ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

101–120 of 280 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Health Conditions and Psychotic Experiences: Cross-Sectional Findings From the American Life Panel.

Oh, Hans, Smith, Lee, Koyanagi, Ai·Frontiers in psychiatry·2020

This study looked at whether people who experience psychotic symptoms (like unusual beliefs or perceptions) also tend to have more physical health problems. Researchers surveyed a representative group of American adults and found that people reporting lifetime psychotic experiences were more likely to have conditions like chronic fatigue syndrome, chronic pain, sleep disorders, migraines, and gastrointestinal problems. The more health conditions someone had, the stronger the association with psychotic experiences.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM unclearCross-Sectional

Emotional Awareness Correlated With Number of Awakenings From Polysomnography in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-A Pilot Study.

Bileviciute-Ljungar, Indre, Friberg, Danielle·Frontiers in psychiatry·2020

This study examined the connection between emotional awareness and sleep problems in ME/CFS patients. Researchers found that patients who had difficulty recognizing and understanding their own emotions also experienced more frequent awakenings during sleep. The study involved 23 ME/CFS patients and 30 healthy controls who completed questionnaires about emotions, while the ME/CFS patients also underwent overnight sleep monitoring.

Sleep

E2 ModerateBehavioralPEM not requiredObservational

Sleep education in primary school prevents future school refusal behavior.

Maeda, Tsutomu, Oniki, Kentaro, Miike, Teruhisa·Pediatrics international : official journal of the Japan Pediatric Society·2019

This study tested whether teaching primary school children about healthy sleep habits could prevent school refusal (persistent avoidance of attending school) later on. Researchers in Japan had students track their sleep for 2 weeks, gave them feedback, and taught them and their parents about the importance of regular sleep schedules. After the program started, school refusal rates dropped dramatically—from 10% of graduates in 2007 to 0% by 2012.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Hematological and Psychophysiological Correlates of Anomalous Information Reception in Mediums: A Preliminary Exploration.

Beischel, Julie, Tassone, Shawn, Boccuzzi, Mark·Explore (New York, N.Y.)·2019

This study looked at whether people who identify as mediums (those who report communicating with deceased individuals) experience more health problems than people who don't. Researchers found that mediums reported significantly more autoimmune diseases, sleep problems, gastrointestinal issues, and other symptoms compared to non-mediums. However, blood tests and heart rate measurements taken during mediumship sessions showed no unusual changes.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Unemployment and work disability in individuals with chronic fatigue syndrome/myalgic encephalomyelitis: a community-based cross-sectional study from Spain.

Castro-Marrero, Jesús, Faro, Mónica, Zaragozá, María Cleofé et al.·BMC public health·2019

This Spanish study looked at 1,086 people with ME/CFS to understand why some are unable to work. Researchers found that more than half (58.6%) were unemployed due to illness. Several factors made work disability more likely, including severe fatigue and pain, autonomic problems (like dizziness or heart issues), neurological symptoms, depression, sleep problems, and having pain start at an older age.

Sleep

E2 ModerateBehavioralPEM not requiredLongitudinal

Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study.

Pedersen, Maria, Asprusten, Tarjei Tørre, Godang, Kristin et al.·Journal of psychosomatic research·2019

This study followed teenagers with acute Epstein-Barr virus (EBV) infection and compared them to healthy teenagers to understand what causes fatigue. Researchers measured 148 different factors including symptoms, quality of life, sleep, emotions, immune markers, and heart rate control at the start of infection and again six months later. They found that fatigue was consistently linked to sleep problems, negative emotions, and poor quality of life, but surprisingly, markers of active infection were not associated with how tired people felt.

SleepAutonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study.

Słomko, Joanna, Newton, Julia L, Kujawski, Sławomir et al.·BMJ open·2019

Researchers in Poland studied 1,400 people who reported feeling very tired to understand how common ME/CFS really is. They found that 69 people actually had ME/CFS based on standard diagnostic criteria. These patients experienced severe fatigue that lasted years, had trouble staying awake during the day, problems with dizziness when standing up, anxiety, and depression—all of which seriously affected their quality of life.

Sleep

E2 ModerateCohortPEM not requiredLongitudinal

Childhood sleep and adolescent chronic fatigue syndrome (CFS/ME): evidence of associations in a UK birth cohort.

Collin, Simon M, Norris, Tom, Gringras, Paul et al.·Sleep medicine·2018

This study tracked children from birth through their teenage years to see if sleep problems in childhood were linked to developing ME/CFS later on. Researchers found that children who slept less at night during early childhood were more likely to develop chronic disabling fatigue as teenagers, and those with trouble falling asleep were at higher risk. Each extra hour of sleep at age 9 or 11 was associated with a significantly lower chance of developing the condition.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Poor self-reported sleep quality and health-related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Castro-Marrero, Jesús, Zaragozá, Maria C, González-Garcia, Sergio et al.·Journal of sleep research·2018

This study looked at sleep problems in 1,455 Spanish ME/CFS patients and found that nearly all of them reported poor sleep quality that wasn't refreshing, even when they slept. The researchers discovered that poor sleep was strongly linked to worse pain, fatigue, anxiety, depression, and lower quality of life overall. Several factors—including pain intensity, mood problems, fibromyalgia, and autonomic nervous system dysfunction—were particularly associated with sleep difficulties.

Pain and SensitizationSleepAutonomic Nervous System

E2 ModerateBehavioralPEM not requiredLongitudinal

Reciprocal associations between daily need-based experiences, energy, and sleep in chronic fatigue syndrome.

Campbell, Rachel, Vansteenkiste, Maarten, Delesie, Liesbeth et al.·Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2018

This study tracked 120 ME/CFS patients for 14 days to understand how their daily psychological needs, energy levels, and sleep quality relate to each other. Researchers found that on days when patients felt their needs were met (feeling in control, capable, and connected to others), they had more energy and better sleep. On days when patients felt frustrated in meeting these needs, they experienced more fatigue and worse sleep quality.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep patterns among patients with chronic fatigue: A polysomnography-based study.

Pajediene, Evelina, Bileviciute-Ljungar, Indre, Friberg, Danielle·The clinical respiratory journal·2018

This study looked at sleep problems in people with chronic fatigue by using a sleep monitoring test called polysomnography. Researchers found that more than half of the fatigued patients who also felt excessively sleepy had treatable sleep disorders like sleep apnea, restless legs, or periodic leg movements. The authors suggest that people with these symptoms should be tested for sleep disorders and treated before being diagnosed with ME/CFS, since fixing the sleep problem might help with fatigue.

Sleep

E2 ModeratePEM not requiredRegistry-Resource

Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit®.

Belcaro, Gianni, Saggino, Aristide, Cornelli, Umberto et al.·Journal of neurosurgical sciences·2018

This study tested whether a supplement made from French oak wood called Robuvit® could help people with ME/CFS who experience fatigue, sleep problems, mood difficulties, and high levels of oxidative stress (cellular damage). Eighteen patients took 300 mg of Robuvit® daily for 8 weeks, while 22 others received standard care. The Robuvit® group showed significant improvements in mood, fatigue, sleep, and oxidative stress levels, with no safety concerns reported.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Physical Activity and Sleep in Chronic Fatigue Syndrome and Fibromyalgia Syndrome: Associations with Symptom Severity in the General Population Cohort LifeLines.

Joustra, Monica L, Zijlema, Wilma L, Rosmalen, Judith G M et al.·Pain research & management·2018

This study looked at how physical activity and sleep relate to symptom severity in ME/CFS and fibromyalgia by comparing nearly 91,000 people from a large population study. Patients with ME/CFS and fibromyalgia were less active and slept longer than healthy controls. Interestingly, both too little and too much physical activity or sleep were linked to worse symptoms, suggesting that finding the right balance is important for managing these conditions.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue and psychosocial variables in autoimmune rheumatic disease and chronic fatigue syndrome: A cross-sectional comparison.

Ali, Sheila, Matcham, Faith, Irving, Katherine et al.·Journal of psychosomatic research·2017

This study compared how people with ME/CFS and people with autoimmune rheumatic diseases (like rheumatoid arthritis) experience fatigue and cope with their symptoms. The researchers found that people with ME/CFS were more fatigued, had worse sleep, and were more likely to avoid activities and struggle with accepting their illness, while people with rheumatic diseases were more likely to worry about damage to their bodies. This suggests that fatigue in these different conditions may need different treatment approaches.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

[Sleep disturbances - an important factor in combination 'minor' symptoms of multiple sclerosis].

Yakupov, E Z, Troshina, Yu V·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2017

This study looked at sleep problems in 54 people with multiple sclerosis (MS) compared to 54 healthy people. Researchers found that people with MS had much more trouble sleeping, and that poor sleep was connected to anxiety, depression, and fatigue. The study suggests that sleep disturbances may play an important role in how MS affects quality of life and fatigue symptoms.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Josev, Elisha K, Jackson, Melinda L, Bei, Bei et al.·Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2017

This study examined sleep problems in teenagers with ME/CFS compared to healthy teenagers. Researchers found that teens with ME/CFS took longer to fall asleep, spent more total time in bed, slept longer overall, woke up later, and reported feeling their sleep was of poorer quality. Anxiety levels were also higher in the ME/CFS group and were connected to worse sleep quality in both groups.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Prevalence of and risk factors for severe cognitive and sleep symptoms in ME/CFS and MS.

Jain, Vageesh, Arunkumar, Amit, Kingdon, Caroline et al.·BMC neurology·2017

This study compared cognitive problems (like trouble concentrating and memory issues) and sleep difficulties in people with ME/CFS and people with MS. Researchers found that cognitive and sleep problems were much more common in ME/CFS patients—98% reported trouble concentrating, and 55% reported severe unrefreshing sleep. The study also identified that ME/CFS patients who were older, current smokers, or had lower incomes were more likely to experience severe symptoms.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Specialist treatment of chronic fatigue syndrome/ME: a cohort study among adult patients in England.

Collin, Simon M, Crawley, Esther·BMC health services research·2017

This study looked at how 952 ME/CFS patients fared after receiving treatment at 11 specialist NHS clinics in England. One year after starting treatment, about 27% felt much better, 37% felt a little better, but 20% felt the same or worse. Even 2-5 years later, 85% of patients still had ME/CFS symptoms, showing that this is a long-lasting condition that often continues despite specialist care.

Pain and SensitizationSleep

E2 ModerateCohortPEM requiredCross-Sectional

Case definitions integrating empiric and consensus perspectives.

Jason, Leonard A, McManimen, Stephanie, Sunnquist, Madison et al.·Fatigue : biomedicine, health & behavior·2016

This study looked at 556 ME/CFS patients from three countries to understand how doctors should diagnose this condition. The researchers found that patients fall into different groups based on their symptoms: some have chronic fatigue alone, some have fatigue with other medical reasons, and some have ME/CFS with additional symptoms like problems with exercise recovery, brain fog, and sleep issues. The groups with more specific ME/CFS symptoms were significantly more disabled than those with just general fatigue.

SleepPost-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCase-Control

Stressful Events in the Onset of Chronic Fatigue Syndrome.

Gimeno Pi, Iraida, Guitard Sein-Echaluce, M Luisa, Rosselló Aubach, Lluís et al.·Revista espanola de salud publica·2016

This study looked at whether stressful life events might trigger ME/CFS by comparing 77 people with the disease to 77 healthy people of similar age, sex, and education. Researchers found that certain stressful experiences—like pregnancy, domestic abuse, workplace bullying, eating disorders, car accidents, money problems, and sleep disruptions—occurred more often in people before they developed ME/CFS. The study suggests that identifying these stressful events in at-risk people might help doctors recognize ME/CFS earlier.

Sleep

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Health Conditions and Psychotic Experiences: Cross-Sectional Findings From the American Life Panel.

Emotional Awareness Correlated With Number of Awakenings From Polysomnography in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-A Pilot Study.

Sleep education in primary school prevents future school refusal behavior.

Hematological and Psychophysiological Correlates of Anomalous Information Reception in Mediums: A Preliminary Exploration.

Unemployment and work disability in individuals with chronic fatigue syndrome/myalgic encephalomyelitis: a community-based cross-sectional study from Spain.

Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study.

Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study.

Childhood sleep and adolescent chronic fatigue syndrome (CFS/ME): evidence of associations in a UK birth cohort.

Poor self-reported sleep quality and health-related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Reciprocal associations between daily need-based experiences, energy, and sleep in chronic fatigue syndrome.

Sleep patterns among patients with chronic fatigue: A polysomnography-based study.

Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit®.

Physical Activity and Sleep in Chronic Fatigue Syndrome and Fibromyalgia Syndrome: Associations with Symptom Severity in the General Population Cohort LifeLines.

Fatigue and psychosocial variables in autoimmune rheumatic disease and chronic fatigue syndrome: A cross-sectional comparison.

[Sleep disturbances - an important factor in combination 'minor' symptoms of multiple sclerosis].

Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Prevalence of and risk factors for severe cognitive and sleep symptoms in ME/CFS and MS.

Specialist treatment of chronic fatigue syndrome/ME: a cohort study among adult patients in England.

Case definitions integrating empiric and consensus perspectives.

Stressful Events in the Onset of Chronic Fatigue Syndrome.

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