ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

301–320 of 2,420 studies

E3 PreliminaryBehavioralPEM requiredCase-Control

A patient who recovered from post-COVID myalgic encephalomyelitis/chronic fatigue syndrome: a case report.

Oka, Takakazu·BioPsychoSocial medicine·2023

This case report describes a nurse who developed ME/CFS symptoms after recovering from COVID-19, including severe fatigue, pain, brain fog, and heart palpitations that lasted over 6 months. She received treatment combining dietary advice, supplements, behavioral strategies, exercise conditioning, and two medications (amitriptyline and a Japanese herbal medicine called hochuekkito), and eventually recovered fully and returned to work. This is the first detailed report showing that someone with post-COVID ME/CFS can recover with comprehensive multimodal treatment.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses.

Nunes, Jean M, Kell, Douglas B, Pretorius, Etheresia·Blood reviews·2023

This review examines how the heart, blood vessels, and blood clotting system may be affected in ME/CFS. Research shows that ME/CFS patients often have problems with blood flow to the brain, abnormal blood clotting, and damaged blood vessel linings—similar to what happens in Long COVID. These cardiovascular and blood abnormalities may contribute to ME/CFS symptoms and could potentially become targets for new treatments.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Electroacupuncture at BL15 attenuates chronic fatigue syndrome by downregulating iNOS/NO signaling in C57BL/6 mice.

Zhu, Yang, Wang, Jingya, Yao, Lin et al.·Anatomical record (Hoboken, N.J. : 2007)·2023

This study tested whether electroacupuncture (a treatment involving tiny needles and electrical stimulation) could help mice with a condition similar to ME/CFS. Researchers found that electroacupuncture improved the mice's ability to move and strengthened their heart function by reducing levels of a particular chemical messenger (nitric oxide) in the body.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Detection of Elevated Level of Tetrahydrobiopterin in Serum Samples of ME/CFS Patients with Orthostatic Intolerance: A Pilot Study.

Gottschalk, Carl Gunnar, Whelan, Ryan, Peterson, Daniel et al.·International journal of molecular sciences·2023

This study looked at a molecule called BH4 in the blood of ME/CFS patients, particularly those who experience dizziness when standing up. The researchers found that ME/CFS patients have higher levels of BH4 than healthy people, and this may be connected to oxidative stress (harmful chemical reactions in the body). This finding could help explain why some ME/CFS patients struggle with dizziness and blood flow problems.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

A Review of Stellate Ganglion Block as an Adjunctive Treatment Modality.

Kirkpatrick, Kennedy, Khan, Mashfee H, Deng, Yi et al.·Cureus·2023

This review article explores a procedure called stellate ganglion block (SGB), where doctors inject local anesthetic into nerve bundles in the neck to calm an overactive nervous system. The authors suggest that several conditions—including chronic fatigue syndrome, long-COVID, and loss of smell—may share a common problem: too much sympathetic nervous system activity (the 'fight or flight' response). Early case reports suggest SGB might help patients with these conditions when standard treatments don't work, though more research is needed.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist.

Bellanti, Joseph A, Novak, Peter, Faitelson, Yoram et al.·The journal of allergy and clinical immunology. In practice·2023

Long COVID is a condition that develops after a COVID-19 infection and can cause symptoms affecting many parts of the body, including heart problems, blood clots, fatigue, and autoimmune issues. This review examines what causes Long COVID and which patients are most at risk, noting that certain groups like Hispanic and Latino communities face higher rates. The authors highlight that while vaccines help prevent severe acute COVID, we still need more research to understand how they affect Long COVID development and progression.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Myalgic encephalomyelitis/chronic fatigue syndrome: an overview of current evidence].

Ludwig, Birgit, Olbert, Elisabeth, Trimmel, Karin et al.·Der Nervenarzt·2023

This review examines what we currently know about ME/CFS, including how it is diagnosed and what treatments have been studied. The authors note that after many years of research, we still don't have clear answers about what causes ME/CFS or proven treatments that work for everyone. They suggest that the high rates of depression and anxiety seen in ME/CFS patients should make us consider whether psychological factors play a role in the condition.

E3 PreliminaryCohortPEM unclearCross-Sectional

Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes.

Schutzer, Steven E, Liu, Tao, Tsai, Chia-Feng et al.·Annals of medicine·2023

Researchers examined the fluid surrounding the brain and spinal cord in people with ME/CFS—some of whom also had fibromyalgia and some who did not. Using advanced technology to measure thousands of proteins in this fluid, they found no significant differences between the two groups. This suggests that ME/CFS and fibromyalgia may not be completely separate diseases, but rather may overlap or be related conditions.

Diagnostics

E3 PreliminaryDiagnosticPEM not required

Evaluation of a Webinar to Increase Health Professionals' Knowledge about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Froehlich, Laura, Niedrich, Jasmin, Hattesohl, Daniel B R et al.·Healthcare (Basel, Switzerland)·2023

Many doctors and health professionals don't know enough about ME/CFS, which makes it harder for patients to get proper care. Researchers created an online webinar to teach German-speaking healthcare workers about ME/CFS and tested whether it helped them learn. The study found that the webinar successfully increased doctors' knowledge about the illness, suggesting that online education could be a practical way to train more healthcare providers.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Role of Tau protein in long COVID and potential therapeutic targets.

Marwaha, Bharat·Frontiers in cellular and infection microbiology·2023

Long COVID causes ongoing fatigue, breathing problems, brain fog, and other symptoms that can last months or years. This review suggests that a protein called tau—which is known to damage the brain in other diseases—may also be involved in Long COVID. The authors propose that future research should look for tau damage in Long COVID patients and that treatments designed to stop tau buildup might help.

NeuroinflammationBiomarkers

E3 PreliminaryCohortPEM unclear

Corona With Lyme: A Long COVID Case Study.

Thor, Danielle C, Suarez, Sergio·Cureus·2023

This study follows one 26-year-old medical student over three years as she developed and recovered from long COVID symptoms after an acute COVID-19 infection. The case documents her journey through various treatments and how her symptoms gradually improved over time. While this is just one person's experience, it provides insight into how long COVID can develop and potentially resolve.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Asthenia, mental fatigue and cognitive dysfunction].

Titova, N V, Bezdolny, Yu N, Katunina, E A·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2023

This article discusses asthenia, which is a condition characterized by extreme tiredness that affects daily functioning and productivity. The authors explain that it's important to distinguish between simple chronic tiredness and chronic fatigue syndrome (CFS), and that fatigue can affect both the body and the mind. The article reviews how the brain may be involved in causing fatigue and cognitive problems, and suggests that a combination treatment using specific medications may help patients with fatigue and thinking difficulties.

Cognitive Impairment

E3 PreliminaryMechanismPEM unclearMechanistic

Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis.

Taylor, Krystyna, Pearson, Matthew, Das, Sayoni et al.·Journal of translational medicine·2023

Researchers studied the genetic differences between people with long COVID to understand why some develop severe symptoms while others mainly experience extreme fatigue. They found that certain genetic variations, especially in genes related to brain function and metabolism, may influence how the disease develops. Importantly, they discovered that some of the same genetic patterns appear in both long COVID and ME/CFS patients, suggesting these conditions may share similar underlying biological mechanisms.

Energy MetabolismImmune System

E3 PreliminaryMechanismPEM requiredMechanistic

Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures.

Van Booven, Derek J, Gamer, Jackson, Joseph, Andrew et al.·International journal of molecular sciences·2023

This study looked at how the bodies of women with ME/CFS respond to exercise compared to healthy women. Researchers collected blood samples at three points: before exercise, during maximum effort, and during recovery. While healthy women's immune cells showed normal changes during exercise, women with ME/CFS showed unusual immune system activity specifically during the recovery period—the time when post-exertional malaise (worsening of symptoms) typically occurs.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Life changing response to successive surgical interventions on cranial venous outflow: A case report on chronic fatigue syndrome.

Higgins, J Nicholas P, Axon, Patrick R, Lever, Andrew M L·Frontiers in neurology·2023

This case report describes one patient with ME/CFS who had narrowing in the veins that drain blood from the brain. Surgery to open one of these narrowed veins led to significant improvement in fatigue and other symptoms over the follow-up period. The authors suggest that blocked brain venous drainage might explain ME/CFS symptoms in some patients, similar to a related condition called intracranial hypertension.

E3 PreliminaryReviewPEM not requiredSystematic-Review

Understanding mental fatigue and its detection: a comparative analysis of assessments and tools.

Kunasegaran, Kaveena, Ismail, Ahamed Miflah Hussain, Ramasamy, Shamala et al.·PeerJ·2023

Mental fatigue is a common problem that makes it harder to concentrate, process information, and make decisions. Currently, doctors mainly ask patients to describe their fatigue using questionnaires, which can be unreliable because people's answers are subjective. This review compared different methods of detecting mental fatigue—including questionnaires, heart rate measurements, stress hormones, brain scans, and eye movement tests—to find the most objective and accurate tool.

Cognitive Impairment

E3 PreliminaryGuidelinePEM unclearGuideline

[Post-COVID Rehabilitation].

Küst, Jutta, Disko, Andreas, Calendo, Luigi Riccardo et al.·Praxis·2023

This guideline explains how to help people recover from post-COVID illness, which can cause lasting fatigue and memory problems that make it hard to work or manage daily life. Since there is no cure yet, treatment focuses on rehabilitation that is tailored to each patient's symptoms and goals, with special attention to gradually rebuilding activity while watching for post-exertional malaise—a worsening of symptoms after physical or mental effort. The approach involves multiple healthcare professionals working together to adjust the workload based on how the patient is doing over time.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearObservational

First insights into multidisciplinary and multispecialty long COVID networks-a SWOT analysis from the perspective of ambulatory health care professionals.

Stengel, Sandra, Gölz, Lea, Kolb, Joachim et al.·Frontiers in medicine·2023

This study looked at how two regional networks in Germany organized care for long COVID patients by having different doctors and therapists work together. Researchers interviewed healthcare professionals from these networks to understand what worked well, what was difficult, and what could be improved. Both networks focused on primary care doctors coordinating care with specialists, though they took slightly different approaches—one emphasized treating individual patients in clinics, while the other connected hospitals and community services across a wider region.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model.

Turner, Simone, Laubscher, Gert Jacobus, Khan, M Asad et al.·Heliyon·2023

Long COVID patients often have abnormal blood clotting that creates tiny, sticky clots resistant to the body's natural clot-dissolving processes. This study developed a faster, more reliable laboratory test using imaging flow cytometry to detect these microclots in blood samples. The new method successfully identified larger and more numerous microclots in Long COVID patients compared to healthy controls, and it could potentially be used in regular hospital labs to help diagnose and treat affected patients.

E3 PreliminaryReviewPEM unclearReview-Narrative

Hypothetical framework for post-COVID 19 condition based on a fibromyalgia pathogenetic model.

Martínez-Lavín, Manuel, Miguel-Álvarez, Adriana·Clinical rheumatology·2023

This study compares three conditions that share similar symptoms: fibromyalgia, ME/CFS, and long COVID. All three cause fatigue, brain fog, and widespread pain. Researchers propose that these conditions may work through the same biological mechanism—specifically, problems with nerve fiber communication in the body—and suggest that long COVID may develop through the same pathway as fibromyalgia.

Neuroinflammation

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

A patient who recovered from post-COVID myalgic encephalomyelitis/chronic fatigue syndrome: a case report.

Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses.

Electroacupuncture at BL15 attenuates chronic fatigue syndrome by downregulating iNOS/NO signaling in C57BL/6 mice.

Detection of Elevated Level of Tetrahydrobiopterin in Serum Samples of ME/CFS Patients with Orthostatic Intolerance: A Pilot Study.

A Review of Stellate Ganglion Block as an Adjunctive Treatment Modality.

The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist.

[Myalgic encephalomyelitis/chronic fatigue syndrome: an overview of current evidence].

Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes.

Evaluation of a Webinar to Increase Health Professionals' Knowledge about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Role of Tau protein in long COVID and potential therapeutic targets.

Corona With Lyme: A Long COVID Case Study.

[Asthenia, mental fatigue and cognitive dysfunction].

Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis.

Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures.

Life changing response to successive surgical interventions on cranial venous outflow: A case report on chronic fatigue syndrome.

Understanding mental fatigue and its detection: a comparative analysis of assessments and tools.

[Post-COVID Rehabilitation].

First insights into multidisciplinary and multispecialty long COVID networks-a SWOT analysis from the perspective of ambulatory health care professionals.

Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model.

Hypothetical framework for post-COVID 19 condition based on a fibromyalgia pathogenetic model.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research