ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

701–720 of 2,422 studies

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Can linguistic analysis be used to identify whether adolescents with a chronic illness are depressed?

Jones, Lauren Stephanie, Anderson, Emma, Loades, Maria et al.·Clinical psychology & psychotherapy·2020

This study looked at whether doctors could use the words young people write in online therapy messages to figure out if they also have depression alongside ME/CFS. Researchers developed a system to analyze language patterns in 16 teenagers' messages, but found it didn't work very well at identifying depression compared to standard depression screening tests. A few language patterns showed promise—for example, teenagers with depression used more words about the past and fewer words showing mixed feelings—but the method overall wasn't reliable enough to be useful.

E3 PreliminaryMechanismPEM requiredCross-Sectional

A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction.

Sweetman, Eiren, Kleffmann, Torsten, Edgar, Christina et al.·Journal of translational medicine·2020

Researchers examined immune cells from ME/CFS patients and compared them to healthy controls, looking at which proteins were present and in what amounts. They found that ME/CFS patients had different patterns of proteins, particularly ones involved in how cells produce energy (through structures called mitochondria). These findings suggest that people with ME/CFS may have problems with energy production in their cells, which could explain why fatigue and post-exertional malaise are core symptoms of the disease.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

Patients' hopes for recovery from myalgic encephalomyelitis and chronic fatigue syndrome: Toward a "recovery in" framework.

Devendorf, Andrew R, Rown, Abigail A, Jason, Leonard A·Chronic illness·2020

This study asked 10 women over age 50 with ME/CFS what recovery means to them. Most patients didn't believe they could fully recover from ME/CFS, but they did believe they could achieve meaningful improvement through learning better coping strategies. Patients defined recovery as being able to function without constant fear of getting worse, returning to activities that matter to them, and having their symptoms improve significantly.

E3 PreliminaryReviewPEM unclearReview-Narrative

Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome.

Komaroff, Anthony L·JAMA·2019

This review article examines what scientists currently understand about how ME/CFS develops and affects the body at a cellular level. Researcher Anthony Komaroff synthesizes evidence suggesting that ME/CFS involves problems with energy production in cells, immune system dysfunction, and nervous system abnormalities. The article helps explain why ME/CFS causes such severe fatigue and why patients often feel worse after physical activity.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study.

Lacerda, Eliana M, McDermott, Clare, Kingdon, Caroline C et al.·Health expectations : an international journal of public participation in health care and health policy·2019

Researchers asked people with ME/CFS and MS about their experiences participating in a major study that collected blood samples and health information. Patients shared their hopes and frustrations about research, what they want scientists to study next, and how they'd like findings to be shared with them. The participants felt that research progress is like slowly putting together a puzzle, and they emphasized how important collaboration and persistence are.

E3 PreliminaryMechanismPEM unclearObservational

Epstein-Barr Virus Induced Gene-2 Upregulation Identifies a Particular Subtype of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Kerr, Jonathan R·Frontiers in pediatrics·2019

This study found that about 38-55% of ME/CFS patients have higher levels of a specific gene called EBI2 turned on in their immune cells. Patients with this EBI2 pattern appear to have more severe symptoms and different antibody levels compared to other ME/CFS patients. Because EBI2 is known to affect both immune function and brain function, finding this subtype could help explain why ME/CFS patients experience such different symptoms and may lead to new treatments.

BiomarkersImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system.

Gherardi, Romain K, Crépeaux, Guillemette, Authier, François-Jérome·Autoimmunity reviews·2019

This review examines whether ME/CFS could be triggered by aluminum-containing substances in certain vaccines. The authors present evidence that aluminum particles may persist in immune cells and travel to the brain, potentially causing the cognitive problems, muscle pain, and fatigue seen in ME/CFS. They argue this condition represents a broader category of vaccine-related adverse effects called ASIA.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurasthenia: Modern Malady or Historical Relic?

Overholser, James C, Beale, Eleanor E·The Journal of nervous and mental disease·2019

This article looks back at a condition called neurasthenia that doctors diagnosed frequently between 1869 and 1930, then largely abandoned. The authors found that many symptoms people with neurasthenia experienced—like exhaustion, mental fog, and physical weakness—are still seen today in conditions like chronic fatigue syndrome (ME/CFS) and fibromyalgia. By understanding neurasthenia's history, modern doctors may better recognize and treat these conditions and improve how they listen to their patients.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroinflammation disorders exacerbated by environmental stressors.

O'Callaghan, James P, Miller, Diane B·Metabolism: clinical and experimental·2019

This review examines how inflammation in the brain and nervous system may be involved in ME/CFS and similar conditions. The authors suggest that various environmental stressors—like infections or other physical demands—can trigger or worsen this brain inflammation, leading to symptoms like fatigue, muscle pain, and brain fog. They propose that stress affects a key hormone system in the body (the HPA axis), which may play a role in how long these symptoms persist.

Neuroinflammation

E3 PreliminaryBehavioralPEM not requiredMechanistic

Mental fatigue is linked with attentional bias for sad stimuli.

Watanabe, Kyosuke, Sasaki, Akihiro T, Tajima, Kanako et al.·Scientific reports·2019

When healthy people become mentally tired from doing difficult thinking tasks, their brains start paying more attention to sad and negative images. This study used computer tasks to measure how people's attention shifts before and after mental exhaustion. The findings suggest that fatigue changes how our brains process sad information, which may help explain why ME/CFS patients often struggle with mood-related challenges.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review.

Cortes Rivera, Mateo, Mastronardi, Claudio, Silva-Aldana, Claudia T et al.·Diagnostics (Basel, Switzerland)·2019

ME/CFS is a serious, long-lasting illness that affects the brain and causes extreme fatigue and other symptoms, but doctors don't yet know what causes it. The condition is three times more common in women than men, usually starts between ages 20 and 45, and currently has no specific cure. This review summarizes what scientists know about ME/CFS by looking at how it affects the nervous system, immune system, and hormones.

Diagnostics

E3 PreliminaryMechanismPEM unclearMechanistic

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients.

Cabanas, H, Muraki, K, Balinas, C et al.·Molecular medicine (Cambridge, Mass.)·2019

This study looked at a specific type of protein channel (called TRPM3) found on immune cells called natural killer cells in ME/CFS patients. The researchers used specialized equipment to measure how these channels function and found they work differently in ME/CFS patients compared to healthy people. This difference could help explain why immune function is impaired in ME/CFS and might point toward new treatment options.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Cannabis-induced Acute Coronary Syndrome: A Coincidence or Not?

Landa, Eric, Vigandt, Erika, Andreev, Alexander et al.·Cureus·2019

This case report describes one patient who had a heart attack (myocardial infarction) shortly after smoking marijuana. The patient was a 42-year-old man with no previous heart problems who experienced chest pain at rest about one hour after using marijuana. The authors suggest that marijuana may have triggered the heart attack, though this is considered a rare occurrence.

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections.

Sepúlveda, Nuno, Carneiro, Jorge, Lacerda, Eliana et al.·Frontiers in immunology·2019

This study suggests that ME/CFS may develop when the body's immune system becomes overprotective in response to common viruses like EBV, HSV-1, or HHV-6. Normally, the immune system fights off infections and then settles down, but in ME/CFS patients, special immune cells called Tregs may keep the immune system in a constant state of alert. Using computer models, researchers showed how this could lead to ongoing inflammation and fatigue.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study.

Takakura, Shu, Oka, Takakazu, Sudo, Nobuyuki·BioPsychoSocial medicine·2019

This small study tested whether a gentle form of yoga (practiced lying down with adjustable resistance) could help ME/CFS patients feel less tired. Nine patients with ME/CFS who hadn't improved with standard treatment practiced this yoga for 3 months. Their fatigue scores improved significantly, and their blood showed changes in tiny molecules called microRNAs that may be related to how the yoga helped reduce their tiredness.

Biomarkers

E3 PreliminaryReviewPEM requiredReview-Narrative

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review.

Larrimore, Christopher, Ramnot, Amanda, Jaghab, Annmarie et al.·The Journal of the American Osteopathic Association·2019

This article reviews what scientists know about ME/CFS, including its symptoms, how it affects the body, and why it's hard to diagnose. The authors discuss both traditional medical approaches and osteopathic treatment (a type of hands-on therapy that focuses on the body's structure and function) as possible ways to help people with ME/CFS feel better. The review emphasizes that ME/CFS is a real, serious illness that deserves more awareness among doctors and better treatment options.

Immune SystemCognitive ImpairmentPost-Exertional Malaise

E3 PreliminaryCohortPEM unclearObservational

HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome.

Rodrigues, Lucas S, da Silva Nali, Luiz H, Leal, Cibele O D et al.·Auto- immunity highlights·2019

This study looked at whether certain viral fragments called HERV-K and HERV-W were more active in the blood of ME/CFS patients. Researchers found that HERV-K was elevated in people with moderate ME/CFS but not in those with severe disease, while HERV-W showed no difference. These findings suggest that viral elements may play a role in ME/CFS, though much more research is needed to understand what this means.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Postural orthostatic tachycardia syndrome (POTS): a common but unfamiliar syndrome.

van der Zalm, T, Alsma, J, van de Poll, S W E et al.·The Netherlands journal of medicine·2019

POTS is a condition where standing up quickly causes your heart to beat much faster than normal, and you may feel dizzy, tired, or unwell. This paper describes two different patients with POTS to show how differently the condition can appear from person to person. The authors explain that POTS can overlap with chronic fatigue syndrome and suggest that simple treatments like drinking more water and salt, along with exercise, often help before considering medications.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearMechanistic

The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS.

Kashi, Alex A, Davis, Ronald W, Phair, Robert D·Diagnostics (Basel, Switzerland)·2019

This study proposes a new theory about what might cause ME/CFS based on how the body processes an amino acid called tryptophan. The researchers suggest that if two proteins involved in tryptophan processing don't work properly together, the body could get stuck in a harmful state that causes ME/CFS symptoms. According to their mathematical model, if we could find a way to reset tryptophan levels back to normal, patients might recover.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Ryabkova, Varvara A, Churilov, Leonid P, Shoenfeld, Yehuda·International journal of molecular sciences·2019

This review explores three interconnected biological processes that may cause fibromyalgia and chronic fatigue syndrome (ME/CFS): the immune system attacking the body's own tissues, inflammation in the nervous system, and damage to small nerve fibers. The authors propose that these three mechanisms work together and may explain why patients experience widespread pain, extreme fatigue, and other symptoms like brain fog and sleep problems. They also examine whether similar mechanisms might explain some adverse reactions to HPV vaccination.

NeuroinflammationImmune System

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Can linguistic analysis be used to identify whether adolescents with a chronic illness are depressed?

A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction.

Patients' hopes for recovery from myalgic encephalomyelitis and chronic fatigue syndrome: Toward a "recovery in" framework.

Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome.

Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study.

Epstein-Barr Virus Induced Gene-2 Upregulation Identifies a Particular Subtype of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system.

Neurasthenia: Modern Malady or Historical Relic?

Neuroinflammation disorders exacerbated by environmental stressors.

Mental fatigue is linked with attentional bias for sad stimuli.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review.

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients.

Cannabis-induced Acute Coronary Syndrome: A Coincidence or Not?

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections.

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study.

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review.

HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome.

Postural orthostatic tachycardia syndrome (POTS): a common but unfamiliar syndrome.

The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS.

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

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