Search and filter 6,145 studies by evidence level, diagnostic criteria, PEM status, and research domain. Each entry links to the original source.
Studies sorted by evidence level, then year. Browse by topic instead →
Evidence level (E0–E3) reflects study type and replication, not methodological quality. A weak systematic review still sits at E0. How evidence levels work →
2401–2420 of 2,420 studies
Parish, J G·The British journal of psychiatry : the journal of mental science·1973
This 1973 study by Parish examined benign myalgic encephalomyelitis (ME), an early medical observation of the condition. The researcher documented cases of ME as a distinct medical illness. This historical paper represents one of the early clinical descriptions of the disease in the medical literature.
The Medical journal of Australia·1970
This 1970 study examined cases of myalgic encephalomyelitis (ME), a condition causing muscle pain and fatigue. The researchers documented patient experiences and clinical features of the illness. This early medical documentation helped establish ME as a recognized clinical condition worthy of scientific investigation.
Innes, S G·Lancet (London, England)·1970
This 1970 case report described patients with symptoms resembling myalgic encephalomyelitis (ME), including muscle pain, fatigue, and neurological symptoms. The study documented clinical presentations that looked similar to what we now call ME/CFS, helping establish early recognition of this condition in medical literature.
McEvedy, C P, Beard, A W·British medical journal·1970
This 1970 study reviewed 15 reported outbreaks of myalgic encephalomyelitis (ME) and concluded that many of these cases may have been caused by mass hysteria or misdiagnosis rather than a physical disease. The authors suggested that future similar cases should be called 'myalgia nervosa' to reflect a psychological rather than biological cause. This interpretation is now considered outdated, as modern research has identified real biological abnormalities in ME/CFS.
Lyle, W H·Lancet (London, England)·1970
This 1970 case study from The Lancet described patients with symptoms resembling myalgic encephalomyelitis (ME), a condition causing extreme tiredness, muscle pain, and brain fog. The researchers documented clinical cases to help doctors recognize and understand this illness pattern, which was not well-known at the time.
Mourad, S, Chidiac, J·Le Journal medical libanais. The Lebanese medical journal·1969
This is an early observational study from 1969 describing cases of benign myalgic encephalomyelitis in Lebanon. The researchers documented patients with this condition, contributing to recognition of ME/CFS as a distinct illness in the Middle East during a period when the disease was still being identified and named around the world.
Kendell, R E·The British journal of psychiatry : the journal of mental science·1967
This 1967 study examined whether people with benign myalgic encephalomyelitis (an early name for ME/CFS) experienced psychiatric symptoms or mental health challenges as a result of their illness. The researchers looked at patients with this condition to understand what psychological effects, if any, accompanied the physical symptoms of the disease.
GSELL, O·Schweizerische medizinische Wochenschrift·1963
This 1963 observational study examined benign myalgic encephalomyelitis (an early name for ME/CFS) and its relationship to a condition called epidemic pseudoneurasthenia. The author documented clinical observations of patients experiencing this illness during what appeared to be epidemic outbreaks, noting the pattern of symptoms and disease presentation.
BORNSTEIN, B, BECHAR, M, LASS, H·Psychiatria et neurologia·1960
This is an early medical case report from 1960 describing five patients with myalgic encephalomyelitis (ME), a condition causing muscle pain and neurological symptoms. The authors documented the clinical features these patients experienced, helping establish that ME was a recognizable medical condition rather than a psychiatric illness. This foundational work contributed to understanding ME as a legitimate organic disease.
RONCHI, W·Minerva medica·1959
This is a historical paper from 1959 examining a new medication approach for chronic fatigue syndrome. However, without access to the full abstract or article text, we cannot provide specific details about which drug was tested or what results were found. This early research represents the beginning of pharmacological investigation into ME/CFS treatment.
DAIKOS, G K, GARZONIS, S, PALEOLOGUE, A et al.·Lancet (London, England)·1959
This 1959 study documented an outbreak of ME/CFS-like illness among nursing students in Athens, Greece. Multiple students developed similar symptoms including muscle pain, fatigue, and neurological problems over a short period. The researchers observed the outbreak and recorded what happened, helping establish that ME/CFS can occur in groups of people.
GALPINE, J F·The British journal of clinical practice·1958
This 1958 case-control study examined patients with benign myalgic encephalomyelitis (an early name for ME/CFS). The researchers documented clinical presentations and characteristics of the condition to help establish it as a distinct medical illness rather than a purely psychological problem.
BHATIA, B B, CHANDRA, S, BHUSHAN, C·Journal of the Indian Medical Association·1958
This is an early case-control study from 1958 examining what was then called benign myalgic encephalomyelitis. The researchers described and compared cases of the condition, though specific details about their findings are not available in the abstract. This represents one of the earliest formal medical investigations into what we now know as ME/CFS.
Recenti progressi in medicina·1957
This is a historical medical report from 1957 describing an outbreak of a disease called myalgic encephalomyelitis (now known as ME/CFS). The report documents cases where patients experienced muscle pain and neurological symptoms during what appeared to be an epidemic. This early observation helped establish that ME/CFS could occur in clusters and affect multiple people.
DEISHER, J B·Northwest medicine·1957
This 1957 study documented cases of ME/CFS (then called Iceland disease) occurring in Alaska. The report describes observations of patients experiencing the illness in a geographic region where the disease had not been previously well-documented. This early observational account helped establish that ME/CFS was not limited to Iceland but could occur in other parts of the world.
ACHESON, E D·Lancet (London, England)·1957
This is an early medical observation from 1957 describing ME/CFS as a benign condition. The study documents cases of people experiencing prolonged fatigue and muscle pain after viral infections. This foundational work helped establish that ME/CFS is a real medical condition deserving clinical attention.
British medical journal·1957
This 1957 study from the British Medical Journal documents cases of myalgic encephalomyelitis occurring in epidemic form—meaning multiple people in a community became ill at the same time. The researchers observed patients with this condition to better understand how it presented and spread.
GALPINE, J F, BRADY, C·Lancet (London, England)·1957
This 1957 case-control study by Galpine and Brady documented cases of myalgic encephalomyelitis and compared them with control groups to understand the condition's features. The researchers aimed to establish that ME was a distinct medical condition with identifiable characteristics, rather than a purely psychological disorder. This early study helped establish the medical legitimacy of what patients and some doctors were observing as a real illness.
BLATTNER, R J·The Journal of pediatrics·1956
This 1956 study describes an outbreak of a disease called Akureyri disease (also known as Iceland disease) that affected multiple people in Iceland. The disease caused muscle pain and fatigue similar to what we now call ME/CFS. This early medical observation helped document that ME/CFS-like illnesses have occurred in clusters and have affected communities for decades.
Lindan, R·Canadian Medical Association journal·1956
This 1956 paper by Lindan describes a condition called benign myalgic encephalomyelitis, an early medical account of what we now know as ME/CFS. The paper helped establish that this illness was a real medical condition worthy of clinical attention, rather than a psychological problem. It represents one of the early attempts to formally document and name the disease in medical literature.
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PET imaging and other studies providing evidence for brain inflammation in ME/CFS.
NeurologyMetabolomics and mitochondrial function studies revealing energy metabolism disruption.
MetabolismStudies identifying potential biological markers for ME/CFS diagnosis and stratification.
Biomarker