ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2261–2280 of 2,423 studies

E3 PreliminaryCohortPEM not requiredCase-Control

[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].

Takahashi, H, Imai, K, Katanuma, A et al.·Arerugi = [Allergy]·1992

This case study describes a 29-year-old woman with ME/CFS who had severe fatigue, fever, swollen lymph nodes, and muscle pain that didn't improve with standard treatments. When doctors gave her intravenous magnesium sulphate once a week for about 6 weeks, her extreme tiredness improved and she was able to do more daily activities, eventually leaving the hospital.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome.

Gerow, G, Poierier, M B, Alt, R·Journal of manipulative and physiological therapeutics·1992

This study describes a 36-year-old woman who came to her doctor with severe fatigue and symptoms that looked like an immune system problem, but was eventually diagnosed with ME/CFS instead. The doctors used specific criteria to confirm the diagnosis. The patient reported feeling somewhat better after receiving chiropractic treatment, though this was only one person's experience.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

[Neuro-psychiatric aspects of chronic fatigue syndrome].

Shimizu, T·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examines the differences between ME/CFS and other conditions that can look similar, particularly fibromyalgia and depression. The authors explain that ME/CFS is not a psychological disorder and that sleep disturbances may play a central role in the condition. They suggest that brain imaging technology could help doctors more accurately identify ME/CFS in the future.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Lozano de León, F, Gutiérrez Fernández, J, Martín Mazuelos, E et al.·Revista clinica espanola·1992

This review summarizes what scientists know about human herpesvirus type 6 (HHV-6), a common virus that most people carry their whole lives. The virus can cause rash illnesses in children and mono-like symptoms in adults, and some research suggests it might play a role in chronic fatigue syndrome and other long-term illnesses.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue syndromes: new thoughts and reinterpretation of previous data.

Downey, D C·Medical hypotheses·1992

This study examined 19 patients with severe fatigue who showed unusual reactions to copper-containing bracelets or necklaces. The researchers found that 8 of these patients had deficiencies in enzymes related to heme (a component of blood), and suggested that problems with copper metabolism and heme processing might explain fatigue in conditions like ME/CFS, multiple sclerosis, and other disorders.

Biomarkers

E3 PreliminaryCommentaryPEM not requiredEditorial

Rheumatic fever and disorders of the musculoskeletal system.

Coovadia, H M·Current opinion in rheumatology·1992

This editorial reviews recent findings about rheumatic fever and other muscle and bone disorders, including a brief mention of chronic fatigue syndrome in children. The authors discuss new understanding of how certain infections cause these conditions and how doctors can better diagnose and treat them.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a depressive disorder.

Higgins, E S·Journal of the South Carolina Medical Association (1975)·1992

This 1992 paper proposes that chronic fatigue syndrome (ME/CFS) may be a form of depression. The author suggests that the fatigue and other symptoms patients experience could be primarily psychiatric in nature rather than caused by physical illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. A review from the general practice perspective.

Holmwood, C, Shannon, C·Australian family physician·1992

This 1992 editorial confirms that ME/CFS is a real condition that significantly impacts people's quality of life, though the exact cause was not yet known. The authors suggest that treatment should focus on supportive counseling, explanation of the condition, psychiatric support when needed, and gradually increasing activity levels to help people return to normal functioning.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in school children].

Kawa, K·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examines chronic fatigue syndrome (ME/CFS) in school-age children, a population that is often overlooked since most known cases occur in adults over 30. The authors emphasize that ME/CFS causes long-lasting, disabling fatigue lasting at least 6 months that cannot be explained by other medical conditions. They stress the importance of understanding how the brain, hormonal system, and immune system interact in ME/CFS, and note that doctors must carefully distinguish ME/CFS from school absence due to other reasons or psychological disorders.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Klonoff, D C·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1992

ME/CFS is a complex illness characterized by persistent fatigue and other symptoms, but doctors currently have no blood test or scan to diagnose it—they rely instead on what patients report. Research has identified that several factors may increase risk of developing ME/CFS, including viral infections, mental health conditions, and allergies, and studies show problems across multiple body systems including immune, nervous, hormone, and muscle function. While there is no cure yet, treatments like exercise, counseling, and medications can help manage some symptoms.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

Psychosocial management of chronic fatigue syndrome in adolescence.

Rikard-Bell, C J, Waters, B G·The Australian and New Zealand journal of psychiatry·1992

This study looked at how to help teenagers with ME/CFS using rehabilitation approaches that focus on practical recovery rather than debating what causes the illness. The authors present two case studies of adolescents with different outcomes and suggest that avoiding arguments about whether ME/CFS is 'all in the mind' or biological helps doctors provide better, more consistent care.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Kitani, T, Kuratsune, H, Yamaguchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

In 1992, Japanese researchers created new diagnostic guidelines to help doctors identify ME/CFS in their patients. These guidelines were based on earlier American standards but included some modifications, such as defining less severe cases and recognizing a form that develops after infections.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.

Goodnick, P J, Sandoval, R, Brickman, A et al.·Biological psychiatry·1992

This study tested whether bupropion, an antidepressant medication, could help ME/CFS patients who didn't benefit from or couldn't tolerate fluoxetine (another antidepressant). Nine patients took 300 mg of bupropion daily for 8 weeks and showed significant improvement in depression symptoms. The researchers also found that bupropion appeared to affect certain brain chemicals and immune markers in ways that correlated with symptom improvement.

Interventions

E3 PreliminaryCohortPEM unclearObservational

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Hashimoto, N, Kuraishi, Y, Yokose, T et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study identified 51 patients with ME/CFS diagnosed using official CDC criteria between 1991 and 1992. Most patients were women in their 20s–30s who had been seen by many doctors before receiving a correct diagnosis. Standard blood tests did not reveal abnormal findings, though some immune markers were mildly abnormal. About 57% of patients showed general improvement, and doctors used various medications to manage severe symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Calabrese, L, Danao, T, Camara, E et al.·American family physician·1992

ME/CFS is a condition where people experience severe, disabling tiredness that starts suddenly and lasts at least six months, often getting worse with physical activity. Patients often have fever, sore throat, and tender lymph nodes, along with sleep problems and muscle pain. Treatment focuses on education, support, gentle exercise, and managing individual symptoms like sleep issues and pain.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Search for retrovirus in the chronic fatigue syndrome.

Gow, J W, Simpson, K, Schliephake, A et al.·Journal of clinical pathology·1992

Researchers tested blood and muscle tissue from 30 ME/CFS patients to see if a virus called a retrovirus might be causing the illness. They used sensitive laboratory techniques to look for viral genetic material. They found no evidence that retroviruses were present in any of the patients tested, suggesting that this particular type of virus is not responsible for ME/CFS.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Winters, E G, Quinet, R J·The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·1992

ME/CFS is a complex illness characterized by severe, debilitating fatigue that often starts suddenly with flu-like symptoms. While researchers have investigated viruses and immune system changes in ME/CFS patients, no single cause has been definitively identified. Currently, there is no specific cure, though cognitive behavioral therapy and certain medications may help some patients manage their condition.

Immune System

E3 PreliminaryBehavioralPEM not required

Chronic fatigue syndrome and women: can therapy help?

Burke, S G·Social work·1992

This article discusses how therapy can help people with ME/CFS, a condition that affects more women than men, typically between ages 25 and 55. The author shares a real case story of a woman with ME/CFS and describes how a mental health professional worked with her to address both the physical symptoms of the illness and emotional challenges like depression that often come with it. The article emphasizes that effective treatment needs to consider the patient's medical condition, emotions, relationships, and life circumstances all together.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Severe chronic fatigue syndrome in chidhood: A discussion of psychopathological mechanisms.

Garralda, M Elena·European child & adolescent psychiatry·1992

This study describes two children with severe ME/CFS and explores how psychological factors might contribute to maintaining the illness. The researchers found that viral infections, depression, personality traits, and family relationships may all play a role in how the condition develops and persists in children. Both children improved with appropriate treatment, suggesting that addressing these various factors together can help with recovery.

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[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].

Chronic fatigue syndrome.

[Neuro-psychiatric aspects of chronic fatigue syndrome].

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Fatigue syndromes: new thoughts and reinterpretation of previous data.

Rheumatic fever and disorders of the musculoskeletal system.

Chronic fatigue syndrome: a depressive disorder.

Chronic fatigue syndrome. A review from the general practice perspective.

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

[Chronic fatigue syndrome in school children].

Chronic fatigue syndrome.

Psychosocial management of chronic fatigue syndrome in adolescence.

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Chronic fatigue syndrome.

Search for retrovirus in the chronic fatigue syndrome.

Chronic fatigue syndrome.

Chronic fatigue syndrome and women: can therapy help?

Severe chronic fatigue syndrome in chidhood: A discussion of psychopathological mechanisms.

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