Giménez-Orenga, Karen, Martín-Martínez, Eva, Oltra, Elisa · Pathogens (Basel, Switzerland) · 2024 · DOI
Researchers found that a virus called Torque Teno Mini Virus 9 (TTMV9) was present at much higher levels in the blood cells of some ME/CFS patients compared to healthy people and patients with fibromyalgia. This virus could potentially be used as a biological marker to identify and categorize certain ME/CFS patients. The findings suggest that viruses may play a role in ME/CFS, though more research is needed to understand exactly how.
ME/CFS lacks validated biomarkers, making diagnosis difficult and delaying treatment. Identifying TTMV9 overexpression in a patient subgroup offers potential for objective patient stratification and may illuminate viral mechanisms underlying ME/CFS pathogenesis, guiding future therapeutic development.
This study does not prove that TTMV9 causes ME/CFS—it only shows correlation in a subset of patients. The cross-sectional design cannot establish temporal relationships or whether TTMV9 elevation is primary cause or secondary consequence. Findings in this pilot study require validation in larger populations before clinical use.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Giménez-Orenga, Karen, Martín-Martínez, Eva, & Oltra, Elisa (2024). Over-Representation of Torque Teno Mini Virus 9 in a Subgroup of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.. Pathogens (Basel, Switzerland). https://doi.org/10.3390/pathogens13090751
BibTeX
@article{mecfsatlas-gimnez-orenga-2024-over-representation,
author = {Giménez-Orenga, Karen and Martín-Martínez, Eva and Oltra, Elisa},
title = {Over-Representation of Torque Teno Mini Virus 9 in a Subgroup of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.},
journal = {Pathogens (Basel, Switzerland)},
year = {2024},
doi = {10.3390/pathogens13090751},
note = {PubMed: 39338942},
url = {https://www.mecfsatlas.com/evidence/gimnez-orenga-2024-over-representation},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/gimnez-orenga-2024-over-representation
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