ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

281–300 of 2,423 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability.

Tankisi, Hatice, Versace, Viviana, Kuppuswamy, Annapoorna et al.·Clinical neurophysiology practice·2024

This review article explains how doctors and researchers can better understand fatigue and 'fatigability'—the reduced ability to sustain physical or mental effort. The authors describe different types of tests that can measure these problems objectively by looking at how the brain, nerves, and muscles work, rather than relying only on what patients report. These specialized tests may help identify the actual cause of fatigue in different conditions, including long COVID and ME/CFS.

E3 PreliminaryReviewPEM unclearReview-Narrative

Nutrition and Chronobiology as Key Components of Multidisciplinary Therapeutic Interventions for Fibromyalgia and Associated Chronic Fatigue Syndrome: A Narrative and Critical Review.

Carrasco-Querol, Noèlia, Cabricano-Canga, Lorena, Bueno Hernández, Nerea et al.·Nutrients·2024

This review examines how diet and body rhythms (sleep-wake cycles) affect fibromyalgia and chronic fatigue syndrome. The authors found that what you eat, nutrient levels, gut bacteria, and your natural circadian rhythm all play important roles in these conditions. They conclude that treating FM/CFS effectively requires paying attention to nutrition and sleep timing alongside other therapies.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review.

Helbing, Dario Lucas, Dommaschk, Eva-Maria, Danyeli, Lena Vera et al.·European archives of psychiatry and clinical neuroscience·2024

This review examines whether a natural supplement called acetylcarnitine might help treat long COVID symptoms like fatigue, brain fog, and depression. Acetylcarnitine is a substance your body normally makes that helps cells produce energy. The authors looked at research showing this supplement has helped some people with similar illnesses like ME/CFS and depression, and they propose studying whether it could help long COVID patients too.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases.

Sokolovska, Liba, Cistjakovs, Maksims, Matroze, Asnate et al.·Microorganisms·2024

This review examines how Human Herpesvirus 6 (HHV-6), a virus that most people carry, might trigger autoimmune diseases where the immune system mistakenly attacks the body's own cells. The virus can hide in the body for years and reactivate later, and it appears to interfere with immune system function. Researchers found evidence linking HHV-6 to several autoimmune conditions, including multiple sclerosis and thyroid disease.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

A Pilot Study on the Effects of Exercise Training on Cardiorespiratory Performance, Quality of Life, and Immunologic Variables in Long COVID.

Abbasi, Asghar, Gattoni, Chiara, Iacovino, Michelina et al.·Journal of clinical medicine·2024

This study tested whether supervised aerobic exercise training could help people with long COVID. Fourteen participants completed 20 sessions of exercise training over 10 weeks. After training, people reported feeling less fatigued, less anxious and depressed, and had better heart and lung fitness—without experiencing harmful immune system changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryGuidelinePEM unclearGuideline

Designing and optimizing clinical trials for long COVID.

Vogel, Julia Moore, Pollack, Beth, Spier, Ezra et al.·Life sciences·2024

This study looked at all the clinical trials being tested for Long COVID on a public database and found that most trials are not well-designed or testing treatments that have enough evidence to justify testing. The researchers recommend that future trials should test actual medications that might cure Long COVID, be able to run remotely so sick patients don't have to travel, compare Long COVID to similar illnesses like ME/CFS, include diverse patients of all backgrounds and illness levels, and involve patients as research partners.

Long COVID Overlap

E3 PreliminaryMechanismPEM not requiredMechanistic

Lacticaseibacillus rhamnosus Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome.

Zhang, Liang, Ni, Xue, Jiang, Minzhi et al.·Microorganisms·2024

Researchers studied special strains of a probiotic bacteria called Lacticaseibacillus rhamnosus to see if they could help with ME/CFS and irritable bowel syndrome (IBS). After testing 21 different strains, they found that two strains (WL11 and WL17) reduced fatigue-related symptoms like weight loss, anxiety, and memory problems in mice with CFS-like illness, and also eased IBS symptoms like gut sensitivity and inflammation. However, these results are from animal studies, so we don't yet know if the same effects will work in people.

Immune System

E3 PreliminaryMechanismPEM requiredCross-Sectional

A Multimodal Magnetic Resonance Imaging Study on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Feasibility and Clinical Correlation.

Kaur, Raminder, Greeley, Brian, Ciok, Alexander et al.·Medicina (Kaunas, Lithuania)·2024

Researchers used two advanced brain imaging techniques together to look for differences between people with ME/CFS and healthy people. The study found specific changes in brain chemistry and activity patterns in ME/CFS patients, particularly in areas related to thinking and fatigue control. The imaging was safe and didn't make patients immediately more fatigued, suggesting these techniques could be useful for studying ME/CFS in the future.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.

Jurek, Joanna Michalina, Castro-Marrero, Jesus·Nutrients·2024

This review examines how changes in gut bacteria may contribute to ME/CFS and long COVID symptoms, and whether taking probiotics or similar microbial preparations might help. The authors looked at existing research to understand the connection between gut health and the brain-immune system, and whether restoring healthy gut bacteria could reduce fatigue, inflammation, and other symptoms in these conditions.

NeuroinflammationImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The molecular fingerprint of neuroinflammation in COVID-19: A comprehensive discussion on molecular mechanisms of neuroinflammation due to SARS-COV2 antigens.

Zayeri, Zeinab Deris, Torabizadeh, Mehdi, Kargar, Masoud et al.·Behavioural brain research·2024

This study explains how COVID-19 can damage the brain and nervous system, causing inflammation and injury. The researchers found that about half of people recovering from COVID-19 develop ME/CFS symptoms, and brain scans show reduced activity in key areas that control memory, movement, and mood. The study focuses on the biological mechanisms—essentially how viruses trigger harmful immune responses in the brain that can lead to long-term neurological problems.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearMechanistic

The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome.

Huitsing, Kaylin, Tritsch, Tara, Arias, Francisco Javier Carrera et al.·Molecular medicine (Cambridge, Mass.)·2024

This study explores why people with ME/CFS often experience dry eyes, sore throats, and stuffy noses. Researchers investigated whether problems with mucin proteins—substances that create protective layers in your mouth, nose, and eyes—might contribute to ME/CFS symptoms. Using computer analysis and genetic data, they hypothesized that weakened mucus membranes could lead to chronic inflammation in these areas, potentially worsening the condition.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Using time diaries to inform occupational therapy practice for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An exploratory study.

Roxburgh, Rachel, Hughes, Julie, Milgate, Wendy·The British journal of occupational therapy·2024

This Australian study looked at how nine people with ME/CFS spend their time each day using a special diary tool. Researchers found that participants spent about 58% of their waking time on leisure and relaxation activities, and their symptoms didn't seem to change much throughout the day. The study suggests that using time diaries could help occupational therapists (specialists who help people manage daily activities) understand better how ME/CFS affects what patients can do, and design better support strategies.

E3 PreliminaryReviewPEM unclearReview-Narrative

Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation.

Theoharides, Theoharis C, Twahir, Assma, Kempuraj, Duraisamy·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2024

This study examines mast cells, which are immune cells found throughout the body, and how they may be involved in conditions like ME/CFS that affect the nervous system and cause abnormal heart rate and blood pressure responses. Mast cells sit near nerve endings and important organs, where they can release chemicals that affect how the body regulates basic functions like temperature and blood pressure. The researchers suggest that controlling mast cell activation might help treat these conditions, though currently there are no proven treatments.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of electroacupuncture on expression of protein phosphorylation in hippocampus tissues of rats with chronic fatigue syndrome.

Yang, Yan, Sun, Zhong-Ren, Li, Chao-Ran et al.·Zhen ci yan jiu = Acupuncture research·2024

Researchers tested whether acupuncture with electrical stimulation could help rats with an artificially induced fatigue-like condition. After 28 days of treatment, the acupuncture-treated rats showed improvements in their overall condition, anxiety levels, and memory compared to untreated rats. The researchers found changes in brain proteins that might explain how the treatment helped.

Cognitive Impairment

E3 PreliminaryCohortPEM unclearCross-Sectional

Over-Representation of Torque Teno Mini Virus 9 in a Subgroup of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.

Giménez-Orenga, Karen, Martín-Martínez, Eva, Oltra, Elisa·Pathogens (Basel, Switzerland)·2024

Researchers found that a virus called Torque Teno Mini Virus 9 (TTMV9) was present at much higher levels in the blood cells of some ME/CFS patients compared to healthy people and patients with fibromyalgia. This virus could potentially be used as a biological marker to identify and categorize certain ME/CFS patients. The findings suggest that viruses may play a role in ME/CFS, though more research is needed to understand exactly how.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Exploring the central mechanism of mind-regulation electroacupuncture in treatment of chronic fatigue syndrome with anxiety and depression comorbidity based on functional magnetic resonance imaging.

Zeng, Xiangxin, Feng, Chuwen, Zhang, Muhua et al.·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2024

This study tested whether a specific type of acupuncture called 'mind-regulation electroacupuncture' could help people with ME/CFS who also have anxiety and depression. Researchers used brain imaging to see how the treatment changed activity patterns in the brains of 30 patients compared to 30 healthy people. After 2 weeks of treatment, patients reported less fatigue, anxiety, depression, and sleep problems, and their brain scans showed changes in areas related to emotions and fatigue.

E3 PreliminaryCohortPEM unclearCase-Control

Case report: Recurrent cervical spinal stenosis masquerading as myalgic encephalomyelitis/chronic fatigue syndrome with orthostatic intolerance.

Edwards, Charles C, Edwards, Charles C, Heinlein, Scott et al.·Frontiers in neurology·2023

This case report describes a woman who was thought to have ME/CFS and experienced symptoms of dizziness upon standing (orthostatic intolerance). Doctors discovered she actually had cervical spinal stenosis—a narrowing of the spinal canal in her neck that was compressing her spinal cord. After surgery to relieve the compression, her ME/CFS and orthostatic intolerance symptoms improved significantly. Years later, her symptoms returned because the surgical implant shifted, compressing the spinal cord again. A second surgery provided similar improvement, suggesting that spinal stenosis may have been causing or worsening her ME/CFS symptoms rather than the other way around.

Autonomic Nervous System

E3 PreliminaryCommentaryPEM not required

The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post-COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog.

Menichetti, Francesco·Journal of clinical medicine·2023

This article discusses how a treatment called hypothalamic phospholipid liposomes might help with ME/CFS and brain fog symptoms in people with Long COVID. These liposomes are small fatty particles that are already available as a supportive treatment for brain and hormone-related problems. The authors suggest this treatment could be helpful based on how it works and their early clinical experiences, though more rigorous testing is still needed.

Cognitive Impairment

E3 PreliminaryCohortPEM unclearCross-Sectional

Contesting misrecognition online: Experiences of epistemic in/justice by vloggers with contested illnesses.

Groenevelt, I P Irene, de Boer, M L Marjolein·Social science & medicine (1982)·2023

This study looked at how seven Dutch women with ME/CFS and other contested illnesses used video blogs (vlogs) to share their experiences online. The researchers found that these women felt their knowledge and experiences were often discredited because of prejudice against their illnesses—a problem called "epistemic injustice." While vlogging helped some women feel more empowered to share their true experiences, they still faced challenges from YouTube's design and social pressure to soften their messages.

E3 PreliminaryReviewPEM unclearReview-Narrative

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

Hanson, Maureen R·PLoS pathogens·2023

This review examines the evidence that viral infections may trigger or contribute to ME/CFS. Researchers looked at how viruses could potentially cause the long-lasting fatigue, pain, and other symptoms that define this condition. The study explores possible mechanisms by which a viral infection might set off a chain of events leading to ME/CFS.

Immune System

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The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability.

Nutrition and Chronobiology as Key Components of Multidisciplinary Therapeutic Interventions for Fibromyalgia and Associated Chronic Fatigue Syndrome: A Narrative and Critical Review.

Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review.

From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases.

A Pilot Study on the Effects of Exercise Training on Cardiorespiratory Performance, Quality of Life, and Immunologic Variables in Long COVID.

Designing and optimizing clinical trials for long COVID.

Lacticaseibacillus rhamnosus Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome.

A Multimodal Magnetic Resonance Imaging Study on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Feasibility and Clinical Correlation.

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.

The molecular fingerprint of neuroinflammation in COVID-19: A comprehensive discussion on molecular mechanisms of neuroinflammation due to SARS-COV2 antigens.

The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome.

Using time diaries to inform occupational therapy practice for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An exploratory study.

Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation.

Effect of electroacupuncture on expression of protein phosphorylation in hippocampus tissues of rats with chronic fatigue syndrome.

Over-Representation of Torque Teno Mini Virus 9 in a Subgroup of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.

Exploring the central mechanism of mind-regulation electroacupuncture in treatment of chronic fatigue syndrome with anxiety and depression comorbidity based on functional magnetic resonance imaging.

Case report: Recurrent cervical spinal stenosis masquerading as myalgic encephalomyelitis/chronic fatigue syndrome with orthostatic intolerance.

The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post-COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog.

Contesting misrecognition online: Experiences of epistemic in/justice by vloggers with contested illnesses.

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

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