ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

921–940 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.

Lee, Ji Hoon, Kim, Jong-Eun, Jang, Young Jin et al.·Molecular carcinogenesis·2016

This study examined a compound called dehydroglyasperin C (DGC) found in licorice root to see if it could prevent cancer by blocking harmful cell changes. Researchers used laboratory mouse cells and found that DGC stopped cells from transforming into cancer cells by interfering with two specific protein pathways (MKK4 and PI3K) that drive this process.

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Assessment of ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome): A Case Study for Health Care Providers.

Brimmer, Dana J, Jones, James F, Boneva, Roumiana et al.·MedEdPORTAL : the journal of teaching and learning resources·2016

This study created an educational course to help medical students, physician assistants, and nursing students better understand ME/CFS and how to care for patients with this condition. The course used videos and slide presentations to teach about ME/CFS symptoms, diagnosis, and management. Students who completed the course showed improved knowledge about ME/CFS and developed more empathy for patients living with this illness.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatifue syndrome.].

Holecek, V, Rokyta, R·Ceskoslovenska fysiologie·2016

This review article provides an overview of ME/CFS, explaining what it is, how common it is, and how doctors diagnose and treat it. The condition lasts about 6 months or longer in adults and at least 3 months in children, causing persistent fatigue and other symptoms. The article covers multiple possible causes including biological, genetic, infectious, and psychological factors, as well as the economic impact of the disease.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders.

Evrensel, Alper, Ceylan, Mehmet Emin·Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2016

This review examines fecal microbiota transplantation (FMT)—a treatment where healthy gut bacteria from a donor are transferred to a patient—and its potential use in treating brain and mental health conditions. While FMT is already proven effective for certain gut infections and inflammatory bowel diseases, researchers are exploring whether it might help with conditions like ME/CFS, autism, and Parkinson's disease. Early results are promising, but much more research is needed to understand if it's safe and effective long-term.

Gut MicrobiomeImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer.

Nicolson, Garth L, Rosenblatt, Steven, de Mattos, Gonzalo Ferreira et al.·Discoveries (Craiova, Romania)·2016

This study examines oral supplements containing special fats (lipids) and antioxidants designed to repair damaged cell membranes, which the authors suggest accumulate in aging and chronic diseases like ME/CFS. The researchers reviewed evidence suggesting these supplements may help reduce fatigue and restore energy-producing mitochondria in cells. The authors propose this approach could benefit people with various conditions including chronic fatigue syndrome, fibromyalgia, and other chronic illnesses.

Energy Metabolism

E3 PreliminaryTrialPEM not requiredRCT

Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome.

Rowe, Peter C, Fontaine, Kevin R, Lauver, Megan et al.·PloS one·2016

Researchers tested whether stretching nerves and soft tissues in the legs—by doing a simple straight leg raise test—could trigger or worsen ME/CFS symptoms. Patients with ME/CFS who received the real stretch experienced more pain, concentration problems, and lightheadedness during and 24 hours after the test, compared to those who received a fake stretch and compared to healthy people. This suggests that physical strain on nerves and tissues may be one reason why ME/CFS symptoms get worse with activity.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders.

Morris, Gerwyn, Carvalho, André F, Anderson, George et al.·Current pharmaceutical design·2016

When the body has chronic inflammation and immune activation, it breaks down an amino acid called tryptophan differently than usual, creating byproducts called TRYCATs. Some of these byproducts can damage nerve cells and mitochondria (the energy factories in cells), while others may protect the brain but at the cost of causing brain fog and emotional problems. This review examines how this abnormal tryptophan breakdown might contribute to ME/CFS and other neurological conditions.

NeuroinflammationEnergy MetabolismImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients.

Nguyen, T, Staines, D, Nilius, B et al.·Biological research·2016

This study looked at special channels called TRPM3 on immune cells (natural killer cells and B cells) that help control calcium flow inside cells. Researchers found that people with ME/CFS have fewer of these channels on certain immune cells and problems with calcium movement compared to healthy people. This suggests that broken calcium control in immune cells might play a role in ME/CFS, though much more research is needed to understand what this means for the illness.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

The role of the hippocampus in the pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Saury, Jean-Michel·Medical hypotheses·2016

This study proposes that a brain structure called the hippocampus—which helps control memory, stress responses, and pain perception—may play a key role in ME/CFS. The researcher suggests that whatever triggers ME/CFS damages the hippocampus, leading to problems with thinking, sleep, and pain regulation, which then causes people to become less active. This reduced activity further damages the hippocampus, creating a harmful cycle that keeps the illness going.

Neuroinflammation

E3 PreliminaryCohortPEM requiredCase-Control

A Pair of Identical Twins Discordant for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Differ in Physiological Parameters and Gut Microbiome Composition.

Giloteaux, Ludovic, Hanson, Maureen R, Keller, Betsy A·The American journal of case reports·2016

This study compared two identical twins—one with ME/CFS and one without—to understand what causes the illness. The affected twin showed reduced exercise capacity, abnormal responses to physical exertion, and differences in immune markers and gut bacteria compared to the healthy twin. These findings suggest that ME/CFS involves problems with how the body responds to exercise and changes in the gut bacteria that may trigger inflammation.

Gut MicrobiomeImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Severity Scales for Use in Primary Health Care to Assess Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Hardcastle, Sharni Lee, Brenu, Ekua Weba, Johnston, Samantha et al.·Health care for women international·2016

ME/CFS affects people very differently—some have mild symptoms while others are severely disabled. This study reviewed different tools doctors can use to measure how severe a patient's ME/CFS is based on their symptoms and ability to function physically and mentally. Using these measurement tools helps doctors and researchers identify different groups of ME/CFS patients, which could lead to better diagnosis and treatment.

Diagnostics

E3 PreliminaryPEM unclear

Caring for people with severe myalgic encephalomyelitis: An interpretative phenomenological analysis of parents' experiences.

Mihelicova, Martina, Siegel, Zachary, Evans, Meredyth et al.·Journal of health psychology·2016

This study listened to parents who care for severely ill ME/CFS patients and asked about their experiences. Researchers found that parents often feel their identity has changed, experience guilt, feel isolated from others, deal with uncertainty about the future, and develop ways to cope with the demands of caregiving. The study provides important insights that could help healthcare providers better support and understand these caregivers.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.

Choi, Hyun Ho, Cho, Young-Seok·Clinical endoscopy·2016

This article reviews fecal microbiota transplantation (FMT), a treatment where healthy gut bacteria from a donor are transferred into a patient's digestive system to treat disease. The procedure can be done several different ways and has shown promise for treating many conditions, including chronic fatigue syndrome. However, many important questions remain unanswered about who should donate, how to do it safely long-term, and how to regulate it properly.

E3 PreliminaryCohortPEM unclearCross-Sectional

Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.

Huth, T K, Brenu, E W, Staines, D R et al.·Gene regulation and systems biology·2016

This study looked at special immune cells called Natural Killer cells and the genes that control them in people with ME/CFS compared to healthy people. Researchers examined specific genetic variations in 20 ME/CFS patients and 20 healthy controls. They found that people with ME/CFS had a lower frequency of a particular genetic pattern related to immune cell control, which may help explain why some ME/CFS patients have weaker immune responses.

Immune System

E3 PreliminaryPEM unclear

Nutritional advice for community patients: insights from a panel discussion.

Thomas, Linda V, Jenkins, Gill, Belton, Julie et al.·British journal of community nursing·2016

A group of nursing and nutrition experts discussed how to help patients with conditions like chronic fatigue syndrome, irritable bowel syndrome, and depression through better nutrition and lifestyle choices. They reviewed real patient examples and recommended that nurses use supportive conversation techniques to understand what patients need, and refer patients to registered dietitians when major diet changes are being considered.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Exploring patients' opinions of activity pacing and a new activity pacing questionnaire for chronic pain and/or fatigue: a qualitative study.

Antcliff, Deborah, Keeley, Philip, Campbell, Malcolm et al.·Physiotherapy·2016

Activity pacing—spreading out tasks and rest periods to manage symptoms—is often recommended for people with chronic fatigue and pain, but patients understand and use it differently. Researchers interviewed 16 patients with conditions like ME/CFS and fibromyalgia to understand their views on pacing and tested a new questionnaire designed to measure it. The study found that pacing is complex and personal; some people avoid activities, others push through, some alternate between activity and rest (boom-bust cycling), and others modify how they do tasks—and the questionnaire was acceptable and easy for patients to use.

E3 PreliminaryCohortPEM unclearCross-Sectional

"You get to know the people and whether they're talking sense or not": Negotiating trust on health-related forums.

Brady, Ellen, Segar, Julia, Sanders, Caroline·Social science & medicine (1982)·2016

This study looked at how people with ME/CFS and diabetes use online forums to find health information and support. Researchers interviewed 40 people total and found that forum users trust advice from others with similar lived experiences, but they also value information from doctors and medical sources. Online forums can provide personalized support, though how comfortable someone is using the internet affects how well they can connect with others.

E3 PreliminaryDiagnosticPEM unclearObservational

"I Always Vet Things": Navigating Privacy and the Presentation of Self on Health Discussion Boards Among Individuals with Long-Term Conditions.

Brady, Ellen, Segar, Julia, Sanders, Caroline·Journal of medical Internet research·2016

This study asked 20 people with ME/CFS and 21 people with diabetes about how they share information on online health forums and what privacy means to them. The researchers found that people carefully decide what personal details to share online, changing their approach depending on the situation and who they're talking to. Rather than having simple rules about what's private or public, people make complex, individual decisions about how much of themselves to reveal.

E3 PreliminaryMechanismPEM unclearMechanistic

Gene Expression in Response to Exercise in Patients with Chronic Fatigue Syndrome: A Pilot Study.

Keech, Andrew, Vollmer-Conna, Ute, Barry, Benjamin K et al.·Frontiers in physiology·2016

Researchers studied whether a single 25-minute exercise session changed the activity of specific genes in white blood cells of ME/CFS patients compared to healthy people. Although ME/CFS patients reported significantly worsened fatigue after exercise, the researchers found no major changes in the 19 genes they measured in either group, suggesting that post-exertional fatigue may not be caused by these particular genes switching on or off.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Maximizing potential impact of experimental research into cognitive processes in health psychology: A systematic approach to material development.

Hughes, Alicia M, Gordon, Rola, Chalder, Trudie et al.·British journal of health psychology·2016

This paper is a guide for researchers on how to properly design experiments that test whether people with conditions like ME/CFS have unconscious biases in how they pay attention to and interpret information about their illness. The authors explain that many past studies used different, untested materials, making it hard to compare results. They provide a step-by-step process and practical tools to help researchers create better, standardized materials for these types of studies.

Cognitive Impairment

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Evidence browser

Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.

Assessment of ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome): A Case Study for Health Care Providers.

[Chronic fatifue syndrome.].

Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders.

Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer.

Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome.

The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders.

Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients.

The role of the hippocampus in the pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

A Pair of Identical Twins Discordant for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Differ in Physiological Parameters and Gut Microbiome Composition.

Severity Scales for Use in Primary Health Care to Assess Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Caring for people with severe myalgic encephalomyelitis: An interpretative phenomenological analysis of parents' experiences.

Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.

Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.

Nutritional advice for community patients: insights from a panel discussion.

Exploring patients' opinions of activity pacing and a new activity pacing questionnaire for chronic pain and/or fatigue: a qualitative study.

"You get to know the people and whether they're talking sense or not": Negotiating trust on health-related forums.

"I Always Vet Things": Navigating Privacy and the Presentation of Self on Health Discussion Boards Among Individuals with Long-Term Conditions.

Gene Expression in Response to Exercise in Patients with Chronic Fatigue Syndrome: A Pilot Study.

Maximizing potential impact of experimental research into cognitive processes in health psychology: A systematic approach to material development.

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