ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

841–860 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Petrescu, Anca D, Kain, Jessica, Liere, Victoria et al.·Frontiers in endocrinology·2018

This review examines how the stress hormone system (HPA axis) works and what happens when it breaks down in people with liver disease. The HPA axis is like your body's control center that manages stress responses and many other important functions. The authors explain how inflammation in the liver can disrupt this system, potentially leading to the fatigue and other symptoms seen in both liver disease and chronic fatigue syndrome.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Brain Science on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Watanabe, Yasuyoshi·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study examined the brains of people with ME/CFS using three types of imaging technology (PET scans, MRI, and MEG) to look for physical differences compared to healthy people. Researchers found that people with ME/CFS have reduced blood flow and energy use in certain brain areas, decreased levels of important chemical messengers, and inflammation in the brain that appears connected to symptom severity. These findings suggest ME/CFS involves real, measurable brain changes rather than being purely psychological.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Narcolepsy and Other 'Central Disorders of Hypersomnolence'].

Mathis, Johannes·Praxis·2018

This article discusses how doctors can tell the difference between several sleep-related conditions that cause excessive daytime sleepiness or fatigue. The authors explain that complaints like tiredness and fatigue are common, but they can have many different causes. Careful diagnosis using sleep studies and other tests is needed to distinguish narcolepsy, idiopathic hypersomnia, and chronic fatigue syndrome from one another, since each condition requires different treatments.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome and quality of life.

Roberts, Deb·Patient related outcome measures·2018

This study looked at how to measure quality of life in people with ME/CFS, since this condition affects many different aspects of daily living in complex ways. The researchers reviewed existing tools that ask patients about their wellbeing and found that current measures don't fully capture the unique experience of ME/CFS. They explored whether a standard quality-of-life questionnaire from the World Health Organization could work for ME/CFS patients and help doctors track how well treatments are working.

E3 PreliminaryReviewPEM unclearReview-Narrative

[History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Watanabe, Yasuyoshi, Kuratsune, Hirohiko·Brain and nerve = Shinkei kenkyu no shinpo·2018

This review summarizes research on ME/CFS conducted in Japan since the disease was first identified there in 1990. Scientists have been searching for objective biological markers to help diagnose ME/CFS and understand what causes it. Recent brain imaging studies found evidence of immune cell activation in the brains of ME/CFS patients, which may be linked to the severity of their symptoms.

NeuroinflammationBiomarkers

E3 PreliminaryMechanismPEM unclearMechanistic

Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation.

Eaton, Natalie, Cabanas, Hélène, Balinas, Cassandra et al.·BMC pharmacology & toxicology·2018

This study examined how a drug called Rituximab affects natural killer (NK) cells—immune cells that help fight infections—in people with ME/CFS. Researchers tested blood samples from 8 ME/CFS patients and 9 healthy people in a lab dish. When exposed to Rituximab, NK cells from ME/CFS patients became less effective at killing infected cells and showed signs of stress, suggesting the drug might harm these already-weakened immune cells.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Dong, Jia-Zi, Wei, Yun-Tao, Xu, Huan-Yu et al.·Zhen ci yan jiu = Acupuncture research·2018

This study tested whether acupuncture at a specific point (ST 36) could improve muscle weakness in rats with a chronic fatigue condition. Researchers found that the treatment increased muscle strength and improved how the rats' muscles produce energy by activating protective cellular pathways. The results suggest acupuncture may help muscle cells work more efficiently and reduce damage from fatigue.

Energy Metabolism

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Measurement error, time lag, unmeasured confounding: Considerations for longitudinal estimation of the effect of a mediator in randomised clinical trials.

Goldsmith, K A, Chalder, T, White, P D et al.·Statistical methods in medical research·2018

This study examined how treatments work in the PACE trial by using advanced statistical methods to track changes in patients' symptoms and functioning over time. The researchers tested different ways of analyzing data to understand whether improvements in one area (like activity levels) might explain improvements in another area (like fatigue). They found that accounting for measurement errors and considering the timing of measurements was important for getting accurate results.

E3 PreliminaryMechanismPEM unclearObservational

Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.

Wallis, Amy, Ball, Michelle, Butt, Henry et al.·Journal of translational medicine·2018

This study tested whether treating an overgrowth of Streptococcus bacteria in the gut could help ME/CFS patients, particularly those with brain fog and sleep problems. Forty-four patients received alternating weeks of an antibiotic and a probiotic for 4 weeks. The treatment reduced the problematic bacteria and improved several symptoms including sleep quality, attention, and memory, though it did not significantly affect fatigue or mood.

SleepCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

Morris, Gerwyn, Stubbs, Brendon, Köhler, Cristiano A et al.·Sleep medicine reviews·2018

This review explores why people with ME/CFS, bipolar disorder, and multiple sclerosis often have severe sleep problems. The authors suggest that inflammation and stress in the body's cells may damage the brain's ability to control sleep and daily rhythms. They propose that when the immune system stays activated, it can trigger harmful processes that disrupt sleep, which then makes inflammation worse—creating a harmful cycle.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Case Study of Homeopathic Bowel Nosode Remedies for Dysbiotic Japanese Patients.

Uchiyama-Tanaka, Yoko·Journal of alternative and complementary medicine (New York, N.Y.)·2018

This study tested homeopathic bowel remedies (made from old bacterial samples) in 28 Japanese patients with digestive problems like constipation and diarrhea. About 70% of patients reported some improvement in their symptoms, and no harmful side effects were reported. The researchers suggest these remedies might be a simpler and cheaper option for treating gut-related digestive issues.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Rahmadi, Ridho, Groot, Perry, van Rijn, Marieke Hc et al.·Statistical methods in medical research·2018

This study developed a new statistical method for finding cause-and-effect relationships in long-term health data, even when sample sizes are small. The researchers tested their method on data from people with chronic fatigue syndrome, Alzheimer's disease, and chronic kidney disease, and found it could identify stable patterns of how different health factors influence each other over time.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Brain function characteristics of chronic fatigue syndrome: A task fMRI study.

Shan, Zack Y, Finegan, Kevin, Bhuta, Sandeep et al.·NeuroImage. Clinical·2018

This study compared brain activity in ME/CFS patients and healthy people while they performed a challenging word-color matching task. ME/CFS patients were slower at the task, and their brains showed different patterns of activity—specifically, the brain signals were less complex and adaptive. The findings suggest that ME/CFS patients' brains may need to work harder or recruit more areas to handle cognitive challenges.

Cognitive Impairment

E3 PreliminaryGuidelinePEM requiredGuideline

[Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Kuratsune, Hirohiko·Brain and nerve = Shinkei kenkyu no shinpo·2018

This document presents official diagnostic criteria for ME/CFS developed by Japanese health authorities in 2016. These criteria were designed to help doctors in primary care clinics recognize and diagnose ME/CFS more consistently. The document also summarizes current treatment approaches and expected outcomes based on practices at major medical centers in Japan.

Diagnostics

E3 PreliminaryGuidelinePEM not requiredGuideline

Therapeutic patient education in adrenal insufficiency.

Guignat, Laurence·Annales d'endocrinologie·2018

This study describes educational programs that help patients with adrenal insufficiency (a condition where the adrenal glands don't make enough hormones) manage their condition safely. The programs teach patients to recognize warning signs of a dangerous crisis, carry emergency medication, adjust their doses for different situations like exercise or travel, and know when to seek medical help. The study notes that similar programs could help people with chronic fatigue syndrome avoid taking too much of their medication.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

The Development of the DePaul Symptom Questionnaire: Original, Expanded, Brief, and Pediatric Versions.

Jason, Leonard A, Sunnquist, Madison·Frontiers in pediatrics·2018

Researchers created a questionnaire called the DePaul Symptom Questionnaire (DSQ) to help doctors and scientists consistently measure ME/CFS symptoms in patients. The questionnaire was refined over time and adapted for different groups, including children. This tool helps ensure that when people are diagnosed with ME/CFS, they're being assessed in the same way across different clinics and studies.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

[Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Nakatomi, Yasuhito, Kuratsune, Hirohiko, Watanabe, Yasuyoshi·Brain and nerve = Shinkei kenkyu no shinpo·2018

Researchers used a special imaging scan called PET to look at the brains of people with ME/CFS and found signs of inflammation (immune system activation) throughout several brain regions. This inflammation was connected to how severe patients' symptoms were, including problems with thinking and memory, as well as widespread pain. This discovery suggests that ME/CFS involves measurable changes in the brain that could eventually lead to better ways to diagnose and treat the condition.

NeuroinflammationBiomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis.

Tomljenovic, Dejan, Baudoin, Tomislav, Megla, Zeljka Bukovec et al.·Medical hypotheses·2018

This study looked at how men and women with seasonal allergies respond differently to nasal irritants. Researchers found that women had stronger burning sensations and higher levels of a nerve-signaling chemical called substance P compared to men when exposed to salt water or allergen challenges. This suggests that women's bodies may process nasal irritation through a different biological pathway involving both immune cells and nerve signals.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Macrophagic myofasciitis-associated dysfunctioning: An update of neuropsychological and neuroimaging features.

Aoun Sebaiti, Mehdi, Abrivard, Marie, Blanc-Durand, Paul et al.·Best practice & research. Clinical rheumatology·2018

Macrophagic myofasciitis (MMF) is a condition where aluminum particles from vaccines remain in muscle tissue and trigger long-term inflammation and immune system problems. People with MMF often experience fatigue, joint and muscle pain, and cognitive difficulties like trouble concentrating and memory problems. Brain imaging shows abnormalities in specific regions, suggesting these cognitive problems are caused by actual changes in the brain.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

Wang, Xue, Qu, Yidi, Zhang, Yongfeng et al.·Oxidative medicine and cellular longevity·2018

This study tested whether a medicinal mushroom called Sarcodon imbricatus could reduce fatigue in mice with chronic fatigue syndrome. The mushroom extract improved the mice's exercise ability, reduced tiredness, and boosted the body's natural antioxidant defenses—systems that protect cells from damage.

Energy Metabolism

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

[Brain Science on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

[Narcolepsy and Other 'Central Disorders of Hypersomnolence'].

Chronic fatigue syndrome and quality of life.

[History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation.

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Measurement error, time lag, unmeasured confounding: Considerations for longitudinal estimation of the effect of a mediator in randomised clinical trials.

Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

Case Study of Homeopathic Bowel Nosode Remedies for Dysbiotic Japanese Patients.

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Brain function characteristics of chronic fatigue syndrome: A task fMRI study.

[Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Therapeutic patient education in adrenal insufficiency.

The Development of the DePaul Symptom Questionnaire: Original, Expanded, Brief, and Pediatric Versions.

[Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis.

Macrophagic myofasciitis-associated dysfunctioning: An update of neuropsychological and neuroimaging features.

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research