ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2921–2940 of 6,209 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Exercise testing in children and adolescents with chronic fatigue syndrome.

Takken, T, Henneken, T, van de Putte, E et al.·International journal of sports medicine·2007

This study tested how well 20 young people with ME/CFS could exercise on a stationary bike and measured their oxygen use. The researchers found that most of these young people had similar exercise capacity to healthy peers their age, though a smaller group showed reduced fitness. The amount of fatigue they experienced was related to how active they were in daily life.

E2 ModerateCohortPEM unclearCross-Sectional

Health status and health care utilization of multiple sclerosis in Canada.

Pohar, Sheri L, Jones, C Allyson, Warren, Sharon et al.·The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2007

This Canadian study compared people living with multiple sclerosis (MS) to people without MS to understand how the disease affects their daily lives and health care needs. People with MS reported much worse overall health, were far more likely to experience fatigue and urinary problems, and had greater health care utilization. The study found that MS significantly burdens patients' quality of life and that their health care needs were often not being met.

E2 ModerateCohortPEM not requiredCross-Sectional

Can submaximal exercise variables predict peak exercise performance in women with chronic fatigue syndrome?

Nijs, Jo, Demol, Seppe, Wallman, Karen·Archives of medical research·2007

Researchers tested whether measurements taken during moderate-intensity exercise could predict how much energy a person with ME/CFS could produce during their maximum effort. In 222 women with ME/CFS, oxygen use at moderate intensity correlated well with peak oxygen use, but the prediction had too much variation to be reliable for individual patients.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.

Niblett, Suzanne H, King, Katrina E, Dunstan, R Hugh et al.·Experimental biology and medicine (Maywood, N.J.)·2007

Researchers compared blood and urine samples from 100 people with ME/CFS and 82 healthy controls to look for abnormalities. While standard blood tests appeared normal, closer examination found subtle differences in blood cell counts and patterns in how patients' bodies were processing and excreting amino acids (building blocks of protein) and other compounds in their urine.

Energy MetabolismImmune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychological, medical, and pharmacological correlates of persistent genital arousal disorder.

Leiblum, Sandra, Seehuus, Martin, Goldmeier, David et al.·The journal of sexual medicine·2007

This study surveyed 156 women about persistent genital arousal disorder (PGAD), a condition involving unwanted arousal sensations. Women with full PGAD were more likely to experience depression, anxiety, panic attacks, and chronic fatigue compared to women with milder symptoms or no condition. The researchers suggest that anxiety and worry about these sensations may play a role in making PGAD worse.

E2 ModerateCohortPEM not requiredObservational

Actuarial analysis of private payer administrative claims data for women with endometriosis.

Mirkin, David, Murphy-Barron, Carrieann, Iwasaki, Kosuke·Journal of managed care pharmacy : JMCP·2007

This study looked at insurance claims from nearly 4 million people to understand how common endometriosis is and how much it costs to treat. Researchers found that women with endometriosis spend significantly more on medical care than other women, have frequent hospital stays and surgeries, and often have other health conditions at the same time—including chronic fatigue syndrome. The study shows endometriosis is a serious, expensive condition that affects many aspects of a woman's health.

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep quality perception in the chronic fatigue syndrome: correlations with sleep efficiency, affective symptoms and intensity of fatigue.

Neu, Daniel, Mairesse, Olivier, Hoffmann, Guy et al.·Neuropsychobiology·2007

ME/CFS patients often report feeling like they have poor sleep quality, even though doctors cannot always find obvious problems when measuring sleep objectively. This study compared how ME/CFS patients and healthy people rated their own sleep quality and found that ME/CFS patients consistently reported worse sleep, despite having similar sleep efficiency measurements. The poor sleep quality perception was somewhat linked to fatigue severity but not related to depression or anxiety symptoms.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls.

Wyller, Vegard Bruun, Due, Reidar, Saul, J Philip et al.·The American journal of cardiology·2007

This study tested how the hearts of adolescents with ME/CFS respond to mild physical stress (tilting the body slightly upright for 15 minutes) compared to healthy teenagers. Researchers found that young people with ME/CFS had abnormal heart and blood vessel responses during this test—their hearts beat faster, their blood pressure increased more, and their stroke volume (amount of blood pumped per heartbeat) decreased more than in healthy controls. These differences suggest that ME/CFS involves problems with how the body regulates blood flow and heart function during even mild stress.

Autonomic Nervous System

E2 ModerateBehavioralPEM unclearCross-Sectional

Alexithymia in adolescents with chronic fatigue syndrome.

van de Putte, Elise M, Engelbert, Raoul H H, Kuis, Wietse et al.·Journal of psychosomatic research·2007

This study looked at whether adolescents with ME/CFS have difficulty identifying and describing their emotions (a trait called alexithymia) more often than healthy teenagers. Researchers found that while some teens with ME/CFS did have this trait, it wasn't significantly different from healthy controls, and it didn't predict who would recover. The study suggests that difficulty with emotions is not a unique feature of ME/CFS in young people.

E2 ModerateCohortPEM not requiredCross-Sectional

[Multiple chemical sensitivity: study of 52 cases].

Nogué, Santiago, Fernández-Solá, Joaquim, Rovira, Elisabet et al.·Medicina clinica·2007

This study looked at 52 patients with multiple chemical sensitivity (MCS)—a condition where people react badly to everyday chemicals like pesticides and cleaning products. Most patients were middle-aged women, and about 60% developed MCS after a workplace chemical exposure. The researchers found that people with MCS often have very similar symptoms to chronic fatigue syndrome, and while their condition stayed stable over time, it significantly reduced their quality of life.

E2 ModerateBehavioralPEM not requiredObservational

Chronic fatigue syndrome treated by acupuncture and moxibustion in combination with psychological approaches in 310 cases.

Guo, Junhua·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2007

This study examined whether a combination of acupuncture, moxibustion (a traditional Chinese medicine technique using heat), and psychological support could help people with chronic fatigue syndrome. Researchers treated 310 patients with this combined approach and found that most patients reported significant improvement in their symptoms. The results suggest this traditional medicine approach may be helpful for managing ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia.

Reeves, William C, Jones, James F, Maloney, Elizabeth et al.·Population health metrics·2007

This study surveyed over 5,600 people in Georgia to find out how many have ME/CFS. Researchers found that about 2.5% of adults aged 18-59 have the condition, which is higher than estimates from other parts of the United States. Interestingly, the disease affected men and women very differently depending on whether they lived in cities or rural areas.

E2 ModerateCohortPEM not requiredObservational

Defining the occurrence and influence of alpha-delta sleep in chronic fatigue syndrome.

Van Hoof, Elke, De Becker, Pascale, Lapp, Charles et al.·The American journal of the medical sciences·2007

This study looked at sleep patterns in 48 ME/CFS patients using overnight sleep recordings. Researchers found that patients had difficulty falling asleep, spent less time in deep restorative sleep, and showed an unusual pattern of brain waves (alpha-delta intrusion) during sleep. Interestingly, this abnormal sleep pattern was linked to anxiety rather than to immune system changes.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.

Sherlin, Leslie, Budzynski, Thomas, Kogan Budzynski, Helen et al.·NeuroImage·2007

Researchers used a special brain scanning technique called LORETA to measure electrical activity in the brains of identical twins—one with ME/CFS and one without. They found that twins with ME/CFS had different patterns of brain activity in specific regions, particularly in areas related to mood, energy management, and the nervous system's stress response. This suggests that ME/CFS may involve measurable differences in how certain parts of the brain function.

E2 ModerateBehavioralPEM not requiredLongitudinal

Incidence, prognosis, and risk factors for fatigue and chronic fatigue syndrome in adolescents: a prospective community study.

Rimes, Katharine A, Goodman, Robert, Hotopf, Matthew et al.·Pediatrics·2007

This study followed 842 British teenagers aged 11-15 for 4-6 months to see how common tiredness and chronic fatigue syndrome (CFS) were and what factors might make them more likely. About 30% of teens developed new fatigue during the study, while less than 1% developed chronic fatigue or CFS. Importantly, most teens who had CFS at the start of the study felt better by the follow-up visit, suggesting that CFS in adolescents often improves over time. Teens with anxiety, depression, or behavior problems were more likely to develop fatigue.

E2 ModerateCohortPEM not requiredCross-Sectional

The relative impact of 13 chronic conditions across three different outcomes.

Perruccio, Anthony V, Power, J Denise, Badley, Elizabeth M·Journal of epidemiology and community health·2007

This study looked at how 13 common long-term health conditions—including ME/CFS and fibromyalgia—affect people's daily activities, overall health, and doctor visits. Researchers used information from over 130,000 Canadians and found that ME/CFS and fibromyalgia had the strongest individual impact on activity limitations and poor health ratings, while conditions like arthritis and heart disease affected the most people overall in the population.

E2 ModerateCohortPEM unclearObservational

A real-time assessment of the effect of exercise in chronic fatigue syndrome.

Yoshiuchi, Kazuhiro, Cook, Dane B, Ohashi, Kyoko et al.·Physiology & behavior·2007

This study looked at what happens to people with ME/CFS after they exercise, tracking their symptoms in real-time using a watch-like computer for a week before and two weeks after exercise. The main finding was that physical symptoms like pain and fatigue got worse in ME/CFS patients, but this didn't happen right away—it took about five days to appear. Interestingly, mental symptoms and thinking abilities didn't show the same delayed worsening pattern that physical symptoms did.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Shortened QT interval: a distinctive feature of the dysautonomia of chronic fatigue syndrome.

Naschitz, Jochanan, Fields, Madeline, Isseroff, Hillel et al.·Journal of electrocardiology·2006

This study examined heart rhythm patterns in ME/CFS patients by measuring a specific electrical timing interval on EKGs (called the QT interval). Researchers found that people with ME/CFS had shorter QT intervals than healthy controls, both when lying down and during a head-up tilt test. This shortened interval appears to be linked to the autonomic nervous system problems common in ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Maes, Michael, Mihaylova, Ivana, De Ruyter, Marcel·Journal of affective disorders·2006

This study found that people with ME/CFS have lower levels of zinc in their blood compared to healthy people. The lower the zinc level, the worse some symptoms were, especially feelings of infection. Zinc helps protect the body from harmful molecules called free radicals, so low zinc may be one reason why ME/CFS involves increased stress and damage in the body.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome and high allostatic load.

Maloney, Elizabeth M, Gurbaxani, Brian M, Jones, James F et al.·Pharmacogenomics·2006

This study looked at whether people with ME/CFS have higher "allostatic load"—a measure of how much physical stress the body is under based on things like blood pressure, cortisol levels, and waist-to-hip ratio. Researchers compared 43 ME/CFS patients to 60 healthy people and found that ME/CFS patients were about twice as likely to have high allostatic load. This suggests that ME/CFS may involve ongoing physical stress on the body's systems.

Endocrine Disruption

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Exercise testing in children and adolescents with chronic fatigue syndrome.

Health status and health care utilization of multiple sclerosis in Canada.

Can submaximal exercise variables predict peak exercise performance in women with chronic fatigue syndrome?

Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.

Psychological, medical, and pharmacological correlates of persistent genital arousal disorder.

Actuarial analysis of private payer administrative claims data for women with endometriosis.

Sleep quality perception in the chronic fatigue syndrome: correlations with sleep efficiency, affective symptoms and intensity of fatigue.

Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls.

Alexithymia in adolescents with chronic fatigue syndrome.

[Multiple chemical sensitivity: study of 52 cases].

Chronic fatigue syndrome treated by acupuncture and moxibustion in combination with psychological approaches in 310 cases.

Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia.

Defining the occurrence and influence of alpha-delta sleep in chronic fatigue syndrome.

Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.

Incidence, prognosis, and risk factors for fatigue and chronic fatigue syndrome in adolescents: a prospective community study.

The relative impact of 13 chronic conditions across three different outcomes.

A real-time assessment of the effect of exercise in chronic fatigue syndrome.

Shortened QT interval: a distinctive feature of the dysautonomia of chronic fatigue syndrome.

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Chronic fatigue syndrome and high allostatic load.

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