ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

801–820 of 2,420 studies

E3 PreliminaryMechanismPEM unclearMechanistic

Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME.

Scheibenbogen, Carmen, Loebel, Madlen, Freitag, Helma et al.·PloS one·2018

This small study tested whether a blood-cleaning procedure called immunoadsorption could help ME/CFS patients who have specific antibodies attacking their nervous system. Ten patients received this treatment over 5 days, and seven reported symptom improvement during the procedure. Three patients had improvements lasting 6-12+ months, suggesting the treatment may help some people, though more research is needed.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach.

Strassheim, Victoria, Welford, Jenny, Ballantine, Rob et al.·Autonomic neuroscience : basic & clinical·2018

This review examines fatigue in people with PoTS (postural tachycardia syndrome), a condition where heart rate increases abnormally when standing. The authors explain why fatigue happens in PoTS, how it overlaps with ME/CFS, and describe practical approaches doctors can use to help manage it by treating the individual causes of fatigue in each patient.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity.

Proal, Amy, Marshall, Trevor·Frontiers in pediatrics·2018

This review explores the idea that ME/CFS may be caused by persistent infections (like Epstein-Barr virus) that disrupt the body's microbial communities and normal cell functions. These infections can interfere with how cells work, how genes are expressed, and how the immune system responds, potentially leading to the chronic symptoms patients experience. The authors suggest that treating ME/CFS might involve helping the immune system fight these persistent infections.

Energy MetabolismImmune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Rahmadi, Ridho, Groot, Perry, van Rijn, Marieke Hc et al.·Statistical methods in medical research·2018

This study developed a new statistical method for finding cause-and-effect relationships in long-term health data, even when sample sizes are small. The researchers tested their method on data from people with chronic fatigue syndrome, Alzheimer's disease, and chronic kidney disease, and found it could identify stable patterns of how different health factors influence each other over time.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Functional brain connectivity of remembered fatigue or happiness in healthy adults: Use of arterial spin labeling.

Boissoneault, Jeff, Sevel, Landrew, Robinson, Michael E et al.·Journal of clinical and experimental neuropsychology·2018

Researchers used brain scans to study what happens in the brain when healthy people remember feeling tired versus happy. They found that fatigue activated different brain regions than happiness did, particularly areas involved in vision and a structure called the globus pallidum. This helps scientists understand the brain basis of fatigue without the complications of studying people who have chronic fatigue syndrome with other medical conditions.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[New Diagnostic Biomarkers for Chronic Fatigue Syndrome].

Yamano, Emi, Kataoka, Yosky·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study looked at the chemicals and compounds in the blood of people with ME/CFS compared to healthy people to find objective markers that could help doctors diagnose the condition. Researchers used advanced testing methods to examine how the body's metabolism, immune system, and hormones differ in people with ME/CFS. The goal was to develop a simple blood test that could definitively identify ME/CFS, since there is currently no reliable diagnostic test.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

Challenges in fibromyalgia diagnosis: from meaning of symptoms to fibromyalgia labeling.

Bidari, Ali, Ghavidel Parsa, Banafsheh, Ghalehbaghi, Babak·The Korean journal of pain·2018

Fibromyalgia (FM) is difficult to diagnose because there is no clear dividing line between having FM and not having it. This review examines why doctors and patients struggle with FM diagnosis, including how symptoms vary between people and over time, and how cultural and emotional factors influence whether a doctor labels someone as having FM. The authors argue that doctors' judgment based on talking with patients may be more reliable than relying only on scoring systems.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.

Lacourt, Tamara E, Vichaya, Elisabeth G, Chiu, Gabriel S et al.·Frontiers in behavioral neuroscience·2018

This study explores why people with ME/CFS experience persistent fatigue by examining how inflammation in the body may damage cells' ability to produce energy. The researchers propose that chronic inflammation forces cells to switch to a less efficient energy-production method, while at the same time the body may be spending energy at rates it cannot sustain, creating an energy crisis. Sleep problems and disrupted body rhythms may also play a role in this imbalance.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Insights & Advances in Care.

Bested, Alison·Alternative therapies in health and medicine·2018

This article reviews current knowledge and treatment options for ME/CFS, a condition that causes severe fatigue and other symptoms that get worse with activity. The author, Dr. Alison Bested, discusses what we know about how the condition affects the body and explores various approaches to managing symptoms and improving quality of life.

E3 PreliminaryMechanismPEM unclearMechanistic

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.

Shao, Changzhuan, Song, Jing, Zhao, Shanguang et al.·Polymers·2018

Researchers tested whether a compound called selenium-polysaccharide (Se-TP) from a Chinese green tea called Ziyang could help rats with fatigue similar to ME/CFS. They found that the treatment improved certain markers in the rats' blood and urine, suggesting it may work by affecting how the body makes and uses steroid hormones and processes amino acids.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Fatigue Is Associated With Altered Monitoring and Preparation of Physical Effort in Patients With Chronic Fatigue Syndrome.

van der Schaaf, Marieke E, Roelofs, Karin, de Lange, Floris P et al.·Biological psychiatry. Cognitive neuroscience and neuroimaging·2018

This study used brain imaging to understand why people with ME/CFS feel so fatigued and struggle with physical effort. Researchers asked patients and healthy people to squeeze a hand device at different force levels and give them feedback on their performance. People with ME/CFS were more likely to use less effort after feedback, especially at higher effort levels, and this related to lower activity in a brain region involved in decision-making and planning.

E3 PreliminaryReviewPEM unclearReview-Narrative

Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome.

Pietrangelo, Tiziana, Fulle, Stefania, Coscia, Francesco et al.·European journal of translational myology·2018

This study found that muscles in people with ME/CFS show patterns similar to muscles in elderly people, even though the patients are young. The researchers discovered problems with how muscles use energy, handle calcium, and produce new muscle protein. Importantly, the findings suggest that appropriate physical activity may actually help rather than harm, though the right type and intensity still need to be determined.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Tutorial: The practical application of longitudinal structural equation mediation models in clinical trials.

Goldsmith, Kimberley A, MacKinnon, David P, Chalder, Trudie et al.·Psychological methods·2018

This tutorial paper explains how researchers can better understand how treatments work by measuring patients multiple times throughout a study, rather than just at the beginning and end. It uses the PACE trial (a study about treatments for ME/CFS) as an example to teach researchers different statistical methods for analyzing whether a treatment works by changing something specific in a patient's body or behavior.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Clinical Criteria of Central Sensitization in Chronic Pelvic and Perineal Pain (Convergences PP Criteria): Elaboration of a Clinical Evaluation Tool Based on Formal Expert Consensus.

Levesque, Amélie, Riant, Thibault, Ploteau, Stéphane et al.·Pain medicine (Malden, Mass.)·2018

This study created a simple checklist to help doctors identify when chronic pelvic pain is caused by the nervous system becoming overly sensitive, rather than from a structural injury or disease they can see on tests. Experts agreed on 10 key signs to look for, including pain that changes in intensity, pain triggered by normal activities, and having other conditions like fibromyalgia or chronic fatigue syndrome alongside pelvic pain.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Yamamura, Takashi, Ono, Hirohiko, Sato, Wakiro·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study found that people with ME/CFS have unusual patterns of immune system chemicals (cytokines) in their blood and spinal fluid, and some patients have antibodies that attack their own bodies. When researchers treated some ME/CFS patients with a medication that removes certain immune cells called B cells, patients improved. This suggests that ME/CFS may be caused by the immune system mistakenly attacking the body.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Changes in fatigue, autonomic functions, and blood biomarkers due to sitting isometric yoga in patients with chronic fatigue syndrome.

Oka, Takakazu, Tanahashi, Tokusei, Sudo, Nobuyuki et al.·BioPsychoSocial medicine·2018

This study tested whether a gentle form of yoga practiced while sitting could help reduce fatigue in ME/CFS patients. Fifteen patients who had not improved with standard treatments did sitting isometric yoga twice a week with an instructor plus daily practice at home for eight weeks. After a single session, patients reported feeling less tired and more energetic, with their bodies showing signs of reduced stress and inflammation.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Macrophagic myofasciitis-associated dysfunctioning: An update of neuropsychological and neuroimaging features.

Aoun Sebaiti, Mehdi, Abrivard, Marie, Blanc-Durand, Paul et al.·Best practice & research. Clinical rheumatology·2018

Macrophagic myofasciitis (MMF) is a condition where aluminum particles from vaccines remain in muscle tissue and trigger long-term inflammation and immune system problems. People with MMF often experience fatigue, joint and muscle pain, and cognitive difficulties like trouble concentrating and memory problems. Brain imaging shows abnormalities in specific regions, suggesting these cognitive problems are caused by actual changes in the brain.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats.

Park, Hyun-Jung, Shim, Hyun Soo, Lee, Sunyoung et al.·BMC complementary and alternative medicine·2018

Researchers tested whether a supplement made from human placenta could help reduce stress-related depression and fatigue in rats. They found that rats treated with this supplement showed improvements in depression-like behaviors and had better antioxidant protection in their brains compared to untreated rats.

E3 PreliminaryReviewPEM unclearReview-Narrative

Recent insights into 3 underrecognized conditions: Myalgic encephalomyelitis-chronic fatigue syndrome, fibromyalgia, and environmental sensitivities-multiple chemical sensitivity.

Hu, Howard, Baines, Cornelia·Canadian family physician Medecin de famille canadien·2018

This review article examines three conditions that doctors often overlook or misunderstand: ME/CFS, fibromyalgia, and multiple chemical sensitivity. The authors discuss why these conditions are frequently underrecognized and how they affect patients' lives. They highlight that these conditions are real medical problems that deserve proper attention and care.

E3 PreliminaryMechanismPEM unclearMechanistic

Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation.

Eaton, Natalie, Cabanas, Hélène, Balinas, Cassandra et al.·BMC pharmacology & toxicology·2018

This study examined how a drug called Rituximab affects natural killer (NK) cells—immune cells that help fight infections—in people with ME/CFS. Researchers tested blood samples from 8 ME/CFS patients and 9 healthy people in a lab dish. When exposed to Rituximab, NK cells from ME/CFS patients became less effective at killing infected cells and showed signs of stress, suggesting the drug might harm these already-weakened immune cells.

Immune System

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Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME.

Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity.

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Functional brain connectivity of remembered fatigue or happiness in healthy adults: Use of arterial spin labeling.

[New Diagnostic Biomarkers for Chronic Fatigue Syndrome].

Challenges in fibromyalgia diagnosis: from meaning of symptoms to fibromyalgia labeling.

The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Insights & Advances in Care.

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.

Fatigue Is Associated With Altered Monitoring and Preparation of Physical Effort in Patients With Chronic Fatigue Syndrome.

Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome.

Tutorial: The practical application of longitudinal structural equation mediation models in clinical trials.

Clinical Criteria of Central Sensitization in Chronic Pelvic and Perineal Pain (Convergences PP Criteria): Elaboration of a Clinical Evaluation Tool Based on Formal Expert Consensus.

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Changes in fatigue, autonomic functions, and blood biomarkers due to sitting isometric yoga in patients with chronic fatigue syndrome.

Macrophagic myofasciitis-associated dysfunctioning: An update of neuropsychological and neuroimaging features.

Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats.

Recent insights into 3 underrecognized conditions: Myalgic encephalomyelitis-chronic fatigue syndrome, fibromyalgia, and environmental sensitivities-multiple chemical sensitivity.

Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research