Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Herrera, Santiago, de Vega, Wilfred C, Ashbrook, David et al.·Epigenetics·2018
This study examined how genes and chemical switches on genes (called methylation) work together in ME/CFS patients. Researchers compared immune cells from people with ME/CFS to healthy people, looking at hundreds of thousands of genetic markers and chemical modifications. They found that certain chemical switches on genes involved in immune function and energy production are different in ME/CFS patients, and these differences are connected to a person's genetic makeup.