ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3141–3160 of 6,161 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Comparative study of anxiety, depression, somatization, functional disability, and illness attribution in adolescents with chronic fatigue or migraine.

Smith, Mark S, Martin-Herz, Susanne P, Womack, William M et al.·Pediatrics·2003

This study compared teenage girls and boys with chronic fatigue, migraine headaches, and healthy peers to understand their emotional health and how much school they missed. Teenagers with chronic fatigue that met official diagnostic criteria had higher rates of anxiety, depression, and physical complaints than the other groups, and missed far more school days. Interestingly, parents of teenagers with unexplained chronic fatigue were less likely to think psychological stress was contributing to their child's illness compared to parents of teenagers with migraines.

E2 ModerateCohortPEM not requiredCase-Control

Symptoms of rhinosinusitis in patients with unexplained chronic fatigue or bodily pain: a pilot study.

Chester, Alexander C·Archives of internal medicine·2003

This study looked at whether people with unexplained chronic fatigue or body pain experience more sinus and nasal symptoms than people without these conditions. Researchers compared 297 patients and found that those with unexplained fatigue were much more likely to report symptoms like facial pressure, headaches, nasal obstruction, and postnasal drip—but not allergies. This suggests that sinus problems may be connected to chronic fatigue in ways doctors haven't fully recognized.

E2 ModerateCohortPEM not requiredCase-Control

Comparison of subjective and objective measures of insomnia in monozygotic twins discordant for chronic fatigue syndrome.

Watson, Nathaniel F, Kapur, Vishesh, Arguelles, Lester M et al.·Sleep·2003

People with ME/CFS report feeling like they sleep poorly and don't rest well, but when researchers measured their actual sleep using medical equipment, the sleep looked similar to their healthy identical twins. The main difference was that people with ME/CFS had more REM sleep (a specific sleep stage) and felt much less refreshed after sleeping, even though the equipment showed they were sleeping normally. This suggests that ME/CFS may involve a mismatch between how sleep actually is and how it feels.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Health and functional status of twins with chronic regional and widespread pain.

Aaron, Leslie A, Arguelles, Lester M, Ashton, Suzanne et al.·The Journal of rheumatology·2002

This study looked at twins where one had chronic pain (either in one area or widespread) and the other did not, to understand how pain affects health and function independent of ME/CFS. Researchers found that chronic pain significantly worsens general health perception, physical functioning, and sleep quality, effects that remain even after accounting for ME/CFS. However, the mental health impact of pain appears closely linked to having ME/CFS symptoms together.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

[Utilization of national insurance in connection with functional somatic disorders].

Brage, Søren·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2002

This study looked at how much money Norway's national insurance system spent on people with chronic fatigue syndrome and other similar long-term conditions in the year 2000. Researchers found that these conditions caused about 3% of all sick leave taken by workers and affected about 6% of people newly approved for disability payments. The study shows that these conditions, particularly fibromyalgia, have a significant financial impact on healthcare systems.

E2 ModerateCohortPEM not requiredCase-Control

Symptom occurrence in persons with chronic fatigue syndrome.

Jason, L A, Torres-Harding, S R, Carrico, A W et al.·Biological psychology·2002

This study compared symptoms between people with ME/CFS, people with depression, and healthy controls to understand which symptoms are specific to ME/CFS. The researchers found that certain pain symptoms (headaches, sore throat, joint and muscle pain) were common in ME/CFS but also appeared in depression. However, ME/CFS patients uniquely experienced widespread muscle weakness and various heart, lung, and nervous system symptoms that weren't seen in the other groups.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

The prevalence of chronic fatigue syndrome in Iceland - a national comparison by gender drawing on four different criteria.

Líndal, Eiríkur, Stefánsson, Jón G, Bergmann, Sverrir·Nordic journal of psychiatry·2002

This study asked over 2,500 Icelanders about symptoms of chronic fatigue syndrome (CFS) to find out how many people have it. Different diagnosis criteria gave very different results—ranging from 0% to 4.9%—showing that how doctors define CFS matters a lot. The study found that women made up most of the people with CFS, and there were some interesting differences between men and women in their symptoms.

Diagnostics

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Validation of a telephone cognitive assessment test battery for use in chronic fatigue syndrome.

McCue, P, Scholey, A B, Herman, C et al.·Journal of telemedicine and telecare·2002

This study tested whether a telephone-based brain function test could accurately detect thinking problems in people with ME/CFS. Researchers compared two versions of the same test—one on a computer and one done by telephone—in 30 people with ME/CFS and 30 healthy people. Both versions showed that people with ME/CFS were significantly slower at thinking tasks involving attention, memory, and focus, confirming that cognitive problems are real and measurable in this illness.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis.

Sinaii, N, Cleary, S D, Ballweg, M L et al.·Human reproduction (Oxford, England)·2002

This study found that women with endometriosis—a painful condition where tissue grows outside the uterus—have much higher rates of ME/CFS, fibromyalgia, and autoimmune diseases compared to the general population. Researchers surveyed nearly 3,700 women with endometriosis and compared their health conditions to published data about women without endometriosis. Women with endometriosis were 150 times more likely to have ME/CFS and nearly twice as likely to have fibromyalgia.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Hemodynamic and neurohumoral responses to head-up tilt in patients with chronic fatigue syndrome.

Timmers, H J L M, Wieling, W, Soetekouw, P M M B et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2002

This study looked at whether ME/CFS patients have problems with blood pressure and heart rate control when standing up or tilting upright. Researchers tested 36 ME/CFS patients and 36 healthy people by tilting them upright for 40 minutes while measuring heart function and stress hormones. About 28% of ME/CFS patients had abnormal responses (like fainting symptoms or rapid heart rate), compared to 17% of healthy controls, though this difference was not statistically significant.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCase-Control

IgM serum antibodies to human cytomegalovirus nonstructural gene products p52 and CM2(UL44 and UL57) are uniquely present in a subset of patients with chronic fatigue syndrome.

Lerner, A Martin, Beqaj, Safedin H, Deeter, Robert G et al.·In vivo (Athens, Greece)·2002

Researchers tested blood samples from ME/CFS patients and healthy controls for specific antibodies to cytomegalovirus (CMV), a common virus. They found that 16 ME/CFS patients had unique antibodies to two CMV proteins (p52 and CM2) that were not found in 77 control subjects, including other ME/CFS patients and healthy people. This suggests these antibodies might be a specific marker for a subset of ME/CFS patients and could indicate an ongoing or incomplete CMV infection in this group.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Treatments for chronic fatigue syndrome and the Internet: a systematic survey of what your patients are reading.

Kisely, Stephen R·The Australian and New Zealand journal of psychiatry·2002

Researchers looked at what information about ME/CFS treatments people were finding on the Internet in 2000. They found that most websites did not provide balanced or accurate information compared to what scientific research actually shows. Only a few websites told readers to check the information with their doctor, and many lacked proper author credentials or sources.

E2 ModerateCohortPEM not requiredCross-Sectional

Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome.

Sargent, Charli, Scroop, Garry C, Nemeth, Peter M et al.·Medicine and science in sports and exercise·2002

This study tested whether people with ME/CFS have reduced oxygen processing ability compared to healthy people. Researchers had 33 ME/CFS patients and 33 matched healthy controls perform exercise tests on stationary bikes while measuring heart rate and oxygen use. The results showed that ME/CFS patients had normal oxygen uptake capacity similar to sedentary healthy people of the same age and gender, contrary to what some earlier studies had reported.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study.

Van Houdenhove, Boudewijn, Neerinckx, Eddy, Onghena, Patrick et al.·Psychotherapy and psychosomatics·2002

This study looked at the everyday frustrations and worries that ME/CFS and fibromyalgia patients experience compared to people with other chronic illnesses like multiple sclerosis and rheumatoid arthritis. Researchers found that ME/CFS and fibromyalgia patients reported more frequent daily hassles and felt more emotionally distressed by them. The main worries for ME/CFS and fibromyalgia patients centered on feeling bad about themselves, feeling uncertain, and not being recognized or understood by others.

E2 ModerateCohortPEM not requiredCase-Control

Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls.

Barron, Diana F, Cohen, Bernard A, Geraghty, Michael T et al.·The Journal of pediatrics·2002

This study compared how flexible the joints are in children with ME/CFS versus healthy children. Researchers found that children with ME/CFS had much more joint flexibility than healthy children—60% of children with ME/CFS had highly flexible joints compared to only 24% of healthy children. This suggests that joint hypermobility (unusually flexible joints) may be more common in ME/CFS.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale).

Zachrisson, Olof, Regland, Björn, Jahreskog, Marianne et al.·Journal of psychosomatic research·2002

Researchers created a simple checklist called the FibroFatigue scale to help doctors measure how severe fibromyalgia and ME/CFS symptoms are and track whether treatments are working. The scale includes 12 questions about common symptoms like pain, tiredness, sleep problems, and concentration difficulties. The new tool was tested on 100 women with both conditions and was found to be reliable and accurate.

E2 ModerateCohortPEM not requiredCross-Sectional

High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients.

Nijs, Jo, Nicolson, Garth L, De Becker, Pascale et al.·FEMS immunology and medical microbiology·2002

This study looked for four types of bacteria called Mycoplasma in the blood of 261 ME/CFS patients in Europe and compared them to 36 healthy people. The researchers found that about 69% of ME/CFS patients had at least one type of Mycoplasma bacteria, compared to only 6% of healthy controls. The most common type found was M. hominis, followed by M. pneumoniae and M. fermentans.

E2 ModerateCohortPEM not requiredCase-Control

Low-dose dexamethasone suppression test in chronic fatigue syndrome and health.

Gaab, Jens, Hüster, Dominik, Peisen, Renate et al.·Psychosomatic medicine·2002

This study looked at how the body's stress-response system (called the HPA axis) works differently in ME/CFS patients compared to healthy people. Researchers measured cortisol levels in saliva at different times of day, and then gave participants a small dose of a steroid medication to see how well the body could shut down cortisol production. They found that ME/CFS patients' cortisol levels dropped much more dramatically and stayed suppressed longer after the medication, suggesting their stress system may be working overtime to control itself.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences.

Servaes, Petra, Prins, Judith, Verhagen, Stans et al.·Journal of psychosomatic research·2002

This study compared 57 women with ME/CFS to 57 women who had breast cancer and were experiencing severe fatigue after treatment. Researchers measured fatigue, physical activity, mood, sleep, and concentration using questionnaires, tests, and activity monitors worn for 12 days. While both groups experienced significant fatigue, ME/CFS patients generally had more severe symptoms overall, though some breast cancer survivors reported similar problems with sleep and concentration.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome.

Koelle, David M, Barcy, Serge, Huang, Meei-Li et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2002

Researchers compared 22 pairs of identical twins—where one twin had ME/CFS and one was healthy—to see if viral infections might cause the illness. They tested blood and saliva samples for antibodies and DNA from 10 different viruses known to hide in the body. Surprisingly, they found no differences in viral markers between the twins with ME/CFS and their healthy siblings.

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Comparative study of anxiety, depression, somatization, functional disability, and illness attribution in adolescents with chronic fatigue or migraine.

Symptoms of rhinosinusitis in patients with unexplained chronic fatigue or bodily pain: a pilot study.

Comparison of subjective and objective measures of insomnia in monozygotic twins discordant for chronic fatigue syndrome.

Health and functional status of twins with chronic regional and widespread pain.

[Utilization of national insurance in connection with functional somatic disorders].

Symptom occurrence in persons with chronic fatigue syndrome.

The prevalence of chronic fatigue syndrome in Iceland - a national comparison by gender drawing on four different criteria.

Validation of a telephone cognitive assessment test battery for use in chronic fatigue syndrome.

High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis.

Hemodynamic and neurohumoral responses to head-up tilt in patients with chronic fatigue syndrome.

IgM serum antibodies to human cytomegalovirus nonstructural gene products p52 and CM2(UL44 and UL57) are uniquely present in a subset of patients with chronic fatigue syndrome.

Treatments for chronic fatigue syndrome and the Internet: a systematic survey of what your patients are reading.

Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome.

Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study.

Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls.

A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale).

High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients.

Low-dose dexamethasone suppression test in chronic fatigue syndrome and health.

Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences.

Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome.

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