ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2241–2260 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Barnes, P R, Taylor, D J, Kemp, G J et al.·Journal of neurology, neurosurgery, and psychiatry·1993

Researchers used a special type of MRI scan to measure how muscles use energy in ME/CFS patients compared to healthy people. They found that most patients had normal muscle energy use, but about a quarter showed unusual patterns in how their muscles handled acid buildup during exercise. This suggests muscle metabolism problems may exist in some, but not all, ME/CFS patients.

Biomarkers

E3 PreliminaryCohortPEM unclearCross-Sectional

Experience at a referral center for patients with suspected Lyme disease in an area of nonendemicity: first 65 patients.

Burdge, D R, O'Hanlon, D P·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1993

Doctors at a hospital created a special clinic to evaluate patients who thought they had Lyme disease, even though Lyme disease is not common in that region. Out of 65 patients referred to the clinic, only 2 actually had Lyme disease. However, the clinic successfully identified other real medical conditions in most patients, including rheumatologic diseases, infections, and chronic fatigue syndrome.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Infection of natural killer cells by human herpesvirus 6.

Lusso, P, Malnati, M S, Garzino-Demo, A et al.·Nature·1993

This study found that a virus called HHV-6 can directly infect and damage natural killer cells, which are important immune cells that normally fight viruses. When HHV-6 infects these cells, it kills them and also causes them to express a protein that makes them vulnerable to HIV infection. This suggests that HHV-6 might be a way the body's natural antiviral defenses get weakened.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of viral infection in polymyositis, dermatomyositis and chronic fatigue syndrome.

Behan, W M, Behan, P O·Bailliere's clinical neurology·1993

This review examines whether viral infections might be responsible for causing three conditions: polymyositis, dermatomyositis, and ME/CFS. The authors looked at evidence connecting viruses to these diseases, which cause muscle weakness and persistent fatigue. Understanding these potential links could help explain why some people develop ME/CFS after infections.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Service delivery for people with chronic fatigue syndrome: a pilot action research study.

Denz-Penhey, H, Murdoch, J C·Family practice·1993

This study looked at how general practices (family doctors' offices) could better serve patients with ME/CFS. Researchers worked with doctors and patients over time to find ways of talking about the condition and organizing services that felt acceptable and helpful to both. The goal was to develop self-management approaches that encouraged the body's natural healing abilities while fitting within what doctors' offices could realistically offer.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: a critical review].

Cathébras, P, Bouchou, K, Charmion, S et al.·La Revue de medecine interne·1993

ME/CFS is a debilitating condition characterized mainly by extreme tiredness of unknown cause. Current diagnostic criteria don't clearly identify a single uniform group of patients, and no clear infectious or immune cause has been definitively proven, though some viruses and immune changes may play a role in some cases. Treatment options are limited but may include antidepressants and cognitive-behavioral therapy.

Diagnostics

E3 PreliminaryCohortPEM unclear

[A case from practice (279). 1. Chronic fatigue syndrome (CFS). 2. Psychosocial problems].

Kiener, S·Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis·1993

This is a case report from a Swiss medical practice describing a patient with chronic fatigue syndrome (CFS) and the psychological and social problems that came along with the condition. The doctor documented how CFS affected this patient's daily life, relationships, and mental health. This type of case study helps doctors recognize CFS in their own patients and understand the broader impact it has beyond just physical symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--symptoms, signs, laboratory tests, and prognosis].

Kanayama, Y·Nihon rinsho. Japanese journal of clinical medicine·1992

This review article describes the main symptoms and characteristics of ME/CFS, including persistent fatigue lasting more than 6 months, low-grade fevers, swollen lymph nodes, muscle and joint pain, and mood-related symptoms. Since no specific blood test or scan can definitively diagnose ME/CFS, doctors must rule out other known causes of fatigue before making the diagnosis. The underlying cause remains unknown, though researchers suspect it may involve an infection combined with psychological factors.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. A review from the general practice perspective.

Holmwood, C, Shannon, C·Australian family physician·1992

This 1992 editorial confirms that ME/CFS is a real condition that significantly impacts people's quality of life, though the exact cause was not yet known. The authors suggest that treatment should focus on supportive counseling, explanation of the condition, psychiatric support when needed, and gradually increasing activity levels to help people return to normal functioning.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Bauermeister, C D, Wagner, C, Brede, H D·Medizinische Monatsschrift fur Pharmazeuten·1992

This 1992 study investigated whether a common virus called human herpesvirus 6 (HHV-6) might be connected to ME/CFS. Researchers examined the relationship between this virus and chronic fatigue syndrome symptoms. While early research suggested a possible link, this study represents early work in understanding whether HHV-6 plays a role in the disease.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Klonoff, D C·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1992

ME/CFS is a complex illness characterized by persistent fatigue and other symptoms, but doctors currently have no blood test or scan to diagnose it—they rely instead on what patients report. Research has identified that several factors may increase risk of developing ME/CFS, including viral infections, mental health conditions, and allergies, and studies show problems across multiple body systems including immune, nervous, hormone, and muscle function. While there is no cure yet, treatments like exercise, counseling, and medications can help manage some symptoms.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

Psychosocial management of chronic fatigue syndrome in adolescence.

Rikard-Bell, C J, Waters, B G·The Australian and New Zealand journal of psychiatry·1992

This study looked at how to help teenagers with ME/CFS using rehabilitation approaches that focus on practical recovery rather than debating what causes the illness. The authors present two case studies of adolescents with different outcomes and suggest that avoiding arguments about whether ME/CFS is 'all in the mind' or biological helps doctors provide better, more consistent care.

E3 PreliminaryCohortPEM not requiredCase-Control

[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].

Takahashi, H, Imai, K, Katanuma, A et al.·Arerugi = [Allergy]·1992

This case study describes a 29-year-old woman with ME/CFS who had severe fatigue, fever, swollen lymph nodes, and muscle pain that didn't improve with standard treatments. When doctors gave her intravenous magnesium sulphate once a week for about 6 weeks, her extreme tiredness improved and she was able to do more daily activities, eventually leaving the hospital.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome, a case of high anti-HHV-6 antibody titer and one associated with primary hyperaldosteronism].

Kato, Y, Kamijima, S, Kashiwagi, A et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study describes two women with ME/CFS who had unusual medical findings. One woman had very high levels of antibodies to HHV-6, a virus that may reactivate in ME/CFS patients. The second woman's ME/CFS symptoms improved when she had high blood pressure and a hormone imbalance, but her symptoms returned after surgery to remove an adrenal gland. These cases suggest that viruses and hormones might play a role in ME/CFS, though more research is needed to understand how.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.

Goodnick, P J, Sandoval, R, Brickman, A et al.·Biological psychiatry·1992

This study tested whether bupropion, an antidepressant medication, could help ME/CFS patients who didn't benefit from or couldn't tolerate fluoxetine (another antidepressant). Nine patients took 300 mg of bupropion daily for 8 weeks and showed significant improvement in depression symptoms. The researchers also found that bupropion appeared to affect certain brain chemicals and immune markers in ways that correlated with symptom improvement.

Interventions

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome.

Gerow, G, Poierier, M B, Alt, R·Journal of manipulative and physiological therapeutics·1992

This study describes a 36-year-old woman who came to her doctor with severe fatigue and symptoms that looked like an immune system problem, but was eventually diagnosed with ME/CFS instead. The doctors used specific criteria to confirm the diagnosis. The patient reported feeling somewhat better after receiving chiropractic treatment, though this was only one person's experience.

Interventions

E3 PreliminaryBehavioralPEM not requiredCase-Control

Severe chronic fatigue syndrome in chidhood: A discussion of psychopathological mechanisms.

Garralda, M Elena·European child & adolescent psychiatry·1992

This study describes two children with severe ME/CFS and explores how psychological factors might contribute to maintaining the illness. The researchers found that viral infections, depression, personality traits, and family relationships may all play a role in how the condition develops and persists in children. Both children improved with appropriate treatment, suggesting that addressing these various factors together can help with recovery.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome: the present concept and historical perspective].

Kitani, T·Nihon rinsho. Japanese journal of clinical medicine·1992

This is an editorial article that reviews what ME/CFS (chronic fatigue syndrome) is and how our understanding of it has changed over time. The author examines the current definition of ME/CFS and discusses its history, helping readers understand how medical perspectives on this illness have evolved.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Viral infection and its causative role for chronic fatigue syndrome].

Okano, M·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examines whether viral infections, particularly Epstein-Barr virus (EBV), cause ME/CFS. The author notes that ME/CFS shares symptoms with chronic EBV infection—including fatigue, swollen lymph nodes, and fever—but the connection remains unclear. The review also discusses a more severe condition called severe chronic active EBV infection and highlights that the true cause and best treatment for ME/CFS are still unknown.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Calabrese, L, Danao, T, Camara, E et al.·American family physician·1992

ME/CFS is a condition where people experience severe, disabling tiredness that starts suddenly and lasts at least six months, often getting worse with physical activity. Patients often have fever, sore throat, and tender lymph nodes, along with sleep problems and muscle pain. Treatment focuses on education, support, gentle exercise, and managing individual symptoms like sleep issues and pain.

Immune System

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Evidence browser

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Experience at a referral center for patients with suspected Lyme disease in an area of nonendemicity: first 65 patients.

Infection of natural killer cells by human herpesvirus 6.

The role of viral infection in polymyositis, dermatomyositis and chronic fatigue syndrome.

Service delivery for people with chronic fatigue syndrome: a pilot action research study.

[Chronic fatigue syndrome: a critical review].

[A case from practice (279). 1. Chronic fatigue syndrome (CFS). 2. Psychosocial problems].

[Chronic fatigue syndrome--symptoms, signs, laboratory tests, and prognosis].

Chronic fatigue syndrome. A review from the general practice perspective.

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Chronic fatigue syndrome.

Psychosocial management of chronic fatigue syndrome in adolescence.

[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].

[Chronic fatigue syndrome, a case of high anti-HHV-6 antibody titer and one associated with primary hyperaldosteronism].

Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.

Chronic fatigue syndrome.

Severe chronic fatigue syndrome in chidhood: A discussion of psychopathological mechanisms.

[Chronic fatigue syndrome: the present concept and historical perspective].

[Viral infection and its causative role for chronic fatigue syndrome].

Chronic fatigue syndrome.

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