ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

921–940 of 2,420 studies

E3 PreliminaryMechanismPEM unclearMechanistic

Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Lunde, Sigrid, Kristoffersen, Einar K, Sapkota, Dipak et al.·PloS one·2016

Researchers tested whether a drug called rituximab, which removes B cells (a type of immune cell) from the blood, helps ME/CFS patients by examining immune system changes. They found that some ME/CFS patients had higher levels of a substance called BAFF that activates B cells, but this didn't predict who would improve with treatment. While some patients did get better with rituximab in earlier trials, the immune cell changes measured in this study didn't fully explain why.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Moxibustion upregulates hippocampal progranulin expression.

Yi, Tao, Qi, Li, Li, Ji et al.·Neural regeneration research·2016

This study tested whether moxibustion, a traditional Chinese medicine technique using heat from burning herbs, could help rats with chronic fatigue syndrome. Researchers found that moxibustion reduced stress hormone levels and increased a protective protein in the brain called progranulin, which appeared to improve the rats' symptoms of fatigue and low mood.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer.

Nicolson, Garth L, Rosenblatt, Steven, de Mattos, Gonzalo Ferreira et al.·Discoveries (Craiova, Romania)·2016

This study examines oral supplements containing special fats (lipids) and antioxidants designed to repair damaged cell membranes, which the authors suggest accumulate in aging and chronic diseases like ME/CFS. The researchers reviewed evidence suggesting these supplements may help reduce fatigue and restore energy-producing mitochondria in cells. The authors propose this approach could benefit people with various conditions including chronic fatigue syndrome, fibromyalgia, and other chronic illnesses.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia syndrome pathology and environmental influences on afflictions with medically unexplained symptoms.

Albrecht, Phillip J, Rice, Frank L·Reviews on environmental health·2016

This review examines fibromyalgia syndrome (FMS) as a model for understanding conditions with symptoms that are difficult to explain medically. The authors discuss how nerve endings in the skin and stress hormones (particularly estrogen) may play a role in causing widespread pain and fatigue. They propose that environmental stress and past trauma can trigger changes in how the nervous system works, leading to increased pain sensitivity.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Exploring patients' opinions of activity pacing and a new activity pacing questionnaire for chronic pain and/or fatigue: a qualitative study.

Antcliff, Deborah, Keeley, Philip, Campbell, Malcolm et al.·Physiotherapy·2016

Activity pacing—spreading out tasks and rest periods to manage symptoms—is often recommended for people with chronic fatigue and pain, but patients understand and use it differently. Researchers interviewed 16 patients with conditions like ME/CFS and fibromyalgia to understand their views on pacing and tested a new questionnaire designed to measure it. The study found that pacing is complex and personal; some people avoid activities, others push through, some alternate between activity and rest (boom-bust cycling), and others modify how they do tasks—and the questionnaire was acceptable and easy for patients to use.

E3 PreliminaryBehavioralPEM not requiredLongitudinal

Neurocognitive improvements after best-practice intervention for chronic fatigue syndrome: Preliminary evidence of divergence between objective indices and subjective perceptions.

Cvejic, Erin, Lloyd, Andrew R, Vollmer-Conna, Uté·Comprehensive psychiatry·2016

This study tested whether a 12-week program combining graded activity and cognitive training could help ME/CFS patients with thinking and memory problems. Researchers measured improvements in two ways: by asking patients how they felt, and by giving them objective tests of mental performance. They found that patients showed real, measurable improvements in processing speed and accuracy on cognitive tests, and their stress response (measured by heart rate patterns) also improved.

Cognitive Impairment

E3 PreliminaryPEM unclear

Nutritional advice for community patients: insights from a panel discussion.

Thomas, Linda V, Jenkins, Gill, Belton, Julie et al.·British journal of community nursing·2016

A group of nursing and nutrition experts discussed how to help patients with conditions like chronic fatigue syndrome, irritable bowel syndrome, and depression through better nutrition and lifestyle choices. They reviewed real patient examples and recommended that nurses use supportive conversation techniques to understand what patients need, and refer patients to registered dietitians when major diet changes are being considered.

E3 PreliminaryCohortPEM unclearCross-Sectional

Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.

Huth, T K, Brenu, E W, Staines, D R et al.·Gene regulation and systems biology·2016

This study looked at special immune cells called Natural Killer cells and the genes that control them in people with ME/CFS compared to healthy people. Researchers examined specific genetic variations in 20 ME/CFS patients and 20 healthy controls. They found that people with ME/CFS had a lower frequency of a particular genetic pattern related to immune cell control, which may help explain why some ME/CFS patients have weaker immune responses.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

"You get to know the people and whether they're talking sense or not": Negotiating trust on health-related forums.

Brady, Ellen, Segar, Julia, Sanders, Caroline·Social science & medicine (1982)·2016

This study looked at how people with ME/CFS and diabetes use online forums to find health information and support. Researchers interviewed 40 people total and found that forum users trust advice from others with similar lived experiences, but they also value information from doctors and medical sources. Online forums can provide personalized support, though how comfortable someone is using the internet affects how well they can connect with others.

E3 PreliminaryReviewPEM not requiredReview-Narrative

ILLNESS IS WORK: Revisiting the concept of illness careers and recognizing the identity work of patients with ME/CFS.

Grue, Jan·Health (London, England : 1997)·2016

This study explores how people with ME/CFS manage their identity and daily life while dealing with an illness that society doesn't fully recognize or understand. The researchers use the concept of "illness as work" to show that patients are actively doing important identity work—constantly adapting to their condition, navigating medical systems, and coping with a stigmatized illness. This framework helps validate the real effort and agency that ME/CFS patients demonstrate every day.

E3 PreliminaryMechanismPEM not requiredMechanistic

Elevated Energy Production in Chronic Fatigue Syndrome Patients.

Lawson, Nick, Hsieh, Chung-Han, March, Dana et al.·Journal of nature and science·2016

This study examined how cells in ME/CFS patients produce energy. Surprisingly, researchers found that patients' blood cells actually produced MORE energy (ATP) than healthy controls, but much of this energy came from sources other than mitochondria (the cell's power plants). The study suggests that ME/CFS fatigue may not be caused by a lack of energy, but rather by an abnormal way the body is producing energy.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Understanding Muscle Dysfunction in Chronic Fatigue Syndrome.

Rutherford, Gina, Manning, Philip, Newton, Julia L·Journal of aging research·2016

This review examined research showing that people with ME/CFS may have problems with how their muscles produce and use energy. Specifically, their muscles appear to rely too heavily on a less efficient energy pathway (lactate dehydrogenase) during and after exercise, and they have difficulty clearing the acidic byproducts that build up. These muscle-level energy problems could explain why ME/CFS patients experience severe fatigue and difficulty maintaining physical activity.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Metabolic mechanism of a polysaccharide from Schisandra chinensis to relieve chronic fatigue syndrome.

Chi, Aiping, Zhang, Yang, Kang, Yijiang et al.·International journal of biological macromolecules·2016

Researchers tested whether a natural substance extracted from Schisandra chinensis (a traditional Chinese fruit) could help reduce fatigue in rats with a condition similar to ME/CFS. They found that the substance, called SCP, helped improve the rats' activity and behavior. The improvement appeared to work by fixing problems in how the rats' bodies were processing energy and certain amino acids.

Energy Metabolism

E3 PreliminaryCohortPEM unclearCross-Sectional

Implementing resources to support the diagnosis and management of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) in primary care: A qualitative study.

Bayliss, Kerin, Riste, Lisa, Band, Rebecca et al.·BMC family practice·2016

This study looked at whether special training and information resources for GPs could help them better diagnose and manage ME/CFS. Researchers interviewed patients and doctors in North West England and found that while the resources were helpful when used properly, most GPs didn't actually use them—either because they were too busy, didn't see enough ME/CFS patients to remember the training, or thought the condition should only be managed by specialists.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearObservational

"I Always Vet Things": Navigating Privacy and the Presentation of Self on Health Discussion Boards Among Individuals with Long-Term Conditions.

Brady, Ellen, Segar, Julia, Sanders, Caroline·Journal of medical Internet research·2016

This study asked 20 people with ME/CFS and 21 people with diabetes about how they share information on online health forums and what privacy means to them. The researchers found that people carefully decide what personal details to share online, changing their approach depending on the situation and who they're talking to. Rather than having simple rules about what's private or public, people make complex, individual decisions about how much of themselves to reveal.

E3 PreliminaryCohortPEM unclearCase-Control

[Fibromyalgia and myalgic encephalomyelitis: The oxygen clue].

Beretta, Pablo·Vertex (Buenos Aires, Argentina)·2016

This study suggests that people with fibromyalgia and ME/CFS may have problems with how their muscles use oxygen. The authors found that patients' symptoms worsened in low-oxygen environments (like high altitudes or low air pressure) and improved with treatments that increase oxygen availability, including hyperbaric oxygen therapy and coenzyme Q10 supplements. Based on three patient cases that improved with medical oxygen treatment, the authors propose that oxygen therapy might help people experiencing severe symptom flare-ups.

E3 PreliminaryMechanismPEM not requiredMechanistic

Effects of Chronic Diurnal Disruption and Acute Inflammatory Challenge on Mice with Latent Murine Gammaherpesvirus Infection.

Trammell, Rita A, Toth, Linda A·Comparative medicine·2016

This study examined how disrupted sleep-wake cycles (like those from shift work) affect mice infected with a dormant virus, especially when their immune systems are weakened. Researchers found that mice exposed to disrupted schedules who then experienced inflammation had higher levels of reactivated virus in their lungs. This suggests that combining poor sleep patterns with immune challenges might trigger symptom flare-ups similar to those seen in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Gene Expression in Response to Exercise in Patients with Chronic Fatigue Syndrome: A Pilot Study.

Keech, Andrew, Vollmer-Conna, Ute, Barry, Benjamin K et al.·Frontiers in physiology·2016

Researchers studied whether a single 25-minute exercise session changed the activity of specific genes in white blood cells of ME/CFS patients compared to healthy people. Although ME/CFS patients reported significantly worsened fatigue after exercise, the researchers found no major changes in the 19 genes they measured in either group, suggesting that post-exertional fatigue may not be caused by these particular genes switching on or off.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatifue syndrome.].

Holecek, V, Rokyta, R·Ceskoslovenska fysiologie·2016

This review article provides an overview of ME/CFS, explaining what it is, how common it is, and how doctors diagnose and treat it. The condition lasts about 6 months or longer in adults and at least 3 months in children, causing persistent fatigue and other symptoms. The article covers multiple possible causes including biological, genetic, infectious, and psychological factors, as well as the economic impact of the disease.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.

Lee, Ji Hoon, Kim, Jong-Eun, Jang, Young Jin et al.·Molecular carcinogenesis·2016

This study examined a compound called dehydroglyasperin C (DGC) found in licorice root to see if it could prevent cancer by blocking harmful cell changes. Researchers used laboratory mouse cells and found that DGC stopped cells from transforming into cancer cells by interfering with two specific protein pathways (MKK4 and PI3K) that drive this process.

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Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Moxibustion upregulates hippocampal progranulin expression.

Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer.

Fibromyalgia syndrome pathology and environmental influences on afflictions with medically unexplained symptoms.

Exploring patients' opinions of activity pacing and a new activity pacing questionnaire for chronic pain and/or fatigue: a qualitative study.

Neurocognitive improvements after best-practice intervention for chronic fatigue syndrome: Preliminary evidence of divergence between objective indices and subjective perceptions.

Nutritional advice for community patients: insights from a panel discussion.

Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.

"You get to know the people and whether they're talking sense or not": Negotiating trust on health-related forums.

ILLNESS IS WORK: Revisiting the concept of illness careers and recognizing the identity work of patients with ME/CFS.

Elevated Energy Production in Chronic Fatigue Syndrome Patients.

Understanding Muscle Dysfunction in Chronic Fatigue Syndrome.

Metabolic mechanism of a polysaccharide from Schisandra chinensis to relieve chronic fatigue syndrome.

Implementing resources to support the diagnosis and management of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) in primary care: A qualitative study.

"I Always Vet Things": Navigating Privacy and the Presentation of Self on Health Discussion Boards Among Individuals with Long-Term Conditions.

[Fibromyalgia and myalgic encephalomyelitis: The oxygen clue].

Effects of Chronic Diurnal Disruption and Acute Inflammatory Challenge on Mice with Latent Murine Gammaherpesvirus Infection.

Gene Expression in Response to Exercise in Patients with Chronic Fatigue Syndrome: A Pilot Study.

[Chronic fatifue syndrome.].

Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.

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