ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2901–2920 of 6,160 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Medical comorbidity in bipolar disorder: implications for functional outcomes and health service utilization.

McIntyre, Roger S, Konarski, Jakub Z, Soczynska, Joanna K et al.·Psychiatric services (Washington, D.C.)·2006

This study looked at how common medical conditions like chronic fatigue syndrome, migraines, and asthma are in people with bipolar disorder, and how these extra health problems affect their daily lives. Researchers found that people with bipolar disorder who also had other medical conditions struggled more with work, needed more help from doctors, and were less likely to be employed than those with bipolar disorder alone.

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.

Mommersteeg, Paula M C, Heijnen, Cobi J, Verbraak, Marc J P M et al.·Psychoneuroendocrinology·2006

This study tested whether burnout affects the body's stress hormone system (cortisol levels) in the same way that chronic stress does. Researchers measured cortisol levels in 74 people with burnout and 35 healthy people using saliva samples and a hormone suppression test. They found no differences between the two groups, suggesting that burnout may not change cortisol patterns the way researchers expected.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCase-Control

Chronic widespread pain and its comorbidities: a population-based study.

Kato, Kenji, Sullivan, Patrick F, Evengård, Birgitta et al.·Archives of internal medicine·2006

This large study of over 44,000 Swedish adults found that chronic widespread pain (a hallmark of fibromyalgia) occurs together with ME/CFS, joint pain, depression, and irritable bowel syndrome much more often than by chance alone. Interestingly, when researchers compared twins, they discovered that shared family genes and home environment—not just the pain condition itself—explained much of why these conditions cluster together.

E2 ModerateCohortPEM not requiredCross-Sectional

Is chronic fatigue syndrome associated with platelet activation?

Kennedy, Gwen, Norris, Gillian, Spence, Vance et al.·Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2006

This study looked at whether people with ME/CFS have problems with blood clotting and platelet activation (small cells in blood that help form clots). Researchers tested 17 patients with CFS and 16 healthy control participants using standard blood tests. They found no evidence that CFS patients have increased clotting problems or overactive platelets.

E2 ModerateCohortPEM not requiredCross-Sectional

Patterns of hypocapnia on tilt in patients with fibromyalgia, chronic fatigue syndrome, nonspecific dizziness, and neurally mediated syncope.

Naschitz, Jochanan E, Mussafia-Priselac, Renata, Kovalev, Yulia et al.·The American journal of the medical sciences·2006

This study looked at whether people with ME/CFS, fibromyalgia, and dizziness breathe too fast when standing up, causing them to exhale too much carbon dioxide (a condition called hypocapnia). Researchers tested 585 people using a tilt table that slowly raises the upper body while measuring breathing patterns. They found that 9-27% of people with these conditions showed abnormal breathing on the tilt test, compared to 0-2% of healthy controls, suggesting this may be a real but not universal feature of these illnesses.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCase-Control

Allostatic load is associated with symptoms in chronic fatigue syndrome patients.

Goertzel, Benjamin N, Pennachin, Cassio, de Souza Coelho, Lucio et al.·Pharmacogenomics·2006

This study looked at whether ME/CFS patients have higher 'allostatic load'—a measure of stress on the body's systems including metabolism, heart function, and hormones. Researchers compared 43 ME/CFS patients to 60 healthy controls and found that ME/CFS patients with higher allostatic load reported worse physical function, more body pain, and more frequent symptoms. The study suggests the body's stress response systems may play a role in ME/CFS severity.

Energy Metabolism

E2 ModerateCohortPEM not requiredCase-Control

Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study.

Reeves, William C, Heim, Christine, Maloney, Elizabeth M et al.·BMC neurology·2006

This study compared sleep patterns in people with ME/CFS and healthy controls using overnight sleep monitoring tests. Researchers found that people with ME/CFS had slightly more breathing interruptions during sleep, but overall sleep architecture (the normal stages and patterns of sleep) was similar between the two groups. The results suggest that while sleep problems are common in ME/CFS, they may not be caused by the same underlying sleep abnormalities seen in other sleep disorders.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Medically evaluated psychological and physical health of Australian Gulf War veterans with chronic fatigue.

Kelsall, Helen, Sim, Malcolm, McKenzie, Dean et al.·Journal of psychosomatic research·2006

This study compared fatigue and health problems in Australian military veterans who served in the Gulf War with similar military personnel who did not deploy there. Researchers found that Gulf War veterans reported more fatigue at all severity levels than the comparison group. Importantly, unexplained chronic fatigue (similar to ME/CFS) was more common in veterans, though true ME/CFS remained rare in both groups, at levels similar to the general population.

E2 ModerateCohortPEM not requiredCross-Sectional

The influence of aerobic fitness and fibromyalgia on cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome.

Cook, Dane B, Nagelkirk, Paul R, Poluri, Ashok et al.·Arthritis and rheumatism·2006

This study compared how people with ME/CFS respond to exercise on a stationary bike, looking at heart rate, breathing, and how hard the exercise felt. People with ME/CFS alone had similar physical responses to healthy controls, but those with ME/CFS and fibromyalgia showed different breathing patterns and found exercise much more painful and exhausting.

E2 ModerateCohortPEM not requiredCase-Control

Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour?

Heesen, C, Nawrath, L, Reich, C et al.·Journal of neurology, neurosurgery, and psychiatry·2006

This study looked at whether immune system chemicals called cytokines might cause fatigue in multiple sclerosis patients, similar to how infection makes you feel tired and sick. Researchers compared blood samples from 15 MS patients with severe fatigue to 15 MS patients without fatigue, and found that those with fatigue had significantly higher levels of inflammatory molecules. This suggests that immune system activation may be a key driver of MS-related fatigue.

E2 ModerateBehavioralPEM not requiredLongitudinal

Long-term predictors of outcome in fatigued employees on sick leave: a 4-year follow-up study.

Leone, Stephanie S, Huibers, Marcus J H, Kant, Ijmert et al.·Psychological medicine·2006

This study followed 127 people who were on sick leave due to fatigue for 4 years to see who would recover and return to work. After 4 years, about one-quarter of the participants were still unable to work due to disability. The study found that people with lower physical functioning at the start were more likely to remain disabled and continue experiencing fatigue.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Mirrored symptoms in mother and child with chronic fatigue syndrome.

van de Putte, Elise M, van Doornen, Lorenz J P, Engelbert, Raoul H H et al.·Pediatrics·2006

This study looked at whether parents of teenagers with ME/CFS also have ME/CFS or similar fatigue symptoms. Researchers compared 40 adolescents with ME/CFS to 36 healthy teens and surveyed both children and parents about fatigue and mood. They found that mothers of teens with ME/CFS were significantly more likely to have fatigue and psychological distress similar to their child, while fathers showed no such pattern.

E2 ModerateCohortPEM not requiredCross-Sectional

Patients with chronic fatigue syndrome have reduced absolute cortical blood flow.

Yoshiuchi, Kazuhiro, Farkas, Jeffrey, Natelson, Benjamin H·Clinical physiology and functional imaging·2006

This study used advanced brain imaging to measure blood flow in the brains of 25 ME/CFS patients and 7 healthy people. Researchers found that ME/CFS patients had less blood flowing to parts of their brain compared to healthy controls, especially those without concurrent psychiatric conditions. This reduced blood flow might help explain some of the cognitive and physical symptoms ME/CFS patients experience.

E2 ModerateCohortPEM not requiredCross-Sectional

Impaired natural immunity, cognitive dysfunction, and physical symptoms in patients with chronic fatigue syndrome: preliminary evidence for a subgroup?

Siegel, Scott D, Antoni, Michael H, Fletcher, Mary Ann et al.·Journal of psychosomatic research·2006

This study looked at whether a specific immune system measure called natural killer cell activity (NKCA) could help identify different subgroups of ME/CFS patients. Researchers compared 41 women with ME/CFS who had low NKCA levels to those with normal levels, measuring their cognitive ability and symptoms. They found that patients with low NKCA reported worse cognitive problems, more daytime dysfunction, and performed worse on thinking tests compared to those with normal NKCA levels.

Immune System

E2 ModerateCohortPEM unclearObservational

Azithromycin in chronic fatigue syndrome (CFS), an analysis of clinical data.

Vermeulen, Ruud C W, Scholte, Hans R·Journal of translational medicine·2006

This study looked at whether azithromycin, an antibiotic with immune-modulating properties, could help ME/CFS patients. Researchers reviewed medical records from 99 patients who tried azithromycin after other treatments weren't sufficient. About 58 patients (roughly 59%) reported feeling better, and these responders had lower levels of a substance called acetylcarnitine in their blood.

Immune System

E2 ModerateCohortPEM not requiredObservational

[The peculiarities of formation and approaches to the treatment of chronic fatigue syndrome in young patients with focal brain damage].

Boĭko, A N, Batysheva, T T, Matvievskaia, O V et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2006

This study looked at chronic fatigue (tiredness that doesn't go away) in young patients who had brain injuries or diseases like multiple sclerosis or other brain conditions. Researchers tested whether a medication called Fezam (made from piracetam and cinnarizin) could help reduce this fatigue. The medication did help reduce fatigue severity, particularly in MS patients, though some patients experienced mild side effects like sleep problems.

Interventions

E2 ModerateBehavioralPEM not requiredCross-Sectional

Well-being in patients with chronic fatigue syndrome: the role of acceptance.

Van Damme, Stefaan, Crombez, Geert, Van Houdenhove, Boudewijn et al.·Journal of psychosomatic research·2006

This study looked at whether accepting ME/CFS—rather than fighting against it—might help patients feel better overall. Ninety-seven patients answered questionnaires about their fatigue, daily functioning, mood, and how much they accepted their illness. The researchers found that patients who accepted their condition reported better emotional health and less anxiety, even when accounting for how severe their fatigue was.

E2 ModerateCohortPEM unclearObservational

The war-related illness and injury study centers: a resource for deployment-related health concerns.

Lincoln, Andrew E, Helmer, Drew A, Schneiderman, Aaron I et al.·Military medicine·2006

This study looked at 53 combat veterans from the Persian Gulf War who had unexplained illnesses after returning home. Researchers found that many of these veterans had chronic fatigue syndrome, depression, and PTSD. When veterans received specialized care through a referral program, they showed a modest improvement in mental health symptoms and used more rehabilitation services.

E2 ModerateCohortPEM not requiredObservational

The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes.

Weir, Peter T, Harlan, Gregory A, Nkoy, Flo L et al.·Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2006

This study looked at how often fibromyalgia is diagnosed in a large group of insured people over a 6-year period. The researchers found that fibromyalgia is diagnosed more often in women than men, though not as dramatically as previous studies suggested. People with fibromyalgia were much more likely to also have other conditions like depression, anxiety, headaches, irritable bowel syndrome, chronic fatigue syndrome, lupus, and rheumatoid arthritis.

E2 ModerateCohortPEM not requiredCross-Sectional

Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome.

Chapenko, S, Krumina, A, Kozireva, S et al.·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study looked at whether two common viruses (HHV-6 and HHV-7) that usually stay dormant in the body might be reactivating in people with ME/CFS. Researchers found that people with ME/CFS were more likely to have both viruses active at the same time, and when both were active, their immune cells showed signs of stress. This suggests these viruses might play a role in ME/CFS, though the study cannot prove they cause the disease.

Immune System

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Medical comorbidity in bipolar disorder: implications for functional outcomes and health service utilization.

Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.

Chronic widespread pain and its comorbidities: a population-based study.

Is chronic fatigue syndrome associated with platelet activation?

Patterns of hypocapnia on tilt in patients with fibromyalgia, chronic fatigue syndrome, nonspecific dizziness, and neurally mediated syncope.

Allostatic load is associated with symptoms in chronic fatigue syndrome patients.

Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study.

Medically evaluated psychological and physical health of Australian Gulf War veterans with chronic fatigue.

The influence of aerobic fitness and fibromyalgia on cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome.

Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour?

Long-term predictors of outcome in fatigued employees on sick leave: a 4-year follow-up study.

Mirrored symptoms in mother and child with chronic fatigue syndrome.

Patients with chronic fatigue syndrome have reduced absolute cortical blood flow.

Impaired natural immunity, cognitive dysfunction, and physical symptoms in patients with chronic fatigue syndrome: preliminary evidence for a subgroup?

Azithromycin in chronic fatigue syndrome (CFS), an analysis of clinical data.

[The peculiarities of formation and approaches to the treatment of chronic fatigue syndrome in young patients with focal brain damage].

Well-being in patients with chronic fatigue syndrome: the role of acceptance.

The war-related illness and injury study centers: a resource for deployment-related health concerns.

The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes.

Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome.

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