ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

361–380 of 2,420 studies

E3 PreliminaryMechanismPEM unclearObservational

Causal Effects between Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two-Sample Mendelian Randomization Study.

He, Gang, Cao, Yu, Ma, Honghao et al.·Frontiers in microbiology·2023

This study used genetic analysis to investigate whether changes in gut bacteria might actually cause ME/CFS, rather than just being associated with it. Researchers found that two types of bacteria—Paraprevotella and Ruminococcaceae_UCG_014—appear to increase the risk of developing ME/CFS. These findings suggest that gut bacteria may play a role in how ME/CFS develops.

Gut MicrobiomeImmune System

E3 PreliminaryBehavioralPEM unclearLongitudinal

'I became more aware of my actions'-A qualitative longitudinal study of a health psychological group intervention for patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Keurulainen, Meeri, Holma, Juha, Wallenius, Elina et al.·Health expectations : an international journal of public participation in health care and health policy·2023

Researchers studied how a 16-week group therapy program helped 10 ME/CFS patients manage their condition better. Participants attended sessions with a psychologist and other patients dealing with the same illness, learning new ways to think about and cope with their symptoms. Most people found the program helpful and reported feeling more in control of their illness, without experiencing harm from it.

E3 PreliminaryCohortPEM unclearCross-Sectional

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity.

Ryabkova, Varvara A, Gavrilova, Natalia Y, Poletaeva, Alina A et al.·Biomedicines·2023

This study looked at immune system antibodies in people with ME/CFS, particularly those who also have fibromyalgia. Researchers measured 33 different types of natural antibodies in patients' blood and found that people with ME/CFS had unusual patterns of these antibodies, especially ones targeting GABA receptors in the brain. While the overall antibody levels didn't always differ from healthy controls, the way these antibodies related to each other was different, and certain patterns correlated with fatigue, pain, and mood symptoms.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Long COVID: mechanisms, risk factors and recovery.

Astin, Rónan, Banerjee, Amitava, Baker, Mark R et al.·Experimental physiology·2023

This review examines Long COVID—a prolonged illness affecting some people after COVID-19 infection—and compares it to similar post-viral conditions like ME/CFS. Researchers found that Long COVID involves problems with the heart and lungs, muscle function, and how the body regulates its nervous system. The review discusses various treatment approaches being tested, including exercise programs, breathing exercises, and techniques to help calm an overactive nervous system.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

[Myalgic Encephalitis/Chronic Fatigue Syndrome: Diagnostic and Therapeutic Approach and Biological Research].

Sato, Wakiro·Brain and nerve = Shinkei kenkyu no shinpo·2023

This article reviews what we currently know about ME/CFS, a serious illness marked by extreme tiredness, sleep problems, difficulty thinking clearly, and difficulty standing up without symptoms getting worse. A key feature is post-exertional malaise—when patients feel much worse after physical or mental activity—which means people with ME/CFS need to carefully manage their activity levels. The article summarizes current approaches to diagnosis and treatment, as well as recent scientific discoveries about what happens in the body during this disease.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

What Long COVID investigators can learn from four decades of ME/CFS research.

Jason, Leonard A, Natelson, Benjamin H, Bonilla, Hector et al.·Brain behavior and immunity integrative·2023

This article reviews 40 years of research on ME/CFS to provide guidance for scientists studying Long COVID. The authors explain how ME/CFS researchers have developed reliable ways to diagnose the illness, define symptoms, and measure severity—lessons that can help Long COVID researchers do the same. By learning from ME/CFS experience, Long COVID researchers may be able to diagnose patients earlier, understand what causes the illness, and find treatments that actually work.

Diagnostics

E3 PreliminaryGuidelinePEM unclearGuideline

[Post-COVID Rehabilitation].

Küst, Jutta, Disko, Andreas, Calendo, Luigi Riccardo et al.·Praxis·2023

This guideline explains how to help people recover from post-COVID illness, which can cause lasting fatigue and memory problems that make it hard to work or manage daily life. Since there is no cure yet, treatment focuses on rehabilitation that is tailored to each patient's symptoms and goals, with special attention to gradually rebuilding activity while watching for post-exertional malaise—a worsening of symptoms after physical or mental effort. The approach involves multiple healthcare professionals working together to adjust the workload based on how the patient is doing over time.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

Modulation of Beta-Adrenergic Autoantibodies Over Time in Post-Viral ME/CFS is Related to Fatigue and Pain Symptoms.

Busch, Lena, Schriek, Carsten, Paul, Matthias et al.·The Israel Medical Association journal : IMAJ·2023

This study followed one patient with ME/CFS that developed after a viral infection and measured special proteins in their blood called autoantibodies that mistakenly attack the body's own receptors. When these autoantibodies increased over time, the patient's fatigue and pain symptoms got worse. The researchers also found changes in nerve fibers in the skin that matched these increases, suggesting these autoantibodies may play a role in ME/CFS symptoms.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

A synthetic data generation system for myalgic encephalomyelitis/chronic fatigue syndrome questionnaires.

Lacasa, Marcos, Prados, Ferran, Alegre, José et al.·Scientific reports·2023

This study created an artificial intelligence tool that can predict what ME/CFS patients might answer on symptom questionnaires. Researchers trained the tool using responses from 2,522 ME/CFS patients from a hospital in Spain, and it learned to predict answers accurately. The tool could help researchers study the disease more easily by generating realistic patient data for testing new ideas.

Diagnostics

E3 PreliminaryBehavioralPEM unclearObservational

Acquiring a new understanding of illness and agency: a narrative study of recovering from chronic fatigue syndrome.

Bakken, Anne Karen, Mengshoel, Anne Marit, Synnes, Oddgeir et al.·International journal of qualitative studies on health and well-being·2023

This study interviewed 14 people who had severe ME/CFS and recovered to learn how healing happened. Researchers found that patients experienced a major shift in how they thought about their illness—moving from feeling helpless and trapped by the disease to taking an active role in their own recovery. The study shows that changes in mindset and taking personal agency in healing were important parts of the recovery process.

E3 PreliminaryMechanismPEM not requiredMechanistic

Broadband Electrical Spectroscopy to Distinguish Single-Cell Ca2+ Changes Due to Ionomycin Treatment in a Skeletal Muscle Cell Line.

Ferguson, Caroline A, Santangelo, Carmen, Marramiero, Lorenzo et al.·Sensors (Basel, Switzerland)·2023

Researchers used a specialized technology to measure electrical changes in muscle cells when calcium levels increased abnormally. They found that calcium buildup—a problem seen in ME/CFS and other muscle diseases—creates detectable electrical differences that can be measured. This new method may eventually help doctors identify calcium problems in patient cells more easily.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Integrated 'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome.

Chaoran, L I, Yan, Yang, Chuwen, Feng et al.·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2023

This study tested whether moxibustion (a traditional Chinese medicine technique using heat) could help treat chronic fatigue syndrome in rats. Researchers found that moxibustion improved fatigue-like symptoms and restored balance to the gut bacteria and chemical levels that were abnormal in fatigued rats. The results suggest that moxibustion may work by fixing problems in the gut microbiome (bacteria) and the metabolites (chemical byproducts) they produce.

Gut Microbiome

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Asthenia, mental fatigue and cognitive dysfunction].

Titova, N V, Bezdolny, Yu N, Katunina, E A·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2023

This article discusses asthenia, which is a condition characterized by extreme tiredness that affects daily functioning and productivity. The authors explain that it's important to distinguish between simple chronic tiredness and chronic fatigue syndrome (CFS), and that fatigue can affect both the body and the mind. The article reviews how the brain may be involved in causing fatigue and cognitive problems, and suggests that a combination treatment using specific medications may help patients with fatigue and thinking difficulties.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredSystematic-Review

Understanding mental fatigue and its detection: a comparative analysis of assessments and tools.

Kunasegaran, Kaveena, Ismail, Ahamed Miflah Hussain, Ramasamy, Shamala et al.·PeerJ·2023

Mental fatigue is a common problem that makes it harder to concentrate, process information, and make decisions. Currently, doctors mainly ask patients to describe their fatigue using questionnaires, which can be unreliable because people's answers are subjective. This review compared different methods of detecting mental fatigue—including questionnaires, heart rate measurements, stress hormones, brain scans, and eye movement tests—to find the most objective and accurate tool.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Development and measurement properties of the PEM/PESE activity questionnaire (PAQ).

Davenport, Todd E, Stevens, Staci R, Stevens, Jared et al.·Work (Reading, Mass.)·2023

This study created and tested a new questionnaire called the PAQ that helps measure how post-exertional malaise (PEM) affects a person's ability to do everyday activities. Patients chose three activities that were important to them and rated how much their performance had changed compared to their good days and before they got sick. The questionnaire was given to 675 people twice to make sure it reliably measured the same thing each time, and the results showed it works well.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM requiredGuideline

Cardiovascular Considerations in the Management of People With Suspected Long COVID.

Quinn, Kieran L, Lam, Grace Y, Walsh, Jillian F et al.·The Canadian journal of cardiology·2023

This review examines how doctors should evaluate and treat heart-related symptoms in people with long COVID. It highlights that about 15% of Canadians infected with COVID-19 develop persistent symptoms lasting more than 12 weeks, including fatigue, shortness of breath, chest pain, and irregular heartbeats. The authors emphasize that doctors need to consider conditions like ME/CFS, postexertional malaise (symptom flare-ups after activity), and dysautonomia (problems with the autonomic nervous system) when evaluating these patients.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Role of Tau protein in long COVID and potential therapeutic targets.

Marwaha, Bharat·Frontiers in cellular and infection microbiology·2023

Long COVID causes ongoing fatigue, breathing problems, brain fog, and other symptoms that can last months or years. This review suggests that a protein called tau—which is known to damage the brain in other diseases—may also be involved in Long COVID. The authors propose that future research should look for tau damage in Long COVID patients and that treatments designed to stop tau buildup might help.

NeuroinflammationBiomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Electroacupuncture at BL15 attenuates chronic fatigue syndrome by downregulating iNOS/NO signaling in C57BL/6 mice.

Zhu, Yang, Wang, Jingya, Yao, Lin et al.·Anatomical record (Hoboken, N.J. : 2007)·2023

This study tested whether electroacupuncture (a treatment involving tiny needles and electrical stimulation) could help mice with a condition similar to ME/CFS. Researchers found that electroacupuncture improved the mice's ability to move and strengthened their heart function by reducing levels of a particular chemical messenger (nitric oxide) in the body.

E3 PreliminaryPEM unclear

Converging Evidence of Similar Symptomatology of ME/CFS and PASC Indicating Multisystemic Dyshomeostasis.

Marks, David F·Biomedicines·2023

This study found that ME/CFS and long COVID (PASC) cause very similar symptoms in patients. Researchers compared symptom reports from two groups and found they matched about 90% of the time. The authors suggest both conditions may involve the body's control systems (nervous system, hormones, and immune system) getting stuck in a broken state, similar to a thermostat that can't turn off.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric validation of the French Multidimensional Chronic Asthenia Scale (MCAS) in a sample of 621 patients with chronic fatigue.

Banovic, Ingrid, Scrima, Fabrizio, Fornasieri, Isabelle et al.·BMC psychology·2023

Researchers tested a new questionnaire called the MCAS to measure chronic fatigue and exhaustion in French-speaking patients. The questionnaire asks about physical tiredness, how much fatigue limits daily life, and how it affects relationships. The study found that the MCAS works well and can detect differences in fatigue severity between people with different conditions, including ME/CFS.

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Evidence Atlas

Evidence browser

Causal Effects between Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two-Sample Mendelian Randomization Study.

'I became more aware of my actions'-A qualitative longitudinal study of a health psychological group intervention for patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity.

Long COVID: mechanisms, risk factors and recovery.

[Myalgic Encephalitis/Chronic Fatigue Syndrome: Diagnostic and Therapeutic Approach and Biological Research].

What Long COVID investigators can learn from four decades of ME/CFS research.

[Post-COVID Rehabilitation].

Modulation of Beta-Adrenergic Autoantibodies Over Time in Post-Viral ME/CFS is Related to Fatigue and Pain Symptoms.

A synthetic data generation system for myalgic encephalomyelitis/chronic fatigue syndrome questionnaires.

Acquiring a new understanding of illness and agency: a narrative study of recovering from chronic fatigue syndrome.

Broadband Electrical Spectroscopy to Distinguish Single-Cell Ca2+ Changes Due to Ionomycin Treatment in a Skeletal Muscle Cell Line.

Integrated 'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome.

[Asthenia, mental fatigue and cognitive dysfunction].

Understanding mental fatigue and its detection: a comparative analysis of assessments and tools.

Development and measurement properties of the PEM/PESE activity questionnaire (PAQ).

Cardiovascular Considerations in the Management of People With Suspected Long COVID.

Role of Tau protein in long COVID and potential therapeutic targets.

Electroacupuncture at BL15 attenuates chronic fatigue syndrome by downregulating iNOS/NO signaling in C57BL/6 mice.

Converging Evidence of Similar Symptomatology of ME/CFS and PASC Indicating Multisystemic Dyshomeostasis.

Psychometric validation of the French Multidimensional Chronic Asthenia Scale (MCAS) in a sample of 621 patients with chronic fatigue.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research