ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2901–2920 of 6,209 studies

E2 ModerateBehavioralPEM unclearCross-Sectional

Alexithymia in adolescents with chronic fatigue syndrome.

van de Putte, Elise M, Engelbert, Raoul H H, Kuis, Wietse et al.·Journal of psychosomatic research·2007

This study looked at whether adolescents with ME/CFS have difficulty identifying and describing their emotions (a trait called alexithymia) more often than healthy teenagers. Researchers found that while some teens with ME/CFS did have this trait, it wasn't significantly different from healthy controls, and it didn't predict who would recover. The study suggests that difficulty with emotions is not a unique feature of ME/CFS in young people.

E2 ModerateCohortPEM not requiredCase-Control

Cold pressor pain sensitivity in monozygotic twins discordant for chronic fatigue syndrome.

Ullrich, Philip M, Afari, Niloofar, Jacobsen, Clemma et al.·Pain medicine (Malden, Mass.)·2007

This study compared identical twins where one had ME/CFS and one did not to understand pain sensitivity. Researchers tested how twins responded to cold pain and found that while people with ME/CFS reported significantly higher levels of pain and fatigue during the test, their actual physical pain thresholds were not substantially different from their unaffected twins. This suggests that the pain experience in ME/CFS may be more about how the brain perceives and processes pain rather than a difference in the body's basic pain detection system.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Journal of affective disorders·2007

This study found that people with ME/CFS have higher levels of immune antibodies (IgA and IgM) that react against bacteria normally found in the gut. The researchers suggest this indicates the gut barrier may be more permeable (leaky), allowing bacterial products to enter the bloodstream and trigger an immune response. The study suggests testing for these antibodies might help identify and treat this potential gut problem in ME/CFS patients.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Publication trends in chronic fatigue syndrome: comparisons with fibromyalgia and fatigue: 1995-2004.

Friedberg, Fred, Sohl, Stephanie, Schmeizer, Brett·Journal of psychosomatic research·2007

This study looked at how many scientific articles about ME/CFS were published between 1995 and 2004, and compared this to articles about fibromyalgia and fatigue. The researchers found that while articles about fibromyalgia and general fatigue increased significantly during this decade, the number of ME/CFS articles stayed relatively flat. This suggests that ME/CFS was not receiving growing research attention compared to similar conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

Hypocapnia is a biological marker for orthostatic intolerance in some patients with chronic fatigue syndrome.

Natelson, Benjamin H, Intriligator, Roxann, Cherniack, Neil S et al.·Dynamic medicine : DM·2007

This study compared how ME/CFS patients and healthy volunteers responded to standing up for 8 minutes. Researchers measured blood pressure, heart rate, breathing rate, and carbon dioxide levels in the blood. ME/CFS patients were more likely than healthy people to have abnormal responses, particularly low carbon dioxide levels (hypocapnia), which was linked to feeling more ill and short of breath.

Biomarkers

E2 ModerateCohortPEM not required

Characteristics of the formation of chronic fatigue syndrome and approaches to its treatment in young patients with focal brain damage.

Boiko, A N, Batysheva, T T, Matvievskaya, O V et al.·Neuroscience and behavioral physiology·2007

This study looked at why people with brain injuries (from multiple sclerosis, stroke, infection, or trauma) develop severe fatigue. Researchers tested 50 patients and gave half of them a medication called Fezam to see if it would help. The medication reduced fatigue symptoms, especially in MS patients, with few side effects.

Interventions

E2 ModerateBehavioralPEM not requiredLongitudinal

[Course, consequences and treatment of prolonged fatigue among workers: an overview of findings from the Maastricht Cohort Study].

Kant, Ij, Jansen, N W H, van Amelsvoort, L G P M et al.·Tijdschrift voor psychiatrie·2007

This study followed over 12,000 workers for 4 years to understand how prolonged fatigue develops and affects people's lives. Researchers found that fatigue often lasts a long time and can lead to serious problems like missed work, job loss, and weakened immunity. When doctors tried treating fatigue with brief talk therapy, it did not help.

E2 ModerateCohortPEM not requiredCross-Sectional

Endometriosis is associated with prevalence of comorbid conditions in migraine.

Tietjen, Gretchen E, Bushnell, Cheryl D, Herial, Nabeel A et al.·Headache·2007

This study found that women with migraines who also have endometriosis (a painful condition affecting the uterus) experience more frequent and severe headaches than women with migraines alone. Women with both conditions were also more likely to have other related conditions like chronic fatigue syndrome, anxiety, and bladder pain. The findings suggest these conditions may share common underlying factors, possibly related to hormones.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Complementary and alternative medical therapy utilization by people with chronic fatiguing illnesses in the United States.

Jones, James F, Maloney, Elizabeth M, Boneva, Roumiana S et al.·BMC complementary and alternative medicine·2007

This study looked at how many people with ME/CFS and similar fatiguing illnesses use complementary and alternative medicine (CAM) therapies like massage, chiropractic care, prayer, and other non-conventional treatments. Researchers surveyed over 880 people across the United States and found that people with ME/CFS-like illness were more likely to use body-based therapies (like massage and chiropractic) and mind-body therapies than people without fatigue.

Interventions

E2 ModerateCohortPEM unclearCross-Sectional

Impact of visual impairment on quality of life: a comparison with quality of life in the general population and with other chronic conditions.

Langelaan, Maaike, de Boer, Michiel R, van Nispen, Ruth M A et al.·Ophthalmic epidemiology·2007

This study looked at how visual impairment affects people's quality of life by comparing visually impaired patients with healthy people and those with other chronic conditions. Researchers found that visual impairment has a significant negative impact on quality of life, affecting people's daily functioning. Interestingly, only a few conditions—including chronic fatigue syndrome—impacted quality of life more severely than visual impairment.

E2 ModerateCohortPEM not requiredCase-Control

A twin study of cognitive function in chronic fatigue syndrome: the effects of sudden illness onset.

Claypoole, Keith H, Noonan, Carolyn, Mahurin, Roderick K et al.·Neuropsychology·2007

This study compared 22 pairs of identical twins where one had ME/CFS and the other was healthy. Researchers gave both twins thinking and memory tests to see if ME/CFS affects the brain. Twins with ME/CFS had slower processing speed, weaker verbal memory, slower motor responses, and more difficulty with complex thinking tasks, even though they had the same genetic background as their healthy twin.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Twin analyses of fatigue.

Schur, Ellen, Afari, Niloofar, Goldberg, Jack et al.·Twin research and human genetics : the official journal of the International Society for Twin Studies·2007

This study looked at whether fatigue and ME/CFS run in families by studying twins. Researchers asked over 1,000 pairs of identical twins and 800 pairs of fraternal twins about their fatigue symptoms. They found that in men, genetics played a bigger role in fatigue, while in women, life circumstances and personal experiences were more important.

E2 ModerateCohortPEM not requiredCross-Sectional

Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells.

Mihaylova, Ivana, DeRuyter, Marcel, Rummens, Jean-Luc et al.·Neuro endocrinology letters·2007

This study looked at immune cell activation in people with ME/CFS by measuring a protein called CD69 on the surface of immune cells. Researchers found that ME/CFS patients had significantly lower levels of this activation marker on their T cells and natural killer cells compared to healthy people, even though the total number of immune cells was normal. This suggests that immune cells in ME/CFS may have trouble becoming activated properly in response to challenges.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

[Multiple chemical sensitivity: study of 52 cases].

Nogué, Santiago, Fernández-Solá, Joaquim, Rovira, Elisabet et al.·Medicina clinica·2007

This study looked at 52 patients with multiple chemical sensitivity (MCS)—a condition where people react badly to everyday chemicals like pesticides and cleaning products. Most patients were middle-aged women, and about 60% developed MCS after a workplace chemical exposure. The researchers found that people with MCS often have very similar symptoms to chronic fatigue syndrome, and while their condition stayed stable over time, it significantly reduced their quality of life.

E2 ModerateCohortPEM not requiredCase-Control

Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based study.

Boneva, Roumiana S, Decker, Michael J, Maloney, Elizabeth M et al.·Autonomic neuroscience : basic & clinical·2007

This study found that people with ME/CFS have a faster heart rate and less heart rate variability (natural changes in heartbeat speed) during sleep compared to healthy people. These differences suggest that the nervous system in ME/CFS patients stays more activated even during sleep, which may be related to chemical imbalances in the body.

SleepAutonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Functioning in individuals with chronic fatigue syndrome: increased impairment with co-occurring multiple chemical sensitivity and fibromyalgia.

Brown, Molly M, Jason, Leonard A·Dynamic medicine : DM·2007

This study looked at 114 people with ME/CFS to see how often they also had fibromyalgia or multiple chemical sensitivity, and whether having more than one condition made their symptoms worse. The researchers found that about 44% had ME/CFS alone, while others had it combined with one or both of the other conditions. People with all three conditions were the most disabled and had the hardest time with daily activities compared to those with ME/CFS alone.

E2 ModerateCohortPEM unclearCross-Sectional

Health status and health care utilization of multiple sclerosis in Canada.

Pohar, Sheri L, Jones, C Allyson, Warren, Sharon et al.·The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2007

This Canadian study compared people living with multiple sclerosis (MS) to people without MS to understand how the disease affects their daily lives and health care needs. People with MS reported much worse overall health, were far more likely to experience fatigue and urinary problems, and had greater health care utilization. The study found that MS significantly burdens patients' quality of life and that their health care needs were often not being met.

E2 ModerateCohortPEM not requiredCross-Sectional

Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls.

Wyller, Vegard Bruun, Due, Reidar, Saul, J Philip et al.·The American journal of cardiology·2007

This study tested how the hearts of adolescents with ME/CFS respond to mild physical stress (tilting the body slightly upright for 15 minutes) compared to healthy teenagers. Researchers found that young people with ME/CFS had abnormal heart and blood vessel responses during this test—their hearts beat faster, their blood pressure increased more, and their stroke volume (amount of blood pumped per heartbeat) decreased more than in healthy controls. These differences suggest that ME/CFS involves problems with how the body regulates blood flow and heart function during even mild stress.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Feeling bad in more ways than one: comorbidity patterns of medically unexplained and psychiatric conditions.

Schur, Ellen A, Afari, Niloofar, Furberg, Helena et al.·Journal of general internal medicine·2007

This study looked at how often nine conditions—including ME/CFS, fibromyalgia, depression, and others—occur together in the same people. Researchers found that these conditions overlap far more than would happen by chance, suggesting they may share common underlying causes. The study identified four different groups of people based on their condition patterns, with one small group having nearly all nine conditions and experiencing the worst health outcomes.

E2 ModerateCohortPEM not requiredLongitudinal

Cortisol and severe fatigue: a longitudinal study in adolescent girls.

Ter Wolbeek, Maike, van Doornen, Lorenz J P, Coffeng, Luc E et al.·Psychoneuroendocrinology·2007

This study looked at whether girls with severe, ongoing fatigue have different stress hormone (cortisol) levels than girls without fatigue. Researchers tested cortisol levels at different times over a year and found that while fatigued girls reported much worse symptoms overall, their cortisol levels were actually normal and similar to non-fatigued girls. This suggests that severe fatigue in adolescents may not be caused by problems with how the body manages stress hormones.

Endocrine Disruption

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Alexithymia in adolescents with chronic fatigue syndrome.

Cold pressor pain sensitivity in monozygotic twins discordant for chronic fatigue syndrome.

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability.

Publication trends in chronic fatigue syndrome: comparisons with fibromyalgia and fatigue: 1995-2004.

Hypocapnia is a biological marker for orthostatic intolerance in some patients with chronic fatigue syndrome.

Characteristics of the formation of chronic fatigue syndrome and approaches to its treatment in young patients with focal brain damage.

[Course, consequences and treatment of prolonged fatigue among workers: an overview of findings from the Maastricht Cohort Study].

Endometriosis is associated with prevalence of comorbid conditions in migraine.

Complementary and alternative medical therapy utilization by people with chronic fatiguing illnesses in the United States.

Impact of visual impairment on quality of life: a comparison with quality of life in the general population and with other chronic conditions.

A twin study of cognitive function in chronic fatigue syndrome: the effects of sudden illness onset.

Twin analyses of fatigue.

Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells.

[Multiple chemical sensitivity: study of 52 cases].

Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based study.

Functioning in individuals with chronic fatigue syndrome: increased impairment with co-occurring multiple chemical sensitivity and fibromyalgia.

Health status and health care utilization of multiple sclerosis in Canada.

Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls.

Feeling bad in more ways than one: comorbidity patterns of medically unexplained and psychiatric conditions.

Cortisol and severe fatigue: a longitudinal study in adolescent girls.

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