ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2361–2380 of 2,423 studies

E3 PreliminaryMechanismPEM unclearObservational

Sensory and cognitive event-related potentials in myalgic encephalomyelitis.

Prasher, D, Smith, A, Findley, L·Journal of neurology, neurosurgery, and psychiatry·1990

This study tested whether ME/CFS patients have objective brain activity differences related to thinking and attention. Researchers used special sensors to measure how the brain responds to sounds and tasks requiring concentration. While basic sensory responses were normal, they found that brain signals related to attention and processing speed were slower in about one-third to one-half of patients tested, suggesting ME/CFS affects how the brain handles information rather than basic sensation.

Cognitive Impairment

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome].

Ewig, S, Dengler, H J·Klinische Wochenschrift·1990

This paper discusses chronic fatigue syndrome (CFS) as a condition that can develop after viral infections like Epstein-Barr virus or Coxsackie-B virus. Researchers noted that CFS may actually be several different diseases with different causes rather than one single condition. The authors emphasize that diagnosis requires ruling out other medical conditions first, and that at this time, we don't have enough knowledge to recommend specific treatments.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

Is chronic fatigue syndrome synonymous with effort syndrome?

Rosen, S D, King, J C, Wilkinson, J B et al.·Journal of the Royal Society of Medicine·1990

This 1990 study examined whether chronic fatigue syndrome (CFS) might actually be caused by a breathing pattern problem called chronic hyperventilation. The researchers found that 93 out of 100 patients diagnosed with CFS showed signs of this breathing issue instead. They suggest doctors should check patients for hyperventilation problems before diagnosing them with ME or CFS.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Management of Lyme disease.

Goodwin, S D, Sproat, T T, Russell, W L·Clinical pharmacy·1990

This review examines Lyme disease, a tick-borne infection caused by a bacterium called Borrelia burgdorferi. The disease has three stages: early flu-like illness with a rash, middle-stage problems affecting the nervous system and heart, and late-stage arthritis or chronic fatigue. Treatment with antibiotics like doxycycline is most effective when started early.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Management of chronic (post-viral) fatigue syndrome.

Wessely, S, David, A, Butler, S et al.·The Journal of the Royal College of General Practitioners·1989

This paper suggests that ME/CFS develops when an initial illness leads to reduced activity, which then worsens fitness and symptoms in a self-reinforcing cycle. The authors propose that cognitive behavioral therapy—a talking therapy that helps patients understand how both physical inactivity and mood problems contribute to their symptoms—combined with gradual return to activity may help break this cycle.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: review of the literature.

Turgeon, S A·Canadian family physician Medecin de famille canadien·1989

This review article examines what was known about ME/CFS in 1989, a time when the condition was still poorly understood. The authors note that while some initially thought the Epstein-Barr virus (which causes mononucleosis) might cause ME/CFS, that theory no longer seems correct. They found evidence that both psychiatric factors and subtle immune system problems may play a role in the illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Treatment of patients with chronic fatigue syndrome.

Gantz, N M, Holmes, G P·Drugs·1989

This 1989 review article examines different ways doctors were treating ME/CFS patients at that time. The authors looked at what treatments were being used and discussed their potential benefits and drawbacks. This early work helped shape how doctors approached ME/CFS care in the following decades.

E3 PreliminaryReviewPEM not requiredReview-Narrative

What's new in human herpesvirus-6? Clinical immunopathology of the HHV-6 infection.

Krueger, G R, Sander, C·Pathology, research and practice·1989

This review examines human herpesvirus-6 (HHV-6), a common virus that most people carry in a dormant state. When the immune system is weakened, this virus can reactivate and potentially cause long-lasting fatigue and other health problems. The authors discuss how HHV-6 might contribute to chronic fatigue syndrome and other conditions, particularly in people with weak immune systems.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: definition, current studies and lessons for fibromyalgia research.

Komaroff, A L, Goldenberg, D·The Journal of rheumatology. Supplement·1989

This review describes ME/CFS as a serious illness where extreme tiredness lasts for more than 6 months, often starting suddenly like the flu. People with ME/CFS frequently experience fever, sore throat, muscle pain, swollen lymph nodes, brain fog, and mood problems. Blood tests sometimes show changes in immune cells and antibodies, and researchers have found links between ME/CFS and several viruses, particularly Epstein-Barr virus, though no virus has been proven to directly cause the disease.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome associated with Epstein-Barr virus infection].

Parras, F, Salvá, F, Reina, J et al.·Medicina clinica·1989

This study describes a patient who developed chronic fatigue syndrome (CFS) after a confirmed Epstein-Barr virus (EBV) infection. EBV is a common virus that usually causes infectious mononucleosis ("mono"), but this patient went on to experience lasting fatigue, loss of appetite, low-grade fever, and mood changes long after the acute infection. The authors emphasize that diagnosing CFS based on symptoms alone can be risky and may lead to misdiagnosis of other serious conditions.

E3 PreliminaryReviewPEM unclearReview-Narrative

Confounding features of the fibromyalgia syndrome: a current perspective of differential diagnosis.

Bennett, R M·The Journal of rheumatology. Supplement·1989

This article discusses how fibromyalgia syndrome can be confused with many other conditions, including chronic fatigue syndrome, because they share similar symptoms like pain and tiredness. When doctors misdiagnose fibromyalgia or take too long to identify it, patients may receive wrong treatments and become frustrated with their care. Understanding the differences between these conditions is important so patients get the correct diagnosis and appropriate help.

Diagnostics

E3 PreliminaryBehavioralPEM unclearObservational

Features of Coxsackie B virus (CBV) infection in children with prolonged physical and psychological morbidity.

Wilson, P M, Kusumakar, V, McCartney, R A et al.·Journal of psychosomatic research·1989

This study looked at 39 children who were sick and tested them for Coxsackie B virus infection. Eighteen of the children had evidence of this virus. Most children, whether infected or not, complained of muscle weakness and tiredness. Children who had the virus were more likely to have family members with the same virus and to feel sad or anxious.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Naloxone-reversible monocyte dysfunction in patients with chronic fatigue syndrome.

Prieto, J, Subirá, M L, Castilla, A et al.·Scandinavian journal of immunology·1989

Researchers examined immune cells called monocytes in 35 ME/CFS patients and 25 healthy people. They found that most ME/CFS patients had monocytes that weren't working properly, but these cells improved dramatically when treated with naloxone, a drug that blocks opioid effects. This suggests that the body's natural opioid-like chemicals may be overactive in ME/CFS and could be damaging immune function.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Immunotherapy and enhanced antibody-dependent cell-mediated cytotoxicity using virally-infected target cells.

Bosse, D, Ades, E W·Journal of clinical & laboratory immunology·1989

This study looked at whether adding a immune-boosting substance called IL-2 to a blood treatment (gammaglobulin) could help the body's immune cells better fight cells infected with Epstein-Barr virus. The researchers found in laboratory tests that IL-2 did enhance this immune response, and they suggested it might help ME/CFS patients who receive gammaglobulin treatment.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. A critical appraisal of the role of Epstein-Barr virus.

Koo, D·The Western journal of medicine·1989

Early research suggested that a virus called Epstein-Barr virus (EBV) might cause ME/CFS, leading to the disease sometimes being called "chronic EBV syndrome." However, this review shows that the antibody levels used to detect EBV exposure are similar in people with ME/CFS, healthy people, and people with other illnesses, making it impossible to prove EBV actually causes the condition. Since most people have been exposed to EBV at some point, we cannot easily tell whether the virus causes ME/CFS or if people with ME/CFS simply show different antibody patterns because they are already sick.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6).

Ablashi, D V, Lusso, P, Hung, C L et al.·International journal of cancer·1988

Researchers grew human herpesvirus 6 (HHV-6) in laboratory cell lines to study how this virus behaves and develops tools to detect it. They found that HHV-6 can infect and replicate in many different types of immune cells and other cell types, not just the B cells initially thought to be vulnerable. Some of these infected cell lines produced large amounts of virus, making them useful for developing tests and studying the virus further.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome--a diagnosis for consideration.

Portwood, M F·The Nurse practitioner·1988

This article helps doctors recognize ME/CFS by describing its many symptoms, which can range from mild tiredness to severe disability. Patients often report feeling exhausted, achy, and unable to concentrate, yet standard medical tests often appear normal. The article emphasizes that doctors should take these symptoms seriously and help patients manage their condition, even though there is currently no cure.

Diagnostics

E3 PreliminaryCohortPEM not requiredCross-Sectional

Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome.

Jones, J F, Williams, M, Schooley, R T et al.·Archives of internal medicine·1988

This 1988 study tested whether people with ME/CFS had unusual antibody patterns against Epstein-Barr virus (EBV), a common virus that causes mononucleosis. Researchers measured antibodies against viral enzymes that are only produced when EBV is actively replicating. A small group of ME/CFS patients with very high EBV antibody levels did show these unusual enzyme antibodies, similar to patterns seen in people with nasopharyngeal cancer.

Immune System

E3 PreliminaryPEM unclear

[Chronic fatigue syndrome; is there a connection with the Epstein-Barr virus?].

Berends, G M, Peeters, M F, Lepoutre, J M et al.·Nederlands tijdschrift voor geneeskunde·1988

This 1988 case study examined whether Epstein-Barr virus (EBV)—a common virus that causes infections like mononucleosis—might be connected to ME/CFS. The researchers looked at individual patient cases to explore possible links between EBV infection and the development of chronic fatigue syndrome symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The chronic fatigue syndrome (myalgic encephalomyelitis)--myth or mystery?

Spracklen, F H·South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1988

This 1988 review article discusses chronic fatigue syndrome (also called myalgic encephalomyelitis) and explains why there has been so much confusion about this condition. The author reviews what doctors know about the illness, including its possible causes and symptoms, and discusses why having a clear definition of the disease is important for research and treatment. The article emphasizes that better understanding and more rigorous studies are needed to help patients.

Diagnostics

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Evidence browser

Sensory and cognitive event-related potentials in myalgic encephalomyelitis.

[Chronic fatigue syndrome].

Is chronic fatigue syndrome synonymous with effort syndrome?

Management of Lyme disease.

Management of chronic (post-viral) fatigue syndrome.

Chronic fatigue syndrome: review of the literature.

Treatment of patients with chronic fatigue syndrome.

What's new in human herpesvirus-6? Clinical immunopathology of the HHV-6 infection.

The chronic fatigue syndrome: definition, current studies and lessons for fibromyalgia research.

[Chronic fatigue syndrome associated with Epstein-Barr virus infection].

Confounding features of the fibromyalgia syndrome: a current perspective of differential diagnosis.

Features of Coxsackie B virus (CBV) infection in children with prolonged physical and psychological morbidity.

Naloxone-reversible monocyte dysfunction in patients with chronic fatigue syndrome.

Immunotherapy and enhanced antibody-dependent cell-mediated cytotoxicity using virally-infected target cells.

Chronic fatigue syndrome. A critical appraisal of the role of Epstein-Barr virus.

Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6).

Chronic fatigue syndrome--a diagnosis for consideration.

Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome.

[Chronic fatigue syndrome; is there a connection with the Epstein-Barr virus?].

The chronic fatigue syndrome (myalgic encephalomyelitis)--myth or mystery?

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