ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

461–480 of 2,423 studies

An Unexpected Journey: The Lived Experiences of Patients with Long-Term Cognitive Sequelae After Recovering from COVID-19.

Loft, Mia I, Foged, Eva M, Koreska, Mai·Qualitative health research·2022

This study listened to people who experienced long-lasting thinking and memory problems after recovering from COVID-19. Patients described how these cognitive symptoms disrupted their daily lives, work, and relationships, and left them feeling anxious and uncertain about their future. The researchers suggest that doctors and researchers could learn from how people with similar conditions—like ME/CFS—manage their symptoms while waiting for treatments.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Characterising DSCATT: A case series of Australian patients with debilitating symptom complexes attributed to ticks.

Schnall, Jesse, Oliver, Georgina, Braat, Sabine et al.·The Australian and New Zealand journal of psychiatry·2022

Researchers studied 29 Australian patients who believed their symptoms were caused by tick bites. Most had severe tiredness, headaches, and joint pain, and many had previously been diagnosed with conditions like ME/CFS or fibromyalgia. When doctors tested these patients, they found no evidence of Lyme disease or other common infections from ticks. The study suggests that tick-attributed illness in Australia remains unexplained and may overlap with other medically unexplained conditions.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Treatment of chronic fatigue syndrome from yangming meridian].

Xue, Kai-Yang, Cui, Jin·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2022

This paper discusses a traditional Chinese medicine approach to treating ME/CFS by focusing on the yangming meridian (energy pathways in the body). The authors propose that ME/CFS is connected to the brain and digestive system and suggest using Chinese herbal medicine combined with acupuncture might help by clearing heat, reducing inflammation, improving energy flow, and strengthening the body.

E3 PreliminaryCommentaryPEM required

Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Lubell, Jeffrey·Journal of translational medicine·2022

This editorial letter explores whether problems with blood vessel function and damage might explain some of the key symptoms of ME/CFS, including pain, inflammation, and post-exertional malaise (the exhaustion that follows physical activity). The author proposes that if blood vessels aren't working properly, they may not deliver enough oxygen and nutrients to tissues, which could trigger the symptoms many ME/CFS patients experience.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearCross-Sectional

Muscle sodium content in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Petter, Elisabeth, Scheibenbogen, Carmen, Linz, Peter et al.·Journal of translational medicine·2022

Researchers used a special type of MRI scan to measure sodium levels in the leg muscles of ME/CFS patients and healthy people. They found that ME/CFS patients had higher sodium buildup in their muscles both at rest and after exercise, and this sodium overload was linked to weaker grip strength. This suggests that muscles in ME/CFS may not be handling sodium properly, which could contribute to fatigue and muscle pain.

E3 PreliminaryCohortPEM not requiredCase-Control

Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention.

Heald, Adrian, Perrin, Raymond, Walther, Andreas et al.·Cardiovascular endocrinology & metabolism·2022

This small study looked at whether a hands-on technique called the Perrin technique—involving gentle massage and movement exercises—could help reduce fatigue in people with Long COVID. Twenty patients received weekly treatment sessions and did daily self-massage at home. On average, both men and women reported about 50% improvement in their fatigue-related symptoms after treatment. While these early results are encouraging, the study is too small to prove this treatment works for everyone.

E3 PreliminaryMechanismPEM unclearMechanistic

Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE).

Gottschalk, Gunnar, Peterson, Daniel, Knox, Konstance et al.·Molecular and cellular neurosciences·2022

Researchers found that people with ME/CFS have higher levels of a protein called ATG13 in their blood compared to healthy people. When they tested this protein on brain immune cells in the lab, it triggered the production of harmful molecules called free radicals (oxidative stress). This suggests that a breakdown in the body's cellular recycling system (autophagy) might contribute to the inflammation and stress response seen in ME/CFS.

NeuroinflammationImmune System

E3 PreliminaryCommentaryPEM unclearEditorial

[Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Who Have Already Visited Some Medical Institutions: The Points of Diagnosis and Treatment].

Shimomura, Tokio·Brain and nerve = Shinkei kenkyu no shinpo·2022

ME/CFS is a debilitating condition characterized primarily by severe fatigue, but doctors currently have no reliable blood tests or biomarkers to definitively diagnose it. This editorial discusses how ME/CFS diagnosis and treatment require specialized medical knowledge, and notes that common treatments like vitamins and herbal medicines have not proven effective. The authors also observed ME/CFS-like symptoms in some COVID-19 patients, which has prompted renewed research into understanding how ME/CFS develops and finding better treatments.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Red ginseng extract improves skeletal muscle energy metabolism and mitochondrial function in chronic fatigue mice.

Zhang, Haijing, Zhao, Chunhui, Hou, Jinli et al.·Frontiers in pharmacology·2022

This study tested whether red ginseng extract could help mice with chronic fatigue by improving how their muscles produce energy. Researchers found that medium and high doses of red ginseng reduced markers of fatigue and improved the function of mitochondria (the "power plants" inside muscle cells), helping restore the muscle's ability to generate energy.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Dehhaghi, Mona, Panahi, Hamed Kazemi Shariat, Kavyani, Bahar et al.·Aging and disease·2022

This review examines how tryptophan, an amino acid we get from food, is processed differently in people with ME/CFS. The body normally converts tryptophan into important substances like serotonin (which affects mood) and NAD+, an energy molecule. The authors propose that this conversion process may become overactive in ME/CFS, depleting NAD+ and making fatigue worse. They suggest that NAD+ supplements might help reduce fatigue and improve quality of life.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclear

Living with myalgic encephalomyelitis/chronic fatigue syndrome: Experiences of occupational disruption for adults in Australia.

Bartlett, Chelsea, Hughes, Julie L, Miller, Laura·The British journal of occupational therapy·2022

This Australian study interviewed five people with ME/CFS about how the illness affected their ability to work and participate in daily activities. Participants described losing the ability to do the things that mattered to them—first hobbies and leisure activities, then work, and eventually basic self-care tasks. They also faced challenges from lack of understanding about ME/CFS, financial difficulties, and limited healthcare support.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Long COVID Citizen Scientists: Developing a Needs-Based Research Agenda by Persons Affected by Long COVID.

Ziegler, Sarah, Raineri, Alessia, Nittas, Vasileios et al.·The patient·2022

This study asked people with Long COVID what research questions matter most to them. Researchers created a group of 28 people with Long COVID and ME/CFS, plus a larger working group of over 240 people, who together identified 68 research questions and ranked which ones were most important. The top five priorities were: finding better treatments and rehabilitation, ensuring continuous care between doctors, improving access to healthcare, training healthcare providers to understand Long COVID, and studying Long COVID in children and teens.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in Cirrhosis.

Bhandari, Krishnagopal, Kapoor, Dharmesh·Journal of clinical and experimental hepatology·2022

This review examines fatigue in patients with liver disease, explaining that fatigue is common and significantly affects quality of life. The authors describe how the liver plays a central role in energy production and how fatigue in liver disease likely has multiple causes involving the gut, muscles, and brain. The article discusses various ways to measure fatigue and different treatment approaches, including lifestyle changes, medications, diet, and exercise.

E3 PreliminaryReviewPEM unclearReview-Narrative

Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?

Sun, Yuanjie, Koyama, Yoshihisa, Shimada, Shoichi·Frontiers in aging neuroscience·2022

This review explores how inflammation in the body's organs—like the gut, lungs, or joints—can trigger inflammation in the brain. The authors describe several pathways by which this happens, including damage to the protective barrier around the brain, activation of immune cells in the brain, and communication through nerves connecting organs to the brain. ME/CFS is highlighted as one disease where this peripheral-to-brain inflammation mechanism may be important.

NeuroinflammationImmune System

E3 PreliminaryBehavioralPEM not requiredObservational

Mechanism of the Huangguoshu waterfall forest environment's promotive effect on human health in Guizhou, China.

Zhu, Zixin, Zhao, Xueke, Ouyang, Qiuyue et al.·Annals of translational medicine·2022

This study looked at whether spending time in a waterfall forest environment in China could help people with ME/CFS feel better. Researchers tracked what participants looked at, measured their fatigue and mood, and checked blood markers for inflammation and antioxidants. They found that people who spent time near the waterfall had less fatigue and depression, lower inflammation, and higher antioxidant levels.

E3 PreliminaryCohortPEM not requiredCross-Sectional

"I Just Want to Feel Safe Going to a Doctor": Experiences of Female Patients with Chronic Conditions in Australia.

Merone, Lea, Tsey, Komla, Russell, Darren et al.·Women's health reports (New Rochelle, N.Y.)·2022

This study interviewed 20 Australian women with various chronic conditions, including chronic fatigue syndrome, to understand their experiences with doctors and the healthcare system. The women reported that their pain and exhaustion were often dismissed or not taken seriously, which created fear and trauma around seeking medical care. The researchers found that women with chronic illnesses need doctors who are more knowledgeable, understanding, and empathetic about their conditions.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy.

Meade, Elaine, Garvey, Mary·International journal of molecular sciences·2022

This review article examines how the nervous and immune systems interact to cause chronic pain and fatigue in conditions like ME/CFS, fibromyalgia, and IBS. The authors explain that childhood trauma and ongoing stress can permanently change how the body's stress response system works, leading to long-term symptoms. They discuss how these systems become dysregulated and contribute to the wide range of symptoms people with these conditions experience.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?

Bornstein, Stefan R, Voit-Bak, Karin, Donate, Timo et al.·Molecular psychiatry·2022

Some people who had COVID-19 continue to experience fatigue and breathing problems long after recovering from the infection, a condition called long-COVID. This pattern of ongoing symptoms looks similar to ME/CFS, another condition that causes persistent fatigue. Researchers found that both conditions may involve the body producing antibodies (immune proteins) that attack certain nerve receptors. A treatment called extracorporeal apheresis, which filters blood to remove these harmful antibodies, showed promise in improving symptoms in ME/CFS patients and might also help those with long-COVID.

Immune System

E3 PreliminaryReviewPEM requiredReview-Narrative

Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM).

Baraniuk, James N·Brain sciences·2022

This review examines a brain region called the midbrain and how it might contribute to post-exertional malaise (PEM)—the worsening of symptoms after activity that happens in ME/CFS. When ME/CFS patients did exercise in a study, their midbrain showed increased activity during mental tasks, while Gulf War Illness patients showed the opposite pattern. The authors suggest that problems in this brain region could explain why ME/CFS patients have trouble with energy, sleep, mood, pain, and temperature control, especially after exertion.

Cognitive ImpairmentPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease.

Sterling, Kathryn G, Dodd, Griffin Kutler, Alhamdi, Shatha et al.·International journal of molecular sciences·2022

This review article examines the connection between gut bacteria, immunity, and the brain in diseases like ME/CFS. The authors explain that the bacteria in our gut can communicate with our brain through chemical signals and nerves, but this communication can be disrupted in certain illnesses. They focus on how the immune system in the gut lining controls which bacteria thrive there, and how changes in these bacterial communities might contribute to neuroimmune diseases.

NeuroinflammationGut MicrobiomeImmune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

An Unexpected Journey: The Lived Experiences of Patients with Long-Term Cognitive Sequelae After Recovering from COVID-19.

Characterising DSCATT: A case series of Australian patients with debilitating symptom complexes attributed to ticks.

[Treatment of chronic fatigue syndrome from yangming meridian].

Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Muscle sodium content in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention.

Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE).

[Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Who Have Already Visited Some Medical Institutions: The Points of Diagnosis and Treatment].

Red ginseng extract improves skeletal muscle energy metabolism and mitochondrial function in chronic fatigue mice.

The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Living with myalgic encephalomyelitis/chronic fatigue syndrome: Experiences of occupational disruption for adults in Australia.

Long COVID Citizen Scientists: Developing a Needs-Based Research Agenda by Persons Affected by Long COVID.

Fatigue in Cirrhosis.

Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?

Mechanism of the Huangguoshu waterfall forest environment's promotive effect on human health in Guizhou, China.

"I Just Want to Feel Safe Going to a Doctor": Experiences of Female Patients with Chronic Conditions in Australia.

The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy.

Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?

Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM).

Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research