ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

381–400 of 2,422 studies

E3 PreliminaryCohortPEM unclearObservational

Bodies in lockdown: Young women's narratives of falling severely ill with ME/CFS during childhood and adolescence.

Krabbe, Silje Helen, Mengshoel, Anne Marit, Schrøder Bjorbækmo, Wenche et al.·Health care for women international·2023

This study listened to the stories of 13 young women who became severely ill with ME/CFS during their childhood or teenage years. The researchers found that these women experienced a gradual loss of their normal, active lives, felt increasingly isolated and abandoned by others, and struggled with uncertainty about their future. The study highlights how challenging and life-altering this illness can be during crucial developmental years.

E3 PreliminaryCommentaryPEM requiredEditorial

Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Vøllestad, Nina K, Mengshoel, Anne Marit·Frontiers in physiology·2023

This paper reviews how post-exertional malaise (PEM)—the worsening of symptoms after physical or mental activity—is experienced and studied in ME/CFS patients. Patients describe PEM in many different ways and report that it can start immediately or be delayed by days, lasting anywhere from a few days to months. When researchers use standardized exercise tests in laboratories, they see more immediate symptom worsening, but the duration still varies widely between patients.

Autonomic Nervous SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

[Myalgic Encephalitis/Chronic Fatigue Syndrome: Diagnostic and Therapeutic Approach and Biological Research].

Sato, Wakiro·Brain and nerve = Shinkei kenkyu no shinpo·2023

This article reviews what we currently know about ME/CFS, a serious illness marked by extreme tiredness, sleep problems, difficulty thinking clearly, and difficulty standing up without symptoms getting worse. A key feature is post-exertional malaise—when patients feel much worse after physical or mental activity—which means people with ME/CFS need to carefully manage their activity levels. The article summarizes current approaches to diagnosis and treatment, as well as recent scientific discoveries about what happens in the body during this disease.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

Serum from Myalgic encephalomyelitis/chronic fatigue syndrome patients causes loss of coherence in cellular circadian rhythms.

Wei, Heather, Adelsheim, Zoe, Fischer, Rita et al.·Journal of neuroimmunology·2023

This study found that blood serum from ME/CFS patients disrupts the internal 24-hour biological clock (circadian rhythm) in cells grown in the laboratory, compared to serum from healthy people. The disruption was linked to how severe patients' sleep problems were. While a protein called TGF-beta contributed to some rhythm changes, it didn't fully explain the effect, suggesting other unknown factors in ME/CFS patients' blood are responsible.

Immune System

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Development and measurement properties of the PEM/PESE activity questionnaire (PAQ).

Davenport, Todd E, Stevens, Staci R, Stevens, Jared et al.·Work (Reading, Mass.)·2023

This study created and tested a new questionnaire called the PAQ that helps measure how post-exertional malaise (PEM) affects a person's ability to do everyday activities. Patients chose three activities that were important to them and rated how much their performance had changed compared to their good days and before they got sick. The questionnaire was given to 675 people twice to make sure it reliably measured the same thing each time, and the results showed it works well.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM requiredGuideline

Cardiovascular Considerations in the Management of People With Suspected Long COVID.

Quinn, Kieran L, Lam, Grace Y, Walsh, Jillian F et al.·The Canadian journal of cardiology·2023

This review examines how doctors should evaluate and treat heart-related symptoms in people with long COVID. It highlights that about 15% of Canadians infected with COVID-19 develop persistent symptoms lasting more than 12 weeks, including fatigue, shortness of breath, chest pain, and irregular heartbeats. The authors emphasize that doctors need to consider conditions like ME/CFS, postexertional malaise (symptom flare-ups after activity), and dysautonomia (problems with the autonomic nervous system) when evaluating these patients.

Post-Exertional Malaise

E3 PreliminaryPEM unclear

Converging Evidence of Similar Symptomatology of ME/CFS and PASC Indicating Multisystemic Dyshomeostasis.

Marks, David F·Biomedicines·2023

This study found that ME/CFS and long COVID (PASC) cause very similar symptoms in patients. Researchers compared symptom reports from two groups and found they matched about 90% of the time. The authors suggest both conditions may involve the body's control systems (nervous system, hormones, and immune system) getting stuck in a broken state, similar to a thermostat that can't turn off.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Whole-body cryotherapy as a treatment for chronic medical conditions?

Tabisz, Hanna, Modlinska, Aleksandra, Kujawski, Sławomir et al.·British medical bulletin·2023

This review article examines whole-body cryotherapy (WBC)—exposing your entire body to very cold temperatures—as a possible treatment for various chronic conditions, including ME/CFS. The authors suggest that because WBC appears to reduce inflammation in the body, it might help conditions involving persistent inflammation. However, they emphasize that current research quality is low and that proper clinical trials are needed before we can know if WBC actually works.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Altered brain connectivity in Long Covid during cognitive exertion: a pilot study.

Barnden, Leighton, Thapaliya, Kiran, Eaton-Fitch, Natalie et al.·Frontiers in neuroscience·2023

Researchers used advanced brain imaging to compare how the brains of Long Covid patients and healthy people respond during a challenging thinking task. They found that Long Covid patients showed different patterns of communication between brain regions, particularly in areas that control alertness, heart rate, and sleep. These brain connection differences were linked to how disabled patients felt and their autonomic nervous system symptoms.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Exploring the arcuate fasciculus from a clinical perspective.

Shao, Zhi Ding, Gong, Yu Juan, Ren, Jing et al.·Frontiers in neuroscience·2023

This review examines a bundle of nerve fibers in the brain called the arcuate fasciculus, which helps connect language centers. Researchers found that several conditions—including ME/CFS, stroke, brain tumors, and others—can damage these nerve fibers in measurable ways. New brain imaging techniques can now visualize and measure this damage, which may help doctors understand what goes wrong and develop better treatments.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Epstein-Barr virus-acquired immunodeficiency in myalgic encephalomyelitis-Is it present in long COVID?

Ruiz-Pablos, Manuel, Paiva, Bruno, Zabaleta, Aintzane·Journal of translational medicine·2023

This study proposes that a virus called Epstein-Barr virus (EBV) may play a central role in both ME/CFS and long COVID by gradually weakening the immune system. The researchers suggest that in people with certain genetic traits, EBV can hide in various body tissues and repeatedly reactivate, causing ongoing inflammation and exhaustion of the immune system. They hypothesize that long COVID may follow a similar pattern, possibly starting with a COVID-19 infection in people whose immune systems struggle to control EBV.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Mitochondria: It is all about energy.

Casanova, Amaloha, Wevers, Anne, Navarro-Ledesma, Santiago et al.·Frontiers in physiology·2023

This review explains that mitochondria—the energy-producing structures in our cells—do much more than just make energy. They also help control sleep-wake cycles, interact with gut bacteria, and regulate the immune system. When mitochondria don't work properly, it may contribute to several diseases including ME/CFS, and the authors suggest that specific lifestyle and physiological strategies might help restore mitochondrial health.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC).

Paniskaki, Krystallenia, Goretzki, Sarah, Anft, Moritz et al.·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2023

This study looked at children who had COVID-19 and developed long-lasting symptoms like breathing problems, fatigue, and brain fog—a condition called pediatric long COVID. Researchers found that these children had more immune cells fighting the virus that were less effective than usual, and these cells released inflammatory chemicals that may have been causing their symptoms. The findings suggest that ongoing immune system activation after COVID-19 might explain why some children develop persistent health problems similar to ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Research progress on central mechanism of acupuncture treatment for chronic fatigue syndrome.

Li, Bin-Bin, Feng, Chu-Wen, Qu, Yuan-Yuan et al.·World journal of acupuncture-moxibustion·2023

This review examined how ME/CFS affects the brain and nervous system by looking at laboratory tests and brain imaging studies. Researchers found that people with ME/CFS have changes in brain structure, abnormal inflammation, and problems with chemical messengers in the brain. The study also explored how acupuncture might help correct some of these brain abnormalities in animal models of the condition.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearMechanistic

Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue.

Oakley, Julia, Hill, Martin, Giess, Adam et al.·Journal of translational medicine·2023

Researchers used advanced DNA sequencing technology to find a structural variant (a large rearrangement in genetic material) in the AKR1C gene region of a patient with severe, unexplained fatigue. This variant appears to alter how the body produces certain steroids and neurochemicals, potentially leading to reduced neuronal activity and widespread tissue dysfunction. The discovery suggests that genetic changes in this region may be a cause of severe chronic fatigue in some patients, and blood tests for specific steroid markers could help identify others with similar underlying issues.

E3 PreliminaryMechanismPEM requiredMechanistic

Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Maya, Jessica, Leddy, Sabrina M, Gottschalk, C Gunnar et al.·International journal of molecular sciences·2023

Researchers studied immune cells called lymphocytes from ME/CFS patients and found that these cells use fatty acids (a type of fuel) differently than healthy people's immune cells do. When immune cells are activated or working hard, ME/CFS patients' cells rely more heavily on burning fat for energy compared to cells from healthy controls. This suggests that ME/CFS patients' immune systems may have a fundamental problem with how they fuel their cells.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Myalgic encephalomyelitis/chronic fatigue syndrome: an overview of current evidence].

Ludwig, Birgit, Olbert, Elisabeth, Trimmel, Karin et al.·Der Nervenarzt·2023

This review examines what we currently know about ME/CFS, including how it is diagnosed and what treatments have been studied. The authors note that after many years of research, we still don't have clear answers about what causes ME/CFS or proven treatments that work for everyone. They suggest that the high rates of depression and anxiety seen in ME/CFS patients should make us consider whether psychological factors play a role in the condition.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Impact of Misdiagnosis in Case-Control Studies of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Malato, João, Graça, Luís, Sepúlveda, Nuno·Diagnostics (Basel, Switzerland)·2023

This study examined how misdiagnosis affects ME/CFS research results. The researchers found that when patients are incorrectly diagnosed with ME/CFS (or vice versa), it becomes much harder for studies to find real connections between potential causes and the disease. To get reliable results, studies need to include at least 500-1000 people per group, which is larger than many current ME/CFS studies.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism.

Lei, Chaofang, Chen, Jiaxu, Huang, Zhen et al.·Frontiers in pharmacology·2023

This study tested whether ginsenoside Rg1, a compound from ginseng, could reduce fatigue in rats with chronic fatigue syndrome. Researchers found that the treatment reversed fatigue behavior and corrected abnormal metabolism patterns in the rats' blood, particularly affecting molecules called taurine and mannose 6-phosphate. The results suggest ginseng-derived compounds might help ME/CFS patients, though human studies would be needed to confirm this.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Exploring the scope of homoeopathy in combating the unfortunate consequences of post-COVID-19 survivors based on non-COVID conditions: a narrative review.

Dixit, Ashish Kumar, Giri, Nibha, Singh, Shishir·Journal of complementary & integrative medicine·2023

This review looked at whether homeopathy—a complementary medicine approach—might help people recover from long-term symptoms after COVID-19. The authors searched published research and found that homeopathy has shown some promise in treating anxiety, depression, pain, and heart problems in other conditions, and they suggest it might be worth studying for post-COVID recovery.

Pain and Sensitization

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Bodies in lockdown: Young women's narratives of falling severely ill with ME/CFS during childhood and adolescence.

Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

[Myalgic Encephalitis/Chronic Fatigue Syndrome: Diagnostic and Therapeutic Approach and Biological Research].

Serum from Myalgic encephalomyelitis/chronic fatigue syndrome patients causes loss of coherence in cellular circadian rhythms.

Development and measurement properties of the PEM/PESE activity questionnaire (PAQ).

Cardiovascular Considerations in the Management of People With Suspected Long COVID.

Converging Evidence of Similar Symptomatology of ME/CFS and PASC Indicating Multisystemic Dyshomeostasis.

Whole-body cryotherapy as a treatment for chronic medical conditions?

Altered brain connectivity in Long Covid during cognitive exertion: a pilot study.

Exploring the arcuate fasciculus from a clinical perspective.

Epstein-Barr virus-acquired immunodeficiency in myalgic encephalomyelitis-Is it present in long COVID?

Mitochondria: It is all about energy.

Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC).

Research progress on central mechanism of acupuncture treatment for chronic fatigue syndrome.

Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue.

Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

[Myalgic encephalomyelitis/chronic fatigue syndrome: an overview of current evidence].

Impact of Misdiagnosis in Case-Control Studies of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism.

Exploring the scope of homoeopathy in combating the unfortunate consequences of post-COVID-19 survivors based on non-COVID conditions: a narrative review.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research