ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2341–2360 of 2,420 studies

E3 PreliminaryCohortPEM unclearObservational

Clinical observations of chronic fatigue syndrome.

Mildon, C A·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This 1991 study documents clinical observations of people with ME/CFS, describing what doctors noticed when examining patients with this condition. The report provides early descriptive information about how the illness presented in patients during that time period. While limited in scope, it contributes to the historical medical record of ME/CFS recognition.

Diagnostics

E3 PreliminaryCohortPEM not requiredObservational

Postinfectious chronic fatigue syndrome: case history of thirty-five patients in Germany.

Hilgers, A, Krueger, G R, Lembke, U et al.·In vivo (Athens, Greece)·1991

This study followed 35 ME/CFS patients in Germany for up to eight years and found that most experienced severe fatigue, joint and muscle pain, sore throats, and various other symptoms. Researchers found evidence of herpesvirus reactivation in about 73% of patients and Epstein-Barr virus in about 34%, suggesting ongoing viral activity may play a role in the condition. While treatments were tried including immune therapy and antiviral drugs, none consistently worked well, though immune globulin therapy showed the most promise.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Pain syndromes, disability, and chronic disease in childhood.

Malleson, P N·Current opinion in rheumatology·1991

This editorial discusses how chronic pain and long-term illnesses affect children, and suggests that conditions like fibromyalgia and chronic fatigue syndrome (ME/CFS) may be related to each other. The author notes that doctors need better training to understand these complex conditions and that psychological factors may play a role in how these illnesses develop and affect children's lives.

Pain and Sensitization

E3 PreliminaryCommentaryPEM not requiredEditorial

Dual infections of the immune system in patients with chronic active Epstein-Barr virus infection mimicking chronic fatigue syndrome.

Purtilo, D T·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This article discusses the importance of distinguishing patients with ME/CFS (the commonly recognized illness) from those who have dual infections or weakened immune systems that only look like ME/CFS. The authors argue that some patients appearing to have ME/CFS may actually have other treatable conditions involving multiple infections, and recommend long-term studies tracking people who develop ME/CFS-like symptoms after documented viral infections.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Clinical indications and diagnostic techniques of human herpesvirus-6 (HHV-6) infection.

Krueger, G R, Ablashi, D V, Josephs, S F et al.·In vivo (Athens, Greece)·1991

This review examines how doctors can diagnose human herpesvirus-6 (HHV-6) infection and its connection to various illnesses, including a condition called postinfectious chronic fatigue syndrome. HHV-6 is a common virus that most people catch in childhood and then carry dormant in their bodies for life. The authors explain which tests doctors should use to accurately identify active HHV-6 infection and discuss why proper diagnosis matters for treatment.

E3 PreliminaryCommentaryPEM not requiredEditorial

Is chronic fatigue syndrome synonymous with effort syndrome?

Rosen, S D, King, J C, Wilkinson, J B et al.·Journal of the Royal Society of Medicine·1990

This 1990 study examined whether chronic fatigue syndrome (CFS) might actually be caused by a breathing pattern problem called chronic hyperventilation. The researchers found that 93 out of 100 patients diagnosed with CFS showed signs of this breathing issue instead. They suggest doctors should check patients for hyperventilation problems before diagnosing them with ME or CFS.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

[Does fibromyalgia exist?].

Serratrice, G·Revue du rhumatisme et des maladies osteo-articulaires·1990

This 1990 editorial questions whether fibromyalgia is a distinct disease, noting that no actual tissue damage (fibrosis) has been found under microscopes. The author argues that fibromyalgia shares symptoms with other conditions like ME/CFS and suggests using the simpler term 'persistent, widespread muscle pain with no recognized organic cause' instead. The author found that only 25% of cases had a clear psychological cause, suggesting most cases have other unexplained factors.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The chronic fatigue syndrome. A multifactorial approach and the treatment possibilities].

Pinardi, G, Scarlato, G·Recenti progressi in medicina·1990

This review describes ME/CFS as a complex condition marked by severe, long-lasting fatigue accompanied by symptoms like sore throat, headaches, muscle pain, and mood changes. While researchers have suspected viruses like Epstein-Barr virus might cause it, the evidence hasn't been convincing due to study design problems. The authors suggest the condition may result from an abnormal immune response rather than a single virus.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Old wine in new bottles: neurasthenia and 'ME'.

Wessely, S·Psychological medicine·1990

This paper compares ME/CFS with an older condition called neurasthenia that was common in the late 1800s and early 1900s. Both illnesses share similar symptoms of extreme fatigue and were popular diagnoses when people believed they were caused by physical (not mental) problems and affected successful, hardworking people. The author argues that understanding ME/CFS requires looking at both brain biology and social factors, not just one or the other.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome].

Ewig, S, Dengler, H J·Klinische Wochenschrift·1990

This paper discusses chronic fatigue syndrome (CFS) as a condition that can develop after viral infections like Epstein-Barr virus or Coxsackie-B virus. Researchers noted that CFS may actually be several different diseases with different causes rather than one single condition. The authors emphasize that diagnosis requires ruling out other medical conditions first, and that at this time, we don't have enough knowledge to recommend specific treatments.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome--a new disease picture?].

Nix, W A·Der Nervenarzt·1990

This editorial from 1990 discusses that ME/CFS was becoming more commonly diagnosed at that time, but doctors weren't sure if it was one distinct disease or simply a label given to many different conditions. The author notes that we still need to understand whether ME/CFS has a physical cause, a psychological cause, or both, and that each patient may need individual evaluation.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Management of Lyme disease.

Goodwin, S D, Sproat, T T, Russell, W L·Clinical pharmacy·1990

This review examines Lyme disease, a tick-borne infection caused by a bacterium called Borrelia burgdorferi. The disease has three stages: early flu-like illness with a rash, middle-stage problems affecting the nervous system and heart, and late-stage arthritis or chronic fatigue. Treatment with antibiotics like doxycycline is most effective when started early.

E3 PreliminaryCommentaryPEM not requiredEditorial

Hyperventilation.

Paulley, J W·Recenti progressi in medicina·1990

This 1990 editorial argues that hyperventilation syndrome (rapid, shallow breathing) is often misdiagnosed as ME/CFS, and that doctors fail to recognize and properly treat it. The author suggests that many patients labeled with ME/CFS actually have hyperventilation triggered by psychological stress and unresolved emotional losses, and recommends treatment combining physiotherapy and psychological counseling.

E3 PreliminaryMechanismPEM unclearObservational

Sensory and cognitive event-related potentials in myalgic encephalomyelitis.

Prasher, D, Smith, A, Findley, L·Journal of neurology, neurosurgery, and psychiatry·1990

This study tested whether ME/CFS patients have objective brain activity differences related to thinking and attention. Researchers used special sensors to measure how the brain responds to sounds and tasks requiring concentration. While basic sensory responses were normal, they found that brain signals related to attention and processing speed were slower in about one-third to one-half of patients tested, suggesting ME/CFS affects how the brain handles information rather than basic sensation.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Isolation of human herpesvirus-6 from clinical specimens using human fibroblast cultures.

Luka, J, Okano, M, Thiele, G·Journal of clinical laboratory analysis·1990

Researchers developed a better way to detect and study human herpesvirus-6 (HHV-6) in blood samples by using a specific type of human cell culture. They successfully isolated HHV-6 from blood samples of three ME/CFS patients, along with samples from other patients with different conditions. The virus samples they found had some genetic differences from previously known HHV-6 strains.

E3 PreliminaryBehavioralPEM unclearCross-Sectional

The neuropsychological dimensions of postinfectious neuromyasthenia (chronic fatigue syndrome): a preliminary report.

Altay, H T, Toner, B B, Brooker, H et al.·International journal of psychiatry in medicine·1990

This study looked at whether ME/CFS patients who reported memory and concentration problems actually showed these difficulties when tested. Surprisingly, the patients performed better than average on standard cognitive tests, even though they felt they had cognitive problems. The researchers suggested that psychological factors might explain why patients' subjective experience didn't match their test results.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome, fibromyalgia and depression].

Martin-Du-Pan, R·Revue medicale de la Suisse romande·1990

This 1990 review article examines the relationships between chronic fatigue syndrome (ME/CFS), fibromyalgia, and depression. The author discusses how these three conditions sometimes occur together and explores whether they share common features or causes. The paper helps clarify how ME/CFS and fibromyalgia are distinct from depression, even though all three can cause fatigue and other overlapping symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome and the psychiatrist.

Abbey, S E, Garfinkel, P E·Canadian journal of psychiatry. Revue canadienne de psychiatrie·1990

This review article examines ME/CFS and the role psychiatrists can play in caring for patients. The authors note that ME/CFS involves thinking difficulties, mood changes, and behavioral symptoms alongside fatigue. They explain what psychiatrists should know about the condition and how they can help in assessment and treatment.

Cognitive Impairment

E3 PreliminaryCommentaryPEM not requiredEditorial

Neurasthenia in the 1980s: chronic mononucleosis, chronic fatigue syndrome, and anxiety and depressive disorders.

Greenberg, D B·Psychosomatics·1990

In the 1980s, doctors thought chronic fatigue syndrome might be caused by a virus called Epstein-Barr virus (the virus that causes mononucleosis). This editorial explains that while this seemed like a logical explanation, the virus is not actually the cause of chronic fatigue syndrome. The author points out that many people with chronic fatigue also have depression or anxiety, and notes that these mental health conditions should be carefully evaluated and treated rather than overlooked.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: a return to common sense.

Denman, A M·Postgraduate medical journal·1990

This 1990 opinion piece argues that ME/CFS should be understood through practical, straightforward clinical observation rather than overly complex theories. The author advocates for a 'common sense' approach to recognizing and managing the condition based on what doctors actually observe in patients.

Diagnostics

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Evidence browser

Clinical observations of chronic fatigue syndrome.

Postinfectious chronic fatigue syndrome: case history of thirty-five patients in Germany.

Pain syndromes, disability, and chronic disease in childhood.

Dual infections of the immune system in patients with chronic active Epstein-Barr virus infection mimicking chronic fatigue syndrome.

Clinical indications and diagnostic techniques of human herpesvirus-6 (HHV-6) infection.

Is chronic fatigue syndrome synonymous with effort syndrome?

[Does fibromyalgia exist?].

[The chronic fatigue syndrome. A multifactorial approach and the treatment possibilities].

Old wine in new bottles: neurasthenia and 'ME'.

[Chronic fatigue syndrome].

[Chronic fatigue syndrome--a new disease picture?].

Management of Lyme disease.

Hyperventilation.

Sensory and cognitive event-related potentials in myalgic encephalomyelitis.

Isolation of human herpesvirus-6 from clinical specimens using human fibroblast cultures.

The neuropsychological dimensions of postinfectious neuromyasthenia (chronic fatigue syndrome): a preliminary report.

[Chronic fatigue syndrome, fibromyalgia and depression].

Chronic fatigue syndrome and the psychiatrist.

Neurasthenia in the 1980s: chronic mononucleosis, chronic fatigue syndrome, and anxiety and depressive disorders.

The chronic fatigue syndrome: a return to common sense.

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