ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

261–280 of 280 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Sleep and circadian rhythm disorders in fibromyalgia.

Korszun, A·Current rheumatology reports·2000

Fibromyalgia is a condition causing widespread muscle pain along with sleep problems and extreme tiredness. This review examines how broken sleep patterns and disrupted body clocks (which control things like stress hormones) play a role in fibromyalgia. The authors suggest that treating sleep disorders, depression, and improving sleep habits—along with careful use of medications—may help relieve symptoms.

Sleep

E3 PreliminaryCohortPEM not requiredCase-Control

[Genioglossal advancement in the surgical treatment of obstructive sleep apnea syndrome in adults].

Foltán, R, Sonka, K·Sbornik lekarsky·2000

This case report describes a 68-year-old woman with severe sleep apnea (a condition where breathing repeatedly stops during sleep) who also had symptoms of chronic fatigue, daytime sleepiness, and morning headaches. Because she couldn't tolerate the standard breathing mask treatment due to anxiety, she had surgery to widen her airway. After surgery, her sleep apnea improved significantly and her fatigue and other symptoms improved.

Sleep

E3 PreliminaryCommentaryPEM unclearEditorial

[Fibromyalgia syndrome].

Matsumoto, Y·Nihon rinsho. Japanese journal of clinical medicine·1999

This paper discusses fibromyalgia syndrome (FMS), a condition characterized by widespread pain, fatigue, sleep problems, and mood changes without visible inflammation or damage on tests. The author explains that while fibromyalgia is recognized as real, some doctors still debate whether it is truly distinct from other conditions. Many people with ME/CFS also meet the criteria for fibromyalgia, but there are some differences between the two conditions—such as signs of viral triggers and low blood chemical levels found in ME/CFS but not usually in fibromyalgia.

Pain and SensitizationSleep

E3 PreliminaryBehavioralPEM not requiredCase-Control

Nefazodone for patients with chronic fatigue syndrome.

Hickie, I·The Australian and New Zealand journal of psychiatry·1999

This small study looked at whether a medication called nefazodone could help ME/CFS patients feel better. Ten patients took the drug and also received advice about sleep and behavioral strategies. Most patients reported some improvement in tiredness, sleep problems, and mood, and half were able to return to work or their normal activities.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Fibromyalgia. A critical review].

Cathébras, P, Lauwers, A, Rousset, H·Annales de medecine interne·1998

Fibromyalgia is a chronic pain condition that affects about 2% of the general population, with symptoms including widespread pain, fatigue, and sleep problems. This review examines how fibromyalgia overlaps with other conditions like ME/CFS and depression, and discusses why current treatments like antidepressants and therapy have limited effectiveness. The authors suggest that fibromyalgia may develop through interconnected factors rather than a single cause.

SleepDiagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia and chronic fatigue syndrome: an update for athletic trainers.

Cramer, C R·Journal of athletic training·1998

This article reviews what we know about ME/CFS and fibromyalgia, two conditions that cause severe fatigue, muscle pain, and sleep problems. The authors looked at medical research and government health information to summarize how these conditions affect people, especially athletes. They discuss various treatments being tested, including exercise, relaxation therapy, and medications, and emphasize the importance of careful medical evaluation and psychological support during diagnosis and treatment.

Pain and SensitizationSleep

E3 PreliminaryCommentaryPEM not requiredEditorial

Periodic limb movements of sleep and the restless legs syndrome.

Williams, D C·Virginia medical quarterly : VMQ·1996

This article examines periodic limb movements during sleep and restless legs syndrome, which are not diseases themselves but signs that something is disturbing the nervous system. The author suggests these conditions may be related to ME/CFS and other disorders, and that they arise from problems in a brainstem region that controls smooth sleep and wakefulness. Various treatments can help reduce symptoms and improve sleep quality.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fibromyalgia syndrome: a review.

Reiffenberger, D H, Amundson, L H·American family physician·1996

Fibromyalgia syndrome is a chronic condition characterized by widespread pain, stiffness, and tender points in muscles and soft tissues, often accompanied by fatigue and sleep problems. It affects women more than men, typically starting around age 49. Treatment combines medication (like certain antidepressants), education, reassurance, and exercise to help manage symptoms.

Pain and SensitizationSleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Lieb, K, Dammann, G, Berger, M et al.·Der Nervenarzt·1996

ME/CFS is a disorder that causes persistent tiredness, but doctors cannot diagnose it with a simple blood test or scan. Instead, doctors use specific clinical criteria to identify the condition, while carefully ruling out other illnesses like depression or sleep problems that can look similar. Currently, there is no cure for ME/CFS, so treatment focuses on managing individual symptoms like poor sleep, pain, and mood changes with a combination of medical care and psychological support.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Leese, G, Chattington, P, Fraser, W et al.·The Journal of clinical endocrinology and metabolism·1996

This study found that nurses who worked night shifts for just 5 days showed abnormal stress hormone patterns similar to those seen in ME/CFS patients. Specifically, their bodies produced high levels of one stress hormone (ACTH) but low levels of another (cortisol) during night shifts. This suggests that disrupted sleep and routine alone may be enough to trigger the hormone imbalances characteristic of ME/CFS.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--psychiatric aspects].

Lemke, M R·Fortschritte der Neurologie-Psychiatrie·1996

This editorial discusses how ME/CFS involves both physical symptoms and mental health aspects that need to be understood together. The authors explain that while doctors have focused heavily on physical symptoms, psychiatric factors—such as stress, sleep problems, and how the body's stress system works—play an important role in the syndrome. An effective approach to ME/CFS requires doctors from different specialties to work together.

SleepImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. 2: Treatment and future research.

Kantrowitz, F G, Farrar, D J, Locke, S E·Behavioral medicine (Washington, D.C.)·1995

This review article examines different ways to treat ME/CFS and outlines important directions for future research. The authors discuss various treatment approaches that have been studied and identify gaps in our current understanding of the condition. The paper emphasizes that while treatment options exist, more research is needed to find more effective therapies.

Sleep

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Determination of observer-rated alpha activity during sleep.

Flanigan, M J, Morehouse, R L, Shapiro, C M·Sleep·1995

Many ME/CFS patients have been reported to show a particular brain wave pattern called 'alpha intrusion' during sleep, which may contribute to poor sleep quality. This study examined whether the way researchers measure brain waves during sleep affects whether they can detect this pattern. The researchers found that the type of electrode placement and reference point used significantly influenced whether alpha waves were observed, suggesting that previous findings about alpha intrusion in ME/CFS patients may depend heavily on the measurement method used.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

Clauw, D J·Medical hypotheses·1995

This paper reviews what doctors and researchers knew in 1995 about fibromyalgia and similar conditions that cause chronic pain and tiredness. The authors noticed that fibromyalgia overlaps significantly with chronic fatigue syndrome, migraines, irritable bowel syndrome, and mood disorders, suggesting these conditions may share common underlying causes rather than being completely separate diseases.

SleepAutonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Sternon, J, Decaux, G, Hoffmann, G·Revue medicale de Bruxelles·1994

This paper describes how doctors can diagnose ME/CFS using specific criteria and discusses what might cause the condition. The authors note that viral infections may trigger ME/CFS, and that anxiety or depression can make symptoms worse. Importantly, they found that some patients improve on their own after a few years, though most don't respond well to available treatments.

SleepDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome. Clinical, social psychological problems and management].

Wessely, S·L'Encephale·1994

This review examines ME/CFS by comparing it to an older condition called neurasthenia and explores what causes the illness. The authors suggest that ME/CFS likely involves multiple factors including brain chemistry changes, difficulty perceiving effort, mood problems, and reduced physical activity—rather than being purely psychological or a muscle problem. They recommend cognitive-behavioral therapy (gradual activity increase) and antidepressants as the main treatments, while warning that too much rest can actually make the condition worse long-term.

Sleep

E3 PreliminaryCohortPEM not requiredCase-Control

Consideration of narcolepsy in the differential diagnosis of chronic fatigue syndrome.

Ambrogetti, A, Olson, L G·The Medical journal of Australia·1994

This study describes four patients who were initially diagnosed with chronic fatigue syndrome (CFS) but actually had a different condition called narcolepsy, which causes extreme daytime sleepiness. When these patients were properly diagnosed with narcolepsy and treated with a medication called methylphenidate, their symptoms improved significantly or resolved completely. The authors suggest that doctors should carefully check for narcolepsy in patients with CFS who report severe daytime sleepiness.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pharmacological approaches to the therapy of chronic fatigue syndrome.

McCluskey, D R·Ciba Foundation symposium·1993

This study examined various medications used to treat ME/CFS and found that none completely resolved symptoms. The researchers suggest that ME/CFS may be caused by a sleep regulation problem in the brain, which leads to not only extreme tiredness but also pain sensitivity, temperature control issues, and mood problems. They propose that medications affecting brain chemicals, especially serotonin, might help and should be tested in larger clinical trials.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

[Neuro-psychiatric aspects of chronic fatigue syndrome].

Shimizu, T·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examines the differences between ME/CFS and other conditions that can look similar, particularly fibromyalgia and depression. The authors explain that ME/CFS is not a psychological disorder and that sleep disturbances may play a central role in the condition. They suggest that brain imaging technology could help doctors more accurately identify ME/CFS in the future.

Sleep

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1991

This review examines three related conditions—fibromyalgia, chronic fatigue syndrome, and myofascial pain—that often occur together and cause pain, tiredness, and sleep problems. Researchers are discovering that these conditions may share common biological causes involving how the body senses pain, hormone imbalances, and problems with muscle function. Unfortunately, the new treatments being tested at that time were not particularly effective.

Pain and SensitizationSleepDiagnostics

← Previous

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Sleep and circadian rhythm disorders in fibromyalgia.

[Genioglossal advancement in the surgical treatment of obstructive sleep apnea syndrome in adults].

[Fibromyalgia syndrome].

Nefazodone for patients with chronic fatigue syndrome.

[Fibromyalgia. A critical review].

Fibromyalgia and chronic fatigue syndrome: an update for athletic trainers.

Periodic limb movements of sleep and the restless legs syndrome.

Fibromyalgia syndrome: a review.

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

[Chronic fatigue syndrome--psychiatric aspects].

Chronic fatigue syndrome. 2: Treatment and future research.

Determination of observer-rated alpha activity during sleep.

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

[Chronic fatigue syndrome].

[Chronic fatigue syndrome. Clinical, social psychological problems and management].

Consideration of narcolepsy in the differential diagnosis of chronic fatigue syndrome.

Pharmacological approaches to the therapy of chronic fatigue syndrome.

[Neuro-psychiatric aspects of chronic fatigue syndrome].

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research