ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2241–2260 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: a critical review].

Cathébras, P, Bouchou, K, Charmion, S et al.·La Revue de medecine interne·1993

ME/CFS is a debilitating condition characterized mainly by extreme tiredness of unknown cause. Current diagnostic criteria don't clearly identify a single uniform group of patients, and no clear infectious or immune cause has been definitively proven, though some viruses and immune changes may play a role in some cases. Treatment options are limited but may include antidepressants and cognitive-behavioral therapy.

Diagnostics

E3 PreliminaryCohortPEM unclearCross-Sectional

Experience at a referral center for patients with suspected Lyme disease in an area of nonendemicity: first 65 patients.

Burdge, D R, O'Hanlon, D P·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1993

Doctors at a hospital created a special clinic to evaluate patients who thought they had Lyme disease, even though Lyme disease is not common in that region. Out of 65 patients referred to the clinic, only 2 actually had Lyme disease. However, the clinic successfully identified other real medical conditions in most patients, including rheumatologic diseases, infections, and chronic fatigue syndrome.

Diagnostics

E3 PreliminaryReviewPEM requiredReview-Narrative

Clinical presentation of chronic fatigue syndrome.

Komaroff, A L·Ciba Foundation symposium·1993

ME/CFS is a long-lasting illness that causes severe tiredness lasting at least six months, along with other symptoms like fever, sore throat, joint pain, and worsening after physical activity. While some symptoms can look like mental health conditions, ME/CFS has physical features—like sudden onset following a flu-like illness and post-exertional exhaustion—that suggest it involves real biological problems. This condition significantly impacts people's ability to work, study, and care for themselves.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Barnes, P R, Taylor, D J, Kemp, G J et al.·Journal of neurology, neurosurgery, and psychiatry·1993

Researchers used a special type of MRI scan to measure how muscles use energy in ME/CFS patients compared to healthy people. They found that most patients had normal muscle energy use, but about a quarter showed unusual patterns in how their muscles handled acid buildup during exercise. This suggests muscle metabolism problems may exist in some, but not all, ME/CFS patients.

Biomarkers

E3 PreliminaryBehavioralPEM unclearConference-Abstract

Muscle histopathology and physiology in chronic fatigue syndrome.

Edwards, R H, Gibson, H, Clague, J E et al.·Ciba Foundation symposium·1993

Researchers examined muscle tissue from 108 ME/CFS patients and 22 healthy people using microscopes to look for structural damage, and tested muscle strength before and after exercise. They found no consistent muscle damage that explained fatigue symptoms, and muscle strength worked normally even after exercise. The study suggests ME/CFS is not caused by a primary muscle disease.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome].

Ewig, S·Deutsche medizinische Wochenschrift (1946)·1993

This is a review article about chronic fatigue syndrome (ME/CFS) published in a German medical journal. The author summarizes existing knowledge about the condition to help doctors and patients understand what was known about this illness in the early 1990s.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: signs and symptoms.

Stern, K·CDS review·1993

This review article examines the signs and symptoms that people with chronic fatigue syndrome (ME/CFS) commonly experience. The study helps identify what doctors should look for when evaluating patients who may have this condition. Understanding these key features is important for recognizing ME/CFS and distinguishing it from other illnesses.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

From the Centers for Disease Control and Prevention. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

JAMA·1993

In the early 1990s, researchers tested whether retroviruses (a type of virus) could be identified in people with ME/CFS using available blood tests. The CDC study found that these retroviral tests could not reliably identify or confirm ME/CFS in patients. This helped clarify that ME/CFS was not caused by the retroviruses being tested at that time.

Diagnostics

E3 PreliminaryCohortPEM unclearCross-Sectional

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Kuratsune, H, Yamaguti, K, Hattori, H et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. Recent advances in diagnosis and treatment.

Bell, D S·Postgraduate medicine·1992

ME/CFS typically starts suddenly with severe tiredness and flu-like symptoms that come and go over months or years. While blood tests sometimes show immune system changes, doctors diagnose ME/CFS mainly by recognizing the pattern of symptoms and ruling out other illnesses. Current treatment focuses on managing symptoms and helping patients cope with this long-lasting, disabling condition.

InterventionsDiagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

E3 PreliminaryBehavioralPEM not required

Chronic fatigue syndrome and women: can therapy help?

Burke, S G·Social work·1992

This article discusses how therapy can help people with ME/CFS, a condition that affects more women than men, typically between ages 25 and 55. The author shares a real case story of a woman with ME/CFS and describes how a mental health professional worked with her to address both the physical symptoms of the illness and emotional challenges like depression that often come with it. The article emphasizes that effective treatment needs to consider the patient's medical condition, emotions, relationships, and life circumstances all together.

E3 PreliminaryMechanismPEM not requiredMechanistic

Immunologically mediated fatigue: a murine model.

Chao, C C, DeLaHunt, M, Hu, S et al.·Clinical immunology and immunopathology·1992

Researchers infected mice with agents that trigger immune system activation and found that the mice became fatigued—they ran much less on their exercise wheels and took longer to groom themselves after swimming. The infected mice also showed elevated levels of a immune signaling molecule called TGF-beta, which is also found at high levels in ME/CFS patients. This study suggests that an overly active immune response may be directly responsible for the fatigue experienced in ME/CFS.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Kitani, T, Kuratsune, H, Yamaguchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

In 1992, Japanese researchers created new diagnostic guidelines to help doctors identify ME/CFS in their patients. These guidelines were based on earlier American standards but included some modifications, such as defining less severe cases and recognizing a form that develops after infections.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Hashimoto, N, Kuraishi, Y, Yokose, T et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study identified 51 patients with ME/CFS diagnosed using official CDC criteria between 1991 and 1992. Most patients were women in their 20s–30s who had been seen by many doctors before receiving a correct diagnosis. Standard blood tests did not reveal abnormal findings, though some immune markers were mildly abnormal. About 57% of patients showed general improvement, and doctors used various medications to manage severe symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue immune dysfunction syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

ME/CFS causes extreme tiredness that lasts longer than six months and may be linked to a viral infection that doesn't go away normally. Researchers found that people with ME/CFS have problems with immune cells, especially natural killer (NK) cells, which normally help fight off viruses and control the immune system. When NK cell function improved in some patients, their ME/CFS symptoms got better, suggesting that fixing these immune cells might be key to recovery.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Wong, R, Lopaschuk, G, Zhu, G et al.·Chest·1992

This study used a special imaging technique (31P NMR spectroscopy) to examine how muscles use energy during exercise in people with ME/CFS compared to healthy volunteers. Patients with ME/CFS became exhausted much faster during exercise (about 8 minutes versus 11 minutes) and had lower levels of ATP, the main energy molecule muscles use. The patterns of energy use looked similar between groups, but happened much more quickly in the ME/CFS group.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Culture and somatic experience: the social course of illness in neurasthenia and chronic fatigue syndrome.

Ware, N C, Kleinman, A·Psychosomatic medicine·1992

This study examines how culture and social life shape the experience of ME/CFS and related illnesses. The researchers found that symptoms don't just come from the body—they are also influenced by what happens in patients' relationships, work, and daily lives. When patients' life circumstances improve, their symptoms often improve too, showing that body and society are deeply connected.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Definition of the chronic fatigue syndrome and its issues].

Hashimoto, N·Nihon rinsho. Japanese journal of clinical medicine·1992

This article reviews how ME/CFS was officially defined by the CDC in 1988 and identifies problems with that definition. The author points out that while the definition tries to rule out other conditions, it has trouble distinguishing ME/CFS from similar conditions like fibromyalgia and depression, and it's difficult to measure in real-world clinical practice.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Use of the polymerase chain reaction to detect Toxoplasma gondii in human blood samples.

Ho-Yen, D O, Joss, A W, Balfour, A H et al.·Journal of clinical pathology·1992

This study tested a laboratory technique called PCR to detect a parasite called Toxoplasma gondii in blood samples. Researchers found that PCR was fast, accurate, and sensitive enough to detect even very small amounts of the parasite. The test helped doctors decide whether patients needed treatment, especially those with weakened immune systems.

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Evidence browser

[Chronic fatigue syndrome: a critical review].

Experience at a referral center for patients with suspected Lyme disease in an area of nonendemicity: first 65 patients.

Clinical presentation of chronic fatigue syndrome.

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Muscle histopathology and physiology in chronic fatigue syndrome.

[The chronic fatigue syndrome].

Chronic fatigue syndrome: signs and symptoms.

From the Centers for Disease Control and Prevention. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Chronic fatigue syndrome. Recent advances in diagnosis and treatment.

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Chronic fatigue syndrome and women: can therapy help?

Immunologically mediated fatigue: a murine model.

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

[Chronic fatigue immune dysfunction syndrome].

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Culture and somatic experience: the social course of illness in neurasthenia and chronic fatigue syndrome.

[Definition of the chronic fatigue syndrome and its issues].

Use of the polymerase chain reaction to detect Toxoplasma gondii in human blood samples.

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