ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

341–360 of 6,122 studies

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Rasa, Santa, Nora-Krukle, Zaiga, Henning, Nina et al.·Journal of translational medicine·2018

This review examined all existing research on whether viruses might cause ME/CFS. Scientists found that while many studies have looked at different viruses, the research has been poorly designed and inconsistent, making it hard to draw firm conclusions. The authors suggest that future studies need better planning and more rigorous methods to properly answer whether viruses play a role in ME/CFS.

E0 ConsensusReviewPEM not requiredSystematic-Review

Measuring School Functioning in Students With Chronic Fatigue Syndrome: A Systematic Review.

Tollit, Michelle, Politis, Jennifer, Knight, Sarah·The Journal of school health·2018

This review looked at 36 studies examining how ME/CFS affects students' school experiences. Researchers found that most studies only measured school absences, but didn't thoroughly look at other important aspects like grades, motivation, or what support students receive. The review highlights that we need better ways to measure and understand how ME/CFS impacts all areas of school life.

E0 ConsensusReviewPEM not requiredReview-Narrative

Antibodies Against GPCR.

Meyer, Carlotto, Heidecke, Harald·Frontiers in bioscience (Landmark edition)·2018

This review examines how the body's own antibodies (immune proteins) can mistakenly attack receptors on cell surfaces called GPCRs, which are involved in many bodily functions. The authors summarize evidence that these misdirected antibodies may play a role in several diseases, including chronic fatigue syndrome (ME/CFS), heart disease, and autoimmune conditions. Understanding these antibodies could help doctors develop better diagnostic tests and treatments.

Immune System

E0 ConsensusReviewPEM unclearSystematic-Review

Effectiveness of Mindfulness- and Relaxation-Based eHealth Interventions for Patients with Medical Conditions: a Systematic Review and Synthesis.

Mikolasek, Michael, Berg, Jonas, Witt, Claudia M et al.·International journal of behavioral medicine·2018

Researchers reviewed 17 online programs that teach mindfulness and relaxation techniques to people with various medical conditions, including chronic fatigue syndrome. These digital programs generally showed benefits for overall health and mood, though they didn't clearly help with stress reduction or mindfulness skills themselves. The findings suggest these programs could be a helpful addition to standard medical treatment.

E0 ConsensusReviewPEM not requiredSystematic-Review

A Review Study on the Beneficial Effects of Baduanjin.

Zou, Liye, Pan, Zhujun, Yeung, Albert et al.·Journal of alternative and complementary medicine (New York, N.Y.)·2018

This review looked at 22 studies about Baduanjin, a gentle Chinese exercise that combines movement with mental focus. The studies suggest that Baduanjin may help improve thinking abilities, mood, sleep, and physical symptoms in people with various conditions, including those with chronic fatigue-like illness. However, the authors note that better-quality, longer-lasting studies are needed before we can be confident about these benefits.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredSystematic-Review

A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review.

Teodoro, Tiago, Edwards, Mark J, Isaacs, Jeremy D·Journal of neurology, neurosurgery, and psychiatry·2018

Many people with ME/CFS report cognitive problems like brain fog, forgetfulness, and difficulty concentrating. This review of 95 studies found that while patients consistently describe these symptoms, standard memory and thinking tests often show normal or only mild problems. The authors suggest that pain, fatigue, and the body's excessive self-monitoring may force the brain to work harder on everyday tasks, making thinking feel more exhausting even when test results look relatively normal.

Cognitive Impairment

E0 ConsensusReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Evidence for an autoimmune disease.

Sotzny, Franziska, Blanco, Julià, Capelli, Enrica et al.·Autoimmunity reviews·2018

This review examines evidence that ME/CFS may be caused by the immune system attacking the body (autoimmune disease). Researchers found that people with ME/CFS have unusual immune patterns, including abnormal antibodies and changes in immune cells. Importantly, a treatment that removes certain immune cells (rituximab) helped about half of ME/CFS patients in clinical trials, suggesting an autoimmune mechanism in at least some people.

Energy MetabolismImmune System

E0 ConsensusReviewPEM unclearSystematic-Review

Exercise therapy is a beneficial intervention for chronic fatigue syndrome (PEDro synthesis).

Dannaway, Jasan, New, Cameron C, New, Charles H et al.·British journal of sports medicine·2018

This review examined multiple studies to determine whether exercise therapy helps people with ME/CFS. The researchers looked at existing evidence to see if physical activity programs could improve fatigue and other symptoms. However, it's important to note that findings on exercise for ME/CFS are complex and sometimes controversial in the patient community.

Interventions

E0 ConsensusReviewPEM not requiredReview-Narrative

Cognitive behavioural therapy in the treatment of chronic fatigue syndrome: A narrative review on efficacy and informed consent.

Geraghty, Keith J, Blease, Charlotte·Journal of health psychology·2018

This review looked at whether cognitive behavioural therapy (CBT)—a type of talk therapy focused on thoughts and behaviors—actually helps ME/CFS patients. The researchers found that CBT may help some people feel less tired in the short term, but there's little proof it works long-term or improves physical abilities. Importantly, CBT can sometimes make people feel worse if it's not done carefully, and much of any improvement might come from the therapist's skill or placebo effect rather than the therapy itself.

Interventions

E0 ConsensusReviewPEM not requiredSystematic-Review

Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome.

Roma, Maria, Marden, Colleen L, De Wandele, Inge et al.·Autonomic neuroscience : basic & clinical·2018

This review looked at research connecting two conditions: orthostatic intolerance (difficulty standing up without dizziness, rapid heartbeat, or fainting) and Ehlers-Danlos syndrome (a connective tissue disorder causing loose joints and flexible skin). The researchers found that people with Ehlers-Danlos syndrome experience orthostatic intolerance symptoms much more often than healthy people, and these symptoms significantly affect their quality of life.

Autonomic Nervous System

E0 ConsensusReviewPEM unclearEditorial

Cognitive behaviour therapy and objective assessments in chronic fatigue syndrome.

McPhee, Graham·Journal of health psychology·2017

This review looked at studies testing whether cognitive behavioral therapy (CBT)—a talking treatment—helps people with ME/CFS. Most studies only asked patients if they felt better, but didn't measure whether they could actually do more physical activities. The review found little evidence that CBT improves what patients can actually do or helps them return to work.

E0 ConsensusReviewPEM unclearSystematic-Review

Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.

Campagnolo, N, Johnston, S, Collatz, A et al.·Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2017

Researchers reviewed 17 studies looking at whether diet changes and supplements could help ME/CFS symptoms like fatigue and quality of life. While a few interventions—including NADH, probiotics, and high-cocoa chocolate—showed promise for reducing fatigue, most studies did not find clear benefits. Overall, there isn't enough strong evidence yet to recommend specific diets or supplements as reliable treatments for ME/CFS.

E0 ConsensusReviewPEM not requiredSystematic-Review

Exercise therapy for chronic fatigue syndrome.

Larun, Lillebeth, Brurberg, Kjetil G, Odgaard-Jensen, Jan et al.·The Cochrane database of systematic reviews·2017

This review looked at eight research studies testing whether exercise therapy helps people with ME/CFS feel less fatigued and improve their daily functioning. Overall, patients who did exercise therapy felt less tired and reported better sleep and physical function compared to those who received standard care or relaxation therapy. Exercise therapy appeared to work about as well as cognitive-behavioral therapy (talking therapy), though more research is needed to figure out the best type, intensity, and duration of exercise for each patient.

Sleep

E0 ConsensusReviewPEM not requiredEditorial

[Chronic Fatigue Syndrome: A Critical Review].

Rollnik, Jens D·Fortschritte der Neurologie-Psychiatrie·2017

This review examines whether ME/CFS is a distinct disease or if its symptoms overlap significantly with depression and other conditions. The authors found that while ME/CFS affects less than 1% of the population, there is no clear biological explanation for what causes it, and there are no universally agreed-upon diagnostic criteria. They recommend trying exercise, antidepressants, and talk therapy, but caution against using aggressive immune therapies without stronger evidence.

Diagnostics

E0 ConsensusReviewPEM unclearReview-Narrative

Pediatric chronic fatigue syndrome: current perspectives.

Crawley, Esther·Pediatric health, medicine and therapeutics·2017

This review examines ME/CFS in children, showing it is a common condition that significantly affects children and their families. The good news is that most children improve when they receive specialized treatment from doctors who understand this illness. The review summarizes what we know about how many children get ME/CFS, what factors may be involved, and what treatments have evidence supporting them.

Interventions

E0 ConsensusReviewPEM unclearReview-Narrative

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome.

Castro-Marrero, Jesus, Sáez-Francàs, Naia, Santillo, Dafna et al.·British journal of pharmacology·2017

This review looked at all available research on treatments for ME/CFS to see what actually helps patients. The researchers found that while some treatments like behavioral therapy, pacing strategies, and nutritional supplements show promise, the evidence is still limited because most studies were small and used different methods. The authors conclude that personalized pacing and treating nutritional deficiencies are reasonable approaches, but much larger and better-designed studies are urgently needed to know what really works.

E0 ConsensusReviewPEM not requiredReview-Narrative

Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study.

Mahjoub, Fatemeh, Salari, Roshanak, Noras, Mohammad Reza et al.·Journal of evidence-based complementary & alternative medicine·2017

This study looked at how traditional Persian medicine approaches fibromyalgia and ME/CFS, which are conditions that cause widespread pain and extreme tiredness. The researchers compared ancient Persian medical texts, particularly writings by the physician Avicenna, with modern understanding of these diseases. They found that traditional medicine recognized fatigue as a complex condition with different types, each with distinct symptoms.

Pain and Sensitization

E0 ConsensusReviewPEM unclearReview-Narrative

Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways.

Morris, Gerwyn, Anderson, George, Maes, Michael·Molecular neurobiology·2017

This review examines why people with ME/CFS often have low cortisol levels (a stress hormone). The researchers found that the problem likely starts with an overactive immune system producing excessive inflammatory markers, which then damages the body's stress-hormone system. This is important because it suggests the low cortisol is a consequence of the disease, not its cause.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Practical management of chronic fatigue syndrome or myalgic encephalomyelitis in childhood.

Brigden, Amberly, Loades, Maria, Abbott, Anna et al.·Archives of disease in childhood·2017

This article provides practical guidance on how doctors should diagnose and treat ME/CFS in children and teenagers. ME/CFS is a serious condition that affects at least 1 in 100 secondary school students in the UK, causing severe fatigue and limiting daily activities. Although effective treatments exist, many young people with ME/CFS don't get diagnosed or receive help they need.

Diagnostics

E0 ConsensusReviewPEM unclearSystematic-Review

Children's experiences of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review and meta-ethnography of qualitative studies.

Parslow, Roxanne M, Harris, Sarah, Broughton, Jessica et al.·BMJ open·2017

This study reviewed 10 research papers about how children with ME/CFS experience their illness. The researchers found that ME/CFS causes major disruption to children's lives, affecting their ability to go to school, see friends, and plan their futures. Children struggle when doctors don't recognize or understand their condition, but they cope better when they have support from family, friends, and healthcare providers who believe their illness is real.

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Evidence browser

Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Measuring School Functioning in Students With Chronic Fatigue Syndrome: A Systematic Review.

Antibodies Against GPCR.

Effectiveness of Mindfulness- and Relaxation-Based eHealth Interventions for Patients with Medical Conditions: a Systematic Review and Synthesis.

A Review Study on the Beneficial Effects of Baduanjin.

A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Evidence for an autoimmune disease.

Exercise therapy is a beneficial intervention for chronic fatigue syndrome (PEDro synthesis).

Cognitive behavioural therapy in the treatment of chronic fatigue syndrome: A narrative review on efficacy and informed consent.

Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome.

Cognitive behaviour therapy and objective assessments in chronic fatigue syndrome.

Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.

Exercise therapy for chronic fatigue syndrome.

[Chronic Fatigue Syndrome: A Critical Review].

Pediatric chronic fatigue syndrome: current perspectives.

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome.

Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study.

Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways.

Practical management of chronic fatigue syndrome or myalgic encephalomyelitis in childhood.

Children's experiences of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review and meta-ethnography of qualitative studies.

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