ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2261–2280 of 2,420 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: considerations relevant to children and adolescents.

Dale, J K, Straus, S E·Advances in pediatric infectious diseases·1992

This paper reviews how ME/CFS (chronic fatigue syndrome) presents differently in children and teenagers compared to adults. The authors discuss important clinical considerations for recognizing and understanding the condition in younger patients. The review highlights that children and adolescents with ME/CFS face unique challenges in diagnosis and management.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Definition of the chronic fatigue syndrome and its issues].

Hashimoto, N·Nihon rinsho. Japanese journal of clinical medicine·1992

This article reviews how ME/CFS was officially defined by the CDC in 1988 and identifies problems with that definition. The author points out that while the definition tries to rule out other conditions, it has trouble distinguishing ME/CFS from similar conditions like fibromyalgia and depression, and it's difficult to measure in real-world clinical practice.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome: the present concept and historical perspective].

Kitani, T·Nihon rinsho. Japanese journal of clinical medicine·1992

This is an editorial article that reviews what ME/CFS (chronic fatigue syndrome) is and how our understanding of it has changed over time. The author examines the current definition of ME/CFS and discusses its history, helping readers understand how medical perspectives on this illness have evolved.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Welch, L S, Sokas, R·Toxicology and industrial health·1992

When workers were exposed to problems in a building (sick-building syndrome), some developed multiple chemical sensitivity (MCS)—a condition where people react to low levels of chemicals. This study looked at 20 people affected by the outbreak and found that most had existing health conditions like allergies or asthma that got worse. Importantly, having ME/CFS did not predict who would develop MCS, and many people had ongoing problems beyond just MCS after leaving the building.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Winters, E G, Quinet, R J·The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·1992

ME/CFS is a complex illness characterized by severe, debilitating fatigue that often starts suddenly with flu-like symptoms. While researchers have investigated viruses and immune system changes in ME/CFS patients, no single cause has been definitively identified. Currently, there is no specific cure, though cognitive behavioral therapy and certain medications may help some patients manage their condition.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Viral infection and its causative role for chronic fatigue syndrome].

Okano, M·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examines whether viral infections, particularly Epstein-Barr virus (EBV), cause ME/CFS. The author notes that ME/CFS shares symptoms with chronic EBV infection—including fatigue, swollen lymph nodes, and fever—but the connection remains unclear. The review also discusses a more severe condition called severe chronic active EBV infection and highlights that the true cause and best treatment for ME/CFS are still unknown.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome, a case of high anti-HHV-6 antibody titer and one associated with primary hyperaldosteronism].

Kato, Y, Kamijima, S, Kashiwagi, A et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study describes two women with ME/CFS who had unusual medical findings. One woman had very high levels of antibodies to HHV-6, a virus that may reactivate in ME/CFS patients. The second woman's ME/CFS symptoms improved when she had high blood pressure and a hormone imbalance, but her symptoms returned after surgery to remove an adrenal gland. These cases suggest that viruses and hormones might play a role in ME/CFS, though more research is needed to understand how.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Kuratsune, H, Yamaguti, K, Hattori, H et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome.

James, D G, Brook, M G, Bannister, B A·Postgraduate medical journal·1992

This 1992 review article discusses chronic fatigue syndrome (ME/CFS), a condition causing severe tiredness that doesn't improve with rest. The authors examine what was known about the illness at that time, including how it affects patients and possible causes. This early medical overview helped establish ME/CFS as a recognized health condition worthy of serious medical attention.

E3 PreliminaryReviewPEM unclearReview-Narrative

Psychological aspects of chronic fatigue syndrome.

Murray, J B·Perceptual and motor skills·1992

This review examined how psychological factors relate to chronic fatigue syndrome (ME/CFS). The author looked at existing research to understand the mental and emotional aspects of living with this illness. This work helps clarify that ME/CFS involves psychological dimensions that are important to understand and address in patient care.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Lozano de León, F, Gutiérrez Fernández, J, Martín Mazuelos, E et al.·Revista clinica espanola·1992

This review summarizes what scientists know about human herpesvirus type 6 (HHV-6), a common virus that most people carry their whole lives. The virus can cause rash illnesses in children and mono-like symptoms in adults, and some research suggests it might play a role in chronic fatigue syndrome and other long-term illnesses.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. Recent advances in diagnosis and treatment.

Bell, D S·Postgraduate medicine·1992

ME/CFS typically starts suddenly with severe tiredness and flu-like symptoms that come and go over months or years. While blood tests sometimes show immune system changes, doctors diagnose ME/CFS mainly by recognizing the pattern of symptoms and ruling out other illnesses. Current treatment focuses on managing symptoms and helping patients cope with this long-lasting, disabling condition.

InterventionsDiagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue immune dysfunction syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

ME/CFS causes extreme tiredness that lasts longer than six months and may be linked to a viral infection that doesn't go away normally. Researchers found that people with ME/CFS have problems with immune cells, especially natural killer (NK) cells, which normally help fight off viruses and control the immune system. When NK cell function improved in some patients, their ME/CFS symptoms got better, suggesting that fixing these immune cells might be key to recovery.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--symptoms, signs, laboratory tests, and prognosis].

Kanayama, Y·Nihon rinsho. Japanese journal of clinical medicine·1992

This review article describes the main symptoms and characteristics of ME/CFS, including persistent fatigue lasting more than 6 months, low-grade fevers, swollen lymph nodes, muscle and joint pain, and mood-related symptoms. Since no specific blood test or scan can definitively diagnose ME/CFS, doctors must rule out other known causes of fatigue before making the diagnosis. The underlying cause remains unknown, though researchers suspect it may involve an infection combined with psychological factors.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Berneman, Z N, Ablashi, D V, Li, G et al.·Proceedings of the National Academy of Sciences of the United States of America·1992

Researchers isolated a virus called HHV-7 from a patient with ME/CFS and studied how it infects cells. They found that HHV-7 is related to another herpesvirus (HHV-6) but is genetically different enough to be classified as its own distinct virus. However, the study found no clear link between HHV-7 and ME/CFS in the general population.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Bauermeister, C D, Wagner, C, Brede, H D·Medizinische Monatsschrift fur Pharmazeuten·1992

This 1992 study investigated whether a common virus called human herpesvirus 6 (HHV-6) might be connected to ME/CFS. Researchers examined the relationship between this virus and chronic fatigue syndrome symptoms. While early research suggested a possible link, this study represents early work in understanding whether HHV-6 plays a role in the disease.

E3 PreliminaryCohortPEM not requiredObservational

Chronic fatigue syndrome: studies on skeletal muscle.

Grau, J M, Casademont, J, Pedrol, E et al.·Clinical neuropathology·1992

This study looked at muscle tissue samples from 20 ME/CFS patients to understand why muscles feel so tired and weak. The researchers found that most patients had either normal muscle tissue or only minor changes, and they did not find the patterns of inflammation typically seen in viral muscle diseases. The study also tested whether L-carnitine supplements could help patients improve over three months, but found no clinical benefit.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Rheumatic fever and disorders of the musculoskeletal system.

Coovadia, H M·Current opinion in rheumatology·1992

This editorial reviews recent findings about rheumatic fever and other muscle and bone disorders, including a brief mention of chronic fatigue syndrome in children. The authors discuss new understanding of how certain infections cause these conditions and how doctors can better diagnose and treat them.

E3 PreliminaryMechanismPEM not requiredMechanistic

Immunologically mediated fatigue: a murine model.

Chao, C C, DeLaHunt, M, Hu, S et al.·Clinical immunology and immunopathology·1992

Researchers infected mice with agents that trigger immune system activation and found that the mice became fatigued—they ran much less on their exercise wheels and took longer to groom themselves after swimming. The infected mice also showed elevated levels of a immune signaling molecule called TGF-beta, which is also found at high levels in ME/CFS patients. This study suggests that an overly active immune response may be directly responsible for the fatigue experienced in ME/CFS.

Immune System

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Evidence browser

The chronic fatigue syndrome: considerations relevant to children and adolescents.

[Definition of the chronic fatigue syndrome and its issues].

[Chronic fatigue syndrome: the present concept and historical perspective].

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Chronic fatigue syndrome.

[Viral infection and its causative role for chronic fatigue syndrome].

[Chronic fatigue syndrome, a case of high anti-HHV-6 antibody titer and one associated with primary hyperaldosteronism].

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

The chronic fatigue syndrome.

Psychological aspects of chronic fatigue syndrome.

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Chronic fatigue syndrome. Recent advances in diagnosis and treatment.

[Chronic fatigue immune dysfunction syndrome].

[Chronic fatigue syndrome--symptoms, signs, laboratory tests, and prognosis].

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Chronic fatigue syndrome: studies on skeletal muscle.

Rheumatic fever and disorders of the musculoskeletal system.

Immunologically mediated fatigue: a murine model.

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