ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

221–238 of 238 studies

E3 PreliminaryPEM unclearPreliminaryReview-NarrativeEditor reviewed

Chronic orofacial muscle pain: a new approach to diagnosis and management.

Klineberg, I, McGregor, N, Butt, H et al.·The Alpha omegan·1998

This study looked at different types of muscle pain conditions, including fibromyalgia and jaw pain, and found they affect men and women differently. The researchers suggest that some people may be genetically vulnerable to chronic pain, and that infections at the start of illness might play a role. They found links between abnormal fat levels, muscle metabolism problems, and fibromyalgia, which may also be connected to chronic fatigue syndrome.

Pain and Sensitization

E3 PreliminaryPEM unclearPreliminaryReview-NarrativeEditor reviewed

Fibromyalgia, chronic fatigue syndrome, and myofascial pain.

Bennett, R·Current opinion in rheumatology·1998

This review examines how fibromyalgia, chronic fatigue syndrome, and widespread pain are related conditions that share similar features. Researchers found that these conditions run in families, involve abnormal pain processing in the nervous system, and may share some underlying biological problems like growth hormone imbalances and low blood pressure. Several medications and treatments showed promise in reducing symptoms.

Pain and Sensitization

E3 PreliminaryPEM unclearPreliminaryReview-NarrativeEditor reviewed

Neurobehavioral properties of chemical sensitivity syndromes.

Weiss, B·Neurotoxicology·1998

This review examines four conditions that involve chemical sensitivity and fatigue-like symptoms: Multiple Chemical Sensitivity Syndrome, Sick Building Syndrome, Chronic Fatigue Syndrome, and Gulf War Syndrome. The authors explore different theories about why people develop these conditions, including psychiatric factors, learned behavioral responses, changes in how the nervous system works, and problems with the immune system's stress response. The review suggests that laboratory studies and controlled clinical trials could help determine which explanations are correct.

Pain and SensitizationEndocrine Disruption

E3 PreliminaryPEM unclearPreliminaryEditorialEditor reviewed

Fibromyalgia and chronic fatigue syndrome: an update for athletic trainers.

Cramer, C R·Journal of athletic training·1998

This article reviews what we know about ME/CFS and fibromyalgia, two conditions that cause severe fatigue, muscle pain, and sleep problems. The authors looked at medical research and government health information to summarize how these conditions affect people, especially athletes. They discuss various treatments being tested, including exercise, relaxation therapy, and medications, and emphasize the importance of careful medical evaluation and psychological support during diagnosis and treatment.

Pain and SensitizationSleep

E3 PreliminaryPEM not requiredWeak / uncertainReview-NarrativeEditor reviewed

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Lieb, K, Dammann, G, Berger, M et al.·Der Nervenarzt·1996

ME/CFS is a disorder that causes persistent tiredness, but doctors cannot diagnose it with a simple blood test or scan. Instead, doctors use specific clinical criteria to identify the condition, while carefully ruling out other illnesses like depression or sleep problems that can look similar. Currently, there is no cure for ME/CFS, so treatment focuses on managing individual symptoms like poor sleep, pain, and mood changes with a combination of medical care and psychological support.

DiagnosticsSleepPain and Sensitization

E3 PreliminaryPEM not requiredPreliminaryMechanisticEditor reviewed

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

Vecchiet, L, Montanari, G, Pizzigallo, E et al.·Neuroscience letters·1996

This study tested whether people with ME/CFS have increased pain sensitivity in their muscles compared to their skin. Researchers found that muscles were significantly more sensitive to pain in ME/CFS patients, while skin sensitivity was normal. They also discovered abnormal structures and damage in muscle cells from ME/CFS patients, including problems with mitochondria (the energy-producing parts of cells) and signs of degeneration.

Pain and Sensitization

E3 PreliminaryPEM not requiredPreliminaryObservationalEditor reviewed

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Lohmann, K, Pröhl, A, Schwarz, E·Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·1996

This study looked at 466 people who had neurological symptoms from toxic chemical exposure and found that 136 of them also had Multiple Chemical Sensitivity (MCS)—a condition where people react strongly to low levels of chemicals. The researchers found that wood preservatives, solvents, and formaldehyde were common culprits, and people with MCS were more likely to have chronic fatigue symptoms and allergies than those without MCS.

Pain and Sensitization

E3 PreliminaryPEM not requiredWeak / uncertainReview-NarrativeEditor reviewed

Fibromyalgia syndrome: a review.

Reiffenberger, D H, Amundson, L H·American family physician·1996

Fibromyalgia syndrome is a chronic condition characterized by widespread pain, stiffness, and tender points in muscles and soft tissues, often accompanied by fatigue and sleep problems. It affects women more than men, typically starting around age 49. Treatment combines medication (like certain antidepressants), education, reassurance, and exercise to help manage symptoms.

Pain and SensitizationSleep

E3 PreliminaryPEM not requiredPreliminaryEditor reviewed

'Repetitive strain injury': from Australia to the UK.

Reilly, P A·Journal of psychosomatic research·1995

In the 1980s, Australia experienced a widespread outbreak of upper limb pain that didn't fit standard medical diagnoses. The UK is now seeing a similar epidemic. This study examines whether the condition is truly caused by workplace activities or whether psychological and social factors play a larger role, similar to what happens in chronic fatigue syndrome.

Pain and Sensitization

E3 PreliminaryPEM not requiredPreliminaryCross-SectionalEditor reviewed

The ocular signs and symptoms of chronic fatigue syndrome.

Caffery, B E, Josephson, J E, Samek, M J·Journal of the American Optometric Association·1994

This study looked at eye problems in 25 people with ME/CFS and found that all of them experienced some eye-related symptoms. The most common issues were problems with tears and the eye's surface, as well as difficulty focusing on close objects. Eye doctors should be aware of these issues when examining ME/CFS patients.

Pain and Sensitization

E3 PreliminaryPEM not requiredPreliminaryCase-ControlEditor reviewed

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Welch, L S, Sokas, R·Toxicology and industrial health·1992

When workers were exposed to problems in a building (sick-building syndrome), some developed multiple chemical sensitivity (MCS)—a condition where people react to low levels of chemicals. This study looked at 20 people affected by the outbreak and found that most had existing health conditions like allergies or asthma that got worse. Importantly, having ME/CFS did not predict who would develop MCS, and many people had ongoing problems beyond just MCS after leaving the building.

Pain and Sensitization

E3 PreliminaryPEM unclearPreliminaryEditorialEditor reviewed

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1991

This review examines three related conditions—fibromyalgia, chronic fatigue syndrome, and myofascial pain—that often occur together and cause pain, tiredness, and sleep problems. Researchers are discovering that these conditions may share common biological causes involving how the body senses pain, hormone imbalances, and problems with muscle function. Unfortunately, the new treatments being tested at that time were not particularly effective.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryPEM not requiredPreliminaryReview-NarrativeEditor reviewed

Depression and chronic fatigue in the patient with chronic pain.

Covington, E C·Primary care·1991

This study explores how chronic pain, fatigue, and depression often occur together in patients. The authors suggest that these three conditions share common causes and may influence each other. Treatment works best when doctors address each problem separately using a combination of physical rehabilitation, education, medications, and counseling.

Pain and Sensitization

E3 PreliminaryPEM unclearWeak / uncertainEditorialEditor reviewed

Pain syndromes, disability, and chronic disease in childhood.

Malleson, P N·Current opinion in rheumatology·1991

This editorial discusses how chronic pain and long-term illnesses affect children, and suggests that conditions like fibromyalgia and chronic fatigue syndrome (ME/CFS) may be related to each other. The author notes that doctors need better training to understand these complex conditions and that psychological factors may play a role in how these illnesses develop and affect children's lives.

Pain and Sensitization

E0 ConsensusPEM unclearModerate confidenceReview-NarrativeMachine-drafted

Sleep, pain, fibromyalgia, and chronic fatigue syndrome.

Landis, Carol A·Handbook of clinical neurology·2011

This review examined the connections between sleep problems, pain, fibromyalgia, and chronic fatigue syndrome (ME/CFS). The author looked at existing research to understand how poor sleep and pain symptoms often occur together in these conditions and how they may be related to each other.

SleepPain and Sensitization

E2 ModeratePEM unclearPreliminaryObservationalMachine-drafted

Effect of noise stress on chronic fatigue syndrome patients.

Beh, H C·The Journal of nervous and mental disease·1997

This study looked at how noise affects people with ME/CFS, examining whether environmental sounds make their symptoms worse. The research observed how patients responded to noise stress as part of understanding the condition better. This type of research helps identify triggers that may worsen fatigue and other ME/CFS symptoms.

Pain and Sensitization

E2 ModeratePEM unclearPreliminaryCross-SectionalMachine-drafted

The localization of pain in chronic fatigue syndrome on a pain drawing according to grid areas.

Líndal, E, Bergmann, S, Thorlacius, S et al.·Perceptual and motor skills·1996

This study looked at where people with ME/CFS experience pain by having them mark painful areas on a body diagram divided into sections. The researchers wanted to understand the pattern of pain locations across different body regions in ME/CFS patients. This type of mapping can help doctors better understand how pain is distributed in the condition.

Pain and Sensitization

E3 PreliminaryPEM unclearPreliminaryReview-NarrativeMachine-drafted

The Interplay between Oxidative Stress, Exercise, and Pain in Health and Disease: Potential Role of Autonomic Regulation and Epigenetic Mechanisms.

Hendrix, Jolien, Nijs, Jo, Ickmans, Kelly et al.·Antioxidants (Basel, Switzerland)·2020

This review examines how physical activity, pain, and a harmful process called oxidative stress (cellular damage from unstable molecules) interact in both healthy people and those with chronic pain conditions. The authors found that the relationships between these three factors are complicated and depend on the type of exercise and which person is being studied. They suggest that the nervous system's automatic functions and changes in how genes are expressed may help explain why these connections work differently in different people.

Autonomic Nervous SystemPain and Sensitization

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Chronic orofacial muscle pain: a new approach to diagnosis and management.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain.

Neurobehavioral properties of chemical sensitivity syndromes.

Fibromyalgia and chronic fatigue syndrome: an update for athletic trainers.

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Fibromyalgia syndrome: a review.

'Repetitive strain injury': from Australia to the UK.

The ocular signs and symptoms of chronic fatigue syndrome.

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Depression and chronic fatigue in the patient with chronic pain.

Pain syndromes, disability, and chronic disease in childhood.

Sleep, pain, fibromyalgia, and chronic fatigue syndrome.

Effect of noise stress on chronic fatigue syndrome patients.

The localization of pain in chronic fatigue syndrome on a pain drawing according to grid areas.

The Interplay between Oxidative Stress, Exercise, and Pain in Health and Disease: Potential Role of Autonomic Regulation and Epigenetic Mechanisms.

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