ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

221–240 of 270 studies

E3 PreliminaryCommentaryPEM unclearEditorial

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied.

Komaroff, Anthony L·Healthcare (Basel, Switzerland)·2021

ME/CFS is a real illness with measurable biological problems in the body, even though standard blood tests often appear normal. Over the past 20 years, advanced research tools have found objective abnormalities in people with ME/CFS. Unfortunately, many doctors aren't aware of this evidence, which can lead them to dismiss patients' symptoms and wrongly suggest there's nothing physically wrong—adding emotional harm on top of the already serious illness.

Biomarkers

E3 PreliminaryPEM unclearRegistry-Resource

mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites.

Mathur, Ravi, Carnes, Megan U, Harding, Alexander et al.·Journal of translational medicine·2021

Researchers created mapMECFS, an online database that brings together research information about ME/CFS from scientists around the world. Instead of having data scattered across different locations and websites, this portal allows researchers to easily find, share, and compare information about the disease in one place. This tool is designed to help scientists discover patterns and connections that might reveal new ways to diagnose and treat ME/CFS.

Biomarkers

E3 PreliminaryReviewPEM requiredReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Deumer, Undine-Sophie, Varesi, Angelica, Floris, Valentina et al.·Journal of clinical medicine·2021

ME/CFS is a long-term illness that causes extreme tiredness, worsening of symptoms after activity, and difficulty thinking clearly. Patients experience these symptoms very differently from one another, and currently there are no blood tests or physical exams that can definitively diagnose the condition. This review examines several potential causes, including past infections, genetic factors, hormone imbalances, and changes in gut bacteria, while exploring whether a simple blood test might someday help diagnose ME/CFS.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome.

Rusin, Andrej, Li, Megan, Cocchetto, Alan et al.·Medical hypotheses·2021

This paper explores the idea that ME/CFS may be caused by damage to mitochondria—the energy-producing parts of cells—possibly triggered by radiation exposure or other environmental stressors like viruses or toxins. When mitochondria cannot produce enough energy, cells throughout the body struggle, and neighboring tissues try to compensate, which may explain why ME/CFS patients experience widespread symptoms like fatigue and immune problems.

Biomarkers

E3 PreliminaryMechanismPEM requiredMechanistic

Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology.

Nepotchatykh, Evguenia, Elremaly, Wesam, Caraus, Iurie et al.·Scientific reports·2020

This study looked at tiny molecules called microRNAs in the blood of severely ill ME/CFS patients before and after a stress challenge designed to trigger post-exertional malaise (the worsening of symptoms after activity). The researchers found that eleven different microRNAs changed in response to this challenge, with patterns that varied depending on symptom severity. These microRNA signatures could potentially be used one day as blood tests to help diagnose ME/CFS.

BiomarkersPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.

Bang, Sohyun, Yoo, DongAhn, Kim, Soo-Jin et al.·Scientific reports·2019

Researchers used artificial intelligence to analyze bacteria in the gut of patients with six different diseases, including ME/CFS, to see if gut bacteria patterns could help identify which disease a person has. They tested different computer learning methods and found that looking at bacteria at the genus level (a specific classification of microorganisms) worked best, and they identified certain bacterial groups that might serve as disease markers.

BiomarkersGut Microbiome

E3 PreliminaryMechanismPEM unclearMechanistic

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study.

Takakura, Shu, Oka, Takakazu, Sudo, Nobuyuki·BioPsychoSocial medicine·2019

This small study tested whether a gentle form of yoga (practiced lying down with adjustable resistance) could help ME/CFS patients feel less tired. Nine patients with ME/CFS who hadn't improved with standard treatment practiced this yoga for 3 months. Their fatigue scores improved significantly, and their blood showed changes in tiny molecules called microRNAs that may be related to how the yoga helped reduce their tiredness.

Biomarkers

E3 PreliminaryMechanismPEM unclearObservational

Epstein-Barr Virus Induced Gene-2 Upregulation Identifies a Particular Subtype of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Kerr, Jonathan R·Frontiers in pediatrics·2019

This study found that about 38-55% of ME/CFS patients have higher levels of a specific gene called EBI2 turned on in their immune cells. Patients with this EBI2 pattern appear to have more severe symptoms and different antibody levels compared to other ME/CFS patients. Because EBI2 is known to affect both immune function and brain function, finding this subtype could help explain why ME/CFS patients experience such different symptoms and may lead to new treatments.

BiomarkersImmune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test.

Tomas, Cara, Lodge, Tiffany A, Potter, Michelle et al.·Scientific reports·2019

This study tested a blood test called the Mitochondrial Energy Score (MES) that is marketed to diagnose ME/CFS by measuring how well cells produce energy. Researchers repeated the test in both ME/CFS patients and healthy people and found no difference between the two groups. They also discovered that waiting even 24 hours before processing blood samples changed the test results significantly, suggesting the test is not reliable enough to use for diagnosis.

Biomarkers

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[New Diagnostic Biomarkers for Chronic Fatigue Syndrome].

Yamano, Emi, Kataoka, Yosky·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study looked at the chemicals and compounds in the blood of people with ME/CFS compared to healthy people to find objective markers that could help doctors diagnose the condition. Researchers used advanced testing methods to examine how the body's metabolism, immune system, and hormones differ in people with ME/CFS. The goal was to develop a simple blood test that could definitively identify ME/CFS, since there is currently no reliable diagnostic test.

Biomarkers

E3 PreliminaryMechanismPEM unclearObservational

[Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Nakatomi, Yasuhito, Kuratsune, Hirohiko, Watanabe, Yasuyoshi·Brain and nerve = Shinkei kenkyu no shinpo·2018

Researchers used a special imaging scan called PET to look at the brains of people with ME/CFS and found signs of inflammation (immune system activation) throughout several brain regions. This inflammation was connected to how severe patients' symptoms were, including problems with thinking and memory, as well as widespread pain. This discovery suggests that ME/CFS involves measurable changes in the brain that could eventually lead to better ways to diagnose and treat the condition.

NeuroinflammationBiomarkers

E3 PreliminaryReviewPEM requiredReview-Narrative

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

VanElzakker, Michael B, Brumfield, Sydney A, Lara Mejia, Paula S·Frontiers in neurology·2018

This review examines different methods scientists use to look for signs of brain inflammation in ME/CFS, including specialized brain scans and blood tests. The authors found that while these techniques show promise, many studies have used inconsistent methods that make it hard to compare results across different research teams. They argue that scientists need better techniques and more careful standardization if we want to find reliable biological markers that could help diagnose ME/CFS.

NeuroinflammationBiomarkers

E3 PreliminaryMechanismPEM unclearObservational

The expression signature of very long non-coding RNA in myalgic encephalomyelitis/chronic fatigue syndrome.

Yang, Chin-An, Bauer, Sandra, Ho, Yu-Chen et al.·Journal of translational medicine·2018

Researchers looked at special molecules called very long non-coding RNAs in the blood of ME/CFS patients to see if they might be disease markers. They found that three of these RNA molecules (NTT, MIAT, and EmX2OS) were present at higher levels in ME/CFS patients compared to healthy people, and two of them (NTT and EmX2OS) increased with disease severity. When they tested these findings in lab cells exposed to oxidative stress and viral signals, the RNA levels increased, suggesting these molecules respond to the kinds of biological stresses that may occur in ME/CFS.

BiomarkersImmune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study.

Castro-Marrero, Jesús, Serrano-Pertierra, Esther, Oliveira-Rodríguez, Myriam et al.·Journal of extracellular vesicles·2018

This small pilot study looked at tiny particles called extracellular vesicles (EVs) in the blood of ME/CFS patients compared to healthy people. The researchers found that ME/CFS patients had higher amounts of these particles, and the particles were smaller than in healthy controls. This suggests that blood tests measuring these particles might one day help doctors identify ME/CFS.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

[History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Watanabe, Yasuyoshi, Kuratsune, Hirohiko·Brain and nerve = Shinkei kenkyu no shinpo·2018

This review summarizes research on ME/CFS conducted in Japan since the disease was first identified there in 1990. Scientists have been searching for objective biological markers to help diagnose ME/CFS and understand what causes it. Recent brain imaging studies found evidence of immune cell activation in the brains of ME/CFS patients, which may be linked to the severity of their symptoms.

NeuroinflammationBiomarkers

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A robust, single-injection method for targeted, broad-spectrum plasma metabolomics.

Li, Kefeng, Naviaux, Jane C, Bright, A Taylor et al.·Metabolomics : Official journal of the Metabolomic Society·2017

Researchers developed a new, efficient blood test that can measure over 600 different molecules (metabolites) in a single sample to help diagnose ME/CFS. The test was validated by showing it could correctly identify ME/CFS patients with 95% accuracy compared to healthy controls, even when tested again more than a year later by different researchers.

Biomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME).

Petty, Robert D, McCarthy, Neil E, Le Dieu, Rifca et al.·PloS one·2016

This study examined tiny molecules called microRNAs in immune cells from ME/CFS patients and healthy people. Researchers found that four specific microRNAs were abnormally high in patients' blood, particularly in natural killer (NK) immune cells. When they tested these microRNAs in the lab, they found they affected how NK cells work, suggesting this might contribute to ME/CFS symptoms.

BiomarkersImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue.

Aoki, Ryo, Kobayashi, Nobuyuki, Suzuki, Go et al.·Biochemical and biophysical research communications·2016

This study looked at whether two common viruses (HHV-6 and HHV-7) in saliva could help doctors tell the difference between normal tiredness and the severe, long-lasting fatigue seen in conditions like ME/CFS. The researchers found that these viruses increased in saliva when people were physically stressed or tired from work, then quickly decreased with rest. Importantly, these viruses did NOT increase in people with ME/CFS, sleep apnea, or depression, suggesting they might be useful markers for normal fatigue but not pathological fatigue.

Biomarkers

E3 PreliminaryMechanismPEM not requiredCase-Control

Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome.

Ciregia, F, Kollipara, L, Giusti, L et al.·Translational psychiatry·2016

This study looked at proteins in the mitochondria—the energy-producing structures in cells—to see if they differ in people with ME/CFS compared to healthy people. Researchers found that two specific proteins (ATPB and ACON) were higher in people with ME/CFS, suggesting these could potentially be useful markers to help identify the condition. The findings also hint that different subgroups of ME/CFS patients may have different protein patterns, which could eventually lead to more personalized treatments.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

Potential use of visible and near-infrared spectroscopy for the analysis and diagnosis of chronic fatigue syndrome (Review).

Sakudo, Akikazu·Molecular medicine reports·2016

This review examines whether a special type of light-based scanning called visible and near-infrared spectroscopy could help diagnose ME/CFS objectively. Currently, doctors diagnose ME/CFS only by listening to patient symptoms, with no blood test or physical measurement available. Researchers found that this light-scanning technique can detect differences in blood samples and thumb tissue between people with ME/CFS and healthy people, suggesting it might identify biological markers of the disease.

Biomarkers

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Evidence Atlas

Evidence browser

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied.

mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome.

Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology.

Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study.

Epstein-Barr Virus Induced Gene-2 Upregulation Identifies a Particular Subtype of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test.

[New Diagnostic Biomarkers for Chronic Fatigue Syndrome].

[Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

The expression signature of very long non-coding RNA in myalgic encephalomyelitis/chronic fatigue syndrome.

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study.

[History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

A robust, single-injection method for targeted, broad-spectrum plasma metabolomics.

MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME).

Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue.

Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome.

Potential use of visible and near-infrared spectroscopy for the analysis and diagnosis of chronic fatigue syndrome (Review).

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