ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

261–270 of 270 studies

E3 PreliminaryCohortPEM unclearCase-Control

A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid.

Baraniuk, James N, Casado, Begona, Maibach, Hilda et al.·BMC neurology·2005

Researchers examined fluid from around the spine (cerebrospinal fluid) in people with ME/CFS and found specific proteins that were present in patients but absent in healthy people. Using advanced laboratory techniques, they identified a set of 5 key proteins that could correctly identify ME/CFS in 80% of cases. These findings suggest ME/CFS may involve immune system and brain inflammation, offering hope for an objective test in the future.

NeuroinflammationBiomarkers

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.

Hokama, Y, Uto, G A, Palafox, N A et al.·Journal of clinical laboratory analysis·2003

Researchers found that people with ME/CFS have unusual lipids (fatty substances) in their blood that react similarly to toxins found in certain poisoned fish. The study tested blood samples from ME/CFS patients and compared them to healthy people and patients with other diseases. About 96% of ME/CFS patients showed high levels of these lipids, suggesting they may be a distinctive feature of the condition.

Biomarkers

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Tarello, W·Comparative immunology, microbiology and infectious diseases·2001

This study looked at 15 dogs and cats that had fatigue symptoms similar to ME/CFS and tested their blood for bacterial infections. Nine out of 15 animals had a type of bacteria called Staphylococcus in their blood. When these animals were treated with an antibiotic drug, all of them got completely better and the bacteria disappeared from their blood.

Biomarkers

E3 PreliminaryMechanismPEM not requiredCase-Control

Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome.

Vojdani, A, Lapp, C W·Immunopharmacology and immunotoxicology·1999

This study found that certain immune proteins called 2-5A and PKR are elevated in the blood of ME/CFS patients, whether their illness was triggered by a viral infection or chemical exposure. The researchers discovered that these two triggers activate these proteins through different biological pathways—viruses primarily use an immune signaling molecule called interferon-beta, while chemicals activate them mainly through heat shock proteins.

BiomarkersImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuroimaging in chronic fatigue syndrome.

Lange, G, Wang, S, DeLuca, J et al.·The American journal of medicine·1998

This review examines how brain imaging scans can help understand ME/CFS. Researchers looked at two main types of scans: MRI scans that show the structure of the brain, and SPECT scans that show blood flow in the brain. The article discusses what these imaging techniques have revealed so far and what challenges doctors face in using them to diagnose ME/CFS.

Biomarkers

E3 PreliminaryCohortPEM not requiredCross-Sectional

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

Neri, G, Bianchedi, M, Croce, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1996

This study tested whether two hearing-related tests could help diagnose ME/CFS. Researchers examined 21 people with suspected ME/CFS using specialized hearing tests that measure how the brainstem processes sound and how the ear muscles respond to loud noises. When both tests were combined, they correctly identified about 82% of people with ME/CFS, suggesting these tests might be useful diagnostic tools.

Biomarkers

E3 PreliminaryMechanismPEM not requiredObservational

Acylcarnitine deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Takahashi, M et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study found that people with ME/CFS have lower levels of acylcarnitine, a substance that helps muscles produce energy, in their blood. Because acylcarnitine plays an important role in how muscles use energy, this deficiency might explain why ME/CFS patients experience fatigue, muscle pain, and weakness. Importantly, acylcarnitine levels tended to improve as patients recovered, suggesting it could be useful for tracking disease severity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Barnes, P R, Taylor, D J, Kemp, G J et al.·Journal of neurology, neurosurgery, and psychiatry·1993

Researchers used a special type of MRI scan to measure how muscles use energy in ME/CFS patients compared to healthy people. They found that most patients had normal muscle energy use, but about a quarter showed unusual patterns in how their muscles handled acid buildup during exercise. This suggests muscle metabolism problems may exist in some, but not all, ME/CFS patients.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue syndromes: new thoughts and reinterpretation of previous data.

Downey, D C·Medical hypotheses·1992

This study examined 19 patients with severe fatigue who showed unusual reactions to copper-containing bracelets or necklaces. The researchers found that 8 of these patients had deficiencies in enzymes related to heme (a component of blood), and suggested that problems with copper metabolism and heme processing might explain fatigue in conditions like ME/CFS, multiple sclerosis, and other disorders.

Biomarkers

E3 PreliminaryCohortPEM unclearCross-Sectional

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Kuratsune, H, Yamaguti, K, Hattori, H et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.

BiomarkersPost-Exertional Malaise

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Evidence browser

A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid.

Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome.

Neuroimaging in chronic fatigue syndrome.

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

Acylcarnitine deficiency in chronic fatigue syndrome.

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Fatigue syndromes: new thoughts and reinterpretation of previous data.

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

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