ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

321–340 of 1,205 studies

E2 ModerateCohortPEM not requiredObservational

Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome.

Nguyen, Chinh Bkrong, Kumar, Surendra, Zucknick, Manuela et al.·Brain, behavior, and immunity·2019

This study looked at blood samples from teenagers with ME/CFS to understand how their immune systems and stress-response chemicals differ from healthy teenagers. Researchers found two distinct subgroups of ME/CFS patients based on immune activity and a stress hormone called norepinephrine. Patients with lower norepinephrine levels had more severe fatigue, while those with higher levels showed different patterns of immune dysfunction.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCase-Control

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome.

Al-Rawaf, Hadeel A, Alghadir, Ahmad H, Gabr, Sami A·Pain practice : the official journal of World Institute of Pain·2019

This study looked at tiny molecules called microRNAs in the blood of adolescents with ME/CFS to see if they could help explain why these patients experience pain. Researchers found that five specific microRNAs were lower in ME/CFS patients compared to healthy teens, and these changes were linked to higher levels of inflammatory chemicals that are known to cause pain. Interestingly, girls with ME/CFS had even lower microRNA levels and higher inflammation markers than boys with the condition.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredLongitudinal

Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study.

Tsai, Shin-Yi, Chen, Hsuan-Ju, Lio, Chon-Fu et al.·Journal of translational medicine·2019

This study found that people with inflammatory bowel disease (IBD) are more than twice as likely to develop ME/CFS compared to people without IBD. The researchers looked at medical records from Taiwan and followed patients over time to see who developed ME/CFS. The increased risk was especially high in men and older adults with IBD who didn't have other chronic conditions.

Evidence Atlas

Evidence browser

Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome.

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome.

Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study.

Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules.

Multidimensional Comparison of Cancer-Related Fatigue and Chronic Fatigue Syndrome: The Role of Psychophysiological Markers.

Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia.

Searching for Serum Antibodies to Neuronal Proteins in Patients With Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Rituximab Serum Concentrations and Anti-Rituximab Antibodies During B-Cell Depletion Therapy for Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome.

Evaluation of four clinical laboratory parameters for the diagnosis of myalgic encephalomyelitis.

Reduction of Glucocorticoid Receptor Function in Chronic Fatigue Syndrome.

Association of T and NK Cell Phenotype With the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies.

Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microarray Differentiates Cases from Controls with High Specificity and Sensitivity.

Association between cytokines and psychiatric symptoms in chronic fatigue syndrome and healthy controls.

Hair and salivary cortisol in a cohort of women with chronic fatigue syndrome.

Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model.

[Investigation of the diagnostic value of anti-dense fine speckled 70/lens epithelium derived growth factor p75 autoantibody for autoimmune diseases].

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Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research