ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2361–2380 of 2,420 studies

E3 PreliminaryBehavioralPEM unclearCross-Sectional

The neuropsychological dimensions of postinfectious neuromyasthenia (chronic fatigue syndrome): a preliminary report.

Altay, H T, Toner, B B, Brooker, H et al.·International journal of psychiatry in medicine·1990

This study looked at whether ME/CFS patients who reported memory and concentration problems actually showed these difficulties when tested. Surprisingly, the patients performed better than average on standard cognitive tests, even though they felt they had cognitive problems. The researchers suggested that psychological factors might explain why patients' subjective experience didn't match their test results.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Naloxone-reversible monocyte dysfunction in patients with chronic fatigue syndrome.

Prieto, J, Subirá, M L, Castilla, A et al.·Scandinavian journal of immunology·1989

Researchers examined immune cells called monocytes in 35 ME/CFS patients and 25 healthy people. They found that most ME/CFS patients had monocytes that weren't working properly, but these cells improved dramatically when treated with naloxone, a drug that blocks opioid effects. This suggests that the body's natural opioid-like chemicals may be overactive in ME/CFS and could be damaging immune function.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Immunotherapy and enhanced antibody-dependent cell-mediated cytotoxicity using virally-infected target cells.

Bosse, D, Ades, E W·Journal of clinical & laboratory immunology·1989

This study looked at whether adding a immune-boosting substance called IL-2 to a blood treatment (gammaglobulin) could help the body's immune cells better fight cells infected with Epstein-Barr virus. The researchers found in laboratory tests that IL-2 did enhance this immune response, and they suggested it might help ME/CFS patients who receive gammaglobulin treatment.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. A critical appraisal of the role of Epstein-Barr virus.

Koo, D·The Western journal of medicine·1989

Early research suggested that a virus called Epstein-Barr virus (EBV) might cause ME/CFS, leading to the disease sometimes being called "chronic EBV syndrome." However, this review shows that the antibody levels used to detect EBV exposure are similar in people with ME/CFS, healthy people, and people with other illnesses, making it impossible to prove EBV actually causes the condition. Since most people have been exposed to EBV at some point, we cannot easily tell whether the virus causes ME/CFS or if people with ME/CFS simply show different antibody patterns because they are already sick.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome associated with Epstein-Barr virus infection].

Parras, F, Salvá, F, Reina, J et al.·Medicina clinica·1989

This study describes a patient who developed chronic fatigue syndrome (CFS) after a confirmed Epstein-Barr virus (EBV) infection. EBV is a common virus that usually causes infectious mononucleosis ("mono"), but this patient went on to experience lasting fatigue, loss of appetite, low-grade fever, and mood changes long after the acute infection. The authors emphasize that diagnosing CFS based on symptoms alone can be risky and may lead to misdiagnosis of other serious conditions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

What's new in human herpesvirus-6? Clinical immunopathology of the HHV-6 infection.

Krueger, G R, Sander, C·Pathology, research and practice·1989

This review examines human herpesvirus-6 (HHV-6), a common virus that most people carry in a dormant state. When the immune system is weakened, this virus can reactivate and potentially cause long-lasting fatigue and other health problems. The authors discuss how HHV-6 might contribute to chronic fatigue syndrome and other conditions, particularly in people with weak immune systems.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Treatment of patients with chronic fatigue syndrome.

Gantz, N M, Holmes, G P·Drugs·1989

This 1989 review article examines different ways doctors were treating ME/CFS patients at that time. The authors looked at what treatments were being used and discussed their potential benefits and drawbacks. This early work helped shape how doctors approached ME/CFS care in the following decades.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Management of chronic (post-viral) fatigue syndrome.

Wessely, S, David, A, Butler, S et al.·The Journal of the Royal College of General Practitioners·1989

This paper suggests that ME/CFS develops when an initial illness leads to reduced activity, which then worsens fitness and symptoms in a self-reinforcing cycle. The authors propose that cognitive behavioral therapy—a talking therapy that helps patients understand how both physical inactivity and mood problems contribute to their symptoms—combined with gradual return to activity may help break this cycle.

E3 PreliminaryBehavioralPEM unclearObservational

Features of Coxsackie B virus (CBV) infection in children with prolonged physical and psychological morbidity.

Wilson, P M, Kusumakar, V, McCartney, R A et al.·Journal of psychosomatic research·1989

This study looked at 39 children who were sick and tested them for Coxsackie B virus infection. Eighteen of the children had evidence of this virus. Most children, whether infected or not, complained of muscle weakness and tiredness. Children who had the virus were more likely to have family members with the same virus and to feel sad or anxious.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: review of the literature.

Turgeon, S A·Canadian family physician Medecin de famille canadien·1989

This review article examines what was known about ME/CFS in 1989, a time when the condition was still poorly understood. The authors note that while some initially thought the Epstein-Barr virus (which causes mononucleosis) might cause ME/CFS, that theory no longer seems correct. They found evidence that both psychiatric factors and subtle immune system problems may play a role in the illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Confounding features of the fibromyalgia syndrome: a current perspective of differential diagnosis.

Bennett, R M·The Journal of rheumatology. Supplement·1989

This article discusses how fibromyalgia syndrome can be confused with many other conditions, including chronic fatigue syndrome, because they share similar symptoms like pain and tiredness. When doctors misdiagnose fibromyalgia or take too long to identify it, patients may receive wrong treatments and become frustrated with their care. Understanding the differences between these conditions is important so patients get the correct diagnosis and appropriate help.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: definition, current studies and lessons for fibromyalgia research.

Komaroff, A L, Goldenberg, D·The Journal of rheumatology. Supplement·1989

This review describes ME/CFS as a serious illness where extreme tiredness lasts for more than 6 months, often starting suddenly like the flu. People with ME/CFS frequently experience fever, sore throat, muscle pain, swollen lymph nodes, brain fog, and mood problems. Blood tests sometimes show changes in immune cells and antibodies, and researchers have found links between ME/CFS and several viruses, particularly Epstein-Barr virus, though no virus has been proven to directly cause the disease.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndromes: relationship to chronic viral infections.

Komaroff, A L·Journal of virological methods·1988

This review examines whether ME/CFS (a condition causing severe, long-lasting tiredness) is connected to chronic viral infections, particularly herpes-type viruses. The authors found that ME/CFS often starts suddenly like the flu and is associated with symptoms like fever, sore throat, and muscle pain. While blood tests sometimes show signs of viral infection, particularly Epstein-Barr virus and human herpesvirus-6, the study could not prove that these viruses actually cause ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis.

Gordon, N·Developmental medicine and child neurology·1988

This is a review article about myalgic encephalomyelitis (ME), a serious condition that causes extreme tiredness, muscle pain, and cognitive difficulties. The author examines what was known about ME in 1988, including how it affects the brain and nervous system, and discusses different theories about what might cause it.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Acyclovir-induced renal failure. Clinical course and histology.

Sawyer, M H, Webb, D E, Balow, J E et al.·The American journal of medicine·1988

This study describes four patients with ME/CFS who developed sudden kidney problems after receiving high-dose acyclovir (an antiviral medication) intravenously. Doctors found needle-shaped crystals in the urine and determined that the medication itself was damaging the kidneys. The good news is that lower doses of acyclovir given by mouth did not cause the same problems.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human B-lymphotropic virus (human herpesvirus-6).

Ablashi, D V, Josephs, S F, Buchbinder, A et al.·Journal of virological methods·1988

This study describes a virus called human herpesvirus-6 (HHV-6) that was newly discovered in 1986. Researchers found that this virus can infect many different types of cells in the body and detected antibodies to it in about 26% of healthy people. Interestingly, they found higher levels of HHV-6 antibodies in people with certain cancers, autoimmune diseases, HIV/AIDS, and chronic fatigue syndrome, suggesting the virus may play a role in these conditions.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome.

Jones, J F, Williams, M, Schooley, R T et al.·Archives of internal medicine·1988

This 1988 study tested whether people with ME/CFS had unusual antibody patterns against Epstein-Barr virus (EBV), a common virus that causes mononucleosis. Researchers measured antibodies against viral enzymes that are only produced when EBV is actively replicating. A small group of ME/CFS patients with very high EBV antibody levels did show these unusual enzyme antibodies, similar to patterns seen in people with nasopharyngeal cancer.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6).

Ablashi, D V, Lusso, P, Hung, C L et al.·International journal of cancer·1988

Researchers grew human herpesvirus 6 (HHV-6) in laboratory cell lines to study how this virus behaves and develops tools to detect it. They found that HHV-6 can infect and replicate in many different types of immune cells and other cell types, not just the B cells initially thought to be vulnerable. Some of these infected cell lines produced large amounts of virus, making them useful for developing tests and studying the virus further.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: a manifestation of Epstein-Barr virus infection?

Schooley, R T·Current clinical topics in infectious diseases·1988

This 1988 editorial discusses whether Epstein-Barr virus (EBV), a common virus that causes mononucleosis, might be responsible for causing chronic fatigue syndrome (ME/CFS). The author examines the connection between EBV infection and the development of long-lasting fatigue and other symptoms that characterize this illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome--a diagnosis for consideration.

Portwood, M F·The Nurse practitioner·1988

This article helps doctors recognize ME/CFS by describing its many symptoms, which can range from mild tiredness to severe disability. Patients often report feeling exhausted, achy, and unable to concentrate, yet standard medical tests often appear normal. The article emphasizes that doctors should take these symptoms seriously and help patients manage their condition, even though there is currently no cure.

Diagnostics

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The neuropsychological dimensions of postinfectious neuromyasthenia (chronic fatigue syndrome): a preliminary report.

Naloxone-reversible monocyte dysfunction in patients with chronic fatigue syndrome.

Immunotherapy and enhanced antibody-dependent cell-mediated cytotoxicity using virally-infected target cells.

Chronic fatigue syndrome. A critical appraisal of the role of Epstein-Barr virus.

[Chronic fatigue syndrome associated with Epstein-Barr virus infection].

What's new in human herpesvirus-6? Clinical immunopathology of the HHV-6 infection.

Treatment of patients with chronic fatigue syndrome.

Management of chronic (post-viral) fatigue syndrome.

Features of Coxsackie B virus (CBV) infection in children with prolonged physical and psychological morbidity.

Chronic fatigue syndrome: review of the literature.

Confounding features of the fibromyalgia syndrome: a current perspective of differential diagnosis.

The chronic fatigue syndrome: definition, current studies and lessons for fibromyalgia research.

Chronic fatigue syndromes: relationship to chronic viral infections.

Myalgic encephalomyelitis.

Acyclovir-induced renal failure. Clinical course and histology.

Human B-lymphotropic virus (human herpesvirus-6).

Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome.

Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6).

Chronic fatigue syndrome: a manifestation of Epstein-Barr virus infection?

Chronic fatigue syndrome--a diagnosis for consideration.

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