ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

761–780 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

[From neurasthenia to post-exertion disease: Evolution of the diagnostic criteria of chronic fatigue syndrome/myalgic encephalomyelitis].

Murga, Íñigo, Lafuente, José-Vicente·Atencion primaria·2019

This study traces how ME/CFS has been named and diagnosed over the past 150+ years, from 'neurasthenia' in the 1800s to today's 'post-exertional malaise.' The researchers reviewed medical literature to show how our understanding of this disease has evolved, and highlight that doctors still diagnose it mainly by symptoms and by ruling out other conditions, since no single biological marker has been found.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Understanding neuromuscular disorders in chronic fatigue syndrome.

Jammes, Yves, Retornaz, Frédérique·F1000Research·2019

This study examined how muscles work differently in people with ME/CFS. Researchers found that both the brain's ability to signal muscles and the muscles' ability to respond are impaired in ME/CFS patients. The muscles also appear to have trouble managing harmful molecules called free radicals, especially after exercise, and they may not be producing enough protective proteins that normally shield cells from damage.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

The DePaul Symptom Questionnaire-2: A Validation Study.

Bedree, Helen, Sunnquist, Madison, Jason, Leonard A·Fatigue : biomedicine, health & behavior·2019

Researchers improved a questionnaire called the DSQ-2 that helps doctors identify and understand ME/CFS by asking patients about their specific symptoms. They tested this updated questionnaire with 399 people who have ME or CFS and found that it works well at measuring the main symptoms of these illnesses, including post-exertional malaise (feeling worse after activity), brain fog, pain, and sleep problems. The questionnaire is now a more reliable tool for both diagnosing ME/CFS and understanding how the illness affects different people.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency.

Fijen, Lauré, Weijmer, Marcel·BMJ case reports·2019

This case report describes an elderly man with ME/CFS who developed serious kidney damage after taking high doses of vitamin C supplements. He also had a pancreatic condition that affected his ability to digest fats properly. The combination of these two factors caused harmful crystal buildup in his kidneys, leading to acute kidney failure that required dialysis treatment.

Energy Metabolism

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.

Bang, Sohyun, Yoo, DongAhn, Kim, Soo-Jin et al.·Scientific reports·2019

Researchers used artificial intelligence to analyze bacteria in the gut of patients with six different diseases, including ME/CFS, to see if gut bacteria patterns could help identify which disease a person has. They tested different computer learning methods and found that looking at bacteria at the genus level (a specific classification of microorganisms) worked best, and they identified certain bacterial groups that might serve as disease markers.

BiomarkersGut Microbiome

E3 PreliminaryMechanismPEM unclearMechanistic

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients.

Cabanas, H, Muraki, K, Balinas, C et al.·Molecular medicine (Cambridge, Mass.)·2019

This study looked at a specific type of protein channel (called TRPM3) found on immune cells called natural killer cells in ME/CFS patients. The researchers used specialized equipment to measure how these channels function and found they work differently in ME/CFS patients compared to healthy people. This difference could help explain why immune function is impaired in ME/CFS and might point toward new treatment options.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Use of Modafinil in Co-existing Major Depression and ErectileDysfunction: A Case Report].

Karaş, Hakan, Kaşer, Muzaffer·Turk psikiyatri dergisi = Turkish journal of psychiatry·2019

This case report describes one patient with depression who also had erectile dysfunction and fatigue. When the antidepressant fluoxetine alone did not fully help his symptoms, doctors added a stimulant medication called modafinil. After adding modafinil, the patient reported improvements in both his fatigue and erectile dysfunction alongside his mood symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Investigating the aetiology of adverse events following HPV vaccination with systems vaccinology.

Campbell-Tofte, Joan, Vrahatis, Aristidis, Josefsen, Knud et al.·Cellular and molecular life sciences : CMLS·2019

This paper proposes a research approach to investigate whether HPV vaccine can cause ME/CFS-like symptoms in some people. The authors suggest using detailed blood and immune system tests to compare vaccinated people who experienced problems with unvaccinated people who have similar symptoms, to see if the vaccine is actually responsible. This type of detailed comparison could help identify who might be at risk and provide objective evidence about vaccine safety.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Paediatric chronic fatigue syndrome patients' and parents' perceptions of recovery.

Harland, Matthew Robert, Parslow, Roxanne Morin, Anderson, Nina et al.·BMJ paediatrics open·2019

This study asked children with ME/CFS and their parents what 'recovery' would look like for them. Researchers found that recovery means different things to different people—some wanted to return to their old activity levels, others focused on having more flexibility in daily routines and not experiencing crashes after activities. Importantly, recovery was about much more than just feeling less tired; it was about rebuilding their lives and returning to normal activities like school and socializing.

E3 PreliminaryCommentaryPEM not required

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences.

Natelson, Benjamin H·Clinical therapeutics·2019

This article examines whether ME/CFS and fibromyalgia are the same illness or two different conditions. The author reviews existing research and concludes that while these conditions share some similarities, they appear to be distinct illnesses with different underlying causes. If they truly are different, it would mean doctors may eventually need different treatment approaches for each condition.

Diagnostics

E3 PreliminaryMechanismPEM requiredObservational

Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies.

Polli, Andrea, Van Oosterwijck, Jessica, Meeus, Mira et al.·Scandinavian journal of pain·2019

This study explored whether exercise-triggered immune system changes in ME/CFS patients are connected to increased pain sensitivity. Researchers compared immune markers and pain thresholds in ME/CFS patients and healthy people before and after two different types of exercise. They found a link between changes in a immune protein called C4a and pain sensitivity in ME/CFS patients, but this connection was weak and only showed up in some measurements.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Network structure underpinning (dys)homeostasis in chronic fatigue syndrome; Preliminary findings.

Clark, James E, Ng, Wan-Fai, Rushton, Stephen et al.·PloS one·2019

This study looked at how three key body systems (nervous system, stress hormone system, and immune system) work together in ME/CFS patients compared to healthy people. Researchers measured blood pressure, heart rate, and stress hormones at rest, then used a special mathematical approach to map how these measurements connect to each other. They found that in ME/CFS patients, these connections form a different pattern than in healthy controls, with a few key measurements being especially influential.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review.

Cortes Rivera, Mateo, Mastronardi, Claudio, Silva-Aldana, Claudia T et al.·Diagnostics (Basel, Switzerland)·2019

ME/CFS is a serious, long-lasting illness that affects the brain and causes extreme fatigue and other symptoms, but doctors don't yet know what causes it. The condition is three times more common in women than men, usually starts between ages 20 and 45, and currently has no specific cure. This review summarizes what scientists know about ME/CFS by looking at how it affects the nervous system, immune system, and hormones.

Diagnostics

E3 PreliminaryCommentaryPEM requiredEditorial

Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit.

Bohne, Victoria J Berdikova, Bohne, Øyvind·Medical hypotheses·2019

This paper proposes that ME/CFS might result from a problem in how the body converts fuel into energy, specifically involving a protein complex called the pyruvate dehydrogenase complex. The researchers suggest that when this complex isn't working properly, it causes lactate (a byproduct of metabolism) to build up suddenly in the body, which could explain the exhaustion and post-exertional malaise (worsening after activity) that patients experience. They propose that the body isn't efficiently recycling important molecules needed for energy production, leading to low energy and fatigue.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearCross-Sectional

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.

Perez, Melanie, Jaundoo, Rajeev, Hilton, Kelly et al.·Frontiers in pediatrics·2019

Researchers analyzed the DNA of 383 ME/CFS patients to look for genetic variations that might make someone more susceptible to developing the illness. They found thousands of genetic differences that were more common in ME/CFS patients compared to the general population, and these differences clustered in three main areas: immune system function, hormone regulation, and metabolism. While this suggests genetics may play a role in ME/CFS vulnerability, it doesn't explain the entire cause of the disease.

Energy MetabolismImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens.

Paredes, Stephania, Cantillo, Santiago, Candido, Kenneth D et al.·International journal of molecular sciences·2019

This review article explains how a brain chemical called serotonin affects pain perception, and how female hormones (estrogens) can influence serotonin levels. The authors examine the connection between serotonin, hormones, and several pain conditions including irritable bowel syndrome, fibromyalgia, and migraines. They suggest that targeting serotonin and hormone pathways might offer new treatment options for pain in the future.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Epstein-Barr virus (EBV) reactivation and therapeutic inhibitors.

Kerr, Jonathan R·Journal of clinical pathology·2019

This review examines how Epstein-Barr virus (EBV), a common virus that most people catch at some point in their lives, can become active again in the body—especially during stress—and may contribute to ME/CFS and other illnesses. The authors discuss ways to test for active EBV and review existing medications and supplements that might help prevent the virus from reactivating.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

The development of a short form of the DePaul Symptom Questionnaire.

Sunnquist, Madison, Lazarus, Savitri, Jason, Leonard A·Rehabilitation psychology·2019

Researchers created a shorter version of a commonly used questionnaire that measures ME/CFS symptoms. Instead of 99 questions, the new version has only 14 questions that capture the most important symptoms. This shorter form works well at identifying people with ME/CFS and can be easier for patients to complete, especially those with fatigue and thinking difficulties.

Diagnostics

E3 PreliminaryCohortPEM unclear

Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome/myalgic encephalomyelitis revealed by PET/MRI.

Sahbai, S, Kauv, P, Abrivard, M et al.·European journal of nuclear medicine and molecular imaging·2019

This study examined a single ME/CFS patient's brain using advanced imaging technology (PET/MRI) that can show both brain activity and blood flow simultaneously. The researchers found that certain areas in the back of the patient's brain showed significantly lower metabolic activity (meaning cells were using less energy), but blood flow to those same areas appeared normal. This unusual pattern suggests that ME/CFS may involve a specific type of brain dysfunction that current standard brain scans might miss.

Energy Metabolism

E3 PreliminaryMechanismPEM unclearMechanistic

Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

Cabanas, Helene, Muraki, Katsuhiko, Staines, Donald et al.·Frontiers in immunology·2019

This study looked at a protein channel called TRPM3 in immune cells from ME/CFS patients and found it wasn't working properly. The researchers discovered that a drug called naltrexone (an opioid blocker used off-label for ME/CFS) could restore the function of this damaged channel in laboratory tests. This finding suggests naltrexone may help ME/CFS symptoms by fixing this broken immune mechanism.

Immune System

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[From neurasthenia to post-exertion disease: Evolution of the diagnostic criteria of chronic fatigue syndrome/myalgic encephalomyelitis].

Understanding neuromuscular disorders in chronic fatigue syndrome.

The DePaul Symptom Questionnaire-2: A Validation Study.

Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency.

Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients.

[Use of Modafinil in Co-existing Major Depression and ErectileDysfunction: A Case Report].

Investigating the aetiology of adverse events following HPV vaccination with systems vaccinology.

Paediatric chronic fatigue syndrome patients' and parents' perceptions of recovery.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences.

Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies.

Network structure underpinning (dys)homeostasis in chronic fatigue syndrome; Preliminary findings.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review.

Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit.

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.

An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens.

Epstein-Barr virus (EBV) reactivation and therapeutic inhibitors.

The development of a short form of the DePaul Symptom Questionnaire.

Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome/myalgic encephalomyelitis revealed by PET/MRI.

Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

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