Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography.
van Campen, C Linda M C, Verheugt, Freek W A, Rowe, Peter C et al.·Clinical neurophysiology practice·2020
This study measured blood flow to the brain in ME/CFS patients while they were tilted upright for 30 minutes. Researchers found that blood flow to the brain dropped significantly more in ME/CFS patients (24-29%) compared to healthy people (7%), even in patients whose heart rate and blood pressure stayed normal. The more symptoms patients experienced from standing, the greater their blood flow reduction.