ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2261–2280 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Berneman, Z N, Ablashi, D V, Li, G et al.·Proceedings of the National Academy of Sciences of the United States of America·1992

Researchers isolated a virus called HHV-7 from a patient with ME/CFS and studied how it infects cells. They found that HHV-7 is related to another herpesvirus (HHV-6) but is genetically different enough to be classified as its own distinct virus. However, the study found no clear link between HHV-7 and ME/CFS in the general population.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Immunologically mediated fatigue: a murine model.

Chao, C C, DeLaHunt, M, Hu, S et al.·Clinical immunology and immunopathology·1992

Researchers infected mice with agents that trigger immune system activation and found that the mice became fatigued—they ran much less on their exercise wheels and took longer to groom themselves after swimming. The infected mice also showed elevated levels of a immune signaling molecule called TGF-beta, which is also found at high levels in ME/CFS patients. This study suggests that an overly active immune response may be directly responsible for the fatigue experienced in ME/CFS.

Immune System

E3 PreliminaryBehavioralPEM not required

Chronic fatigue syndrome and women: can therapy help?

Burke, S G·Social work·1992

This article discusses how therapy can help people with ME/CFS, a condition that affects more women than men, typically between ages 25 and 55. The author shares a real case story of a woman with ME/CFS and describes how a mental health professional worked with her to address both the physical symptoms of the illness and emotional challenges like depression that often come with it. The article emphasizes that effective treatment needs to consider the patient's medical condition, emotions, relationships, and life circumstances all together.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Therapy of chronic fatigue syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examined different treatment options for ME/CFS by looking at past clinical studies. Researchers found that while most treatments tested didn't work well, a few showed promise—including intravenous immunoglobulin therapy, magnesium supplements, and treatments designed to boost natural killer cells (immune cells that help fight infection). The authors suggest that immune system problems may play a role in ME/CFS, and fixing these problems might help patients feel better.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Psychosocial management of chronic fatigue syndrome in adolescence.

Rikard-Bell, C J, Waters, B G·The Australian and New Zealand journal of psychiatry·1992

This study looked at how to help teenagers with ME/CFS using rehabilitation approaches that focus on practical recovery rather than debating what causes the illness. The authors present two case studies of adolescents with different outcomes and suggest that avoiding arguments about whether ME/CFS is 'all in the mind' or biological helps doctors provide better, more consistent care.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Buchwald, D, Garrity, D, Pascualy, R et al.·Toxicology and industrial health·1992

This is a review article that examines what was known about chronic fatigue syndrome in the early 1990s. The authors looked at existing research to summarize the characteristics, possible causes, and impacts of this condition. This paper helped establish an early framework for understanding ME/CFS as a medical condition worthy of scientific investigation.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Culture and somatic experience: the social course of illness in neurasthenia and chronic fatigue syndrome.

Ware, N C, Kleinman, A·Psychosomatic medicine·1992

This study examines how culture and social life shape the experience of ME/CFS and related illnesses. The researchers found that symptoms don't just come from the body—they are also influenced by what happens in patients' relationships, work, and daily lives. When patients' life circumstances improve, their symptoms often improve too, showing that body and society are deeply connected.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: a joint paediatric-psychiatric approach.

Vereker, M I·Archives of disease in childhood·1992

This 1992 paper discusses how ME/CFS (then called chronic fatigue syndrome) in children should be evaluated and treated by working together between pediatric doctors and mental health specialists. The authors suggest that understanding both the physical and emotional aspects of the illness is important for helping young patients.

E3 PreliminaryReviewPEM unclearReview-Narrative

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Bauermeister, C D, Wagner, C, Brede, H D·Medizinische Monatsschrift fur Pharmazeuten·1992

This 1992 study investigated whether a common virus called human herpesvirus 6 (HHV-6) might be connected to ME/CFS. Researchers examined the relationship between this virus and chronic fatigue syndrome symptoms. While early research suggested a possible link, this study represents early work in understanding whether HHV-6 plays a role in the disease.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. A review from the general practice perspective.

Murdoch, J C·Australian family physician·1992

This 1992 review examines ME/CFS from the perspective of general practitioners (GPs) in Australia. The paper discusses how GPs can recognize, understand, and manage ME/CFS in their patients, highlighting the challenges of diagnosing a condition that doesn't show up on standard blood tests. It emphasizes that ME/CFS is a real medical condition deserving of proper clinical attention and patient support.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Kitani, T, Kuratsune, H, Yamaguchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

In 1992, Japanese researchers created new diagnostic guidelines to help doctors identify ME/CFS in their patients. These guidelines were based on earlier American standards but included some modifications, such as defining less severe cases and recognizing a form that develops after infections.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Search for retrovirus in the chronic fatigue syndrome.

Gow, J W, Simpson, K, Schliephake, A et al.·Journal of clinical pathology·1992

Researchers tested blood and muscle tissue from 30 ME/CFS patients to see if a virus called a retrovirus might be causing the illness. They used sensitive laboratory techniques to look for viral genetic material. They found no evidence that retroviruses were present in any of the patients tested, suggesting that this particular type of virus is not responsible for ME/CFS.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a depressive disorder.

Higgins, E S·Journal of the South Carolina Medical Association (1975)·1992

This 1992 paper proposes that chronic fatigue syndrome (ME/CFS) may be a form of depression. The author suggests that the fatigue and other symptoms patients experience could be primarily psychiatric in nature rather than caused by physical illness.

E3 PreliminaryCohortPEM unclearCross-Sectional

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Kuratsune, H, Yamaguti, K, Hattori, H et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearObservational

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Wong, R, Lopaschuk, G, Zhu, G et al.·Chest·1992

This study used a special imaging technique (31P NMR spectroscopy) to examine how muscles use energy during exercise in people with ME/CFS compared to healthy volunteers. Patients with ME/CFS became exhausted much faster during exercise (about 8 minutes versus 11 minutes) and had lower levels of ATP, the main energy molecule muscles use. The patterns of energy use looked similar between groups, but happened much more quickly in the ME/CFS group.

Post-Exertional Malaise

E3 PreliminaryPEM not required

Epstein-Barr virus-related persistent erythema multiforme in chronic fatigue syndrome.

Drago, F, Romagnoli, M, Loi, A et al.·Archives of dermatology·1992

This case study describes a single patient with ME/CFS who developed an unusual, long-lasting skin rash called erythema multiforme that didn't respond to standard steroid treatment. Researchers found evidence of Epstein-Barr virus (EBV)—the virus that causes infectious mononucleosis—in the skin lesions and other body tissues. The rash improved when the patient was treated with an antiviral medication (acyclovir), but returned when the medication was stopped.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

E3 PreliminaryCohortPEM unclearObservational

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Hashimoto, N, Kuraishi, Y, Yokose, T et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study identified 51 patients with ME/CFS diagnosed using official CDC criteria between 1991 and 1992. Most patients were women in their 20s–30s who had been seen by many doctors before receiving a correct diagnosis. Standard blood tests did not reveal abnormal findings, though some immune markers were mildly abnormal. About 57% of patients showed general improvement, and doctors used various medications to manage severe symptoms.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Use of the polymerase chain reaction to detect Toxoplasma gondii in human blood samples.

Ho-Yen, D O, Joss, A W, Balfour, A H et al.·Journal of clinical pathology·1992

This study tested a laboratory technique called PCR to detect a parasite called Toxoplasma gondii in blood samples. Researchers found that PCR was fast, accurate, and sensitive enough to detect even very small amounts of the parasite. The test helped doctors decide whether patients needed treatment, especially those with weakened immune systems.

E3 PreliminaryCommentaryPEM not requiredEditorial

Rheumatic fever and disorders of the musculoskeletal system.

Coovadia, H M·Current opinion in rheumatology·1992

This editorial reviews recent findings about rheumatic fever and other muscle and bone disorders, including a brief mention of chronic fatigue syndrome in children. The authors discuss new understanding of how certain infections cause these conditions and how doctors can better diagnose and treat them.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Immunologically mediated fatigue: a murine model.

Chronic fatigue syndrome and women: can therapy help?

[Therapy of chronic fatigue syndrome].

Psychosocial management of chronic fatigue syndrome in adolescence.

Chronic fatigue syndrome.

Culture and somatic experience: the social course of illness in neurasthenia and chronic fatigue syndrome.

Chronic fatigue syndrome: a joint paediatric-psychiatric approach.

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Chronic fatigue syndrome. A review from the general practice perspective.

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Search for retrovirus in the chronic fatigue syndrome.

Chronic fatigue syndrome: a depressive disorder.

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Epstein-Barr virus-related persistent erythema multiforme in chronic fatigue syndrome.

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Use of the polymerase chain reaction to detect Toxoplasma gondii in human blood samples.

Rheumatic fever and disorders of the musculoskeletal system.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research