ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

761–780 of 2,423 studies

E3 PreliminaryCohortPEM unclearCross-Sectional

Dismissing chronic illness: A qualitative analysis of negative health care experiences.

McManimen, Stephanie, McClellan, Damani, Stoothoff, Jamie et al.·Health care for women international·2019

This study looked at why some ME/CFS patients feel dismissed by their doctors. Researchers asked patients online to describe negative experiences with healthcare providers and found common themes in how they were treated. The study highlights that many doctors don't have proper training about ME/CFS, which leads to unhelpful advice like exercising more or seeing a psychiatrist, and suggests ways the healthcare system can better support these patients.

E3 PreliminaryReviewPEM unclearReview-Narrative

Differential diagnosis between "chronic fatigue" and "chronic fatigue syndrome".

Son, Chang-Gue·Integrative medicine research·2019

This article discusses the important difference between regular chronic fatigue (long-lasting tiredness) and Chronic Fatigue Syndrome (ME/CFS), a serious medical condition. The author explains why it's crucial to distinguish between these two conditions, since ME/CFS involves specific symptoms and has different causes than simple persistent tiredness.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Cannabis-induced Acute Coronary Syndrome: A Coincidence or Not?

Landa, Eric, Vigandt, Erika, Andreev, Alexander et al.·Cureus·2019

This case report describes one patient who had a heart attack (myocardial infarction) shortly after smoking marijuana. The patient was a 42-year-old man with no previous heart problems who experienced chest pain at rest about one hour after using marijuana. The authors suggest that marijuana may have triggered the heart attack, though this is considered a rare occurrence.

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

The DePaul Symptom Questionnaire-2: A Validation Study.

Bedree, Helen, Sunnquist, Madison, Jason, Leonard A·Fatigue : biomedicine, health & behavior·2019

Researchers improved a questionnaire called the DSQ-2 that helps doctors identify and understand ME/CFS by asking patients about their specific symptoms. They tested this updated questionnaire with 399 people who have ME or CFS and found that it works well at measuring the main symptoms of these illnesses, including post-exertional malaise (feeling worse after activity), brain fog, pain, and sleep problems. The questionnaire is now a more reliable tool for both diagnosing ME/CFS and understanding how the illness affects different people.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency.

Fijen, Lauré, Weijmer, Marcel·BMJ case reports·2019

This case report describes an elderly man with ME/CFS who developed serious kidney damage after taking high doses of vitamin C supplements. He also had a pancreatic condition that affected his ability to digest fats properly. The combination of these two factors caused harmful crystal buildup in his kidneys, leading to acute kidney failure that required dialysis treatment.

Energy Metabolism

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.

Bang, Sohyun, Yoo, DongAhn, Kim, Soo-Jin et al.·Scientific reports·2019

Researchers used artificial intelligence to analyze bacteria in the gut of patients with six different diseases, including ME/CFS, to see if gut bacteria patterns could help identify which disease a person has. They tested different computer learning methods and found that looking at bacteria at the genus level (a specific classification of microorganisms) worked best, and they identified certain bacterial groups that might serve as disease markers.

BiomarkersGut Microbiome

E3 PreliminaryCohortPEM not requiredCase-Control

[Use of Modafinil in Co-existing Major Depression and ErectileDysfunction: A Case Report].

Karaş, Hakan, Kaşer, Muzaffer·Turk psikiyatri dergisi = Turkish journal of psychiatry·2019

This case report describes one patient with depression who also had erectile dysfunction and fatigue. When the antidepressant fluoxetine alone did not fully help his symptoms, doctors added a stimulant medication called modafinil. After adding modafinil, the patient reported improvements in both his fatigue and erectile dysfunction alongside his mood symptoms.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.

Perez, Melanie, Jaundoo, Rajeev, Hilton, Kelly et al.·Frontiers in pediatrics·2019

Researchers analyzed the DNA of 383 ME/CFS patients to look for genetic variations that might make someone more susceptible to developing the illness. They found thousands of genetic differences that were more common in ME/CFS patients compared to the general population, and these differences clustered in three main areas: immune system function, hormone regulation, and metabolism. While this suggests genetics may play a role in ME/CFS vulnerability, it doesn't explain the entire cause of the disease.

Energy MetabolismImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurasthenia: Modern Malady or Historical Relic?

Overholser, James C, Beale, Eleanor E·The Journal of nervous and mental disease·2019

This article looks back at a condition called neurasthenia that doctors diagnosed frequently between 1869 and 1930, then largely abandoned. The authors found that many symptoms people with neurasthenia experienced—like exhaustion, mental fog, and physical weakness—are still seen today in conditions like chronic fatigue syndrome (ME/CFS) and fibromyalgia. By understanding neurasthenia's history, modern doctors may better recognize and treat these conditions and improve how they listen to their patients.

Diagnostics

E3 PreliminaryCohortPEM unclearCross-Sectional

Paediatric chronic fatigue syndrome patients' and parents' perceptions of recovery.

Harland, Matthew Robert, Parslow, Roxanne Morin, Anderson, Nina et al.·BMJ paediatrics open·2019

This study asked children with ME/CFS and their parents what 'recovery' would look like for them. Researchers found that recovery means different things to different people—some wanted to return to their old activity levels, others focused on having more flexibility in daily routines and not experiencing crashes after activities. Importantly, recovery was about much more than just feeling less tired; it was about rebuilding their lives and returning to normal activities like school and socializing.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome and chronic pain conditions - vitally protective systems gone wrong.

Pedersen, Maria·Scandinavian journal of pain·2019

This review explains that ME/CFS and chronic pain conditions share important similarities—both involve protective body signals that were helpful in the short term but become problematic when they persist long-term. The authors suggest that our brain's tendency to anticipate and predict threats may play a role in keeping these conditions going, which helps explain why treatments focusing on stress relief and changing thought patterns can sometimes help patients improve.

Pain and Sensitization

E3 PreliminaryCommentaryPEM not required

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences.

Natelson, Benjamin H·Clinical therapeutics·2019

This article examines whether ME/CFS and fibromyalgia are the same illness or two different conditions. The author reviews existing research and concludes that while these conditions share some similarities, they appear to be distinct illnesses with different underlying causes. If they truly are different, it would mean doctors may eventually need different treatment approaches for each condition.

Diagnostics

E3 PreliminaryMechanismPEM requiredObservational

Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies.

Polli, Andrea, Van Oosterwijck, Jessica, Meeus, Mira et al.·Scandinavian journal of pain·2019

This study explored whether exercise-triggered immune system changes in ME/CFS patients are connected to increased pain sensitivity. Researchers compared immune markers and pain thresholds in ME/CFS patients and healthy people before and after two different types of exercise. They found a link between changes in a immune protein called C4a and pain sensitivity in ME/CFS patients, but this connection was weak and only showed up in some measurements.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Network structure underpinning (dys)homeostasis in chronic fatigue syndrome; Preliminary findings.

Clark, James E, Ng, Wan-Fai, Rushton, Stephen et al.·PloS one·2019

This study looked at how three key body systems (nervous system, stress hormone system, and immune system) work together in ME/CFS patients compared to healthy people. Researchers measured blood pressure, heart rate, and stress hormones at rest, then used a special mathematical approach to map how these measurements connect to each other. They found that in ME/CFS patients, these connections form a different pattern than in healthy controls, with a few key measurements being especially influential.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review.

Cortes Rivera, Mateo, Mastronardi, Claudio, Silva-Aldana, Claudia T et al.·Diagnostics (Basel, Switzerland)·2019

ME/CFS is a serious, long-lasting illness that affects the brain and causes extreme fatigue and other symptoms, but doctors don't yet know what causes it. The condition is three times more common in women than men, usually starts between ages 20 and 45, and currently has no specific cure. This review summarizes what scientists know about ME/CFS by looking at how it affects the nervous system, immune system, and hormones.

Diagnostics

E3 PreliminaryCommentaryPEM requiredEditorial

Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit.

Bohne, Victoria J Berdikova, Bohne, Øyvind·Medical hypotheses·2019

This paper proposes that ME/CFS might result from a problem in how the body converts fuel into energy, specifically involving a protein complex called the pyruvate dehydrogenase complex. The researchers suggest that when this complex isn't working properly, it causes lactate (a byproduct of metabolism) to build up suddenly in the body, which could explain the exhaustion and post-exertional malaise (worsening after activity) that patients experience. They propose that the body isn't efficiently recycling important molecules needed for energy production, leading to low energy and fatigue.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens.

Paredes, Stephania, Cantillo, Santiago, Candido, Kenneth D et al.·International journal of molecular sciences·2019

This review article explains how a brain chemical called serotonin affects pain perception, and how female hormones (estrogens) can influence serotonin levels. The authors examine the connection between serotonin, hormones, and several pain conditions including irritable bowel syndrome, fibromyalgia, and migraines. They suggest that targeting serotonin and hormone pathways might offer new treatment options for pain in the future.

Pain and Sensitization

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

The development of a short form of the DePaul Symptom Questionnaire.

Sunnquist, Madison, Lazarus, Savitri, Jason, Leonard A·Rehabilitation psychology·2019

Researchers created a shorter version of a commonly used questionnaire that measures ME/CFS symptoms. Instead of 99 questions, the new version has only 14 questions that capture the most important symptoms. This shorter form works well at identifying people with ME/CFS and can be easier for patients to complete, especially those with fatigue and thinking difficulties.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Oxidative stress in exercise training: the involvement of inflammation and peripheral signals.

Magherini, Francesca, Fiaschi, Tania, Marzocchini, Riccardo et al.·Free radical research·2019

When we exercise, our bodies produce harmful molecules called free radicals that can damage cells. While some free radicals are normal and needed for muscle function, too many can cause problems. This review explains how intense exercise, stress, and not eating enough can create excessive free radicals and inflammation, which might lead to chronic fatigue and overtraining syndrome—conditions where the body cannot recover properly from exercise.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types.

Tomas, Cara, Brown, Audrey E, Newton, Julia L et al.·PeerJ·2019

This study looked at whether the powerhouses of cells (mitochondria) work differently in ME/CFS patients compared to healthy people. Researchers tested muscle cells and immune cells from the blood using a special technique to measure how well different parts of the mitochondrial energy-production system functioned. Surprisingly, they found no significant differences between ME/CFS patients and healthy controls, suggesting that if mitochondria aren't working properly in ME/CFS, the problem may occur before it reaches the mitochondria itself.

Energy Metabolism

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Dismissing chronic illness: A qualitative analysis of negative health care experiences.

Differential diagnosis between "chronic fatigue" and "chronic fatigue syndrome".

Cannabis-induced Acute Coronary Syndrome: A Coincidence or Not?

The DePaul Symptom Questionnaire-2: A Validation Study.

Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency.

Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.

[Use of Modafinil in Co-existing Major Depression and ErectileDysfunction: A Case Report].

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.

Neurasthenia: Modern Malady or Historical Relic?

Paediatric chronic fatigue syndrome patients' and parents' perceptions of recovery.

Chronic Fatigue Syndrome and chronic pain conditions - vitally protective systems gone wrong.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences.

Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies.

Network structure underpinning (dys)homeostasis in chronic fatigue syndrome; Preliminary findings.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review.

Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit.

An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens.

The development of a short form of the DePaul Symptom Questionnaire.

Oxidative stress in exercise training: the involvement of inflammation and peripheral signals.

Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types.

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Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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