ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

241–260 of 1,185 studies

E2 ModerateCohortPEM not requiredObservational

HERV-W ENV antigenemia and correlation of increased anti-SARS-CoV-2 immunoglobulin levels with post-COVID-19 symptoms.

Giménez-Orenga, Karen, Pierquin, Justine, Brunel, Joanna et al.·Frontiers in immunology·2022

This study found that a dormant virus-like element called HERV-W, which exists naturally in our DNA, may reactivate and remain active long after COVID-19 infection has cleared in people with long COVID. The researchers also discovered that people with higher levels of certain immune proteins (antibodies) against SARS-CoV-2, especially IgE antibodies, tended to have worse physical function. These findings suggest that HERV-W activation and lingering antibody responses might help explain why some people develop long-lasting COVID symptoms.

BiomarkersImmune System

E2 ModerateCohortPEM unclearCross-Sectional

Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways.

Maes, Michael, Al-Rubaye, Haneen Tahseen, Almulla, Abbas F et al.·International journal of environmental research and public health·2022

This study found that Long COVID patients have significantly lower quality of life compared to healthy people, and this decline is mostly explained by three factors: mood and pain-related symptoms (like depression, anxiety, and fatigue), signs of ongoing inflammation in the body, and problems with how the body processes calcium. The severity of the initial infection—measured by high fever and low oxygen levels—also plays a role by triggering these inflammatory and immune problems that persist afterward.

Immune SystemNeuroinflammation

E2 ModerateCohortPEM unclearCross-Sectional

Systemic antibody responses against human microbiota flagellins are overrepresented in chronic fatigue syndrome patients.

Vogl, Thomas, Kalka, Iris N, Klompus, Shelley et al.·Science advances·2022

Researchers found that people with severe ME/CFS have different immune responses against bacteria in their gut compared to healthy people. Specifically, their blood contains more antibodies (immune proteins) that target flagella, which are whip-like structures used by certain gut bacteria to move. This immune signature was so distinctive that a computer algorithm could use it to help identify ME/CFS patients.

Evidence Atlas

Evidence browser

HERV-W ENV antigenemia and correlation of increased anti-SARS-CoV-2 immunoglobulin levels with post-COVID-19 symptoms.

Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways.

Systemic antibody responses against human microbiota flagellins are overrepresented in chronic fatigue syndrome patients.

Pathway Phenotypes Underpinning Depression, Anxiety, and Chronic Fatigue Symptoms Due to Acute Rheumatoid Arthritis: A Precision Nomothetic Psychiatry Analysis.

Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious mononucleosis.

Predictors for Developing Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Following Infectious Mononucleosis.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?

Genetic risk factors for ME/CFS identified using combinatorial analysis.

Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome.

Survey of Anti-Pathogen Antibody Levels in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

No replication of previously reported association with genetic variants in the T cell receptor alpha (TRA) locus for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

How mycobacterium tuberculosis infection could lead to the increasing risks of chronic fatigue syndrome and the potential immunological effects: a population-based retrospective cohort study.

Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severity.

Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

Are Circulating Fibroblast Growth Factor 21 and N-Terminal Prohormone of Brain Natriuretic Peptide Promising Novel Biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping.

The antinuclear antibody dense fine speckled pattern and possible clinical associations: An indication of a proinflammatory microenvironment.

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Risks for Developing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in College Students Following Infectious Mononucleosis: A Prospective Cohort Study.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research