mijusković, P, Lilić, D et al.·Vojnosanitetski pregled·1993

This 1993 study examined whether Epstein-Barr virus (EBV)—a common virus that causes mononucleosis—might be connected to chronic fatigue syndrome (ME/CFS). Researchers compared a group of people with ME/CFS to a control group to see if EBV infection patterns differed between them. The study aimed to explore whether EBV could play a role in developing or maintaining ME/CFS symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Is chronic fatigue syndrome an infectious disease?

Mawle, A C, Reyes, M, Schmid, D S·Infectious agents and disease·1993

This 1993 paper examines whether chronic fatigue syndrome (ME/CFS) might be caused by an infection. The authors reviewed evidence about infectious agents and their possible role in ME/CFS development. While the study explores this connection, it does not provide definitive answers about whether an infection causes the illness.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pharmacological approaches to the therapy of chronic fatigue syndrome.

McCluskey, D R·Ciba Foundation symposium·1993

This study examined various medications used to treat ME/CFS and found that none completely resolved symptoms. The researchers suggest that ME/CFS may be caused by a sleep regulation problem in the brain, which leads to not only extreme tiredness but also pain sensitivity, temperature control issues, and mood problems. They propose that medications affecting brain chemicals, especially serotonin, might help and should be tested in larger clinical trials.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Low NK syndrome and its relationship to chronic fatigue syndrome.

Aoki, T, Miyakoshi, H, Usuda, Y et al.·Clinical immunology and immunopathology·1993

This study examined whether people with chronic fatigue syndrome (ME/CFS) have lower numbers or reduced function of natural killer (NK) cells, which are part of the immune system that helps fight infections and abnormal cells. The researchers found that some ME/CFS patients showed low NK cell levels or activity, suggesting the immune system may not be working normally in this condition. This finding could help explain why people with ME/CFS experience persistent exhaustion and infections.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Society, mind and body in chronic fatigue syndrome: an anthropological view.

Ware, N C·Ciba Foundation symposium·1993

This study interviewed 50 people with chronic fatigue to understand how their daily lives, families, and work environments shaped their experience of illness. The researchers found that people often traced their illness to stressful life events and busy lifestyles, and that having ME/CFS sometimes led them to make positive changes by slowing down. The study also explains why ME/CFS patients often feel dismissed—society tends to separate 'mind' from 'body,' making psychological factors seem less real than physical ones.

E3 PreliminaryMechanismPEM unclearObservational

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Wong, R, Lopaschuk, G, Zhu, G et al.·Chest·1992

This study used a special imaging technique (31P NMR spectroscopy) to examine how muscles use energy during exercise in people with ME/CFS compared to healthy volunteers. Patients with ME/CFS became exhausted much faster during exercise (about 8 minutes versus 11 minutes) and had lower levels of ATP, the main energy molecule muscles use. The patterns of energy use looked similar between groups, but happened much more quickly in the ME/CFS group.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Buchwald, D, Garrity, D, Pascualy, R et al.·Toxicology and industrial health·1992

This is a review article that examines what was known about chronic fatigue syndrome in the early 1990s. The authors looked at existing research to summarize the characteristics, possible causes, and impacts of this condition. This paper helped establish an early framework for understanding ME/CFS as a medical condition worthy of scientific investigation.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. A review from the general practice perspective.

Murdoch, J C·Australian family physician·1992

This 1992 review examines ME/CFS from the perspective of general practitioners (GPs) in Australia. The paper discusses how GPs can recognize, understand, and manage ME/CFS in their patients, highlighting the challenges of diagnosing a condition that doesn't show up on standard blood tests. It emphasizes that ME/CFS is a real medical condition deserving of proper clinical attention and patient support.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: a joint paediatric-psychiatric approach.

Vereker, M I·Archives of disease in childhood·1992

This 1992 paper discusses how ME/CFS (then called chronic fatigue syndrome) in children should be evaluated and treated by working together between pediatric doctors and mental health specialists. The authors suggest that understanding both the physical and emotional aspects of the illness is important for helping young patients.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Therapy of chronic fatigue syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examined different treatment options for ME/CFS by looking at past clinical studies. Researchers found that while most treatments tested didn't work well, a few showed promise—including intravenous immunoglobulin therapy, magnesium supplements, and treatments designed to boost natural killer cells (immune cells that help fight infection). The authors suggest that immune system problems may play a role in ME/CFS, and fixing these problems might help patients feel better.

Immune System

E3 PreliminaryPEM not required

Epstein-Barr virus-related persistent erythema multiforme in chronic fatigue syndrome.

Drago, F, Romagnoli, M, Loi, A et al.·Archives of dermatology·1992

This case study describes a single patient with ME/CFS who developed an unusual, long-lasting skin rash called erythema multiforme that didn't respond to standard steroid treatment. Researchers found evidence of Epstein-Barr virus (EBV)—the virus that causes infectious mononucleosis—in the skin lesions and other body tissues. The rash improved when the patient was treated with an antiviral medication (acyclovir), but returned when the medication was stopped.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Chronic Fatigue Syndrome: Do herbs or homeopathy help?

Leyton, E, Pross, H·Canadian family physician Medecin de famille canadien·1992

This study tested whether herbal and homeopathic treatments could help six ME/CFS patients feel better. Researchers tracked symptoms and measured blood markers before and after treatment. The treatments did not produce any measurable improvements in symptoms or immune function.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue syndromes: new thoughts and reinterpretation of previous data.

Downey, D C·Medical hypotheses·1992

This study examined 19 patients with severe fatigue who showed unusual reactions to copper-containing bracelets or necklaces. The researchers found that 8 of these patients had deficiencies in enzymes related to heme (a component of blood), and suggested that problems with copper metabolism and heme processing might explain fatigue in conditions like ME/CFS, multiple sclerosis, and other disorders.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. Recent advances in diagnosis and treatment.

Bell, D S·Postgraduate medicine·1992

ME/CFS typically starts suddenly with severe tiredness and flu-like symptoms that come and go over months or years. While blood tests sometimes show immune system changes, doctors diagnose ME/CFS mainly by recognizing the pattern of symptoms and ruling out other illnesses. Current treatment focuses on managing symptoms and helping patients cope with this long-lasting, disabling condition.

InterventionsDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome.

Ur, E, White, P D, Grossman, A·European archives of psychiatry and clinical neuroscience·1992

This paper proposes that certain immune signals in the brain called cytokines (particularly IL-1 and IL-6) may become overactive in ME/CFS and depression, triggering a chain reaction in the body's stress system that produces fatigue and other symptoms. The authors suggest that viral infections might trigger this cytokine activation. While this is a theoretical proposal rather than a study with patient data, it offered an important new way of thinking about what causes chronic fatigue and depression.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue immune dysfunction syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

ME/CFS causes extreme tiredness that lasts longer than six months and may be linked to a viral infection that doesn't go away normally. Researchers found that people with ME/CFS have problems with immune cells, especially natural killer (NK) cells, which normally help fight off viruses and control the immune system. When NK cell function improved in some patients, their ME/CFS symptoms got better, suggesting that fixing these immune cells might be key to recovery.

Immune System

E3 PreliminaryCohortPEM unclearObservational

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Hashimoto, N, Kuraishi, Y, Yokose, T et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study identified 51 patients with ME/CFS diagnosed using official CDC criteria between 1991 and 1992. Most patients were women in their 20s–30s who had been seen by many doctors before receiving a correct diagnosis. Standard blood tests did not reveal abnormal findings, though some immune markers were mildly abnormal. About 57% of patients showed general improvement, and doctors used various medications to manage severe symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Winters, E G, Quinet, R J·The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·1992

ME/CFS is a complex illness characterized by severe, debilitating fatigue that often starts suddenly with flu-like symptoms. While researchers have investigated viruses and immune system changes in ME/CFS patients, no single cause has been definitively identified. Currently, there is no specific cure, though cognitive behavioral therapy and certain medications may help some patients manage their condition.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Chronic fatigue syndrome: studies on skeletal muscle.

Grau, J M, Casademont, J, Pedrol, E et al.·Clinical neuropathology·1992

This study looked at muscle tissue samples from 20 ME/CFS patients to understand why muscles feel so tired and weak. The researchers found that most patients had either normal muscle tissue or only minor changes, and they did not find the patterns of inflammation typically seen in viral muscle diseases. The study also tested whether L-carnitine supplements could help patients improve over three months, but found no clinical benefit.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

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Evidence browser

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Is chronic fatigue syndrome an infectious disease?

Pharmacological approaches to the therapy of chronic fatigue syndrome.

Low NK syndrome and its relationship to chronic fatigue syndrome.

Society, mind and body in chronic fatigue syndrome: an anthropological view.

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Chronic fatigue syndrome.

Chronic fatigue syndrome. A review from the general practice perspective.

Chronic fatigue syndrome: a joint paediatric-psychiatric approach.

[Therapy of chronic fatigue syndrome].

Epstein-Barr virus-related persistent erythema multiforme in chronic fatigue syndrome.

Chronic Fatigue Syndrome: Do herbs or homeopathy help?

Fatigue syndromes: new thoughts and reinterpretation of previous data.

Chronic fatigue syndrome. Recent advances in diagnosis and treatment.

Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome.

[Chronic fatigue immune dysfunction syndrome].

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Chronic fatigue syndrome.

Chronic fatigue syndrome: studies on skeletal muscle.

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

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