ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

841–860 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Espejo, José Andrés, García-Escudero, María, Oltra, Elisa·International journal of molecular sciences·2018

This review examines how manual therapy—such as massage and physical manipulation—might help people with fibromyalgia and ME/CFS by studying what happens at the cellular and molecular level. The authors argue that manual therapy could work by triggering the body's natural healing responses, and they suggest it might be particularly helpful for ME/CFS patients because it can gently condition muscles without requiring strenuous exercise that typically worsens symptoms.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric Properties and Factor Structure of a Long and Shortened Version of the Cognitive and Behavioural Responses Questionnaire.

Ryan, Elizabeth G, Vitoratou, Silia, Goldsmith, Kimberley A et al.·Psychosomatic medicine·2018

This study tested a questionnaire designed to measure how people with ME/CFS think and behave in response to their illness—such as pushing through fatigue or avoiding activity. Researchers created a shorter, easier-to-use version of the original questionnaire by removing unnecessary questions while keeping the important ones. Both versions were found to be reliable and accurate tools for understanding these psychological responses.

Cognitive Impairment

E3 PreliminaryMechanismPEM unclearMechanistic

Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation.

Eaton, Natalie, Cabanas, Hélène, Balinas, Cassandra et al.·BMC pharmacology & toxicology·2018

This study examined how a drug called Rituximab affects natural killer (NK) cells—immune cells that help fight infections—in people with ME/CFS. Researchers tested blood samples from 8 ME/CFS patients and 9 healthy people in a lab dish. When exposed to Rituximab, NK cells from ME/CFS patients became less effective at killing infected cells and showed signs of stress, suggesting the drug might harm these already-weakened immune cells.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Watanabe, Yasuyoshi, Kuratsune, Hirohiko·Brain and nerve = Shinkei kenkyu no shinpo·2018

This review summarizes research on ME/CFS conducted in Japan since the disease was first identified there in 1990. Scientists have been searching for objective biological markers to help diagnose ME/CFS and understand what causes it. Recent brain imaging studies found evidence of immune cell activation in the brains of ME/CFS patients, which may be linked to the severity of their symptoms.

NeuroinflammationBiomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

[Brain Science on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Watanabe, Yasuyoshi·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study examined the brains of people with ME/CFS using three types of imaging technology (PET scans, MRI, and MEG) to look for physical differences compared to healthy people. Researchers found that people with ME/CFS have reduced blood flow and energy use in certain brain areas, decreased levels of important chemical messengers, and inflammation in the brain that appears connected to symptom severity. These findings suggest ME/CFS involves real, measurable brain changes rather than being purely psychological.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Noda, Mami, Ifuku, Masataka, Hossain, Md Shamim et al.·Frontiers in psychiatry·2018

This review examines how brain inflammation might cause ME/CFS symptoms. When the body fights off a viral infection, special immune cells in the brain called microglia and astrocytes can become overactive and trigger a chain of events that reduces serotonin levels—a chemical important for mood and energy. Understanding this pathway could help researchers develop new treatments for ME/CFS.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Narcolepsy and Other 'Central Disorders of Hypersomnolence'].

Mathis, Johannes·Praxis·2018

This article discusses how doctors can tell the difference between several sleep-related conditions that cause excessive daytime sleepiness or fatigue. The authors explain that complaints like tiredness and fatigue are common, but they can have many different causes. Careful diagnosis using sleep studies and other tests is needed to distinguish narcolepsy, idiopathic hypersomnia, and chronic fatigue syndrome from one another, since each condition requires different treatments.

Sleep

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Measurement error, time lag, unmeasured confounding: Considerations for longitudinal estimation of the effect of a mediator in randomised clinical trials.

Goldsmith, K A, Chalder, T, White, P D et al.·Statistical methods in medical research·2018

This study examined how treatments work in the PACE trial by using advanced statistical methods to track changes in patients' symptoms and functioning over time. The researchers tested different ways of analyzing data to understand whether improvements in one area (like activity levels) might explain improvements in another area (like fatigue). They found that accounting for measurement errors and considering the timing of measurements was important for getting accurate results.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Petrescu, Anca D, Kain, Jessica, Liere, Victoria et al.·Frontiers in endocrinology·2018

This review examines how the stress hormone system (HPA axis) works and what happens when it breaks down in people with liver disease. The HPA axis is like your body's control center that manages stress responses and many other important functions. The authors explain how inflammation in the liver can disrupt this system, potentially leading to the fatigue and other symptoms seen in both liver disease and chronic fatigue syndrome.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.

Wallis, Amy, Ball, Michelle, Butt, Henry et al.·Journal of translational medicine·2018

This study tested whether treating an overgrowth of Streptococcus bacteria in the gut could help ME/CFS patients, particularly those with brain fog and sleep problems. Forty-four patients received alternating weeks of an antibiotic and a probiotic for 4 weeks. The treatment reduced the problematic bacteria and improved several symptoms including sleep quality, attention, and memory, though it did not significantly affect fatigue or mood.

SleepCognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Case Study of Homeopathic Bowel Nosode Remedies for Dysbiotic Japanese Patients.

Uchiyama-Tanaka, Yoko·Journal of alternative and complementary medicine (New York, N.Y.)·2018

This study tested homeopathic bowel remedies (made from old bacterial samples) in 28 Japanese patients with digestive problems like constipation and diarrhea. About 70% of patients reported some improvement in their symptoms, and no harmful side effects were reported. The researchers suggest these remedies might be a simpler and cheaper option for treating gut-related digestive issues.

E3 PreliminaryMechanismPEM not requiredMechanistic

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Dong, Jia-Zi, Wei, Yun-Tao, Xu, Huan-Yu et al.·Zhen ci yan jiu = Acupuncture research·2018

This study tested whether acupuncture at a specific point (ST 36) could improve muscle weakness in rats with a chronic fatigue condition. Researchers found that the treatment increased muscle strength and improved how the rats' muscles produce energy by activating protective cellular pathways. The results suggest acupuncture may help muscle cells work more efficiently and reduce damage from fatigue.

Energy Metabolism

E3 PreliminaryMechanismPEM unclearCross-Sectional

Brain function characteristics of chronic fatigue syndrome: A task fMRI study.

Shan, Zack Y, Finegan, Kevin, Bhuta, Sandeep et al.·NeuroImage. Clinical·2018

This study compared brain activity in ME/CFS patients and healthy people while they performed a challenging word-color matching task. ME/CFS patients were slower at the task, and their brains showed different patterns of activity—specifically, the brain signals were less complex and adaptive. The findings suggest that ME/CFS patients' brains may need to work harder or recruit more areas to handle cognitive challenges.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

Morris, Gerwyn, Stubbs, Brendon, Köhler, Cristiano A et al.·Sleep medicine reviews·2018

This review explores why people with ME/CFS, bipolar disorder, and multiple sclerosis often have severe sleep problems. The authors suggest that inflammation and stress in the body's cells may damage the brain's ability to control sleep and daily rhythms. They propose that when the immune system stays activated, it can trigger harmful processes that disrupt sleep, which then makes inflammation worse—creating a harmful cycle.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The link between idiopathic intracranial hypertension, fibromyalgia, and chronic fatigue syndrome: exploration of a shared pathophysiology.

Hulens, Mieke, Rasschaert, Ricky, Vansant, Greet et al.·Journal of pain research·2018

This review paper proposes that ME/CFS, fibromyalgia, and a condition called idiopathic intracranial hypertension (IICH—where pressure builds up around the brain) may share similar underlying causes. All three conditions cause widespread pain, fatigue, cognitive problems, and other symptoms that could potentially be explained by increased pressure in the fluid surrounding the brain and spinal cord.

Pain and SensitizationCognitive Impairment

E3 PreliminaryGuidelinePEM requiredGuideline

[Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Kuratsune, Hirohiko·Brain and nerve = Shinkei kenkyu no shinpo·2018

This document presents official diagnostic criteria for ME/CFS developed by Japanese health authorities in 2016. These criteria were designed to help doctors in primary care clinics recognize and diagnose ME/CFS more consistently. The document also summarizes current treatment approaches and expected outcomes based on practices at major medical centers in Japan.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

The Development of the DePaul Symptom Questionnaire: Original, Expanded, Brief, and Pediatric Versions.

Jason, Leonard A, Sunnquist, Madison·Frontiers in pediatrics·2018

Researchers created a questionnaire called the DePaul Symptom Questionnaire (DSQ) to help doctors and scientists consistently measure ME/CFS symptoms in patients. The questionnaire was refined over time and adapted for different groups, including children. This tool helps ensure that when people are diagnosed with ME/CFS, they're being assessed in the same way across different clinics and studies.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

[Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Nakatomi, Yasuhito, Kuratsune, Hirohiko, Watanabe, Yasuyoshi·Brain and nerve = Shinkei kenkyu no shinpo·2018

Researchers used a special imaging scan called PET to look at the brains of people with ME/CFS and found signs of inflammation (immune system activation) throughout several brain regions. This inflammation was connected to how severe patients' symptoms were, including problems with thinking and memory, as well as widespread pain. This discovery suggests that ME/CFS involves measurable changes in the brain that could eventually lead to better ways to diagnose and treat the condition.

NeuroinflammationBiomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

Wang, Xue, Qu, Yidi, Zhang, Yongfeng et al.·Oxidative medicine and cellular longevity·2018

This study tested whether a medicinal mushroom called Sarcodon imbricatus could reduce fatigue in mice with chronic fatigue syndrome. The mushroom extract improved the mice's exercise ability, reduced tiredness, and boosted the body's natural antioxidant defenses—systems that protect cells from damage.

Energy Metabolism

E3 PreliminaryCohortPEM unclearObservational

Using the internet to cope with chronic fatigue syndrome/myalgic encephalomyelitis in adolescence: a qualitative study.

Brigden, Amberly, Barnett, Julie, Parslow, Roxanne Morin et al.·BMJ paediatrics open·2018

This study looked at how teenagers with ME/CFS use the internet to understand and cope with their condition. Researchers interviewed 9 young people (ages 12-17) about which websites and online spaces they visited. The teenagers found that official health websites were helpful when first diagnosed, but over time they preferred online communities where they could read other patients' stories, get emotional support, and connect with peers who understood what they were going through.

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Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Psychometric Properties and Factor Structure of a Long and Shortened Version of the Cognitive and Behavioural Responses Questionnaire.

Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation.

[History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

[Brain Science on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

[Narcolepsy and Other 'Central Disorders of Hypersomnolence'].

Measurement error, time lag, unmeasured confounding: Considerations for longitudinal estimation of the effect of a mediator in randomised clinical trials.

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.

Case Study of Homeopathic Bowel Nosode Remedies for Dysbiotic Japanese Patients.

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Brain function characteristics of chronic fatigue syndrome: A task fMRI study.

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

The link between idiopathic intracranial hypertension, fibromyalgia, and chronic fatigue syndrome: exploration of a shared pathophysiology.

[Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

The Development of the DePaul Symptom Questionnaire: Original, Expanded, Brief, and Pediatric Versions.

[Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

Using the internet to cope with chronic fatigue syndrome/myalgic encephalomyelitis in adolescence: a qualitative study.

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